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The map label for this gene is kinA [H]

Identifier: 118478434

GI number: 118478434

Start: 2962079

End: 2964346

Strand: Reverse

Name: kinA [H]

Synonym: BALH_2802

Alternate gene names: 118478434

Gene position: 2964346-2962079 (Counterclockwise)

Preceding gene: 118478435

Following gene: 118478433

Centisome position: 56.39

GC content: 32.76

Gene sequence:

>2268_bases
ATGTTCTTTTCTTTTCCATACATGGGATTTTCCTACGATCTTCGAGTTGTTCCTCTTATTCTATCTTTTATTTACTTTGG
TCGTATTGCTGGTTGCATTACGTTAATTAGCATAATTATAATGCGCATTTTTCACATAGGAGGGTATTGGGAACCTCCTG
TGATTGCTTATTTAGGTATGAGTATCCTGTTTGTTAGTTTTAAAACATATTTTAAAAACCTTCATCCTTTTAAAAGTGCA
TCTTTATATTTTTCTGTTTTTGTCGGAATAAAGTGGTTAGTTGGCGTATTATTTAATACTACATTACTTTACACAGGAGG
CTTATTATATATAGCGTTAGGACTTTTAATTGGGCTATTTCTTATGGAAGCTTACCAGAGATTGTATTATTTAACAAAGG
ACTTATCTAAAATGAATCGAGAATTAAAAAAATCGAAGCAAGAACTTACAGATACCGTACATGAGCTTCAAGGAGGAATT
TTTAAATTTAAAAAAGTGGGTAAGCACTTTATACACACTTTATGTGATGGACAGTTTTATTATCAAAACGGATTTTACTC
TGAACAGGTGGTAGGAAAAAGCTTACGTACTATTGATGCTTCTATTATTCCTCCACATTTAGTTCCACAATTGATGAAGT
ACTATCTTCAGGCATGGGAAGGAAAAGAAATTATATTTGAATTACCTTGGCCAAATGATAAAACTATTATTCTTATTGCG
CTTAGGCCGATTAAACGAAATGGACAAGTTATTGAAGTTGTTGGTTCTACAGTCGATATAACCGAAAGGAAAAAGGTAGA
ATCAGAATTAAGCGCTACCAAAGAATTATTAGAATCATTTATAAAGCACAATCTAGATGCTATTACCATTTCTGATCGAG
AAGGGCATATTTTACAAGCGAATAAAGCTTATGAAAAGATATTTGGGTGGTCATCACAAGAAATCATAGGTAAGAGATTA
CCTTGTGTACCAGATTTTTTAATGGAAGAATCGCTTAAAAATATTCGGAAAATTCTAACGGGTGAATCTGTAGTTACTAG
ATTAGAAACTGTTAGACAACGTAACGATGGGAGTCTTCTTGATGTCAGTTTGACAGTTTCTCCTATACTAGATGTAAGAG
GAAATGTGATAGCTTTATCAGCAATATGTAGAGACATCTCTGAAAGGAAACAAGCAGAAAGAGAACGGCATCGATTACAC
CAGCAATTAAGAGATAGTGAAATGAAATACCGTGCACTAATCGAACAAGCAACTGATGCGGTATATGTAGTAGAGCTGAA
TGAAGATAATGCTCCAAGTCGATTTATTGAGGTAAACCCTGTTGGGTGTAGAAGATTTGGATATAGTAGAGAAGAGTTGC
TCTCATTATCATTTTCAAATATAGTACCACAAGATTCTCAAATGATCGTAAGGTTATTAGAAAAAATTAAAAAGGGACAA
ACTTCCTTCACTTTGCAAGATGAATATGTTTTTCCAACAGGAAAAGTAATAACAACTGAGTTTAGTGTTCGTGTTTTTAA
CTTAAATGGTAAAAAAGTTTTCCTAAGTATTTCTCGTGATATCACTGAACGGCTAAAAACAGAAGAATTATTACGAAAAT
CTGAAAAACTTGCTGTTGTAGGACAATTAGCGACTGTAATGGCTCATGAGATTAATAATCCATTAACTGCAATGAAAGGG
TTCATGCAATTACTAAAATCAACGAAAAATGAGAATAATCAGGGTTATATTAATATAGTATCATCAGAGATTGAGCGTAT
AGAGAGCATAACAACTGAATTTATGGCGGTAGCCAAACCACAGGTGGTAAAAATACAACCTAATGATATTAGTGTGCTAA
TGGATCAAGTTTTAATGCTACTACAACCTCAAGCAATGATGAATAATATAAAATTTAGAATCGATCTTAACCCTGGTATT
CCATTGATTTCATGTGAAGGAAATCAATTAAAACAAGTATTTGTTAATATATTAAAAAATGCAATTGAATCTATGCCGAT
GGGAGGGGAAATTCTAATTCAATTAAATATACTTGATAATAATCAATTAAGCATTTGTTTTATCGATCAAGGGTGTGGGA
TTCCAAAAGAACGTATACCATACCTCGGAGAACCTTTTTATAGTATTAAAGAAGAGGGGATTGGCTTAGGGTTAATGATC
TGTTATAAAATCATTGAAACACATAAGGGAAAGGTATTTATTGAGAGTGAAGTGAATAAGGGGACTATAGTTGAAGTCAC
TCTCCCTATTTGTACACTTCAAAATTAA

Upstream 100 bases:

>100_bases
TTCTTTATTAGTTAGCGCAGCAATATTTATTCAAGTGTTTACAATTAATTCCAATTGATATTTCGAAAAGCTCTATGGAG
GGATTATTGCAGTTACGTTA

Downstream 100 bases:

>100_bases
TATATTCTTTTACTGAAATTTTTAAGAAACCATACAGAATGTAATGCTAATGTTAATTAATGAAATAATAAAGAGAAGAA
CACTGGTAAAATTGTACCCT

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Sensor histidine kinase E [H]

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MFFSFPYMGFSYDLRVVPLILSFIYFGRIAGCITLISIIIMRIFHIGGYWEPPVIAYLGMSILFVSFKTYFKNLHPFKSA
SLYFSVFVGIKWLVGVLFNTTLLYTGGLLYIALGLLIGLFLMEAYQRLYYLTKDLSKMNRELKKSKQELTDTVHELQGGI
FKFKKVGKHFIHTLCDGQFYYQNGFYSEQVVGKSLRTIDASIIPPHLVPQLMKYYLQAWEGKEIIFELPWPNDKTIILIA
LRPIKRNGQVIEVVGSTVDITERKKVESELSATKELLESFIKHNLDAITISDREGHILQANKAYEKIFGWSSQEIIGKRL
PCVPDFLMEESLKNIRKILTGESVVTRLETVRQRNDGSLLDVSLTVSPILDVRGNVIALSAICRDISERKQAERERHRLH
QQLRDSEMKYRALIEQATDAVYVVELNEDNAPSRFIEVNPVGCRRFGYSREELLSLSFSNIVPQDSQMIVRLLEKIKKGQ
TSFTLQDEYVFPTGKVITTEFSVRVFNLNGKKVFLSISRDITERLKTEELLRKSEKLAVVGQLATVMAHEINNPLTAMKG
FMQLLKSTKNENNQGYINIVSSEIERIESITTEFMAVAKPQVVKIQPNDISVLMDQVLMLLQPQAMMNNIKFRIDLNPGI
PLISCEGNQLKQVFVNILKNAIESMPMGGEILIQLNILDNNQLSICFIDQGCGIPKERIPYLGEPFYSIKEEGIGLGLMI
CYKIIETHKGKVFIESEVNKGTIVEVTLPICTLQN

Sequences:

>Translated_755_residues
MFFSFPYMGFSYDLRVVPLILSFIYFGRIAGCITLISIIIMRIFHIGGYWEPPVIAYLGMSILFVSFKTYFKNLHPFKSA
SLYFSVFVGIKWLVGVLFNTTLLYTGGLLYIALGLLIGLFLMEAYQRLYYLTKDLSKMNRELKKSKQELTDTVHELQGGI
FKFKKVGKHFIHTLCDGQFYYQNGFYSEQVVGKSLRTIDASIIPPHLVPQLMKYYLQAWEGKEIIFELPWPNDKTIILIA
LRPIKRNGQVIEVVGSTVDITERKKVESELSATKELLESFIKHNLDAITISDREGHILQANKAYEKIFGWSSQEIIGKRL
PCVPDFLMEESLKNIRKILTGESVVTRLETVRQRNDGSLLDVSLTVSPILDVRGNVIALSAICRDISERKQAERERHRLH
QQLRDSEMKYRALIEQATDAVYVVELNEDNAPSRFIEVNPVGCRRFGYSREELLSLSFSNIVPQDSQMIVRLLEKIKKGQ
TSFTLQDEYVFPTGKVITTEFSVRVFNLNGKKVFLSISRDITERLKTEELLRKSEKLAVVGQLATVMAHEINNPLTAMKG
FMQLLKSTKNENNQGYINIVSSEIERIESITTEFMAVAKPQVVKIQPNDISVLMDQVLMLLQPQAMMNNIKFRIDLNPGI
PLISCEGNQLKQVFVNILKNAIESMPMGGEILIQLNILDNNQLSICFIDQGCGIPKERIPYLGEPFYSIKEEGIGLGLMI
CYKIIETHKGKVFIESEVNKGTIVEVTLPICTLQN
>Mature_755_residues
MFFSFPYMGFSYDLRVVPLILSFIYFGRIAGCITLISIIIMRIFHIGGYWEPPVIAYLGMSILFVSFKTYFKNLHPFKSA
SLYFSVFVGIKWLVGVLFNTTLLYTGGLLYIALGLLIGLFLMEAYQRLYYLTKDLSKMNRELKKSKQELTDTVHELQGGI
FKFKKVGKHFIHTLCDGQFYYQNGFYSEQVVGKSLRTIDASIIPPHLVPQLMKYYLQAWEGKEIIFELPWPNDKTIILIA
LRPIKRNGQVIEVVGSTVDITERKKVESELSATKELLESFIKHNLDAITISDREGHILQANKAYEKIFGWSSQEIIGKRL
PCVPDFLMEESLKNIRKILTGESVVTRLETVRQRNDGSLLDVSLTVSPILDVRGNVIALSAICRDISERKQAERERHRLH
QQLRDSEMKYRALIEQATDAVYVVELNEDNAPSRFIEVNPVGCRRFGYSREELLSLSFSNIVPQDSQMIVRLLEKIKKGQ
TSFTLQDEYVFPTGKVITTEFSVRVFNLNGKKVFLSISRDITERLKTEELLRKSEKLAVVGQLATVMAHEINNPLTAMKG
FMQLLKSTKNENNQGYINIVSSEIERIESITTEFMAVAKPQVVKIQPNDISVLMDQVLMLLQPQAMMNNIKFRIDLNPGI
PLISCEGNQLKQVFVNILKNAIESMPMGGEILIQLNILDNNQLSICFIDQGCGIPKERIPYLGEPFYSIKEEGIGLGLMI
CYKIIETHKGKVFIESEVNKGTIVEVTLPICTLQN

Specific function: Phosphorylates the sporulation-regulatory protein spo0A under biofilm growth conditions. Also able to weakly phosphorylate spo0F [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=368, Percent_Identity=29.8913043478261, Blast_Score=165, Evalue=1e-41,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=27.1966527196653, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI48994928, Length=456, Percent_Identity=22.3684210526316, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1790300, Length=306, Percent_Identity=24.8366013071895, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786600, Length=282, Percent_Identity=22.3404255319149, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=266, Percent_Identity=28.1954887218045, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=248, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=23.4513274336283, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 86064; Mature: 86064

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCEEEEECCCCCEEEEEEECEEECCC
>Mature Secondary Structure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HHHHHHCCCCCEEEEECCCCCEEEEEEECEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]