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The map label for this gene is nprE [H]

Identifier: 118478097

GI number: 118478097

Start: 2619096

End: 2620841

Strand: Reverse

Name: nprE [H]

Synonym: BALH_2452

Alternate gene names: 118478097

Gene position: 2620841-2619096 (Counterclockwise)

Preceding gene: 118478098

Following gene: 118478096

Centisome position: 49.85

GC content: 35.05

Gene sequence:

>1746_bases
TTGTACAAGCTTTCTATTTCAAAAATTATACGAGGTGAAAAAATGAAAAACAAAAAGACGTTAACTAAGGTAGCATTAAC
AACGGGTTTAGCTTTAACAGCAGTAGCACCATACGGAGTAGGTCATGCAGAGGAAACAGATCAACTACAAGTTCAAATTC
AGGAGGAATCGTTCCGTTCGGGTGAACTTACACAACCGTCACAAAAGGCACCAGAGAATGTAGTAAAAGATGCTCTGAAG
GAGAAAACAGAACAAGCTCTTTCTCCAAAGCAAGTCAATGGAGAAACAGGAGTAGATTATAAAGTTCTTCAAAAACGTGG
TTCATATGATGGGACTACACTTGTACGTATTCAGCAAACATACAAAGGGAAAGAAGTATATGGCCATCAATTAACTGCAC
ACGTAGATAATAGCGGTGTTATTAAAAGTGTTTCAGGTGATAGTGCGCAAAATTTAAAACAAGAAGAATTGAAAAAACCT
ATCAATCTATCAAAAGATGAAGCAACACAATATATTTATACGAAGTACGGGAACGACATCAATTTTATTTCTGAGCCAGA
AGTTAAAGAAGTTATTTTTGTTGATGAAAATAACGGACAAGCTAGTAATGCATATCAGGTTACATTTGAAGCTGCAACAC
CAAACTATGTTTCCGGAACTTATTTAATAAATGCACAAAATGGTGATATGTTAAAAAATATGGTACAACAATCTAACTTA
AAAGCAAGTGAAAAACTAGTTGGAGCCCTAAAGAAAAGTAAAAAAAGCAGTCTTACATCATTAACGGGCACTGGAAAAGA
TGATTTAGGTATTTCTCGTTCATTTGGTATCTCTAAACAAAGTAATGGCAAATATGCTCTGGCTGATTATACAAGAGGGC
AAGGGATTGAAACATATGATGTGAATTACAGAGATATTACGAAAGAAGAAAGCTATTATCCTGGTACATTAGCAACTAGT
ACTTCAACAACATTTAACGATCCAAAAGCAGTAAGTGCTCATTACTTAGCAACAAAAGTTTTTGATTTTTATAAAGATAA
ATACAATCGTAATAGCTTTGATAATCAGGGACAAAAGGTAGTTTCAGTTGTACATGCTTGGGATTCTGGAGATACGAATG
ATCCGAAAAATTGGCAGAATGCGTTAAGTGCTAATAATGGTAGTATGCTTGTATATGGAGATCCTATCGTCAAAGCATAT
GACGTAGCTGGGCATGAATTTACACATGCTGTTACTTCTAGTGAATCTAATCTTGAATATTACGGTGAATCTGGTGCGAT
TAATGAGGCACTATCTGATATTATGGGAACATCTATTGAGAAATATGTGAATAATGGAAGCTTTAACTGGACGATGGGAG
AACAAACTGGATCTGTCTTCCGTGATATGGAAAACCCAGCTTCTGTTCCATCTTCACTTGGAGTACCTTATCCAGATGAT
TACAGTGAATTTAATGATTTTAATGGATGGGATCAAGGTGGCGTTCATTTTAATTCAAGCATTATTAATAAAGTTGCGTA
TCTCATCGCAAAAGGCGGAACTCATAACGGTGTAACTGTTAAAGGAATTGGTGAAGATAAAATGTTTGATATTTTCTATT
ACGCCAATACAGATGAGTTAAACATGACTTCTAATTTCAAAGAATTGAGATCAGCATGTATTCGAGTGGCAACTAATAAA
TATGGTGCAAATTCAGCTGAAGTTCAAGCAGTACAAAAGGCATTTGATGCAGCAAAAATTAAGTAA

Upstream 100 bases:

>100_bases
TTTCTTAATTTGTATCATGGTCCTTATATTATGTAATTTTGCATAATGTTACATAAATTGTGTATTTTCCCTTTTTTTCG
ACAGAAACAGCAAGTATACT

Downstream 100 bases:

>100_bases
GTTAGAAATATAGTTCTTATTTATATATTAATACATTATGAAAAAACAGCTAATGTCATTTTAAGGATATTAGCTGTTTT
TTTGTATCAATGTATTGTTG

Product: extracellular neutral metalloprotease, bacillolysin

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MYKLSISKIIRGEKMKNKKTLTKVALTTGLALTAVAPYGVGHAEETDQLQVQIQEESFRSGELTQPSQKAPENVVKDALK
EKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQTYKGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKP
INLSKDEATQYIYTKYGNDINFISEPEVKEVIFVDENNGQASNAYQVTFEAATPNYVSGTYLINAQNGDMLKNMVQQSNL
KASEKLVGALKKSKKSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATS
TSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKVVSVVHAWDSGDTNDPKNWQNALSANNGSMLVYGDPIVKAY
DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTGSVFRDMENPASVPSSLGVPYPDD
YSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSACIRVATNK
YGANSAEVQAVQKAFDAAKIK

Sequences:

>Translated_581_residues
MYKLSISKIIRGEKMKNKKTLTKVALTTGLALTAVAPYGVGHAEETDQLQVQIQEESFRSGELTQPSQKAPENVVKDALK
EKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQTYKGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKP
INLSKDEATQYIYTKYGNDINFISEPEVKEVIFVDENNGQASNAYQVTFEAATPNYVSGTYLINAQNGDMLKNMVQQSNL
KASEKLVGALKKSKKSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATS
TSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKVVSVVHAWDSGDTNDPKNWQNALSANNGSMLVYGDPIVKAY
DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTGSVFRDMENPASVPSSLGVPYPDD
YSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSACIRVATNK
YGANSAEVQAVQKAFDAAKIK
>Mature_581_residues
MYKLSISKIIRGEKMKNKKTLTKVALTTGLALTAVAPYGVGHAEETDQLQVQIQEESFRSGELTQPSQKAPENVVKDALK
EKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQTYKGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKP
INLSKDEATQYIYTKYGNDINFISEPEVKEVIFVDENNGQASNAYQVTFEAATPNYVSGTYLINAQNGDMLKNMVQQSNL
KASEKLVGALKKSKKSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATS
TSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKVVSVVHAWDSGDTNDPKNWQNALSANNGSMLVYGDPIVKAY
DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTGSVFRDMENPASVPSSLGVPYPDD
YSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSACIRVATNK
YGANSAEVQAVQKAFDAAKIK

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 63886; Mature: 63886

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKLSISKIIRGEKMKNKKTLTKVALTTGLALTAVAPYGVGHAEETDQLQVQIQEESFRS
CEEECHHHHHCCCHHCCHHHHHHHHHHHCHHHEEECCCCCCCCCCCCEEEEEEECCCCCC
GELTQPSQKAPENVVKDALKEKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQT
CCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECC
YKGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKPINLSKDEATQYIYTKYGNDI
CCCCHHCCCEEEEEECCCCEEEECCCCCHHHCCHHHHHCCCCCCHHHHHEEEEEEECCCC
NFISEPEVKEVIFVDENNGQASNAYQVTFEAATPNYVSGTYLINAQNGDMLKNMVQQSNL
CCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCEECEEEEEECCCCHHHHHHHHHCCC
KASEKLVGALKKSKKSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYD
CHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEE
VNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKV
CCHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VSVVHAWDSGDTNDPKNWQNALSANNGSMLVYGDPIVKAYDVAGHEFTHAVTSSESNLEY
HHHHHHCCCCCCCCCHHHHHHHCCCCCCEEEECCCCEEEEECCCCHHHHHHCCCCCCCEE
YGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTGSVFRDMENPASVPSSLGVPYPDD
ECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCHHCCCHHCCCCCCCC
YSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDEL
HHHCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCC
NMTSNFKELRSACIRVATNKYGANSAEVQAVQKAFDAAKIK
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYKLSISKIIRGEKMKNKKTLTKVALTTGLALTAVAPYGVGHAEETDQLQVQIQEESFRS
CEEECHHHHHCCCHHCCHHHHHHHHHHHCHHHEEECCCCCCCCCCCCEEEEEEECCCCCC
GELTQPSQKAPENVVKDALKEKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQT
CCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECC
YKGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKPINLSKDEATQYIYTKYGNDI
CCCCHHCCCEEEEEECCCCEEEECCCCCHHHCCHHHHHCCCCCCHHHHHEEEEEEECCCC
NFISEPEVKEVIFVDENNGQASNAYQVTFEAATPNYVSGTYLINAQNGDMLKNMVQQSNL
CCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCEECEEEEEECCCCHHHHHHHHHCCC
KASEKLVGALKKSKKSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYD
CHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEE
VNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKV
CCHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VSVVHAWDSGDTNDPKNWQNALSANNGSMLVYGDPIVKAYDVAGHEFTHAVTSSESNLEY
HHHHHHCCCCCCCCCHHHHHHHCCCCCCEEEECCCCEEEEECCCCHHHHHHCCCCCCCEE
YGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTGSVFRDMENPASVPSSLGVPYPDD
ECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCHHCCCHHCCCCCCCC
YSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDEL
HHHCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCC
NMTSNFKELRSACIRVATNKYGANSAEVQAVQKAFDAAKIK
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]