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The map label for this gene is ciaH [H]

Identifier: 118476260

GI number: 118476260

Start: 591025

End: 592275

Strand: Direct

Name: ciaH [H]

Synonym: BALH_0512

Alternate gene names: 118476260

Gene position: 591025-592275 (Clockwise)

Preceding gene: 118476259

Following gene: 118476261

Centisome position: 11.24

GC content: 34.77

Gene sequence:

>1251_bases
ATGAAAAAGGGAAGCATGTTTCAGAAGACGCGTATTCGATTGACTATATTGAATTCATTAGTATTTATCATTTTGATAGG
CGTATTAGGTAGTATCATTTATTCTTACACATATAAGCGTATTTATAGTGGAGTAAATGAATCGATAGAAAAAGCCGTTC
AACATAGAAAGAATGCAGATGATAAAAAACTACCTAAAAAAATTAGGGGATATCCTCCAATTGGGGATCCAAGGATAATG
GAGTTAACTTGGCTTGGAAATACGGTGGAGATAGATATTGAAAACGGCAAACGTCGTTTTATTTTTGAAGACAATTTGGA
AAAGTTTTCTCCAAAGAAATTAGGAACTTTGCAAGATATAGAAGTACAAGGACGATATTTTAGAATATTTGCATTTCAGA
AAGATGCAAAAATAGTTCAAATTGCAAGGGATATAACGGCTGAAAAAGAAATGTTACATACTTTATTTTTAATTCTTGTG
ATAGGGTGTAGCATAGGAAGTCTATGTGCAATAGGAATCGGATTTTTCTTAGCTGGCAGGGCACTCGTACCTATTCAAAA
TTCATGGGAAAAACAGCAACAATTTGTGTCGGACGCATCACATGAATTAAGGACACCGCTTGCGGTTATTCAATCCAAAA
CAGATATATTATTTCAGTCACCATCTGCGACAATAGAAGAAAAAGCGATGGATATTTCTACGATTTCAAAGGAGTGTAGA
CGATTATCTAAGCTTGTAGCTAATTTATTATTGTTAGCACGTTCAGATTCTAATCAAATTGAGATGGATAAGAAAATATT
TGAATTGGATAAATTGTTAGAAGAAATAGTAGAGCCATATAAGGAAATTGCTTCCTACCAAGAAAAAGAGATGATATTGA
AAGTAGAGCATGACATATCATTTATGGGTGATAGGGAGAGAATTCATCAAATGATGGTCATATTGTTAGATAATGCGATG
AAGTATACAAATGAGGGAGGACATATACAAATCGATTGTACGCAAACGAACAGTTCGATTCGTATACGAGTGAAAGATGA
TGGGATAGGAGTGAAACGCGAGGACATTCCGAAACTATTTGATCGTTTTTATCAAGGAGATAAAGCAAGAAGTACGTCAG
AAGGAGCGGGATTAGGCCTTTCAATCGCAAATTGGATTGTAGAAAAGCATTATGGGAAAATATCAGTAGAGAGCAGATGG
GGAGAGGGCACTTGTTTTGAAGTGATTCTTCCGAAAAACCAAAGAATATAA

Upstream 100 bases:

>100_bases
TAGAAGTGTATGTACATCATTTACGTAAAAAATTAGAGCCATTCGGTTATCAGAAAGATATTCAAACCGTTCGTGGTATT
GGATATATATTAAAAGAACA

Downstream 100 bases:

>100_bases
GTGAGAAGACGATCTTGTTTTTACAAGGTCGTCTTTTTTAAGGGAAAGTTAAGAAACTATTTATAACATGTATGATATAC
GGAAAGTTCGCCCTATAAAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKKGSMFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIM
ELTWLGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILV
IGCSIGSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECR
RLSKLVANLLLLARSDSNQIEMDKKIFELDKLLEEIVEPYKEIASYQEKEMILKVEHDISFMGDRERIHQMMVILLDNAM
KYTNEGGHIQIDCTQTNSSIRIRVKDDGIGVKREDIPKLFDRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESRW
GEGTCFEVILPKNQRI

Sequences:

>Translated_416_residues
MKKGSMFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIM
ELTWLGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILV
IGCSIGSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECR
RLSKLVANLLLLARSDSNQIEMDKKIFELDKLLEEIVEPYKEIASYQEKEMILKVEHDISFMGDRERIHQMMVILLDNAM
KYTNEGGHIQIDCTQTNSSIRIRVKDDGIGVKREDIPKLFDRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESRW
GEGTCFEVILPKNQRI
>Mature_416_residues
MKKGSMFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIM
ELTWLGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILV
IGCSIGSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECR
RLSKLVANLLLLARSDSNQIEMDKKIFELDKLLEEIVEPYKEIASYQEKEMILKVEHDISFMGDRERIHQMMVILLDNAM
KYTNEGGHIQIDCTQTNSSIRIRVKDDGIGVKREDIPKLFDRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESRW
GEGTCFEVILPKNQRI

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=33.4763948497854, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.5964125560538, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=30.2631578947368, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=32, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=29.004329004329, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=31.3636363636364, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=27.0742358078603, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=28.3783783783784, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=24.4343891402715, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=27.1255060728745, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=27.3109243697479, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790551, Length=238, Percent_Identity=26.890756302521, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788713, Length=233, Percent_Identity=27.0386266094421, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787374, Length=222, Percent_Identity=27.027027027027, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=221, Percent_Identity=25.7918552036199, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=25.6038647342995, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=219, Percent_Identity=28.7671232876712, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=24.2152466367713, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789808, Length=220, Percent_Identity=26.3636363636364, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47558; Mature: 47558

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGSMFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNAD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DKKLPKKIRGYPPIGDPRIMELTWLGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDI
HHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEEEECCHHHCCCHHCCCCCCE
EVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILVIGCSIGSLCAIGIGFFLAGR
EECCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
ALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECR
EEECCCCCHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
RLSKLVANLLLLARSDSNQIEMDKKIFELDKLLEEIVEPYKEIASYQEKEMILKVEHDIS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCH
FMGDRERIHQMMVILLDNAMKYTNEGGHIQIDCTQTNSSIRIRVKDDGIGVKREDIPKLF
HCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHH
DRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESRWGEGTCFEVILPKNQRI
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MKKGSMFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNAD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DKKLPKKIRGYPPIGDPRIMELTWLGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDI
HHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEEEECCHHHCCCHHCCCCCCE
EVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILVIGCSIGSLCAIGIGFFLAGR
EECCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
ALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECR
EEECCCCCHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
RLSKLVANLLLLARSDSNQIEMDKKIFELDKLLEEIVEPYKEIASYQEKEMILKVEHDIS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCH
FMGDRERIHQMMVILLDNAMKYTNEGGHIQIDCTQTNSSIRIRVKDDGIGVKREDIPKLF
HCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHH
DRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESRWGEGTCFEVILPKNQRI
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]