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The map label for this gene is hutH [H]

Identifier: 117919938

GI number: 117919938

Start: 1736785

End: 1738422

Strand: Direct

Name: hutH [H]

Synonym: Shewana3_1490

Alternate gene names: 117919938

Gene position: 1736785-1738422 (Clockwise)

Preceding gene: 117919937

Following gene: 117919939

Centisome position: 34.93

GC content: 51.83

Gene sequence:

>1638_bases
ATGAATAAATCCATATTGATGGCCTCACTCACCTTGAGTCTACTTTCAGGCAGCGCGCTCGCGATGGAGCAAGTTGTACT
CGATGGTAAACATTTAACCCAAGACCAAGCCTGGGCAATTGCCGATGGTGCAAAAGTGAAGATTGCACCTCAGGCCAAGA
CCCAACTCGTGAAAGCCAACGCACTACTGATGGAAGCGGCGCGTCTGGGCAAACCTGTGTATGGCTTAACCGTGGGCGTT
GGGCTAAACAAAGATCACAAGCTGTTCGATGCTAACGGTAAGTTGAGTGATGCCGTGCTCGACGCCTCTCGAAGCTTTAA
CCTCAGCACCCTGCGTGCCCACAGTGCCGGTGTCGGTGAAGCCGCGCCCATCCGCTTAACACGCTTAGCCTTAGCCGTGC
GGTTAAATACCATGTTGGCCGGACAAACCGGTGTGCAACCTGTGGTGGCCGAGCTTTATGAAGCCTATCTTAATCAGGGA
CTGACCCCTGTGATCCCAGCCAAGGGCACGGTAGGTGAAGCGGATATTCTGCTGTCATCCCATGTCGGTTTAGCCATGAT
TGGTGAATGGGAGGTGTTCTACAAAGGTCAGCGTGTGAGCAGTAAAGAGGCGATGGCAGATGCGGGGATCACGCCCTTAG
CGCCTATGGGGAAAGACGCGCTATCGATTTTGTCTAACAATGCCTTTGCAGTCGCCTATGCCATGCAAGGTTACCGTGAG
GCGAAGCAATTGTTGTCCGTATCGCCCACCGTCTTTGGCTTAAGCCTTGAGGGATTAAACGGTAACGTGGCGCCATTCTT
GCCGCAAACCAACGACATTCGGCCGTTCCCTTACATTAAATCGGCCACCAGTGACATTCTCAAGCAGCTCGATGGTAGCT
ATTTATGGCAGCTTAACGATGAGCGTCCATTACAGGATCCATTAAGCTTTAGAACCACGGCTTACACCTTTGCAGGCGCC
GAGCAGGCCCTAGCTTCATTAGTTGAAGTGATCAATATCCAAATCAACCATTCGGACGATAACCCAGCCGTGATTGTGGG
CGCGTCGAACCAGTATGCCCAGTTCCCACAAGTGGCTAAATATTTGGTCGAAGGGCAGGGCGGTGTGTTCCCTACCACAA
ACTTTGAGCCGCTGCCTGTGGCACTCGCGGTGCAAAACCTGAGTGTGGCCCTGACCCATGTGTCCCATAACAGTGTGATG
CGTACCATTCATCTGTCCGATGAGCACTTTACTAAGCTGACGCGCTTCCTGAGTGCTCCGGAGAATCAAGGCCATGCCTT
CGGTGCGATTCAAAAAGCCTTTGTGGATATGCAAGTGCGCAATAAGCAGTTAGCCACGCCAGTCTCCTTCGATGGGATCT
CTATCGCCGGCGGGATTGAAGATACCTTCACTAACCTTAAGTTGGCGTCGGATAACCTGATCCAAATCGTGGATAACACC
CGAGTCATCTACGGTTTAGAACTGTTGCACTCTACTCAAGCGATTGATTTACGTAAGCAAGCTCACCCAGAGCTACAACT
CGGCAAGGCCACGCAAGCCATGTACAAGGCCTACCGTGAAAAAGTGCCTTTTGTCGCCAAGGACCGTCCGTTTACCCCCG
ATATCCAAGCGTCAACTGACTTTATTGCAAACTATTAA

Upstream 100 bases:

>100_bases
CACTGGGCGTAATGCCGGTCGTAACTGCGCCGCGGCGAGTGCTGTGACGCTCAAGCAAGTTTAGTTTTTATCAAAAATAA
TAAAATGTTGGAGAATGATA

Downstream 100 bases:

>100_bases
TCTACGATGCGGGGCGCGATGCCCCGCCTAGGAAGACTCTGATGTTAAAACCCGTATTTATTCTATTACTCGGTGTCGTG
CTGGCAACGCCTATGGCCGC

Product: phenylalanine/histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MNKSILMASLTLSLLSGSALAMEQVVLDGKHLTQDQAWAIADGAKVKIAPQAKTQLVKANALLMEAARLGKPVYGLTVGV
GLNKDHKLFDANGKLSDAVLDASRSFNLSTLRAHSAGVGEAAPIRLTRLALAVRLNTMLAGQTGVQPVVAELYEAYLNQG
LTPVIPAKGTVGEADILLSSHVGLAMIGEWEVFYKGQRVSSKEAMADAGITPLAPMGKDALSILSNNAFAVAYAMQGYRE
AKQLLSVSPTVFGLSLEGLNGNVAPFLPQTNDIRPFPYIKSATSDILKQLDGSYLWQLNDERPLQDPLSFRTTAYTFAGA
EQALASLVEVINIQINHSDDNPAVIVGASNQYAQFPQVAKYLVEGQGGVFPTTNFEPLPVALAVQNLSVALTHVSHNSVM
RTIHLSDEHFTKLTRFLSAPENQGHAFGAIQKAFVDMQVRNKQLATPVSFDGISIAGGIEDTFTNLKLASDNLIQIVDNT
RVIYGLELLHSTQAIDLRKQAHPELQLGKATQAMYKAYREKVPFVAKDRPFTPDIQASTDFIANY

Sequences:

>Translated_545_residues
MNKSILMASLTLSLLSGSALAMEQVVLDGKHLTQDQAWAIADGAKVKIAPQAKTQLVKANALLMEAARLGKPVYGLTVGV
GLNKDHKLFDANGKLSDAVLDASRSFNLSTLRAHSAGVGEAAPIRLTRLALAVRLNTMLAGQTGVQPVVAELYEAYLNQG
LTPVIPAKGTVGEADILLSSHVGLAMIGEWEVFYKGQRVSSKEAMADAGITPLAPMGKDALSILSNNAFAVAYAMQGYRE
AKQLLSVSPTVFGLSLEGLNGNVAPFLPQTNDIRPFPYIKSATSDILKQLDGSYLWQLNDERPLQDPLSFRTTAYTFAGA
EQALASLVEVINIQINHSDDNPAVIVGASNQYAQFPQVAKYLVEGQGGVFPTTNFEPLPVALAVQNLSVALTHVSHNSVM
RTIHLSDEHFTKLTRFLSAPENQGHAFGAIQKAFVDMQVRNKQLATPVSFDGISIAGGIEDTFTNLKLASDNLIQIVDNT
RVIYGLELLHSTQAIDLRKQAHPELQLGKATQAMYKAYREKVPFVAKDRPFTPDIQASTDFIANY
>Mature_545_residues
MNKSILMASLTLSLLSGSALAMEQVVLDGKHLTQDQAWAIADGAKVKIAPQAKTQLVKANALLMEAARLGKPVYGLTVGV
GLNKDHKLFDANGKLSDAVLDASRSFNLSTLRAHSAGVGEAAPIRLTRLALAVRLNTMLAGQTGVQPVVAELYEAYLNQG
LTPVIPAKGTVGEADILLSSHVGLAMIGEWEVFYKGQRVSSKEAMADAGITPLAPMGKDALSILSNNAFAVAYAMQGYRE
AKQLLSVSPTVFGLSLEGLNGNVAPFLPQTNDIRPFPYIKSATSDILKQLDGSYLWQLNDERPLQDPLSFRTTAYTFAGA
EQALASLVEVINIQINHSDDNPAVIVGASNQYAQFPQVAKYLVEGQGGVFPTTNFEPLPVALAVQNLSVALTHVSHNSVM
RTIHLSDEHFTKLTRFLSAPENQGHAFGAIQKAFVDMQVRNKQLATPVSFDGISIAGGIEDTFTNLKLASDNLIQIVDNT
RVIYGLELLHSTQAIDLRKQAHPELQLGKATQAMYKAYREKVPFVAKDRPFTPDIQASTDFIANY

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=537, Percent_Identity=22.3463687150838, Blast_Score=119, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17567831, Length=536, Percent_Identity=20.8955223880597, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 58765; Mature: 58765

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSILMASLTLSLLSGSALAMEQVVLDGKHLTQDQAWAIADGAKVKIAPQAKTQLVKAN
CCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHH
ALLMEAARLGKPVYGLTVGVGLNKDHKLFDANGKLSDAVLDASRSFNLSTLRAHSAGVGE
HHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCCHHHHHHHCCCCCCCEEEEECCCCCCC
AAPIRLTRLALAVRLNTMLAGQTGVQPVVAELYEAYLNQGLTPVIPAKGTVGEADILLSS
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHEEEEC
HVGLAMIGEWEVFYKGQRVSSKEAMADAGITPLAPMGKDALSILSNNAFAVAYAMQGYRE
CCCEEEEECEEEEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHH
AKQLLSVSPTVFGLSLEGLNGNVAPFLPQTNDIRPFPYIKSATSDILKQLDGSYLWQLND
HHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECC
ERPLQDPLSFRTTAYTFAGAEQALASLVEVINIQINHSDDNPAVIVGASNQYAQFPQVAK
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCHHHHHHHH
YLVEGQGGVFPTTNFEPLPVALAVQNLSVALTHVSHNSVMRTIHLSDEHFTKLTRFLSAP
HHHCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHCCC
ENQGHAFGAIQKAFVDMQVRNKQLATPVSFDGISIAGGIEDTFTNLKLASDNLIQIVDNT
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHCCEEECCCCEEEEECCC
RVIYGLELLHSTQAIDLRKQAHPELQLGKATQAMYKAYREKVPFVAKDRPFTPDIQASTD
EEEEEHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCH
FIANY
HHCCC
>Mature Secondary Structure
MNKSILMASLTLSLLSGSALAMEQVVLDGKHLTQDQAWAIADGAKVKIAPQAKTQLVKAN
CCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHH
ALLMEAARLGKPVYGLTVGVGLNKDHKLFDANGKLSDAVLDASRSFNLSTLRAHSAGVGE
HHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCCHHHHHHHCCCCCCCEEEEECCCCCCC
AAPIRLTRLALAVRLNTMLAGQTGVQPVVAELYEAYLNQGLTPVIPAKGTVGEADILLSS
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHEEEEC
HVGLAMIGEWEVFYKGQRVSSKEAMADAGITPLAPMGKDALSILSNNAFAVAYAMQGYRE
CCCEEEEECEEEEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHH
AKQLLSVSPTVFGLSLEGLNGNVAPFLPQTNDIRPFPYIKSATSDILKQLDGSYLWQLND
HHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECC
ERPLQDPLSFRTTAYTFAGAEQALASLVEVINIQINHSDDNPAVIVGASNQYAQFPQVAK
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCHHHHHHHH
YLVEGQGGVFPTTNFEPLPVALAVQNLSVALTHVSHNSVMRTIHLSDEHFTKLTRFLSAP
HHHCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHCCC
ENQGHAFGAIQKAFVDMQVRNKQLATPVSFDGISIAGGIEDTFTNLKLASDNLIQIVDNT
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHCCEEECCCCEEEEECCC
RVIYGLELLHSTQAIDLRKQAHPELQLGKATQAMYKAYREKVPFVAKDRPFTPDIQASTD
EEEEEHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCH
FIANY
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]