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The map label for this gene is proC [H]

Identifier: 117919642

GI number: 117919642

Start: 1400185

End: 1401003

Strand: Reverse

Name: proC [H]

Synonym: Shewana3_1193

Alternate gene names: 117919642

Gene position: 1401003-1400185 (Counterclockwise)

Preceding gene: 117919643

Following gene: 117919641

Centisome position: 28.18

GC content: 50.67

Gene sequence:

>819_bases
ATGAGTCAACAAAAAATCTGCTTTATCGGTGCGGGCAATATGACCCGTAGTATTATCAGCGGCTTAATTCGTAGCGGCTA
TCCTGCTGCGCTAGTGCAAGCTACCAATCCTAGCCAAGGTAAACTCGATGCCCTCGCCGCCGACTTTGGTGTGCGTGTAT
CCCAAGACAATTTCAGCGCCGCCCAAGATGCCGATGTCATCGTATTATCCGTCAAGCCGCAGTTGATGGAGCAAGTCTGC
CAAGCACTGCAAGGCATTGATATGTCTAACAAGCTGGTCATTACCATTGCCGCAGGGATTAAAGCAGAGCGCTACAGCCA
ATATTTAGCGCAATCCATTACACTGGTTCGCACTATGCCAAACACGCCCATGCAAATCGGTGTTGGTATGACAGGTCTCT
ACGCGCCGCAGCCCCTCTCTGATGCCCAACAAGCCATTGCCGAACGCTTGATGTCCAGCGGCGGAGAAATTGTGTGGGTG
AATGAGGAGTCAGAGATTAATCAAGTGATTGCCCTTGCGGGTAGTTCACCTGCCTATTTCTTCCTGCTGATGGAATCTAT
GATTGATGCTGGCAAGCAAATGGGCATGGATGAAGCCAAAGCCAGAAGCTTAGTACAGCAAGCGGCCCTCGGTGCTGCTA
TGATGGCAAAGCAAAATCCTGAGCTTACGCTGGGTAATTTACGGGAGAATGTCACCTCGAAGGGCGGCACAACAGCGCAA
GCCATCGCCACATTTGAAGCGGCGGATCTCCGTGGTGTGGTCAAAAATGCGATGGAAAACTGCATCAAACGTGCAGAGGA
AATGGCCAATACTTTTTGA

Upstream 100 bases:

>100_bases
ACATTAAATAGAAATTTTTATCCGGCCTAATAACGCTAATTCAATGATATTAATGCTGAATGTTATCCACTCAGCCTAGG
CCAGACATTATGGGGTACAC

Downstream 100 bases:

>100_bases
TCCAGCAATGGCTGGGTGACTCACTCACTTTTAACGCGGGCGTTTTTAATCGGACTCATATAGGCAGAAATCTCGATGAA
TGCATTAACCTTTTTGATCA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSQQKICFIGAGNMTRSIISGLIRSGYPAALVQATNPSQGKLDALAADFGVRVSQDNFSAAQDADVIVLSVKPQLMEQVC
QALQGIDMSNKLVITIAAGIKAERYSQYLAQSITLVRTMPNTPMQIGVGMTGLYAPQPLSDAQQAIAERLMSSGGEIVWV
NEESEINQVIALAGSSPAYFFLLMESMIDAGKQMGMDEAKARSLVQQAALGAAMMAKQNPELTLGNLRENVTSKGGTTAQ
AIATFEAADLRGVVKNAMENCIKRAEEMANTF

Sequences:

>Translated_272_residues
MSQQKICFIGAGNMTRSIISGLIRSGYPAALVQATNPSQGKLDALAADFGVRVSQDNFSAAQDADVIVLSVKPQLMEQVC
QALQGIDMSNKLVITIAAGIKAERYSQYLAQSITLVRTMPNTPMQIGVGMTGLYAPQPLSDAQQAIAERLMSSGGEIVWV
NEESEINQVIALAGSSPAYFFLLMESMIDAGKQMGMDEAKARSLVQQAALGAAMMAKQNPELTLGNLRENVTSKGGTTAQ
AIATFEAADLRGVVKNAMENCIKRAEEMANTF
>Mature_271_residues
SQQKICFIGAGNMTRSIISGLIRSGYPAALVQATNPSQGKLDALAADFGVRVSQDNFSAAQDADVIVLSVKPQLMEQVCQ
ALQGIDMSNKLVITIAAGIKAERYSQYLAQSITLVRTMPNTPMQIGVGMTGLYAPQPLSDAQQAIAERLMSSGGEIVWVN
EESEINQVIALAGSSPAYFFLLMESMIDAGKQMGMDEAKARSLVQQAALGAAMMAKQNPELTLGNLRENVTSKGGTTAQA
IATFEAADLRGVVKNAMENCIKRAEEMANTF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=32.2344322344322, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI24797097, Length=273, Percent_Identity=32.2344322344322, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=30.9963099630996, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI198041662, Length=273, Percent_Identity=24.9084249084249, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=34.3173431734317, Blast_Score=147, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=31.3207547169811, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17540664, Length=282, Percent_Identity=27.6595744680851, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320861, Length=286, Percent_Identity=24.8251748251748, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21358587, Length=272, Percent_Identity=31.25, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=29.6428571428571, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24647700, Length=172, Percent_Identity=31.3953488372093, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28975; Mature: 28844

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQKICFIGAGNMTRSIISGLIRSGYPAALVQATNPSQGKLDALAADFGVRVSQDNFSA
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEECCCCCCC
AQDADVIVLSVKPQLMEQVCQALQGIDMSNKLVITIAAGIKAERYSQYLAQSITLVRTMP
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC
NTPMQIGVGMTGLYAPQPLSDAQQAIAERLMSSGGEIVWVNEESEINQVIALAGSSPAYF
CCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHEEEECCCCCHHH
FLLMESMIDAGKQMGMDEAKARSLVQQAALGAAMMAKQNPELTLGNLRENVTSKGGTTAQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCHHH
AIATFEAADLRGVVKNAMENCIKRAEEMANTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQQKICFIGAGNMTRSIISGLIRSGYPAALVQATNPSQGKLDALAADFGVRVSQDNFSA
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEECCCCCCC
AQDADVIVLSVKPQLMEQVCQALQGIDMSNKLVITIAAGIKAERYSQYLAQSITLVRTMP
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC
NTPMQIGVGMTGLYAPQPLSDAQQAIAERLMSSGGEIVWVNEESEINQVIALAGSSPAYF
CCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHEEEECCCCCHHH
FLLMESMIDAGKQMGMDEAKARSLVQQAALGAAMMAKQNPELTLGNLRENVTSKGGTTAQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCHHH
AIATFEAADLRGVVKNAMENCIKRAEEMANTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]