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The map label for this gene is menA [H]

Identifier: 118478469

GI number: 118478469

Start: 3009162

End: 3010073

Strand: Reverse

Name: menA [H]

Synonym: BALH_2841

Alternate gene names: 118478469

Gene position: 3010073-3009162 (Counterclockwise)

Preceding gene: 118478470

Following gene: 118478468

Centisome position: 57.26

GC content: 37.83

Gene sequence:

>912_bases
ATGGGGACAGAAAAAGAAATTAGTTCCGCTAAATTAATATGGAAGATGACGCGCCCGCATACGTTAACGGCGACGTTTTC
TCCTGTAATTTTAGGAACAGTGGCATCACTTTATGTTGCCAAAATTGATTGGCTGTTATTTATTGCGATGATGGTTGCAT
GTTTAGCATTGCAAATCGCAACGAACTTATTTAATGAGTACTATGATTTCAAACGTGGATTAGATACCGCTGATTCTGTT
GGCATCGGTGGCGGAATTGTCCGTCATGGATTGAAACCAAAAAATGTGTTAACAGTTGCGCTTTTATTGTATGTAGTAGC
AGCAATTATTGGAGTTTATATTTGTATGAATAGTAGCTGGTGGTTAGTCGTCATCGGTTTAATTGGAATGGCGGTTGGCT
ATTTATATACAGGTGGTCCATTACCAATTGCCTACACTCCGTTTGGAGAATTAGTTTCTGGCTTGTTAATGGGGATATGT
TTTGTACTCATTGCTTTCTTTATTCAAACGAATACGATAACGATTGAAAGTGTATTGATTTCCATTCCAATTGGAATTTT
AGTCGGTGCAATCAACATGTCAAATAATATCCGGGATATCGAAGAAGATATTAAAGGTGGAAGAAAGACGTTAGTAATCC
TTCTCGGGAGAGAGAAAGCAGTGGTAACACTTGCTATAGCCTTTTTCATTGCTTATTTATGGATCGCGGTAATTGTATTG
ATGGGTTATATAAGCCCTTGGGCATTAGTGATGTTCCTAGGTTTGAGAAAGCCAATTTCTGCCATTCAAAGTTTCCAAAA
AGGAGCAAAAGATCCCGGGTATATGCGCATCGCTATGAAATCAACAGCGATGACAAATACGATTTTTGGCTTCTTATTAT
CAGCAGGATTACTAATTAGTTACTTGTTTTAA

Upstream 100 bases:

>100_bases
CACCAATTCATTTTTTGCTATAATAGATGCGTGGCAGAAAACAGATAGAAAGATACTGCTAGTAATTTATACTTAAAATG
TAGGGAGATTGAACTGAGTT

Downstream 100 bases:

>100_bases
ATAAAAATATTGTTAAGTGAATTAACCCCAATTTCTCAATTTTACTATGGAGAGATTGGGGTTTTTATTTTGACTAAGTT
TAACGTTAAGAGTCGAAATG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MGTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMVACLALQIATNLFNEYYDFKRGLDTADSV
GIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSWWLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGIC
FVLIAFFIQTNTITIESVLISIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAVVTLAIAFFIAYLWIAVIVL
MGYISPWALVMFLGLRKPISAIQSFQKGAKDPGYMRIAMKSTAMTNTIFGFLLSAGLLISYLF

Sequences:

>Translated_303_residues
MGTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMVACLALQIATNLFNEYYDFKRGLDTADSV
GIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSWWLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGIC
FVLIAFFIQTNTITIESVLISIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAVVTLAIAFFIAYLWIAVIVL
MGYISPWALVMFLGLRKPISAIQSFQKGAKDPGYMRIAMKSTAMTNTIFGFLLSAGLLISYLF
>Mature_302_residues
GTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMVACLALQIATNLFNEYYDFKRGLDTADSVG
IGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSWWLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGICF
VLIAFFIQTNTITIESVLISIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAVVTLAIAFFIAYLWIAVIVLM
GYISPWALVMFLGLRKPISAIQSFQKGAKDPGYMRIAMKSTAMTNTIFGFLLSAGLLISYLF

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=232, Percent_Identity=31.0344827586207, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1790365, Length=298, Percent_Identity=26.1744966442953, Blast_Score=89, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737429, Length=290, Percent_Identity=27.5862068965517, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32994; Mature: 32863

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMVACLALQIA
CCCCHHHHHHHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNLFNEYYDFKRGLDTADSVGIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSW
HHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
WLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGICFVLIAFFIQTNTITIESVLI
HHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAVVTLAIAFFIAYLWIAVIVL
HHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
MGYISPWALVMFLGLRKPISAIQSFQKGAKDPGYMRIAMKSTAMTNTIFGFLLSAGLLIS
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
YLF
HCC
>Mature Secondary Structure 
GTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMVACLALQIA
CCCHHHHHHHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNLFNEYYDFKRGLDTADSVGIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSW
HHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
WLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGICFVLIAFFIQTNTITIESVLI
HHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAVVTLAIAFFIAYLWIAVIVL
HHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
MGYISPWALVMFLGLRKPISAIQSFQKGAKDPGYMRIAMKSTAMTNTIFGFLLSAGLLIS
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
YLF
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]