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The map label for this gene is pphA [H]

Identifier: 118476258

GI number: 118476258

Start: 589503

End: 590207

Strand: Direct

Name: pphA [H]

Synonym: BALH_0510

Alternate gene names: 118476258

Gene position: 589503-590207 (Clockwise)

Preceding gene: 118476257

Following gene: 118476259

Centisome position: 11.21

GC content: 35.18

Gene sequence:

>705_bases
ATGAAAAGAATTCTTGTTATTAGTGATATTCATGGAGAGATAGAAAAGTTCGAACAGTTATTGGTAGAGGCTCAATACGA
TGTAAGGCAGGATCAATTAATTTTACTGGGGGATTATGTAGATCGTGGTCCAAATGCGTGTGCAGTAATTGAAAAAGTAA
AAGAGTTAAAAGAAGATGGAGCCTTCGTTCTAAAGGGCAATCATGAAGATATGATGATTAAGGCGTTAACGACAGATGAG
GAACGTTCATGGAACCATTGGGTAAAAAGGAATGGTGGAGATAAGACGTTATACAGCTATGGATTTGTAGAAGGAGATAT
TGTGGTTAATGAGGGGAATTTCAAAAAAACGATTTTACAATCTCGTGTATTAGAGAAACATGTAAAGTTTATTCAAAAAT
TAGACCATTACATTGAAACAGAAGAGTATATATTTGTACATGCTGGTGTTGAGCCATTGAAACGAGTTTCTGAATGTGAA
CCATATACGTTAATGTGGATCCGTAATGAGTTTCATAATGGATATAGTGGCGAAAAGGTTGTTGTATTTGGCCATACGGA
AACAAAAACGCTTCATGGAAATGATAATTGTAATGTCTATTTTGGAAATAACCGTATTATAGGAATTGATGGTGGTGCTG
TATATGGTGGCCAGCTAAATTGTTTAGAATTGCCGAGTAAAAAGGTGTACGTAGTAAAAAGTTGA

Upstream 100 bases:

>100_bases
GCTTTGTTTGTAATAAAAGTGATTCTGAATATGATTTCGGAAATTTCTGTCGTTTTGAACTATAATTATAAAGAGAGTGG
TTTAGAAAGAAGGGGATAAT

Downstream 100 bases:

>100_bases
AAGAGATAAGGAGAATCTTATTTCTTTCAACTTTTTATTAAGCAAAATTTAAGGAAGAGTTTTTATAATAAGTCTTTCAA
ATTTTATATCAAAAAAACGT

Product: serine/threonine protein phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKRILVISDIHGEIEKFEQLLVEAQYDVRQDQLILLGDYVDRGPNACAVIEKVKELKEDGAFVLKGNHEDMMIKALTTDE
ERSWNHWVKRNGGDKTLYSYGFVEGDIVVNEGNFKKTILQSRVLEKHVKFIQKLDHYIETEEYIFVHAGVEPLKRVSECE
PYTLMWIRNEFHNGYSGEKVVVFGHTETKTLHGNDNCNVYFGNNRIIGIDGGAVYGGQLNCLELPSKKVYVVKS

Sequences:

>Translated_234_residues
MKRILVISDIHGEIEKFEQLLVEAQYDVRQDQLILLGDYVDRGPNACAVIEKVKELKEDGAFVLKGNHEDMMIKALTTDE
ERSWNHWVKRNGGDKTLYSYGFVEGDIVVNEGNFKKTILQSRVLEKHVKFIQKLDHYIETEEYIFVHAGVEPLKRVSECE
PYTLMWIRNEFHNGYSGEKVVVFGHTETKTLHGNDNCNVYFGNNRIIGIDGGAVYGGQLNCLELPSKKVYVVKS
>Mature_234_residues
MKRILVISDIHGEIEKFEQLLVEAQYDVRQDQLILLGDYVDRGPNACAVIEKVKELKEDGAFVLKGNHEDMMIKALTTDE
ERSWNHWVKRNGGDKTLYSYGFVEGDIVVNEGNFKKTILQSRVLEKHVKFIQKLDHYIETEEYIFVHAGVEPLKRVSECE
PYTLMWIRNEFHNGYSGEKVVVFGHTETKTLHGNDNCNVYFGNNRIIGIDGGAVYGGQLNCLELPSKKVYVVKS

Specific function: Plays a key role in signaling protein misfolding via the CpxR/CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr an

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081988, Length=230, Percent_Identity=26.9565217391304, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR006186 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 26828; Mature: 26828

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRILVISDIHGEIEKFEQLLVEAQYDVRQDQLILLGDYVDRGPNACAVIEKVKELKEDG
CCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCC
AFVLKGNHEDMMIKALTTDEERSWNHWVKRNGGDKTLYSYGFVEGDIVVNEGNFKKTILQ
EEEEECCCCCEEEEEECCCCCCCCHHHHHCCCCCCEEEEECEEECCEEEECCCHHHHHHH
SRVLEKHVKFIQKLDHYIETEEYIFVHAGVEPLKRVSECEPYTLMWIRNEFHNGYSGEKV
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCEEEEEEEEHHCCCCCCCEE
VVFGHTETKTLHGNDNCNVYFGNNRIIGIDGGAVYGGQLNCLELPSKKVYVVKS
EEEECCCCEEEECCCCEEEEECCCEEEEECCCEEECCEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MKRILVISDIHGEIEKFEQLLVEAQYDVRQDQLILLGDYVDRGPNACAVIEKVKELKEDG
CCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCC
AFVLKGNHEDMMIKALTTDEERSWNHWVKRNGGDKTLYSYGFVEGDIVVNEGNFKKTILQ
EEEEECCCCCEEEEEECCCCCCCCHHHHHCCCCCCEEEEECEEECCEEEECCCHHHHHHH
SRVLEKHVKFIQKLDHYIETEEYIFVHAGVEPLKRVSECEPYTLMWIRNEFHNGYSGEKV
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCEEEEEEEEHHCCCCCCCEE
VVFGHTETKTLHGNDNCNVYFGNNRIIGIDGGAVYGGQLNCLELPSKKVYVVKS
EEEECCCCEEEECCCCEEEEECCCEEEEECCCEEECCEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9130712; 9097040; 9278503 [H]