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The map label for this gene is kynU

Identifier: 118478121

GI number: 118478121

Start: 2641705

End: 2642991

Strand: Reverse

Name: kynU

Synonym: BALH_2478

Alternate gene names: 118478121

Gene position: 2642991-2641705 (Counterclockwise)

Preceding gene: 118478123

Following gene: 118478120

Centisome position: 50.27

GC content: 37.14

Gene sequence:

>1287_bases
ATGTATAAAGAACCATTTCAACCAACTTATGAGTATGCGCTTGAATGTGATAAACATGATGAACTGAAAGATTTTCAAAC
TGAATTTTATAAAAAAGAAGGAACAATATATTTAGATGGAAACTCATTAGGGCTACTTTCAAAAAGAGCAGAGAAATCGT
TATTTACGTTGCTAGATTCATGGAAAGAGTATGGCATTGACGGCTGGACCGAGGGTGAGCATCCGTGGTTTTTCCTTTCG
GAGAAATTAGGTGAATTGACTGCACCTCTTATTGGAGCTTTACCGGAAGAAACTATTGTAACCGGTTCCACGACAACGAA
TATTCATCAAGTAATCGCAACTTTCTATGAGCCGAAAGGAATTCGGACAAAAATTCTTGCGGATGAATTAACATTTCCGT
CAGATATATATGCACTTCAAAGTCAAATTCGTTTAAAGGGCCTAGATCCAGATGAGCATTTAGTACGAGTGAAGAGCCGA
GATGGTAGAACACTTTCTGAAGATGATATTATTCATGCGATGACAGATGATGTCGCTTTAATTTTATTGCCTTCTGTACT
GTATAGAAGCGGCCAAATTCTTGATATGAAACGTTTAACAGCGGAAGCGCATAAGCGTGGTATTCATATCGGGTTCGATT
TATGTCACTCAATCGGTTCTATTCCGCATCATTTCAAAGAATGGGATGTTGATTTCGCTATTTGGTGTAATTATAAATAC
TTAAACGCAGGACCTGGTGGTGTTGCTGGCCTTTATGTAAATAAAAAACATTTTAATAGACTTCCAGGCTTGTCTGGCTG
GTTTAGTTCTAGAAAAGATAAGCAGTTTGATATGGAACATACATTAACTGCAGCAGACCATGCCGGTGCATATCAAATTG
GTACTCCTCATGTATTAAGTACAGCGCCGTTAATCGGCTCTCTTGAAATTTTTAAAGAGGCTGGTATAGAGCGTTTACGT
GAAAAATCTCTACATATTACAAGATTCATGCTTAATTTAATTGCTCATGAATTAAGTGATTTTGGATTTACAATTGGAAA
TCCATTAGAGGATGAAAAACGAGGCGGGCATATTTATTTAGAGCATGCAGAAGCAGCACGTATATGTAAAGCGTTAAAAG
CAAATGGAGTAATTCCAGATTTTAGAGCGCCAAATGGAGTGAGACTTGCGCCAGTTGCTTTATATAACACATACGAAGAA
GTGTGGCATTCTGTTCAAATATTAAAGAAAATCATGAAAGATGAAGAATATAAGCAGTTTGAAAATAAGCGAGAGGTTGT
GGCATAA

Upstream 100 bases:

>100_bases
TATATAAAGTCAACTGACATAATATCATTGACGTTATATCAACTAAGGTGATATATTTCAATTAGTTAGAATAAAAAGAA
AATTAAGAGAAGGTGACACC

Downstream 100 bases:

>100_bases
GTATGAAAACATCAGAGTGGATTGATATTTCACAACCGCTAAATAATGATATTGCTACTTGGCCAGGGGATACACCATTC
TCGTATGAAGTTTCATGGTC

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLFTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSR
DGRTLSEDDIIHAMTDDVALILLPSVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
LNAGPGGVAGLYVNKKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLSTAPLIGSLEIFKEAGIERLR
EKSLHITRFMLNLIAHELSDFGFTIGNPLEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWHSVQILKKIMKDEEYKQFENKREVVA

Sequences:

>Translated_428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLFTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSR
DGRTLSEDDIIHAMTDDVALILLPSVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
LNAGPGGVAGLYVNKKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLSTAPLIGSLEIFKEAGIERLR
EKSLHITRFMLNLIAHELSDFGFTIGNPLEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWHSVQILKKIMKDEEYKQFENKREVVA
>Mature_428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLFTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSR
DGRTLSEDDIIHAMTDDVALILLPSVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
LNAGPGGVAGLYVNKKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLSTAPLIGSLEIFKEAGIERLR
EKSLHITRFMLNLIAHELSDFGFTIGNPLEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWHSVQILKKIMKDEEYKQFENKREVVA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family

Homologues:

Organism=Homo sapiens, GI4504937, Length=446, Percent_Identity=33.8565022421525, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI74101437, Length=285, Percent_Identity=35.4385964912281, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17550466, Length=391, Percent_Identity=35.0383631713555, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6323261, Length=450, Percent_Identity=34.8888888888889, Blast_Score=244, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KYNU_BACAH (A0REX2)

Other databases:

- EMBL:   CP000485
- RefSeq:   YP_895272.1
- ProteinModelPortal:   A0REX2
- SMR:   A0REX2
- STRING:   A0REX2
- EnsemblBacteria:   EBBACT00000069457
- GeneID:   4542619
- GenomeReviews:   CP000485_GR
- KEGG:   btl:BALH_2478
- NMPDR:   fig|412694.5.peg.2406
- eggNOG:   COG3844
- GeneTree:   EBGT00050000000895
- HOGENOM:   HBG523016
- OMA:   MTDDIAL
- ProtClustDB:   CLSK904618
- BioCyc:   BTHU412694:BALH_2478-MONOMER
- GO:   GO:0005737
- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR14084
- TIGRFAMs:   TIGR01814

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =3.7.1.3

Molecular weight: Translated: 48637; Mature: 48637

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: BINDING 104-104 BINDING 105-105 BINDING 213-213 BINDING 216-216 BINDING 238-238 BINDING 267-267 BINDING 295-295

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLFTLLDS
CCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WKEYGIDGWTEGEHPWFFLSEKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKG
HHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCC
IRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSRDGRTLSEDDIIHAMTDDVAL
CEEEEEHHHCCCCHHHHHHHHHHEECCCCCHHHEEEEECCCCCCCCCCCEEHHHHCCHHH
ILLPSVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
HHHHHHHHCCCCEEHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHCCCCEEEEEEEEE
LNAGPGGVAGLYVNKKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLS
EECCCCCEEEEEEEHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCCEECCCCCHHC
TAPLIGSLEIFKEAGIERLREKSLHITRFMLNLIAHELSDFGFTIGNPLEDEKRGGHIYL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
EHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEEVWHSVQILKKIMKDEEYKQF
ECHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ENKREVVA
HHHHCCCC
>Mature Secondary Structure
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLFTLLDS
CCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WKEYGIDGWTEGEHPWFFLSEKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKG
HHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCC
IRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSRDGRTLSEDDIIHAMTDDVAL
CEEEEEHHHCCCCHHHHHHHHHHEECCCCCHHHEEEEECCCCCCCCCCCEEHHHHCCHHH
ILLPSVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
HHHHHHHHCCCCEEHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHCCCCEEEEEEEEE
LNAGPGGVAGLYVNKKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLS
EECCCCCEEEEEEEHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCCEECCCCCHHC
TAPLIGSLEIFKEAGIERLREKSLHITRFMLNLIAHELSDFGFTIGNPLEDEKRGGHIYL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
EHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEEVWHSVQILKKIMKDEEYKQF
ECHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ENKREVVA
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA