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The map label for this gene is rfbD [C]

Identifier: 117919829

GI number: 117919829

Start: 1596531

End: 1597406

Strand: Direct

Name: rfbD [C]

Synonym: Shewana3_1381

Alternate gene names: 117919829

Gene position: 1596531-1597406 (Clockwise)

Preceding gene: 117919828

Following gene: 117919830

Centisome position: 32.11

GC content: 41.78

Gene sequence:

>876_bases
ATGAAAATATTAGTCACCGGAAGTAATGGCCAAGTAGGTAGCTGCCTAGTAAAACTCTTAAACCAGATACCAGAGATTGA
ATTTTTGGCTGTAGATCGTGAGCAGCTCGATATTACTGACTATGAAGCAGTAAACAAACTGGTTAGTGAATTCAAACCAG
ATGCCATTATTAATGCAGCGGCGCACACGGCTGTTGATAAAGCAGAGCAAGAAGTCGAACTTTCATATGCCATTAACCGT
GATGGTCCACAATTTTTAGCCCAAGCCGCCAATAGTGTTGGTGCAACCATACTACATATCTCAACCGACTATGTATTTGC
AGGTGATAAAGTTGGTGAGTATGTTGAAACTGATGAAGTTGCACCGCAAGGAATATATGGTAAAAGCAAACTCGCAGGCG
AACTTGCTGTTGCTGCAGCTTGCCCGCGTCATATTATTATGCGAACTGCTTGGGTATTTTGCGAAACTGGTAATAACTTT
ATAAAAACCATGCTTCGATTAGCGCAATCCCGTGATGAACTTGGCGTTGTGGCTGATCAATTTGGTGGCCCAACCTATGC
TGGTGATATCGCCAATACACTTATTGAAATAGCCCAAGCGCTGTATGCAGGCAATACTCACTATGGGATTTATCATTTTT
CTGGGTTGCCTCATGTTAGTTGGTATCAATTTTCCTGTCAGATCTTTAAGCAGGCCAAGGCTCAGAAGCTCGTTAGTAAA
GATATGCTAATAAACGGCATATCCTCTGAACAATACCCGACCCCTGTTAAACGTCCTGCTAACTCTAAATTGAGTTGTCG
AAAAATTGAGCAAACCTTTGGTGTTAAGCCCTGCGACTGGCAATCGGCTTTAAATAACTTAATGGGTTATTTTTAA

Upstream 100 bases:

>100_bases
AGTCTTGATTGCTTTGTGTTGAATGTTGAGTTTTCTGTCTCAGCATTCAGCATTCAGCATTCAGCATTTACTTACACCTC
ACAATTAACAATTCAACACT

Downstream 100 bases:

>100_bases
ATCATATTAGTTGCTTATTTCACTTCTAACTCATCCCCGGTATTAACAATTAAATTAAAGATTAACTATACACTAATTAT
ATGAAGATAATTAATACTAA

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKILVTGSNGQVGSCLVKLLNQIPEIEFLAVDREQLDITDYEAVNKLVSEFKPDAIINAAAHTAVDKAEQEVELSYAINR
DGPQFLAQAANSVGATILHISTDYVFAGDKVGEYVETDEVAPQGIYGKSKLAGELAVAAACPRHIIMRTAWVFCETGNNF
IKTMLRLAQSRDELGVVADQFGGPTYAGDIANTLIEIAQALYAGNTHYGIYHFSGLPHVSWYQFSCQIFKQAKAQKLVSK
DMLINGISSEQYPTPVKRPANSKLSCRKIEQTFGVKPCDWQSALNNLMGYF

Sequences:

>Translated_291_residues
MKILVTGSNGQVGSCLVKLLNQIPEIEFLAVDREQLDITDYEAVNKLVSEFKPDAIINAAAHTAVDKAEQEVELSYAINR
DGPQFLAQAANSVGATILHISTDYVFAGDKVGEYVETDEVAPQGIYGKSKLAGELAVAAACPRHIIMRTAWVFCETGNNF
IKTMLRLAQSRDELGVVADQFGGPTYAGDIANTLIEIAQALYAGNTHYGIYHFSGLPHVSWYQFSCQIFKQAKAQKLVSK
DMLINGISSEQYPTPVKRPANSKLSCRKIEQTFGVKPCDWQSALNNLMGYF
>Mature_291_residues
MKILVTGSNGQVGSCLVKLLNQIPEIEFLAVDREQLDITDYEAVNKLVSEFKPDAIINAAAHTAVDKAEQEVELSYAINR
DGPQFLAQAANSVGATILHISTDYVFAGDKVGEYVETDEVAPQGIYGKSKLAGELAVAAACPRHIIMRTAWVFCETGNNF
IKTMLRLAQSRDELGVVADQFGGPTYAGDIANTLIEIAQALYAGNTHYGIYHFSGLPHVSWYQFSCQIFKQAKAQKLVSK
DMLINGISSEQYPTPVKRPANSKLSCRKIEQTFGVKPCDWQSALNNLMGYF

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=290, Percent_Identity=29.3103448275862, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI11034825, Length=290, Percent_Identity=29.3103448275862, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1788352, Length=292, Percent_Identity=40.0684931506849, Blast_Score=223, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 31907; Mature: 31907

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGSNGQVGSCLVKLLNQIPEIEFLAVDREQLDITDYEAVNKLVSEFKPDAIINAA
CEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCHHCCCCHHHHHHHHHHHHCCCHHHHHH
AHTAVDKAEQEVELSYAINRDGPQFLAQAANSVGATILHISTDYVFAGDKVGEYVETDEV
HHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCEEEEEEECCEEEECCHHCCHHHHCCC
APQGIYGKSKLAGELAVAAACPRHIIMRTAWVFCETGNNFIKTMLRLAQSRDELGVVADQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHCCHHHCHHHHH
FGGPTYAGDIANTLIEIAQALYAGNTHYGIYHFSGLPHVSWYQFSCQIFKQAKAQKLVSK
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
DMLINGISSEQYPTPVKRPANSKLSCRKIEQTFGVKPCDWQSALNNLMGYF
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKILVTGSNGQVGSCLVKLLNQIPEIEFLAVDREQLDITDYEAVNKLVSEFKPDAIINAA
CEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCHHCCCCHHHHHHHHHHHHCCCHHHHHH
AHTAVDKAEQEVELSYAINRDGPQFLAQAANSVGATILHISTDYVFAGDKVGEYVETDEV
HHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCEEEEEEECCEEEECCHHCCHHHHCCC
APQGIYGKSKLAGELAVAAACPRHIIMRTAWVFCETGNNFIKTMLRLAQSRDELGVVADQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHCCHHHCHHHHH
FGGPTYAGDIANTLIEIAQALYAGNTHYGIYHFSGLPHVSWYQFSCQIFKQAKAQKLVSK
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
DMLINGISSEQYPTPVKRPANSKLSCRKIEQTFGVKPCDWQSALNNLMGYF
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]