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The map label for this gene is fklB [H]

Identifier: 117919414

GI number: 117919414

Start: 1132545

End: 1133162

Strand: Direct

Name: fklB [H]

Synonym: Shewana3_0965

Alternate gene names: 117919414

Gene position: 1132545-1133162 (Clockwise)

Preceding gene: 117919413

Following gene: 117919415

Centisome position: 22.78

GC content: 47.41

Gene sequence:

>618_bases
ATGTCTGATAAATTCAGTACTGTTGAACAGCAAGCAAGCTATGGTGTAGGTCGTCAAATGGGCGAGCAACTGGCTGCTAA
TTCTTTTGAAGGTGTGGATATTGCTGCCGTTCAAGCAGGTTTAGCCGATGCATTTGCTGGCGTTGAAAGCGCTGTATCTA
TGCAAGATATGCAAGTTGCATTCACTGAGATCAGCCGTCGCATTCAAGCGGCTCAAGAGCAAGCTGCAGCAGAAGCTTCT
GCCGAAGGCGAAGCCTTTTTAGCTGAAAACGCTAAGCGTGCAGGCGTGATCGTGACTGACTCTGGTCTGCAATACGAAGT
ATTAGTTCAAGGTAGCGGTGCAAAACCAACCTACGAAGACACAGTACGTACTCACTACCATGGTTCTTTCATCAATGGTG
ACGTGTTCGACAGCTCTGTTGTTCGTGGTCAACCAGCTGAATTCCCAGTATCTGGCGTTATCGCTGGCTGGACTGAAGCT
CTGCAACTGATGCCAGTTGGTACCAAGTTAAAGTTATTCGTTCCACATCACTTAGCATACGGTGAGCGTGGTGCGGGTGC
TTCTATTCCTCCATACTCAACGTTAGTATTCGAAGTCGAGTTATTAGACATCGTCTAA

Upstream 100 bases:

>100_bases
CGCCGCCAAAGTTAAATAAGCAGTCAGTTTATCAGCATAGGGCGTGGAACTATGATAAACTGGCGCGCAAAATTCCATTG
AACATTGAGAGTCGTTAATT

Downstream 100 bases:

>100_bases
TGTGATTGAAACGCCTAAGCCAGTCTTAGGCGTTTTTGTATGGAAGTGATGAACAGGTTTGAGGAGATTGAAATGGGTGG
ACAAGTGAGAGTTGCAATTG

Product: peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSDKFSTVEQQASYGVGRQMGEQLAANSFEGVDIAAVQAGLADAFAGVESAVSMQDMQVAFTEISRRIQAAQEQAAAEAS
AEGEAFLAENAKRAGVIVTDSGLQYEVLVQGSGAKPTYEDTVRTHYHGSFINGDVFDSSVVRGQPAEFPVSGVIAGWTEA
LQLMPVGTKLKLFVPHHLAYGERGAGASIPPYSTLVFEVELLDIV

Sequences:

>Translated_205_residues
MSDKFSTVEQQASYGVGRQMGEQLAANSFEGVDIAAVQAGLADAFAGVESAVSMQDMQVAFTEISRRIQAAQEQAAAEAS
AEGEAFLAENAKRAGVIVTDSGLQYEVLVQGSGAKPTYEDTVRTHYHGSFINGDVFDSSVVRGQPAEFPVSGVIAGWTEA
LQLMPVGTKLKLFVPHHLAYGERGAGASIPPYSTLVFEVELLDIV
>Mature_204_residues
SDKFSTVEQQASYGVGRQMGEQLAANSFEGVDIAAVQAGLADAFAGVESAVSMQDMQVAFTEISRRIQAAQEQAAAEASA
EGEAFLAENAKRAGVIVTDSGLQYEVLVQGSGAKPTYEDTVRTHYHGSFINGDVFDSSVVRGQPAEFPVSGVIAGWTEAL
QLMPVGTKLKLFVPHHLAYGERGAGASIPPYSTLVFEVELLDIV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=48.2758620689655, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=48.2758620689655, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=48.2758620689655, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=40.5660377358491, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=40.5660377358491, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=37.7358490566038, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI192448443, Length=87, Percent_Identity=40.2298850574713, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI7706131, Length=107, Percent_Identity=36.4485981308411, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082390, Length=204, Percent_Identity=55.8823529411765, Blast_Score=225, Evalue=1e-60,
Organism=Escherichia coli, GI1789745, Length=211, Percent_Identity=38.8625592417062, Blast_Score=128, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=42.4528301886792, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17540882, Length=87, Percent_Identity=43.6781609195402, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320727, Length=106, Percent_Identity=45.2830188679245, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=110, Percent_Identity=42.7272727272727, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=46.5909090909091, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=46.5909090909091, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=39.622641509434, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=36.7924528301887, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24647110, Length=96, Percent_Identity=42.7083333333333, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21703; Mature: 21572

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKFSTVEQQASYGVGRQMGEQLAANSFEGVDIAAVQAGLADAFAGVESAVSMQDMQVA
CCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTEISRRIQAAQEQAAAEASAEGEAFLAENAKRAGVIVTDSGLQYEVLVQGSGAKPTYED
HHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEEECCCCEEEEEEECCCCCCCHHH
TVRTHYHGSFINGDVFDSSVVRGQPAEFPVSGVIAGWTEALQLMPVGTKLKLFVPHHLAY
HHHHEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHEECCCCEEEEEECHHHHC
GERGAGASIPPYSTLVFEVELLDIV
CCCCCCCCCCCCEEEEEEEEEEECC
>Mature Secondary Structure 
SDKFSTVEQQASYGVGRQMGEQLAANSFEGVDIAAVQAGLADAFAGVESAVSMQDMQVA
CCCHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTEISRRIQAAQEQAAAEASAEGEAFLAENAKRAGVIVTDSGLQYEVLVQGSGAKPTYED
HHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEEECCCCEEEEEEECCCCCCCHHH
TVRTHYHGSFINGDVFDSSVVRGQPAEFPVSGVIAGWTEALQLMPVGTKLKLFVPHHLAY
HHHHEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHEECCCCEEEEEECHHHHC
GERGAGASIPPYSTLVFEVELLDIV
CCCCCCCCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]