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The map label for this gene is holA [H]

Identifier: 117919448

GI number: 117919448

Start: 1168812

End: 1169843

Strand: Reverse

Name: holA [H]

Synonym: Shewana3_0999

Alternate gene names: 117919448

Gene position: 1169843-1168812 (Counterclockwise)

Preceding gene: 117919449

Following gene: 117919447

Centisome position: 23.53

GC content: 50.1

Gene sequence:

>1032_bases
ATGCGTGTTTATCCTGATCAACTCTCCCGCCATCTCAATCCGCTTCACGCTTGCTACCTGATTTTTGGTGATGATCCTTG
GTTGCTCGAAACCTCCAAGGATCAGATCCGCCAAGCAGCCAAACGCCAAGGGTTTGAAGAGCGCGTTCAGTTAATTCAAG
AAACGGGTTTTAACTGGGGTGACTTGACCCAAGAATGGCAATCCATGAGCCTGTTTTCTAGTCGGCGCATCATTGAGCTA
ACACTGCCCAACGCAAAACCCGGTGCTGATGGTTCGGCGGCGCTACAAGCGTTACTACAAACGCCAAATCCCGATGTGTT
GCTGATCCTCGAAGGCCCCAAACTCGCCAGCGAGCAAACCAATAGCAAGTGGTTCAAAACCTTGGATAGTTTAGGGATTT
ATTTGCCCTGCACTACGCCAGAGAGCGACCAATTCAGACGTTGGCTCGACTCACGAATTGCGCACTTTAAGCTGAATTTA
CAACCCGATGCGCGCGCTATGCTGTACACACTCTACGAAGGGAATTTACTCGCCGCCGATCAGGCCATGCAGTTGCTGCA
ACTGTTAAGCCCAAGCCAGCCCATCGGCGCCGACGAATTAAGCCATTACTTTGAAGATCAATCCCGCTTTACTGTGTTTC
AGCTCACCGATGCACTGCTGAATAATCGTCAAGACAGTGCTCAGCATATGCTGGCCCAGCTCAACGGTGAAGGCACGGCC
ATGCCGATTTTACTCTGGGCCTTATTCAAAGAGCTGCAGTTACTGCTTAGCCTCAAGAGTGAACAAGCCCAAGGCGCGCC
CTTAAATAGCTTGTTTGGTAAACATCGAATTTGGGATAAACGCAAACCCTTGTACCAGACCGCGTTGCAGCGCTTAAGCC
TCACCCAAATCGAACATATGCTTGCCTTCGCGTCTAAGCTGGAGCTAAACCTTAAGCAATTAGGCCATGAAGATTGGACA
GGGCTTAGCCACCTGTGCTTATTATTCGATCCTAAGGCCCACGGCCATTTGGCCCATATCAGCTTAGATTAA

Upstream 100 bases:

>100_bases
GCGGCCGACCGGATCCTGCAATCCATGGCCAGCACAGAGGTGAATTAATGCAGGGTCCAAATTAATGTGGAACTGCAATA
AAATGTGGAGAGTGATTTAA

Downstream 100 bases:

>100_bases
GGCTCTGACTGAATGCGTATCGGTATTTTAGGCGGCACCTTCGACCCCATACATTACGGCCATATTCGCCCCGCGATGGA
AGTCAAAGCCAGCCTCAAGC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRVYPDQLSRHLNPLHACYLIFGDDPWLLETSKDQIRQAAKRQGFEERVQLIQETGFNWGDLTQEWQSMSLFSSRRIIEL
TLPNAKPGADGSAALQALLQTPNPDVLLILEGPKLASEQTNSKWFKTLDSLGIYLPCTTPESDQFRRWLDSRIAHFKLNL
QPDARAMLYTLYEGNLLAADQAMQLLQLLSPSQPIGADELSHYFEDQSRFTVFQLTDALLNNRQDSAQHMLAQLNGEGTA
MPILLWALFKELQLLLSLKSEQAQGAPLNSLFGKHRIWDKRKPLYQTALQRLSLTQIEHMLAFASKLELNLKQLGHEDWT
GLSHLCLLFDPKAHGHLAHISLD

Sequences:

>Translated_343_residues
MRVYPDQLSRHLNPLHACYLIFGDDPWLLETSKDQIRQAAKRQGFEERVQLIQETGFNWGDLTQEWQSMSLFSSRRIIEL
TLPNAKPGADGSAALQALLQTPNPDVLLILEGPKLASEQTNSKWFKTLDSLGIYLPCTTPESDQFRRWLDSRIAHFKLNL
QPDARAMLYTLYEGNLLAADQAMQLLQLLSPSQPIGADELSHYFEDQSRFTVFQLTDALLNNRQDSAQHMLAQLNGEGTA
MPILLWALFKELQLLLSLKSEQAQGAPLNSLFGKHRIWDKRKPLYQTALQRLSLTQIEHMLAFASKLELNLKQLGHEDWT
GLSHLCLLFDPKAHGHLAHISLD
>Mature_343_residues
MRVYPDQLSRHLNPLHACYLIFGDDPWLLETSKDQIRQAAKRQGFEERVQLIQETGFNWGDLTQEWQSMSLFSSRRIIEL
TLPNAKPGADGSAALQALLQTPNPDVLLILEGPKLASEQTNSKWFKTLDSLGIYLPCTTPESDQFRRWLDSRIAHFKLNL
QPDARAMLYTLYEGNLLAADQAMQLLQLLSPSQPIGADELSHYFEDQSRFTVFQLTDALLNNRQDSAQHMLAQLNGEGTA
MPILLWALFKELQLLLSLKSEQAQGAPLNSLFGKHRIWDKRKPLYQTALQRLSLTQIEHMLAFASKLELNLKQLGHEDWT
GLSHLCLLFDPKAHGHLAHISLD

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=345, Percent_Identity=39.1304347826087, Blast_Score=196, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39032; Mature: 39032

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYPDQLSRHLNPLHACYLIFGDDPWLLETSKDQIRQAAKRQGFEERVQLIQETGFNWG
CCCCHHHHHHHCCHHHEEEEEECCCCCEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCHH
DLTQEWQSMSLFSSRRIIELTLPNAKPGADGSAALQALLQTPNPDVLLILEGPKLASEQT
HHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
NSKWFKTLDSLGIYLPCTTPESDQFRRWLDSRIAHFKLNLQPDARAMLYTLYEGNLLAAD
CHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHEEEEECCCCCCEEEEEEECCCEEEHH
QAMQLLQLLSPSQPIGADELSHYFEDQSRFTVFQLTDALLNNRQDSAQHMLAQLNGEGTA
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
MPILLWALFKELQLLLSLKSEQAQGAPLNSLFGKHRIWDKRKPLYQTALQRLSLTQIEHM
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LAFASKLELNLKQLGHEDWTGLSHLCLLFDPKAHGHLAHISLD
HHHHHHHHHHHHHCCCCCCCCHHHEEEEECCCCCCEEEEEECC
>Mature Secondary Structure
MRVYPDQLSRHLNPLHACYLIFGDDPWLLETSKDQIRQAAKRQGFEERVQLIQETGFNWG
CCCCHHHHHHHCCHHHEEEEEECCCCCEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCHH
DLTQEWQSMSLFSSRRIIELTLPNAKPGADGSAALQALLQTPNPDVLLILEGPKLASEQT
HHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
NSKWFKTLDSLGIYLPCTTPESDQFRRWLDSRIAHFKLNLQPDARAMLYTLYEGNLLAAD
CHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHEEEEECCCCCCEEEEEEECCCEEEHH
QAMQLLQLLSPSQPIGADELSHYFEDQSRFTVFQLTDALLNNRQDSAQHMLAQLNGEGTA
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
MPILLWALFKELQLLLSLKSEQAQGAPLNSLFGKHRIWDKRKPLYQTALQRLSLTQIEHM
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LAFASKLELNLKQLGHEDWTGLSHLCLLFDPKAHGHLAHISLD
HHHHHHHHHHHHHCCCCCCCCHHHEEEEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]