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The map label for this gene is estA [H]

Identifier: 118478106

GI number: 118478106

Start: 2629968

End: 2630822

Strand: Direct

Name: estA [H]

Synonym: BALH_2462

Alternate gene names: 118478106

Gene position: 2629968-2630822 (Clockwise)

Preceding gene: 118478105

Following gene: 118478109

Centisome position: 50.03

GC content: 37.08

Gene sequence:

>855_bases
ATGACCGAAAAGATATTTAAAATAAACGGGATTGATATATGTACAGAAAGCTTTGGGAATCCTAAAAACCCAGCTATTTT
ATTAATTATGGGTGCAACATGTTCAATGATTTATTGGGATGAAGAGTTTTGTGAACGGTTGGCTAACAGCGGGAAATTTG
TTATTCGTTTTGATAACCGTGATGTCGGACGCTCTGTTGCATATGAACCAGGAGCTTCCAATTATACCGTTACAGATATG
GCTGAAGATGCAATTGGGGTATTAGATGCTTATCATATTGATAAGGCGCATCTATTTGGTATGTCATTAGGTGGTATGAT
TGCTCAAATCGCTGCTGTAAAACATCCGGAAAGAATTTTAACGTTAACATTACTAGCTACAAGTGTGATAGGGTCTGACA
ATAATACTCGTAATTTACCACCAATGGATGAAAGAATTTTAACACATCACGCAAATGGCGCACATTTAGATTGGACAAAC
AAAAATGTTATATCAGAATATTTAATTTCAGGATATCGCCTATTATGTGGATCAAAACGTACATTTGATGAAACAAGGAG
TTACAAACAAGTCAAACAAGAAATTGAACGAGCTAACAATTTATTAAGCATGTTTAATCACGCTTTACTTCAAGGCGATG
ATGCATATGAAGGGGCGCTTCACTCCATACAAGCACCTACATTAGTCATTCACGGAACAGACGATACTGCACTCCCTTTT
GAACATGGTCTCGCACTTATTGATGAAATTCCTAACTCAGCTCTAGTAACCCTTGAAGGCGCAGGACATGAAAATCATCC
TGATGATTGGGAAGACATCATTCATGCAGTTACTGAGCATACATCTAAATTATAG

Upstream 100 bases:

>100_bases
TTTGGGGGTAATTATGCAAGAAACAAAGCAAATCTTATGCACCGTAGAGTCATTCAAAATTGTATTTTAAATTAAATTCA
AAAGAAATGGAGAGAACTCT

Downstream 100 bases:

>100_bases
ATAAATAACGAATAGAAGGGGCACATCACAATTTGTGTCCCCTCTATTCGTTACATGTAAAAAAGCCCATCATTGTATCC
GTATGTATAATGATGGGCAA

Product: carboxylesterase

Products: alcohol; carboxylate

Alternate protein names: Aminohydrolase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MTEKIFKINGIDICTESFGNPKNPAILLIMGATCSMIYWDEEFCERLANSGKFVIRFDNRDVGRSVAYEPGASNYTVTDM
AEDAIGVLDAYHIDKAHLFGMSLGGMIAQIAAVKHPERILTLTLLATSVIGSDNNTRNLPPMDERILTHHANGAHLDWTN
KNVISEYLISGYRLLCGSKRTFDETRSYKQVKQEIERANNLLSMFNHALLQGDDAYEGALHSIQAPTLVIHGTDDTALPF
EHGLALIDEIPNSALVTLEGAGHENHPDDWEDIIHAVTEHTSKL

Sequences:

>Translated_284_residues
MTEKIFKINGIDICTESFGNPKNPAILLIMGATCSMIYWDEEFCERLANSGKFVIRFDNRDVGRSVAYEPGASNYTVTDM
AEDAIGVLDAYHIDKAHLFGMSLGGMIAQIAAVKHPERILTLTLLATSVIGSDNNTRNLPPMDERILTHHANGAHLDWTN
KNVISEYLISGYRLLCGSKRTFDETRSYKQVKQEIERANNLLSMFNHALLQGDDAYEGALHSIQAPTLVIHGTDDTALPF
EHGLALIDEIPNSALVTLEGAGHENHPDDWEDIIHAVTEHTSKL
>Mature_283_residues
TEKIFKINGIDICTESFGNPKNPAILLIMGATCSMIYWDEEFCERLANSGKFVIRFDNRDVGRSVAYEPGASNYTVTDMA
EDAIGVLDAYHIDKAHLFGMSLGGMIAQIAAVKHPERILTLTLLATSVIGSDNNTRNLPPMDERILTHHANGAHLDWTNK
NVISEYLISGYRLLCGSKRTFDETRSYKQVKQEIERANNLLSMFNHALLQGDDAYEGALHSIQAPTLVIHGTDDTALPFE
HGLALIDEIPNSALVTLEGAGHENHPDDWEDIIHAVTEHTSKL

Specific function: May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Hydrolase RutD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR019913 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.1.1.1

Molecular weight: Translated: 31459; Mature: 31328

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKIFKINGIDICTESFGNPKNPAILLIMGATCSMIYWDEEFCERLANSGKFVIRFDNR
CCCCEEEECCCEEEHHHCCCCCCCEEEEEECCCEEEEEECHHHHHHHHCCCCEEEEECCC
DVGRSVAYEPGASNYTVTDMAEDAIGVLDAYHIDKAHLFGMSLGGMIAQIAAVKHPERIL
CCCCEEEECCCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHH
TLTLLATSVIGSDNNTRNLPPMDERILTHHANGAHLDWTNKNVISEYLISGYRLLCGSKR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHEECCCCC
TFDETRSYKQVKQEIERANNLLSMFNHALLQGDDAYEGALHSIQAPTLVIHGTDDTALPF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCH
EHGLALIDEIPNSALVTLEGAGHENHPDDWEDIIHAVTEHTSKL
HHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEKIFKINGIDICTESFGNPKNPAILLIMGATCSMIYWDEEFCERLANSGKFVIRFDNR
CCCEEEECCCEEEHHHCCCCCCCEEEEEECCCEEEEEECHHHHHHHHCCCCEEEEECCC
DVGRSVAYEPGASNYTVTDMAEDAIGVLDAYHIDKAHLFGMSLGGMIAQIAAVKHPERIL
CCCCEEEECCCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHH
TLTLLATSVIGSDNNTRNLPPMDERILTHHANGAHLDWTNKNVISEYLISGYRLLCGSKR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHEECCCCC
TFDETRSYKQVKQEIERANNLLSMFNHALLQGDDAYEGALHSIQAPTLVIHGTDDTALPF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCH
EHGLALIDEIPNSALVTLEGAGHENHPDDWEDIIHAVTEHTSKL
HHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: carboxylic ester; H2O

Specific reaction: A carboxylic ester + H2O = an alcohol + a carboxylate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA