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The map label for this gene is hflC [H]

Identifier: 117919053

GI number: 117919053

Start: 703661

End: 704554

Strand: Direct

Name: hflC [H]

Synonym: Shewana3_0600

Alternate gene names: 117919053

Gene position: 703661-704554 (Clockwise)

Preceding gene: 117919052

Following gene: 117919054

Centisome position: 14.15

GC content: 45.97

Gene sequence:

>894_bases
ATGGGTAGATTAAGTATTGTTCTGATTGCCATCGTATTAGGCATAGGTCTGTCATCTGTGATGGTGGTTAACGAAGGCGA
ACGTGCGATTGTGGCGCGTTTCGGTGAAATCGTTAAAGACAAGGTTGACGGCAAACCAGTGACCCGCGTTTTCGCCCCTG
GCATACACTTTAAAGTGCCGGTGATCGATAAAGTGAAGTTACTCGATGCGCGTATCCAAACCTTAGATGGTGCAGCGGAT
CGTTTCGTCACCTCTGAGAAGAAAGATTTGATGGTCGACTCCTATGTGAAGTGGCGTATTTTCGACTTCGAAAAATACTA
CCTCTCCACTAACGGTGGTATTAAGTCGAATGCCGAGACCTTACTACAACGTAAGATCAACAACGACTTACGTACCGAGT
TTGGTCGCCGCACTATCAAAGAAATCGTTTCTGGTAAACGCGATGAGCTGCAAAATGATGCGTTAGAAAACGCCTCTGAA
AGCGCTAAAGACTTAGGTATTGAAGTGGTTGATGTGCGTGTGAAGCAAATCAACCTACCTGCAAACGTGAGTAACAGTAT
TTACCAACGTATGCGTGCCGAGCGTCAAGCGGTTGCTAAAGAGCATAGAGCACAGGGTAAAGAGCAGTCTGAAATTATCC
GTGCGACCATTGATGCCAACGTGACCGTGAAGATTGCCGAAGCCGAGCGTAAAGCCTTAACCATCCGCGGTGAAGGTGAT
GCGCAAGCCGCGAAAATTTATTCTGATGCTTACAGTAAAGATCCCGAGTTTTTCAGCTTCTTACGTAGCTTAGATGCTTA
CCGTGCGAGTTTCTCCGGTAACTCTGACGTCATGGTATTAGAACCTGATAGCGAGTTCTTCAAATATATGAAGAGCACTT
CACCTAAGAAGTAA

Upstream 100 bases:

>100_bases
GAACGTCAATTCTTCATCTATGTCAACGACTCGCATTGGTGAGCCTTTGAGTGGACGCCCTTCTCGCGAGGACCGTGCTC
GCCAAGGGAGGGAGTAATCC

Downstream 100 bases:

>100_bases
GCAATCAATAGTGTATTGAAATGGGTCCTGAAAACAGGGCCCATTTTTTTATCTGCAGGAAAATGTAAAGTGACAAAATG
GGAGTTGGAGTTATATTAGC

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MGRLSIVLIAIVLGIGLSSVMVVNEGERAIVARFGEIVKDKVDGKPVTRVFAPGIHFKVPVIDKVKLLDARIQTLDGAAD
RFVTSEKKDLMVDSYVKWRIFDFEKYYLSTNGGIKSNAETLLQRKINNDLRTEFGRRTIKEIVSGKRDELQNDALENASE
SAKDLGIEVVDVRVKQINLPANVSNSIYQRMRAERQAVAKEHRAQGKEQSEIIRATIDANVTVKIAEAERKALTIRGEGD
AQAAKIYSDAYSKDPEFFSFLRSLDAYRASFSGNSDVMVLEPDSEFFKYMKSTSPKK

Sequences:

>Translated_297_residues
MGRLSIVLIAIVLGIGLSSVMVVNEGERAIVARFGEIVKDKVDGKPVTRVFAPGIHFKVPVIDKVKLLDARIQTLDGAAD
RFVTSEKKDLMVDSYVKWRIFDFEKYYLSTNGGIKSNAETLLQRKINNDLRTEFGRRTIKEIVSGKRDELQNDALENASE
SAKDLGIEVVDVRVKQINLPANVSNSIYQRMRAERQAVAKEHRAQGKEQSEIIRATIDANVTVKIAEAERKALTIRGEGD
AQAAKIYSDAYSKDPEFFSFLRSLDAYRASFSGNSDVMVLEPDSEFFKYMKSTSPKK
>Mature_296_residues
GRLSIVLIAIVLGIGLSSVMVVNEGERAIVARFGEIVKDKVDGKPVTRVFAPGIHFKVPVIDKVKLLDARIQTLDGAADR
FVTSEKKDLMVDSYVKWRIFDFEKYYLSTNGGIKSNAETLLQRKINNDLRTEFGRRTIKEIVSGKRDELQNDALENASES
AKDLGIEVVDVRVKQINLPANVSNSIYQRMRAERQAVAKEHRAQGKEQSEIIRATIDANVTVKIAEAERKALTIRGEGDA
QAAKIYSDAYSKDPEFFSFLRSLDAYRASFSGNSDVMVLEPDSEFFKYMKSTSPKK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=315, Percent_Identity=53.015873015873, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI1786697, Length=251, Percent_Identity=23.5059760956175, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193209764, Length=205, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569493, Length=205, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 33259; Mature: 33128

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLSIVLIAIVLGIGLSSVMVVNEGERAIVARFGEIVKDKVDGKPVTRVFAPGIHFKVP
CCHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHEECCCCEEECC
VIDKVKLLDARIQTLDGAADRFVTSEKKDLMVDSYVKWRIFDFEKYYLSTNGGIKSNAET
CHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHCEEEEEEEEEEEEEEECCCCCCCHHHH
LLQRKINNDLRTEFGRRTIKEIVSGKRDELQNDALENASESAKDLGIEVVDVRVKQINLP
HHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCC
ANVSNSIYQRMRAERQAVAKEHRAQGKEQSEIIRATIDANVTVKIAEAERKALTIRGEGD
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEECCCEEEEEEECCCEEEEEECCCC
AQAAKIYSDAYSKDPEFFSFLRSLDAYRASFSGNSDVMVLEPDSEFFKYMKSTSPKK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
GRLSIVLIAIVLGIGLSSVMVVNEGERAIVARFGEIVKDKVDGKPVTRVFAPGIHFKVP
CHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHEECCCCEEECC
VIDKVKLLDARIQTLDGAADRFVTSEKKDLMVDSYVKWRIFDFEKYYLSTNGGIKSNAET
CHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHCEEEEEEEEEEEEEEECCCCCCCHHHH
LLQRKINNDLRTEFGRRTIKEIVSGKRDELQNDALENASESAKDLGIEVVDVRVKQINLP
HHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCC
ANVSNSIYQRMRAERQAVAKEHRAQGKEQSEIIRATIDANVTVKIAEAERKALTIRGEGD
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEECCCEEEEEEECCCEEEEEECCCC
AQAAKIYSDAYSKDPEFFSFLRSLDAYRASFSGNSDVMVLEPDSEFFKYMKSTSPKK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]