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The map label for this gene is capA [H]

Identifier: 118477314

GI number: 118477314

Start: 1777602

End: 1778705

Strand: Reverse

Name: capA [H]

Synonym: BALH_1630

Alternate gene names: 118477314

Gene position: 1778705-1777602 (Counterclockwise)

Preceding gene: 118477318

Following gene: 118477307

Centisome position: 33.83

GC content: 35.14

Gene sequence:

>1104_bases
ATGAAAACTTTACTAAAACGATTTTTGTTAATAGCCTTTTGTATTACACCAATTGTTGTATTAATTAACCACTCTTTTAC
TTCAAAGGCGACAGACAAACCCGATTTCCAAAACAAATCTAGTAAAACTGCTTCAAAAAGCGACAAGAAAATAGAAGACC
CGGAAATTACACTCACCTTCTCTGGTGATACAATGTTCGATTGGCAATTACGTCCGGTAATCGAAAAAAACGGGGCTGAT
TACCCATTCCAGTATGTAAAAGAAGAAATAACAAAAGCTGATATTTCCTTCGTTAATTTAGAGTCAGCATTTACAACGAA
AGAAAAGAAAGCACCTGGACAATTGTTTTGGATTAAAAGTGATCCATCCACGCTTAAAGCTATAAAAAACACTGGATATG
ACATCGTAAATATTGGGAATAACCATACACTTGATTATGGTCAAGAGGGGTTACTAGACACAATCTCTCACGTAGAAAAA
TTAAAGTTCCCTTACATTGGAGCCGGAAAAAATGAAAAAGATGCATATACTGCACGAGAAATGACTGTAAAAGGAAAAAA
ATTCAAATTCCTTTCGTTCGTCCGATTTATGCCTGATTTTACTTGGGTAGCTGATGACAATAAACCTGGCGTTGCGAACG
GATATGATTTAAATCTTGTAACAAAAACAATTAAAGAGCAAAAGAAAGATGCAGACTATTTAATTATATATATGCATTGG
GGCGTTGAAAAATCAAATCGTCCGGTAGAATACCAAAAACAATATGCAAGTAAAATGGTTACAGCAGGAGCCGACGCGAT
TATTGGAAGTCACCCACATTGGTTACAAGGGTTTGAATATTATAATAACGTTCCTATCGCTTACTCCTTAGGAAACTTTT
TATTCCCAAGTTATGTGAGCGGGAAAAGCGCCGAGACTGGCGTATTAACTTTAACTTTTAAAGGAAAGGATGTCCAAATG
TCATTCAATCCTTATATCATTCGCAACAACCAAGTTTCCCCTGTAAATGAGGAAGAAAAGAAAAAAGCTCTACAATATTT
ACAAGAAGTTTCAACCGATGTAGAAATTGATGATACAGGGAAAATAATAAATAAACGCCACTAA

Upstream 100 bases:

>100_bases
AACATAAACCGCATTTTTTTGTATCTGTACATACACCAATTACTTTTTATAGACTCATTGCTAATCTAATTGCGAGATAA
ACTCAAAAGGGAAGGTATTT

Downstream 100 bases:

>100_bases
ACAGTACAAGATCCATTTCTCTGTAACATACATTAGAGAATAGGTGATGAATATGCTAAAGAGCTTATTAGAAAATATAG
TTCTCTTAGAAAATATCTAT

Product: capsule biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKTLLKRFLLIAFCITPIVVLINHSFTSKATDKPDFQNKSSKTASKSDKKIEDPEITLTFSGDTMFDWQLRPVIEKNGAD
YPFQYVKEEITKADISFVNLESAFTTKEKKAPGQLFWIKSDPSTLKAIKNTGYDIVNIGNNHTLDYGQEGLLDTISHVEK
LKFPYIGAGKNEKDAYTAREMTVKGKKFKFLSFVRFMPDFTWVADDNKPGVANGYDLNLVTKTIKEQKKDADYLIIYMHW
GVEKSNRPVEYQKQYASKMVTAGADAIIGSHPHWLQGFEYYNNVPIAYSLGNFLFPSYVSGKSAETGVLTLTFKGKDVQM
SFNPYIIRNNQVSPVNEEEKKKALQYLQEVSTDVEIDDTGKIINKRH

Sequences:

>Translated_367_residues
MKTLLKRFLLIAFCITPIVVLINHSFTSKATDKPDFQNKSSKTASKSDKKIEDPEITLTFSGDTMFDWQLRPVIEKNGAD
YPFQYVKEEITKADISFVNLESAFTTKEKKAPGQLFWIKSDPSTLKAIKNTGYDIVNIGNNHTLDYGQEGLLDTISHVEK
LKFPYIGAGKNEKDAYTAREMTVKGKKFKFLSFVRFMPDFTWVADDNKPGVANGYDLNLVTKTIKEQKKDADYLIIYMHW
GVEKSNRPVEYQKQYASKMVTAGADAIIGSHPHWLQGFEYYNNVPIAYSLGNFLFPSYVSGKSAETGVLTLTFKGKDVQM
SFNPYIIRNNQVSPVNEEEKKKALQYLQEVSTDVEIDDTGKIINKRH
>Mature_367_residues
MKTLLKRFLLIAFCITPIVVLINHSFTSKATDKPDFQNKSSKTASKSDKKIEDPEITLTFSGDTMFDWQLRPVIEKNGAD
YPFQYVKEEITKADISFVNLESAFTTKEKKAPGQLFWIKSDPSTLKAIKNTGYDIVNIGNNHTLDYGQEGLLDTISHVEK
LKFPYIGAGKNEKDAYTAREMTVKGKKFKFLSFVRFMPDFTWVADDNKPGVANGYDLNLVTKTIKEQKKDADYLIIYMHW
GVEKSNRPVEYQKQYASKMVTAGADAIIGSHPHWLQGFEYYNNVPIAYSLGNFLFPSYVSGKSAETGVLTLTFKGKDVQM
SFNPYIIRNNQVSPVNEEEKKKALQYLQEVSTDVEIDDTGKIINKRH

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 41735; Mature: 41735

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLLKRFLLIAFCITPIVVLINHSFTSKATDKPDFQNKSSKTASKSDKKIEDPEITLTF
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
SGDTMFDWQLRPVIEKNGADYPFQYVKEEITKADISFVNLESAFTTKEKKAPGQLFWIKS
CCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHCCEEEEEHHHHCCCCCCCCCEEEEEEC
DPSTLKAIKNTGYDIVNIGNNHTLDYGQEGLLDTISHVEKLKFPYIGAGKNEKDAYTARE
CCHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHH
MTVKGKKFKFLSFVRFMPDFTWVADDNKPGVANGYDLNLVTKTIKEQKKDADYLIIYMHW
EEECCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE
GVEKSNRPVEYQKQYASKMVTAGADAIIGSHPHWLQGFEYYNNVPIAYSLGNFLFPSYVS
CCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHCCCCEEEECCCHHCCHHCC
GKSAETGVLTLTFKGKDVQMSFNPYIIRNNQVSPVNEEEKKKALQYLQEVSTDVEIDDTG
CCCCCCEEEEEEECCCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEECCCC
KIINKRH
CCCCCCC
>Mature Secondary Structure
MKTLLKRFLLIAFCITPIVVLINHSFTSKATDKPDFQNKSSKTASKSDKKIEDPEITLTF
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
SGDTMFDWQLRPVIEKNGADYPFQYVKEEITKADISFVNLESAFTTKEKKAPGQLFWIKS
CCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHCCEEEEEHHHHCCCCCCCCCEEEEEEC
DPSTLKAIKNTGYDIVNIGNNHTLDYGQEGLLDTISHVEKLKFPYIGAGKNEKDAYTARE
CCHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHH
MTVKGKKFKFLSFVRFMPDFTWVADDNKPGVANGYDLNLVTKTIKEQKKDADYLIIYMHW
EEECCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE
GVEKSNRPVEYQKQYASKMVTAGADAIIGSHPHWLQGFEYYNNVPIAYSLGNFLFPSYVS
CCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHCCCCEEEECCCHHCCHHCC
GKSAETGVLTLTFKGKDVQMSFNPYIIRNNQVSPVNEEEKKKALQYLQEVSTDVEIDDTG
CCCCCCEEEEEEECCCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEECCCC
KIINKRH
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]