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The map label for this gene is nhaC [H]

Identifier: 117919367

GI number: 117919367

Start: 1073023

End: 1074360

Strand: Reverse

Name: nhaC [H]

Synonym: Shewana3_0918

Alternate gene names: 117919367

Gene position: 1074360-1073023 (Counterclockwise)

Preceding gene: 117919372

Following gene: 117919366

Centisome position: 21.61

GC content: 49.1

Gene sequence:

>1338_bases
TTGAGTCAATCAGCCCAAACCACTGCACCGAGTAGCCCGGCATCCTTTATTGCCCTGTTACCCTTATTCGTTTTTTTAAG
TCTGTTTATTGGCGCAGGCGTCTATTTCCAAAGCCAAGGTGTAGACTTTGCCTTCTATCAATTACCGAGTGTGATTGCCA
TTCTGCCAGCCATAATTCTGGCCTTGGTATTATCAAAACAAAAACTCAATCAAGCGATTGATACCTTTATCGGCGGTATT
GGCCACAGCAATATTATTGCTATGTGTTTGATTTACTTGCTGGCTGGCGGTTTTGCTGCGGTAGCGAAAGCCACTGGTGG
TGTCGATGCGACCGTTGCCTTAGGTTTATCCCTTATTCCTTCAAACCTATTACTGCCCGGCTTTTTTGTGATTGCCGCCT
TTATTGCCACCGCAATGGGTACCTCAATGGGCACAATCGCCGCCGTGGCACCTATCGCCTTAGGCGTTGCCGATCAGGCA
CAAATTGATTATGCCCTGATGGCGGGCGCCGTGATGTCTGGCGCACTGTTTGGCGATAACCTTTCGATTATTTCGGATAC
CACTATTGCGGCCACTCGTACTCAAGGCTGTGATATGAAAGATAAATTCCGCGAGAACCTGATTTTTGCGATCCCTGCTT
CACTGCTAACTTTTGTCGCCTTTGTGATTGCAGGCCAAGGCCAAGCCGATCTAGCCGCTCAGGATATCGACTTTATCAAG
GTGATTCCTTACCTGACGATTCTGGTATTAGCAGTCGCAGGGTTAAACGTGTTCGTCGTCTTGACCTTAGGCATTCTGCT
GGCGGGCGCTGCGGGATTCCTGACCATGGACTATGGCGTTATCCAATTTGGTAAGGATATCTACGCGGGCTTTAGCAATA
TGCAGGAAATCTTCATCCTGTCGATGTTAGTCGGTGGTTTAGCAGCGCTGATGCAGCAACAAGGTGGTTTAGCCTTTGTG
AGCAAACAGATTGAAAAGCTCATCACCCGTTTCTCAAAAGCTCAAGGTGAAGCCTCATGCCGCGCGGCCGAATTAGGCAT
GGCAGGGATTGTGGCCGTCACCAACAGCTGCGTTGCCAACAACACAGTGTCTATCGTAGTGACGGGTGATATTGCTAAAG
ATCTGGCAGAAAAACACGGTGTTAGCCCTAAGCGTGCGGCCAGTGTACTCGATATTTTTGCCTGTATTATCCAAGGATTA
ATTCCCTATGGCGCCCAAGCACTGCTAATCGCTTCAACCTTTAGCATCACACCGCTGGCGGCTGTATCCCACGCTTGGTA
CTGCATGATCCTAGCGGCTGTCGCGATTGCGATTGTGATTTTCCGTAAGCGCCACTAA

Upstream 100 bases:

>100_bases
ACCAAGTTGCTAGGATATGATGCCAAAGCGGCATAGATTTTAAGCGAGTTCGACTGCCAAGGATCCCGCGGAAAACCCGC
CGAGTAAAAGAGACATTACA

Downstream 100 bases:

>100_bases
TCTTATTCGACTGTCGATAACACCAAGGGAGCTATTAGCTCCCTTTGTTTTTATCAGCCGAAAGATCAAATCAGGCCGAG
ACTTGCCATCAGTTTCGGAT

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSQSAQTTAPSSPASFIALLPLFVFLSLFIGAGVYFQSQGVDFAFYQLPSVIAILPAIILALVLSKQKLNQAIDTFIGGI
GHSNIIAMCLIYLLAGGFAAVAKATGGVDATVALGLSLIPSNLLLPGFFVIAAFIATAMGTSMGTIAAVAPIALGVADQA
QIDYALMAGAVMSGALFGDNLSIISDTTIAATRTQGCDMKDKFRENLIFAIPASLLTFVAFVIAGQGQADLAAQDIDFIK
VIPYLTILVLAVAGLNVFVVLTLGILLAGAAGFLTMDYGVIQFGKDIYAGFSNMQEIFILSMLVGGLAALMQQQGGLAFV
SKQIEKLITRFSKAQGEASCRAAELGMAGIVAVTNSCVANNTVSIVVTGDIAKDLAEKHGVSPKRAASVLDIFACIIQGL
IPYGAQALLIASTFSITPLAAVSHAWYCMILAAVAIAIVIFRKRH

Sequences:

>Translated_445_residues
MSQSAQTTAPSSPASFIALLPLFVFLSLFIGAGVYFQSQGVDFAFYQLPSVIAILPAIILALVLSKQKLNQAIDTFIGGI
GHSNIIAMCLIYLLAGGFAAVAKATGGVDATVALGLSLIPSNLLLPGFFVIAAFIATAMGTSMGTIAAVAPIALGVADQA
QIDYALMAGAVMSGALFGDNLSIISDTTIAATRTQGCDMKDKFRENLIFAIPASLLTFVAFVIAGQGQADLAAQDIDFIK
VIPYLTILVLAVAGLNVFVVLTLGILLAGAAGFLTMDYGVIQFGKDIYAGFSNMQEIFILSMLVGGLAALMQQQGGLAFV
SKQIEKLITRFSKAQGEASCRAAELGMAGIVAVTNSCVANNTVSIVVTGDIAKDLAEKHGVSPKRAASVLDIFACIIQGL
IPYGAQALLIASTFSITPLAAVSHAWYCMILAAVAIAIVIFRKRH
>Mature_444_residues
SQSAQTTAPSSPASFIALLPLFVFLSLFIGAGVYFQSQGVDFAFYQLPSVIAILPAIILALVLSKQKLNQAIDTFIGGIG
HSNIIAMCLIYLLAGGFAAVAKATGGVDATVALGLSLIPSNLLLPGFFVIAAFIATAMGTSMGTIAAVAPIALGVADQAQ
IDYALMAGAVMSGALFGDNLSIISDTTIAATRTQGCDMKDKFRENLIFAIPASLLTFVAFVIAGQGQADLAAQDIDFIKV
IPYLTILVLAVAGLNVFVVLTLGILLAGAAGFLTMDYGVIQFGKDIYAGFSNMQEIFILSMLVGGLAALMQQQGGLAFVS
KQIEKLITRFSKAQGEASCRAAELGMAGIVAVTNSCVANNTVSIVVTGDIAKDLAEKHGVSPKRAASVLDIFACIIQGLI
PYGAQALLIASTFSITPLAAVSHAWYCMILAAVAIAIVIFRKRH

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 46174; Mature: 46043

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSAQTTAPSSPASFIALLPLFVFLSLFIGAGVYFQSQGVDFAFYQLPSVIAILPAIIL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
ALVLSKQKLNQAIDTFIGGIGHSNIIAMCLIYLLAGGFAAVAKATGGVDATVALGLSLIP
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCC
SNLLLPGFFVIAAFIATAMGTSMGTIAAVAPIALGVADQAQIDYALMAGAVMSGALFGDN
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
LSIISDTTIAATRTQGCDMKDKFRENLIFAIPASLLTFVAFVIAGQGQADLAAQDIDFIK
CEEEECCEEEEECCCCCCHHHHHHHCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VIPYLTILVLAVAGLNVFVVLTLGILLAGAAGFLTMDYGVIQFGKDIYAGFSNMQEIFIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
SMLVGGLAALMQQQGGLAFVSKQIEKLITRFSKAQGEASCRAAELGMAGIVAVTNSCVAN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHCC
NTVSIVVTGDIAKDLAEKHGVSPKRAASVLDIFACIIQGLIPYGAQALLIASTFSITPLA
CCEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEEHHCCCCHHH
AVSHAWYCMILAAVAIAIVIFRKRH
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQSAQTTAPSSPASFIALLPLFVFLSLFIGAGVYFQSQGVDFAFYQLPSVIAILPAIIL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
ALVLSKQKLNQAIDTFIGGIGHSNIIAMCLIYLLAGGFAAVAKATGGVDATVALGLSLIP
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCC
SNLLLPGFFVIAAFIATAMGTSMGTIAAVAPIALGVADQAQIDYALMAGAVMSGALFGDN
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
LSIISDTTIAATRTQGCDMKDKFRENLIFAIPASLLTFVAFVIAGQGQADLAAQDIDFIK
CEEEECCEEEEECCCCCCHHHHHHHCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VIPYLTILVLAVAGLNVFVVLTLGILLAGAAGFLTMDYGVIQFGKDIYAGFSNMQEIFIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
SMLVGGLAALMQQQGGLAFVSKQIEKLITRFSKAQGEASCRAAELGMAGIVAVTNSCVAN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHCC
NTVSIVVTGDIAKDLAEKHGVSPKRAASVLDIFACIIQGLIPYGAQALLIASTFSITPLA
CCEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEEHHCCCCHHH
AVSHAWYCMILAAVAIAIVIFRKRH
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]