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The map label for this gene is cysG1 [H]

Identifier: 117919314

GI number: 117919314

Start: 1004410

End: 1005240

Strand: Direct

Name: cysG1 [H]

Synonym: Shewana3_0862

Alternate gene names: 117919314

Gene position: 1004410-1005240 (Clockwise)

Preceding gene: 117919311

Following gene: 117919315

Centisome position: 20.2

GC content: 50.06

Gene sequence:

>831_bases
ATGGAAATTTTATCTTTACCGGGCCAAAGGGCGAAGGGCAAAGTCTGGCTGGTTGGCGCAGGCCCCGGAGACGTTGAACT
CTTAACCCTCAAGGCTTGGCGCATTCTTAAGTCAGCCGACGCTGTGCTATACGATGCGCTCGTCAGCCAAGATATCCTCG
ATTTAATCCCTAAGGATGCAGAGAAGATTGCCGTCGGCAAACGTGCCGGTAAGCATAGTGCTGCGCAAGATGAAATTAAT
CAGTTACTGGTGACTAAAGCCTATACCCGTAAAAACGTGGTACGCCTCAAGGGCGGCGATCCCTTTATTTTTGGCCGCGG
TGGTGAAGAGTTACAAACCTTAGTTGAAGCAGGCGTCGAATTTGAAGTGGTTCCTGGCATTACCGCCGCCAGTGGCACTT
CGGCCTATGCGGGCATTCCCTTAACCCACAGGGATTATGCCCAAGGGGTGACTTTTATTACTGGCCATTGTCAGCTTGAA
AGCCGTCCGATGGACTGGCAGGGGTATGCTAATTCAAACAATACCTTAGTTGTGTATATGGGGATTTTAAATGCGGGCAT
TATTCGTCAAGGACTAATCGATGCTGGCCGTAGCCCAAACACACCTGTGGCGATTGTCTCTAAGGCGACCACTCAGTCGC
AGCAACGTTTTATTGGTCAATTAGATTCACTCGAGCAGCTCGCGGCCGATCCGCAATTGCAAATGCCCGCCCTGATGATT
ATTGGCGAAGTGGTTGCGTTAGCTGACAGCTTAAATTGGTTCCAACCTAAAGGTGAAGGCGAGTCATCACTCGATACCAC
TGATGCCGCCAAGATTGTGGCAAAAATTTAG

Upstream 100 bases:

>100_bases
TTGTTATTTCTTTTTGATATAACAATTAATGATTTTATATTTATTAAGGAATATAACTAGGGCTATATTGCTACACATTG
ATCTCATATCGGGGAATGTG

Downstream 100 bases:

>100_bases
TTAAATCAGATTTTTTAGAAATAGTTAAGTTAAATCCAGCTGCCTGTCGCAGCCCATTTTAGGTAAACGGAGAAGAGTAT
GGCCGGGCGTGAATTAAGCC

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MEILSLPGQRAKGKVWLVGAGPGDVELLTLKAWRILKSADAVLYDALVSQDILDLIPKDAEKIAVGKRAGKHSAAQDEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVEFEVVPGITAASGTSAYAGIPLTHRDYAQGVTFITGHCQLE
SRPMDWQGYANSNNTLVVYMGILNAGIIRQGLIDAGRSPNTPVAIVSKATTQSQQRFIGQLDSLEQLAADPQLQMPALMI
IGEVVALADSLNWFQPKGEGESSLDTTDAAKIVAKI

Sequences:

>Translated_276_residues
MEILSLPGQRAKGKVWLVGAGPGDVELLTLKAWRILKSADAVLYDALVSQDILDLIPKDAEKIAVGKRAGKHSAAQDEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVEFEVVPGITAASGTSAYAGIPLTHRDYAQGVTFITGHCQLE
SRPMDWQGYANSNNTLVVYMGILNAGIIRQGLIDAGRSPNTPVAIVSKATTQSQQRFIGQLDSLEQLAADPQLQMPALMI
IGEVVALADSLNWFQPKGEGESSLDTTDAAKIVAKI
>Mature_276_residues
MEILSLPGQRAKGKVWLVGAGPGDVELLTLKAWRILKSADAVLYDALVSQDILDLIPKDAEKIAVGKRAGKHSAAQDEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVEFEVVPGITAASGTSAYAGIPLTHRDYAQGVTFITGHCQLE
SRPMDWQGYANSNNTLVVYMGILNAGIIRQGLIDAGRSPNTPVAIVSKATTQSQQRFIGQLDSLEQLAADPQLQMPALMI
IGEVVALADSLNWFQPKGEGESSLDTTDAAKIVAKI

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=243, Percent_Identity=56.3786008230453, Blast_Score=265, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6322922, Length=238, Percent_Identity=34.8739495798319, Blast_Score=125, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 29535; Mature: 29535

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILSLPGQRAKGKVWLVGAGPGDVELLTLKAWRILKSADAVLYDALVSQDILDLIPKDA
CCCCCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EKIAVGKRAGKHSAAQDEINQLLVTKAYTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHCCCC
FEVVPGITAASGTSAYAGIPLTHRDYAQGVTFITGHCQLESRPMDWQGYANSNNTLVVYM
EEEECCEEECCCCCCCCCCCCCCHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEE
GILNAGIIRQGLIDAGRSPNTPVAIVSKATTQSQQRFIGQLDSLEQLAADPQLQMPALMI
HHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
IGEVVALADSLNWFQPKGEGESSLDTTDAAKIVAKI
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEILSLPGQRAKGKVWLVGAGPGDVELLTLKAWRILKSADAVLYDALVSQDILDLIPKDA
CCCCCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EKIAVGKRAGKHSAAQDEINQLLVTKAYTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHCCCC
FEVVPGITAASGTSAYAGIPLTHRDYAQGVTFITGHCQLESRPMDWQGYANSNNTLVVYM
EEEECCEEECCCCCCCCCCCCCCHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEE
GILNAGIIRQGLIDAGRSPNTPVAIVSKATTQSQQRFIGQLDSLEQLAADPQLQMPALMI
HHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
IGEVVALADSLNWFQPKGEGESSLDTTDAAKIVAKI
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA