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The map label for this gene is yfnA [H]

Identifier: 118476280

GI number: 118476280

Start: 617520

End: 618935

Strand: Direct

Name: yfnA [H]

Synonym: BALH_0534

Alternate gene names: 118476280

Gene position: 617520-618935 (Clockwise)

Preceding gene: 118476279

Following gene: 118476281

Centisome position: 11.75

GC content: 37.08

Gene sequence:

>1416_bases
GTGGCCAACCTATTTAAAAAGAAATCCGTTACGCAATTGTTAGGGGAAAGTAAAAGTAAAACTTTAACGAAAACGCTAGG
GGCATTTGACCTAACAATGCTAGGGATTGGTGCGATAATTGGTACAGGAGTACTAGTATTAACAGGATTAGTAGCAGCAA
GAGATGCTGGTCCAGCAGTTATTTTTTCATTCATGATTGCAGCGATCGTTTGTGGATTTGCAGCGTTGTGTTATGCAGAA
GTTGCATCTACACTTCCGGTTTCAGGTAGTGTGTACACATATTCATATGCGACAATTGGTGAGTTTATTGCTCATCTAAT
GGGATGGACATTATTATCCGTATATGTCGTAACAACTGCCGCAGTAGCTGGTGGATGGACGGGTTATTTTAATAACTTAG
TAAGTGGATTTGGATTAGAAATTCCAACAGAGCTGTTAAAGATTCCATCACAAGGTGGGATTGTGAATTTACCAGCAGTA
GTTATTACATTAGTTTTAACTTGGTTACTATCAAGAGGTACGAAAGAAAGTAAGCGTGTGAATAACATAATGGTATTAAT
TAAAATTGGTATTGTTATTTTATTCATTGCAGTTGGTGCGTTTTATGTACAACCAGAAAACTGGACACCATTTGCACCAT
ACGGTATTAGCGGAATCTTTGCCGGCGGAGCAGCAGTATTCTTTGCTTTCTTAGGATTTGATGCATTAGCAACTTCTGCT
GAAGAAGTAAAAAATCCACAACGTGATTTACCGATTGGTATTATTGCTTCGTTAGTAATTTGTACAATCATTTATGTTGT
AGTTTGTCTCGTTATGACAGGTATGGTTTCTTATAAAGAGTTAGATGTACCAGAGGCTATGGCATATGTGTTAGAGGTTG
TCGGACAAGATAAAGTAGCAGGTGTAATCGCAGTTGGAGCTGTAATTGGTATTATGGCTGTAATCTTTGCTTACATTTAT
GCAACGACACGTGTATTCTTCGCGATGAGCCGTGACGGTTTATTACCAAAATCATTTGCGAAAATTAATAAGAAGACAGA
AGCGCCAGTATTTTCAACTTGGTTAACAGGTATTGGTAGTGCTTTAATTGCTGGATTTATCGATTTAAAAGAATTGTCGA
ATTTAGCGAATATTGGAGCATTGTTAACATTTGCGATGGTAGGTGTGTCAGTTATTATTCTTCGTAAAACACATCCGAAC
TTAAAACGAGGCTTTGTGGTACCACTTGTACCAACGCTACCGCTTATTTCAATCGCATGTTGTCTATTCTTAATGTTTAA
CCTACCATTAACAACATGGATTTACTTCGGTATTTGGTTAGCAATTGGAGTAGTTGTATACTTTGTATATTCGAAAAAGC
ATAGTCATTTAAAAGACGATGGAAGTTCGCAGGATAATTTAGAACAAGCTAATTAA

Upstream 100 bases:

>100_bases
AAGCATTATACAAAACAAAATCGAACAATATATAAACCAACATGATAAGAGCTAAGAGTGAATATCTCTTAGCTCTTCTT
GGCAAAAGGGGGCATACATC

Downstream 100 bases:

>100_bases
AAGCTGAATTAAAAGGGATATAAGATAGTAAGTCTTGTGCGTCTAGGGAGCGCGCAAGGCTTTTTTCTTTTGGGCAAAAT
GTATATTCTTTTTTGTATGA

Product: amino acid permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MANLFKKKSVTQLLGESKSKTLTKTLGAFDLTMLGIGAIIGTGVLVLTGLVAARDAGPAVIFSFMIAAIVCGFAALCYAE
VASTLPVSGSVYTYSYATIGEFIAHLMGWTLLSVYVVTTAAVAGGWTGYFNNLVSGFGLEIPTELLKIPSQGGIVNLPAV
VITLVLTWLLSRGTKESKRVNNIMVLIKIGIVILFIAVGAFYVQPENWTPFAPYGISGIFAGGAAVFFAFLGFDALATSA
EEVKNPQRDLPIGIIASLVICTIIYVVVCLVMTGMVSYKELDVPEAMAYVLEVVGQDKVAGVIAVGAVIGIMAVIFAYIY
ATTRVFFAMSRDGLLPKSFAKINKKTEAPVFSTWLTGIGSALIAGFIDLKELSNLANIGALLTFAMVGVSVIILRKTHPN
LKRGFVVPLVPTLPLISIACCLFLMFNLPLTTWIYFGIWLAIGVVVYFVYSKKHSHLKDDGSSQDNLEQAN

Sequences:

>Translated_471_residues
MANLFKKKSVTQLLGESKSKTLTKTLGAFDLTMLGIGAIIGTGVLVLTGLVAARDAGPAVIFSFMIAAIVCGFAALCYAE
VASTLPVSGSVYTYSYATIGEFIAHLMGWTLLSVYVVTTAAVAGGWTGYFNNLVSGFGLEIPTELLKIPSQGGIVNLPAV
VITLVLTWLLSRGTKESKRVNNIMVLIKIGIVILFIAVGAFYVQPENWTPFAPYGISGIFAGGAAVFFAFLGFDALATSA
EEVKNPQRDLPIGIIASLVICTIIYVVVCLVMTGMVSYKELDVPEAMAYVLEVVGQDKVAGVIAVGAVIGIMAVIFAYIY
ATTRVFFAMSRDGLLPKSFAKINKKTEAPVFSTWLTGIGSALIAGFIDLKELSNLANIGALLTFAMVGVSVIILRKTHPN
LKRGFVVPLVPTLPLISIACCLFLMFNLPLTTWIYFGIWLAIGVVVYFVYSKKHSHLKDDGSSQDNLEQAN
>Mature_470_residues
ANLFKKKSVTQLLGESKSKTLTKTLGAFDLTMLGIGAIIGTGVLVLTGLVAARDAGPAVIFSFMIAAIVCGFAALCYAEV
ASTLPVSGSVYTYSYATIGEFIAHLMGWTLLSVYVVTTAAVAGGWTGYFNNLVSGFGLEIPTELLKIPSQGGIVNLPAVV
ITLVLTWLLSRGTKESKRVNNIMVLIKIGIVILFIAVGAFYVQPENWTPFAPYGISGIFAGGAAVFFAFLGFDALATSAE
EVKNPQRDLPIGIIASLVICTIIYVVVCLVMTGMVSYKELDVPEAMAYVLEVVGQDKVAGVIAVGAVIGIMAVIFAYIYA
TTRVFFAMSRDGLLPKSFAKINKKTEAPVFSTWLTGIGSALIAGFIDLKELSNLANIGALLTFAMVGVSVIILRKTHPNL
KRGFVVPLVPTLPLISIACCLFLMFNLPLTTWIYFGIWLAIGVVVYFVYSKKHSHLKDDGSSQDNLEQAN

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of D-Alanine, D-Serine And Glycine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258614003, Length=424, Percent_Identity=37.0283018867925, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI258614005, Length=424, Percent_Identity=37.0283018867925, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI4507047, Length=432, Percent_Identity=36.3425925925926, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI258645169, Length=424, Percent_Identity=36.5566037735849, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI181337167, Length=393, Percent_Identity=35.3689567430025, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI110347453, Length=404, Percent_Identity=35.3960396039604, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI114326544, Length=432, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI114326550, Length=432, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI186910308, Length=476, Percent_Identity=26.0504201680672, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI186910306, Length=476, Percent_Identity=26.0504201680672, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI186910304, Length=476, Percent_Identity=26.0504201680672, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI33286428, Length=463, Percent_Identity=26.9978401727862, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI115648063, Length=454, Percent_Identity=25.9911894273128, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI115648022, Length=454, Percent_Identity=25.9911894273128, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI7657683, Length=402, Percent_Identity=26.3681592039801, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI71979932, Length=225, Percent_Identity=30.6666666666667, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI187423910, Length=449, Percent_Identity=24.0534521158129, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI7657591, Length=449, Percent_Identity=24.0534521158129, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI33286430, Length=245, Percent_Identity=28.9795918367347, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI9790235, Length=312, Percent_Identity=24.0384615384615, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790653, Length=442, Percent_Identity=24.2081447963801, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081869, Length=412, Percent_Identity=25, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788480, Length=352, Percent_Identity=25, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082023, Length=445, Percent_Identity=26.0674157303371, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081708, Length=492, Percent_Identity=20.1219512195122, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1786694, Length=399, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786302, Length=429, Percent_Identity=21.6783216783217, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789017, Length=407, Percent_Identity=24.0786240786241, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082250, Length=466, Percent_Identity=23.6051502145923, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI2367353, Length=336, Percent_Identity=24.4047619047619, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786908, Length=343, Percent_Identity=24.198250728863, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790584, Length=268, Percent_Identity=25.7462686567164, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=387, Percent_Identity=34.625322997416, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17533459, Length=409, Percent_Identity=34.4743276283619, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17531343, Length=404, Percent_Identity=32.1782178217822, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17537453, Length=383, Percent_Identity=24.2819843342037, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17540018, Length=199, Percent_Identity=29.6482412060301, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32566699, Length=380, Percent_Identity=24.4736842105263, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17568033, Length=441, Percent_Identity=22.4489795918367, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71982608, Length=455, Percent_Identity=22.1978021978022, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71982612, Length=455, Percent_Identity=22.1978021978022, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32566695, Length=334, Percent_Identity=23.6526946107784, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193208714, Length=334, Percent_Identity=23.6526946107784, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666159, Length=423, Percent_Identity=37.8250591016548, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI221512776, Length=423, Percent_Identity=37.8250591016548, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24668806, Length=420, Percent_Identity=34.7619047619048, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI21356285, Length=420, Percent_Identity=34.7619047619048, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24668802, Length=420, Percent_Identity=34.7619047619048, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24667468, Length=417, Percent_Identity=34.5323741007194, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI161077963, Length=406, Percent_Identity=36.2068965517241, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI281366235, Length=410, Percent_Identity=34.1463414634146, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI116007820, Length=410, Percent_Identity=34.1463414634146, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI116007818, Length=413, Percent_Identity=34.1404358353511, Blast_Score=208, Evalue=8e-54,
Organism=Drosophila melanogaster, GI85725152, Length=413, Percent_Identity=34.1404358353511, Blast_Score=208, Evalue=8e-54,
Organism=Drosophila melanogaster, GI21357367, Length=443, Percent_Identity=27.9909706546275, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI221331183, Length=467, Percent_Identity=26.7665952890792, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17647653, Length=467, Percent_Identity=26.7665952890792, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24664379, Length=467, Percent_Identity=26.7665952890792, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45550968, Length=474, Percent_Identity=26.3713080168776, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921172, Length=474, Percent_Identity=26.3713080168776, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24651635, Length=414, Percent_Identity=25.3623188405797, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24651633, Length=414, Percent_Identity=25.3623188405797, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641995, Length=400, Percent_Identity=24.5, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641993, Length=400, Percent_Identity=24.5, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50293; Mature: 50162

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ANLFKKKSVTQLLGESKSKTLTKTLGAFDLTMLGIGAIIGTGVLVLTGLVAARDAGPAV
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]