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The map label for this gene is mutY [H]

Identifier: 117919630

GI number: 117919630

Start: 1388541

End: 1389659

Strand: Reverse

Name: mutY [H]

Synonym: Shewana3_1181

Alternate gene names: 117919630

Gene position: 1389659-1388541 (Counterclockwise)

Preceding gene: 117919636

Following gene: 117919629

Centisome position: 27.95

GC content: 48.61

Gene sequence:

>1119_bases
ATGAAATCTACAGCCTCCTTTGCTACACGTATCGTTAATTGGTACGACACCCACGGTCGTAAAACCCTCCCTTGGCAGCA
AGATAAAACCCCATATCGAGTATGGGTTTCTGAGATTATGTTGCAACAAACTCAGGTAGCGACTGTAATCCCCTATTACC
AGCGTTTTATGGCACGTTTCCCCGATGTGTTAGCCCTCGCTAACGCGCCGGATGATGAAGTACTGCATCATTGGACTGGG
CTTGGTTATTACGCCAGAGCTCGCAATCTACATAAAGCCGCTAAGATGGTTCGCGATCTGTATCAGGGGCAATTTCCAAC
AGACTTTGAGCAAGTGTTAGCGCTGCCAGGTATTGGCCGCTCGACAGCAGGTGCAGTGTTATCCCTATCACTTGGGCAAC
ATCATCCGATCCTTGATGGCAATGTTAAGCGCGTATTAGCAAGACATGGCGCGATTGCGGGCTGGCCCGGTCAAAAACCT
GTGGAAGAACAACTCTGGCAATTAACCGAGCAGTTAACGCCAGAGCAGGATATTCAAAAATATAACCAAGCCATGATGGA
TATTGGTGCCAGTATTTGTACTCGCAGCAAACCCAATTGTGCCGCTTGCCCAGTGGCTATTGATTGCAAAGCTCAATTAA
TGGGAAGACAAACTGAGTTCCCCGGTAAAAAGCCTAAGAAAACTATCCCAGAGAAAGCCGCTTGGATGTTGGTTTTACTC
AAAGATAACCAAGTCTTCTTGGCTAAGCGCCCTCCTGCCGGCATTTGGGGCGGACTCTGGTGCTTCCCCGAATTTAGTAC
TCAAGCCGCACTCAATGCAGAGCTTGAGGCCCAGGGTTATCACGCCGCACAACTCGAACCATTAATCGGTTTTAGGCATA
CCTTTAGCCATTTCCATTTAGATATTCAGCCCATGCTACTGAATTTAGATAGCCAAGCAAATGGCTACGACAAGCAAACC
TTGGGTATGCAGAGCGTGGGCGCAGTCATGGAACAAAACCAGTCTCTCTGGTATAACATCAATCAACCTTCCAAAGTGGG
ACTCGCCTCCGCAACCGAGCGCGTGTTGGCCAACTTGGGATCACTCGTAGCTATTGCTAGCAACCTCGACAGTCAGTAA

Upstream 100 bases:

>100_bases
GAGGCGAAGTATAACAAGATTATCCTAGAGAGCGAATCTAGGCCGATTTTTCGATGGGGTGTTACTTGTTTGCCAACCAA
TCTCCCGCTACACTGCGCCG

Downstream 100 bases:

>100_bases
GGAATAATCATGGCGCGTACAGTCAATTGCGTATATTTAAACAAAGAAGCCGACGGCCTAGACTTTCAACTGTATCCAGG
TGATTTAGGTAAACGTATTT

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKSTASFATRIVNWYDTHGRKTLPWQQDKTPYRVWVSEIMLQQTQVATVIPYYQRFMARFPDVLALANAPDDEVLHHWTG
LGYYARARNLHKAAKMVRDLYQGQFPTDFEQVLALPGIGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIAGWPGQKP
VEEQLWQLTEQLTPEQDIQKYNQAMMDIGASICTRSKPNCAACPVAIDCKAQLMGRQTEFPGKKPKKTIPEKAAWMLVLL
KDNQVFLAKRPPAGIWGGLWCFPEFSTQAALNAELEAQGYHAAQLEPLIGFRHTFSHFHLDIQPMLLNLDSQANGYDKQT
LGMQSVGAVMEQNQSLWYNINQPSKVGLASATERVLANLGSLVAIASNLDSQ

Sequences:

>Translated_372_residues
MKSTASFATRIVNWYDTHGRKTLPWQQDKTPYRVWVSEIMLQQTQVATVIPYYQRFMARFPDVLALANAPDDEVLHHWTG
LGYYARARNLHKAAKMVRDLYQGQFPTDFEQVLALPGIGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIAGWPGQKP
VEEQLWQLTEQLTPEQDIQKYNQAMMDIGASICTRSKPNCAACPVAIDCKAQLMGRQTEFPGKKPKKTIPEKAAWMLVLL
KDNQVFLAKRPPAGIWGGLWCFPEFSTQAALNAELEAQGYHAAQLEPLIGFRHTFSHFHLDIQPMLLNLDSQANGYDKQT
LGMQSVGAVMEQNQSLWYNINQPSKVGLASATERVLANLGSLVAIASNLDSQ
>Mature_372_residues
MKSTASFATRIVNWYDTHGRKTLPWQQDKTPYRVWVSEIMLQQTQVATVIPYYQRFMARFPDVLALANAPDDEVLHHWTG
LGYYARARNLHKAAKMVRDLYQGQFPTDFEQVLALPGIGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIAGWPGQKP
VEEQLWQLTEQLTPEQDIQKYNQAMMDIGASICTRSKPNCAACPVAIDCKAQLMGRQTEFPGKKPKKTIPEKAAWMLVLL
KDNQVFLAKRPPAGIWGGLWCFPEFSTQAALNAELEAQGYHAAQLEPLIGFRHTFSHFHLDIQPMLLNLDSQANGYDKQT
LGMQSVGAVMEQNQSLWYNINQPSKVGLASATERVLANLGSLVAIASNLDSQ

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=370, Percent_Identity=35.1351351351351, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298650, Length=370, Percent_Identity=35.1351351351351, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298654, Length=370, Percent_Identity=35.1351351351351, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298652, Length=370, Percent_Identity=35.1351351351351, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI6912520, Length=370, Percent_Identity=35.1351351351351, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI190358497, Length=370, Percent_Identity=35.1351351351351, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1789331, Length=355, Percent_Identity=57.7464788732394, Blast_Score=437, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41505; Mature: 41505

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTASFATRIVNWYDTHGRKTLPWQQDKTPYRVWVSEIMLQQTQVATVIPYYQRFMARF
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDVLALANAPDDEVLHHWTGLGYYARARNLHKAAKMVRDLYQGQFPTDFEQVLALPGIGR
CHHEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCC
STAGAVLSLSLGQHHPILDGNVKRVLARHGAIAGWPGQKPVEEQLWQLTEQLTPEQDIQK
CCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHH
YNQAMMDIGASICTRSKPNCAACPVAIDCKAQLMGRQTEFPGKKPKKTIPEKAAWMLVLL
HHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEE
KDNQVFLAKRPPAGIWGGLWCFPEFSTQAALNAELEAQGYHAAQLEPLIGFRHTFSHFHL
ECCEEEEEECCCCCCCCCEEECCCCCCHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHEE
DIQPMLLNLDSQANGYDKQTLGMQSVGAVMEQNQSLWYNINQPSKVGLASATERVLANLG
EEEEEEEECCCCCCCCCHHHHCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHH
SLVAIASNLDSQ
HHHHHHHCCCCC
>Mature Secondary Structure
MKSTASFATRIVNWYDTHGRKTLPWQQDKTPYRVWVSEIMLQQTQVATVIPYYQRFMARF
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDVLALANAPDDEVLHHWTGLGYYARARNLHKAAKMVRDLYQGQFPTDFEQVLALPGIGR
CHHEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCC
STAGAVLSLSLGQHHPILDGNVKRVLARHGAIAGWPGQKPVEEQLWQLTEQLTPEQDIQK
CCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHH
YNQAMMDIGASICTRSKPNCAACPVAIDCKAQLMGRQTEFPGKKPKKTIPEKAAWMLVLL
HHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEE
KDNQVFLAKRPPAGIWGGLWCFPEFSTQAALNAELEAQGYHAAQLEPLIGFRHTFSHFHL
ECCEEEEEECCCCCCCCCEEECCCCCCHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHEE
DIQPMLLNLDSQANGYDKQTLGMQSVGAVMEQNQSLWYNINQPSKVGLASATERVLANLG
EEEEEEEECCCCCCCCCHHHHCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHH
SLVAIASNLDSQ
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]