Click here to switch to the map view.

The map label for this gene is mutX [H]

Identifier: 118478063

GI number: 118478063

Start: 2588589

End: 2589110

Strand: Direct

Name: mutX [H]

Synonym: BALH_2418

Alternate gene names: 118478063

Gene position: 2588589-2589110 (Clockwise)

Preceding gene: 118478062

Following gene: 118478064

Centisome position: 49.24

GC content: 29.31

Gene sequence:

>522_bases
ATGTACAAGCACACTTTATGTTTCATAAAAAGAAATGAAGAGATACTTATGCTAAATAGAAAATATGACCCTGTAAAAGG
GTTATGGAATGGTGTAGGAGGAAAGATAGAAAAGGGAGAAACACCTCTAGAAAATGCAATTCGTGAAATAAAAGAAGAGA
CTAATATAAAAGTTACGCATGATCAAATTCAATTTAAAGGCATTATTAAGTGGGAGGATTCTTCATATTCTGGCGGAATG
TATATTTATCTAGTAGAGTTACTTCATGAATTTATATATCACACTCCAAAAAAAGTCTCAGAAGGAATTCTAGATTGGAA
AGAGATTTCTTGGATTCTAAGTGACTATAATTACGGTGTAGGAGAGATGATACCTAAATTTTTAGTTGAAGTACTCTACA
ATGAATTAATATTAGAGCACAATTTTGTTTTATCTAATCATAAATTAATAAATTATAGGAATCAGAAATTGGTTAAGCAG
GATAGGTTACTTACTTCTTTATATAATACTATTCGCTTATAA

Upstream 100 bases:

>100_bases
TCTATGAGACCAATATTAATTGAAGCAGGGACACAATCTGCAGCAATCCATCTTATATCTCCAGTAAGAGCTTATTAAAA
ACGGAGGAAGGAATCAAATT

Downstream 100 bases:

>100_bases
ATAACAAACTAAGAGAAAATGAAAATTTCAGATAGGAGATTCGATATGTGGACAACAAATATTATCAAAACTCCAAGAGG
AAAGTTTGAATATTTTCTAA

Product: MutT/Nudix family protein

Products: dAMP; pyrophosphate [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MYKHTLCFIKRNEEILMLNRKYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTHDQIQFKGIIKWEDSSYSGGM
YIYLVELLHEFIYHTPKKVSEGILDWKEISWILSDYNYGVGEMIPKFLVEVLYNELILEHNFVLSNHKLINYRNQKLVKQ
DRLLTSLYNTIRL

Sequences:

>Translated_173_residues
MYKHTLCFIKRNEEILMLNRKYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTHDQIQFKGIIKWEDSSYSGGM
YIYLVELLHEFIYHTPKKVSEGILDWKEISWILSDYNYGVGEMIPKFLVEVLYNELILEHNFVLSNHKLINYRNQKLVKQ
DRLLTSLYNTIRL
>Mature_173_residues
MYKHTLCFIKRNEEILMLNRKYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTHDQIQFKGIIKWEDSSYSGGM
YIYLVELLHEFIYHTPKKVSEGILDWKEISWILSDYNYGVGEMIPKFLVEVLYNELILEHNFVLSNHKLINYRNQKLVKQ
DRLLTSLYNTIRL

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 20524; Mature: 20524

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKHTLCFIKRNEEILMLNRKYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTH
CCCCEEEEEECCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEEEE
DQIQFKGIIKWEDSSYSGGMYIYLVELLHEFIYHTPKKVSEGILDWKEISWILSDYNYGV
CEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHCCCCH
GEMIPKFLVEVLYNELILEHNFVLSNHKLINYRNQKLVKQDRLLTSLYNTIRL
HHHHHHHHHHHHHHHHHHHCCEEECCCEEECHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYKHTLCFIKRNEEILMLNRKYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTH
CCCCEEEEEECCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEEEE
DQIQFKGIIKWEDSSYSGGMYIYLVELLHEFIYHTPKKVSEGILDWKEISWILSDYNYGV
CEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHCCCCH
GEMIPKFLVEVLYNELILEHNFVLSNHKLINYRNQKLVKQDRLLTSLYNTIRL
HHHHHHHHHHHHHHHHHHHCCEEECCCEEECHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]