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The map label for this gene is purC [H]

Identifier: 118476042

GI number: 118476042

Start: 327934

End: 328710

Strand: Direct

Name: purC [H]

Synonym: BALH_0285

Alternate gene names: 118476042

Gene position: 327934-328710 (Clockwise)

Preceding gene: 118476041

Following gene: 118476043

Centisome position: 6.24

GC content: 35.39

Gene sequence:

>777_bases
GTGCCATTCTTTATAAAAACATTATTCACATTTTTCAAACTACAGGGGGCTTGCGAAATGCAAAAGCTAGAATTGCTGTA
TGAAGGTAAGGCAAAAAGAATTTATCGTACAGAATCAGCAGATATGGTTTGGGTAGAGTACAAAGATAGTGCGACTGCTT
TCAATGGGGAGAAAAAAGAGACGATTACAGGAAAAGGTCGTTTGAACAATGAGATTACAACTTTATTGTTCAGAAAGTTA
CAAGAAGTAGGAATTAAAACACATTTTGTTGAGAAGTTATCTGAGACAGAGCAACTTGTTAAAAAAGTGAGTATTATTCC
TTTAGAAGTTGTCACAAGAAATGTAATTGCAGGAAGTCTTTCAAAACGATTAGGAATGGAAGAGGGAACTGTACTTGCAG
AACCAATCGTAGAATTTTACTTCAAAGATGATGATTTAGGAGATCCGCTTGTAACAGAAGATCATATTCGTGTATTAAAC
GTTGCATCGCCAGAGCAAGTAAGCGTATTACGAGATATGGCTCTACAAATCAATCAAGTGTTGATTGATCATTTCGCAAG
CTGTCGTGTAAGATTAGTAGATTTCAAATTAGAGTTTGGTGTAACGGATGAAGGAGAAATCATATTAGCAGATGAAATTT
CACCAGATACTTGCCGTTTATGGGATGAAACGAGCAATGAAAAGTTTGATAAAGACGTATTCCGTCGTGATCTTGGAAAT
TTAACAGATGCTTATGAAGAGATTTTAAAACGTTTAGGGGGAATTTCACATGTATAA

Upstream 100 bases:

>100_bases
TTTAACTATGAGCATCATATGCAACACGTTGATACAATCTTTGAACGCCTAGGATTAAACGAAGCGTAAAATTTCATATG
GCACAGAATAGAGTCATTCT

Downstream 100 bases:

>100_bases
AGTTAAGGTATATGTAACATTAAGAGAAAGCGTATTAGATCCACAAGGAACAGCAGTAAAAGGAGCACTTCATAGTCTTT
CATTCACAGAAGTACAAGAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MPFFIKTLFTFFKLQGACEMQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKL
QEVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLN
VASPEQVSVLRDMALQINQVLIDHFASCRVRLVDFKLEFGVTDEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGN
LTDAYEEILKRLGGISHV

Sequences:

>Translated_258_residues
MPFFIKTLFTFFKLQGACEMQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKL
QEVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLN
VASPEQVSVLRDMALQINQVLIDHFASCRVRLVDFKLEFGVTDEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGN
LTDAYEEILKRLGGISHV
>Mature_257_residues
PFFIKTLFTFFKLQGACEMQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKLQ
EVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLNV
ASPEQVSVLRDMALQINQVLIDHFASCRVRLVDFKLEFGVTDEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNL
TDAYEEILKRLGGISHV

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=236, Percent_Identity=34.7457627118644, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI5453539, Length=236, Percent_Identity=34.7457627118644, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI119220559, Length=243, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-25,
Organism=Escherichia coli, GI1788820, Length=234, Percent_Identity=43.5897435897436, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17531275, Length=232, Percent_Identity=37.9310344827586, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24583917, Length=249, Percent_Identity=30.9236947791165, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 29487; Mature: 29356

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFFIKTLFTFFKLQGACEMQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKE
CCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCC
TITGKGRLNNEITTLLFRKLQEVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSL
EEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQV
HHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
LIDHFASCRVRLVDFKLEFGVTDEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGN
HHHHHHHCEEEEEEEEEEECCCCCCCEEEECCCCCCHHCCCCCCCCCHHHHHHHHHHHCC
LTDAYEEILKRLGGISHV
HHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PFFIKTLFTFFKLQGACEMQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKE
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCC
TITGKGRLNNEITTLLFRKLQEVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSL
EEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQV
HHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
LIDHFASCRVRLVDFKLEFGVTDEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGN
HHHHHHHCEEEEEEEEEEECCCCCCCEEEECCCCCCHHCCCCCCCCCHHHHHHHHHHHCC
LTDAYEEILKRLGGISHV
HHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA