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The map label for this gene is fkpA [H]

Identifier: 117919354

GI number: 117919354

Start: 1053397

End: 1054167

Strand: Direct

Name: fkpA [H]

Synonym: Shewana3_0903

Alternate gene names: 117919354

Gene position: 1053397-1054167 (Clockwise)

Preceding gene: 117919346

Following gene: 117919355

Centisome position: 21.19

GC content: 43.58

Gene sequence:

>771_bases
ATGAAATCGATTTATAAATTATCGTTAGTTGCATTGGCTGTTATTGGCCTATCTGCTTGTAATCAAGAAGAAAAAGCAAC
AAATGCAAGCACAAATGTTGAATTAACGACTGAAGCACAAAAAGAAGCCTACAGTGTTGGCGCTTCAATCGGTCGTTATA
TGTCTGGCCATATCAAAGAGCAAGAAGAATTAGGCCTGCCAGTTGACCGTGCGCTGATCGTGACTGGTTTTACTAACGGT
CTGAATGACCAACTGAAATTAACCGAAGAAGAAATGCAAACCATTCTTCAAGGTTTAGACAAAAAGTTAAACGACAAACG
TACAGAACAAGCTAAAGCCATTGCAGCGAAAAACATCGAGGACGGTAAAAAGTTCCTCGAGGAAAACAAAGCTAAGCCTG
GCGTAGTAACCACTGAATCGGGTCTGCAATACGAAGTGTTAACACCAGGTTCTGGTGACAAGCCAGCGGCTGAAGACACT
GTAGAAGTGGATTACGTAGGTACTCTGCTTGACGGCACTGAGTTTGATAGCTCATACAAACGTGGTCAAACGGCTAAGTT
CCCATTAAACCGCGTTATTCCAGGCTGGACCGAAGGCGTACAGTTAATGCCTGTGGGCGCTAAGTACAAGTTTGTGATCC
CTGCAAACTTAGCTTACGGCGACCGTGATACTGGTACTATTCCACCAAACTCAACCCTGATTTTTGAAGTTGAACTGAAA
TCAATTGAGAAAGCACAAGCGGCTCCTGCTGCTGAGCCTGCTAAAAAGTAA

Upstream 100 bases:

>100_bases
TTAACACATAACAGAATCTAGTTGGTATAACCCAGATAACTAGTATACAGTTGTCGCGCTTAGGTTATTGTAACCGCTTG
AGGATGCTGAGGAAGCTTTA

Downstream 100 bases:

>100_bases
TTTACAGTGTAACGGCTTAACTCGGGTTAAGTTTTGCACTCATAGAATACCGCCCACCTAGGGCGGTATTTTTTTGCAGT
CGAAATGACTAAGCAATGCT

Product: peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MKSIYKLSLVALAVIGLSACNQEEKATNASTNVELTTEAQKEAYSVGASIGRYMSGHIKEQEELGLPVDRALIVTGFTNG
LNDQLKLTEEEMQTILQGLDKKLNDKRTEQAKAIAAKNIEDGKKFLEENKAKPGVVTTESGLQYEVLTPGSGDKPAAEDT
VEVDYVGTLLDGTEFDSSYKRGQTAKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGDRDTGTIPPNSTLIFEVELK
SIEKAQAAPAAEPAKK

Sequences:

>Translated_256_residues
MKSIYKLSLVALAVIGLSACNQEEKATNASTNVELTTEAQKEAYSVGASIGRYMSGHIKEQEELGLPVDRALIVTGFTNG
LNDQLKLTEEEMQTILQGLDKKLNDKRTEQAKAIAAKNIEDGKKFLEENKAKPGVVTTESGLQYEVLTPGSGDKPAAEDT
VEVDYVGTLLDGTEFDSSYKRGQTAKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGDRDTGTIPPNSTLIFEVELK
SIEKAQAAPAAEPAKK
>Mature_256_residues
MKSIYKLSLVALAVIGLSACNQEEKATNASTNVELTTEAQKEAYSVGASIGRYMSGHIKEQEELGLPVDRALIVTGFTNG
LNDQLKLTEEEMQTILQGLDKKLNDKRTEQAKAIAAKNIEDGKKFLEENKAKPGVVTTESGLQYEVLTPGSGDKPAAEDT
VEVDYVGTLLDGTEFDSSYKRGQTAKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGDRDTGTIPPNSTLIFEVELK
SIEKAQAAPAAEPAKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=44.8598130841121, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=44.8598130841121, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI206725530, Length=89, Percent_Identity=47.1910112359551, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI17149844, Length=89, Percent_Identity=47.1910112359551, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI17149842, Length=89, Percent_Identity=47.1910112359551, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI192448443, Length=96, Percent_Identity=39.5833333333333, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI33469985, Length=83, Percent_Identity=40.9638554216867, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1789745, Length=256, Percent_Identity=40.234375, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI87082390, Length=213, Percent_Identity=42.7230046948357, Blast_Score=153, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17540882, Length=89, Percent_Identity=46.0674157303371, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561782, Length=89, Percent_Identity=49.438202247191, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=43.3962264150943, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=91, Percent_Identity=51.6483516483517, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=105, Percent_Identity=41.9047619047619, Blast_Score=75, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323482, Length=119, Percent_Identity=39.4957983193277, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323566, Length=119, Percent_Identity=37.8151260504202, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=45.7943925233645, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=47.2527472527472, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=47.2527472527472, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583150, Length=108, Percent_Identity=37.962962962963, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356629, Length=89, Percent_Identity=48.314606741573, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 27683; Mature: 27683

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIYKLSLVALAVIGLSACNQEEKATNASTNVELTTEAQKEAYSVGASIGRYMSGHIKE
CCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
QEELGLPVDRALIVTGFTNGLNDQLKLTEEEMQTILQGLDKKLNDKRTEQAKAIAAKNIE
HHHCCCCCCCEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
DGKKFLEENKAKPGVVTTESGLQYEVLTPGSGDKPAAEDTVEVDYVGTLLDGTEFDSSYK
HHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHH
RGQTAKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGDRDTGTIPPNSTLIFEVELK
CCCCCCCCHHHCCCCCCCCEEEEECCCEEEEEEECCEECCCCCCCCCCCCCEEEEEEEHH
SIEKAQAAPAAEPAKK
HHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKSIYKLSLVALAVIGLSACNQEEKATNASTNVELTTEAQKEAYSVGASIGRYMSGHIKE
CCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
QEELGLPVDRALIVTGFTNGLNDQLKLTEEEMQTILQGLDKKLNDKRTEQAKAIAAKNIE
HHHCCCCCCCEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
DGKKFLEENKAKPGVVTTESGLQYEVLTPGSGDKPAAEDTVEVDYVGTLLDGTEFDSSYK
HHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHH
RGQTAKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGDRDTGTIPPNSTLIFEVELK
CCCCCCCCHHHCCCCCCCCEEEEECCCEEEEEEECCEECCCCCCCCCCCCCEEEEEEEHH
SIEKAQAAPAAEPAKK
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]