BacMap

Definition	Shewanella sp. ANA-3 chromosome chromosome 1, complete sequence.
Accession	NC_008577
Length	4,972,204

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The map label for this gene is butA [H]

Identifier: 117918760

GI number: 117918760

Start: 339908

End: 340669

Strand: Direct

Name: butA [H]

Synonym: Shewana3_0303

Alternate gene names: 117918760

Gene position: 339908-340669 (Clockwise)

Preceding gene: 117918758

Following gene: 117918761

Centisome position: 6.84

GC content: 53.28

Gene sequence:

>762_bases
ATGCGTTTACTGAATAAAACCGCGGTGGTGACGGGGGCTGCCGGGGGCATAGGGCAAGCGATCATCCGTAAACTACTCGC
CGAAGGGGCTCGCGTTGTTGCTGCCGATCTGTCGGCCGATGCGCTCAAAGTATTTAACGATTTTCCCGCCGATAAGTTGG
TGACTTTTAGCGTCGATGTGACCGACTACAAGCAAGTTGAAGCCATGGTCAAGCATGCGGCTGACCAGTTCGGTCAGCTC
GATATTCTGATCAATAATGCCGGCATAGGCTTGGCTAAGCCGCTGTTACAGCATGATCCTATTAATGATTTTGAACCTGT
CACCAATGTAAACCAAAAAGGCGTGTACCACGGCATCCTTGCCGGTGGCCGTCAATTCCAAGCCCAAGGCTCTCGGGGCG
TGATTTTAAATACTTCGTCGGTTTACGCGCAGATCGCCTCAGAAATGACTTTCACCTACAACGTCAGTAAAGCCGCCGTC
GACATGATGACCAAATGCGCCGCGCTTGAACTGGCGCCGCTTGGCGTGCGGGTTTGCGCCGTGGCGCCGGGCCGTGTCGA
CACACCTATGCTGCGTCAATACGAGGCGCTCGGGTTGTGGGAACACATTCGTAAAGAGCAAATGCGTCAAGAATTTACCC
AACCGAATGAGATTGCCGATGTGGTGGCGTTTCTGGTTAGTGACGAGGCCAACTGCATCAATGGCTGCACAGTGAACGCC
TCCGACGGCTTTGAAAACTTTAAATATCCACTGCTGGGGTAG

Upstream 100 bases:

>100_bases
ATCAAATTTGGCTCGTAATAAGTCAAGAATATGTGCAATTAACCATCTAAATTAACAACGTCTTAATAATGAAATTGATA
AATATAAAAAGAGGACAGCT

Downstream 100 bases:

>100_bases
TGGAAGCTTGACCCGACACAATAACAACAATGAGGAATGCAAACATGGCTCTACCCGAAGTGATTAATCATCAAGACTTT
TTATTAACCCTCAATACCAA

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MRLLNKTAVVTGAAGGIGQAIIRKLLAEGARVVAADLSADALKVFNDFPADKLVTFSVDVTDYKQVEAMVKHAADQFGQL
DILINNAGIGLAKPLLQHDPINDFEPVTNVNQKGVYHGILAGGRQFQAQGSRGVILNTSSVYAQIASEMTFTYNVSKAAV
DMMTKCAALELAPLGVRVCAVAPGRVDTPMLRQYEALGLWEHIRKEQMRQEFTQPNEIADVVAFLVSDEANCINGCTVNA
SDGFENFKYPLLG

Sequences:

>Translated_253_residues
MRLLNKTAVVTGAAGGIGQAIIRKLLAEGARVVAADLSADALKVFNDFPADKLVTFSVDVTDYKQVEAMVKHAADQFGQL
DILINNAGIGLAKPLLQHDPINDFEPVTNVNQKGVYHGILAGGRQFQAQGSRGVILNTSSVYAQIASEMTFTYNVSKAAV
DMMTKCAALELAPLGVRVCAVAPGRVDTPMLRQYEALGLWEHIRKEQMRQEFTQPNEIADVVAFLVSDEANCINGCTVNA
SDGFENFKYPLLG
>Mature_253_residues
MRLLNKTAVVTGAAGGIGQAIIRKLLAEGARVVAADLSADALKVFNDFPADKLVTFSVDVTDYKQVEAMVKHAADQFGQL
DILINNAGIGLAKPLLQHDPINDFEPVTNVNQKGVYHGILAGGRQFQAQGSRGVILNTSSVYAQIASEMTFTYNVSKAAV
DMMTKCAALELAPLGVRVCAVAPGRVDTPMLRQYEALGLWEHIRKEQMRQEFTQPNEIADVVAFLVSDEANCINGCTVNA
SDGFENFKYPLLG

Specific function: Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=30.3149606299213, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=32.1285140562249, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI4758504, Length=194, Percent_Identity=35.0515463917526, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI31542939, Length=233, Percent_Identity=30.9012875536481, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=28.740157480315, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI66933014, Length=223, Percent_Identity=32.2869955156951, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI5031737, Length=239, Percent_Identity=28.8702928870293, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=31.2, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=29.1304347826087, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI83715985, Length=179, Percent_Identity=33.5195530726257, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI22507405, Length=210, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI224922801, Length=175, Percent_Identity=31.4285714285714, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI19743808, Length=221, Percent_Identity=28.0542986425339, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=28.125, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI209862901, Length=216, Percent_Identity=28.7037037037037, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI19923983, Length=216, Percent_Identity=28.7037037037037, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI150247226, Length=189, Percent_Identity=31.7460317460317, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4503301, Length=226, Percent_Identity=26.5486725663717, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=29.6442687747036, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=28.1632653061224, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=33.0708661417323, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=31.0483870967742, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790717, Length=243, Percent_Identity=28.8065843621399, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=26.9076305220884, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=29.6747967479675, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=29.7959183673469, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787820, Length=181, Percent_Identity=27.0718232044199, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367365, Length=241, Percent_Identity=27.8008298755187, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=30, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788459, Length=169, Percent_Identity=29.585798816568, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789057, Length=260, Percent_Identity=25, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=25.7028112449799, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=243, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=31.4393939393939, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562906, Length=250, Percent_Identity=31.6, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562910, Length=245, Percent_Identity=29.3877551020408, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17562908, Length=253, Percent_Identity=29.6442687747036, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=28.90625, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=30.5882352941176, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=247, Percent_Identity=31.5789473684211, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=251, Percent_Identity=29.8804780876494, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI72000259, Length=253, Percent_Identity=31.2252964426877, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=249, Percent_Identity=32.1285140562249, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=243, Percent_Identity=30.0411522633745, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=251, Percent_Identity=29.8804780876494, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=243, Percent_Identity=28.3950617283951, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=243, Percent_Identity=27.1604938271605, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=30.8, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538480, Length=262, Percent_Identity=29.7709923664122, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=258, Percent_Identity=28.2945736434109, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=29.1338582677165, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=245, Percent_Identity=27.3469387755102, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=268, Percent_Identity=28.3582089552239, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=273, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=260, Percent_Identity=26.1538461538462, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=29.8804780876494, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=255, Percent_Identity=26.2745098039216, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=230, Percent_Identity=29.1304347826087, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=230, Percent_Identity=29.1304347826087, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=26.615969581749, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=197, Percent_Identity=32.48730964467, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=199, Percent_Identity=28.1407035175879, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI86565303, Length=214, Percent_Identity=28.5046728971963, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115534660, Length=216, Percent_Identity=26.8518518518519, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=246, Percent_Identity=28.0487804878049, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=246, Percent_Identity=27.2357723577236, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17737361, Length=233, Percent_Identity=35.1931330472103, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=31.6, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI23397609, Length=257, Percent_Identity=35.0194552529183, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21357041, Length=260, Percent_Identity=31.5384615384615, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=30.952380952381, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=29.296875, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=29.3650793650794, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24644337, Length=192, Percent_Identity=32.2916666666667, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21355319, Length=253, Percent_Identity=32.0158102766798, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221331218, Length=219, Percent_Identity=30.5936073059361, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24665243, Length=219, Percent_Identity=30.5936073059361, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221331216, Length=219, Percent_Identity=30.1369863013699, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24665247, Length=219, Percent_Identity=30.1369863013699, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI116007236, Length=203, Percent_Identity=29.064039408867, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648693, Length=240, Percent_Identity=30, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21355889, Length=240, Percent_Identity=30, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28571387, Length=202, Percent_Identity=30.1980198019802, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.304 [H]

Molecular weight: Translated: 27288; Mature: 27288

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLNKTAVVTGAAGGIGQAIIRKLLAEGARVVAADLSADALKVFNDFPADKLVTFSVDV
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCEEEEEECC
TDYKQVEAMVKHAADQFGQLDILINNAGIGLAKPLLQHDPINDFEPVTNVNQKGVYHGIL
CHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
AGGRQFQAQGSRGVILNTSSVYAQIASEMTFTYNVSKAAVDMMTKCAALELAPLGVRVCA
HCCCEEECCCCCEEEEECHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHEECCCCEEEEE
VAPGRVDTPMLRQYEALGLWEHIRKEQMRQEFTQPNEIADVVAFLVSDEANCINGCTVNA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEC
SDGFENFKYPLLG
CCCCCCCCCCCCC
>Mature Secondary Structure
MRLLNKTAVVTGAAGGIGQAIIRKLLAEGARVVAADLSADALKVFNDFPADKLVTFSVDV
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCEEEEEECC
TDYKQVEAMVKHAADQFGQLDILINNAGIGLAKPLLQHDPINDFEPVTNVNQKGVYHGIL
CHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
AGGRQFQAQGSRGVILNTSSVYAQIASEMTFTYNVSKAAVDMMTKCAALELAPLGVRVCA
HCCCEEECCCCCEEEEECHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHEECCCCEEEEE
VAPGRVDTPMLRQYEALGLWEHIRKEQMRQEFTQPNEIADVVAFLVSDEANCINGCTVNA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEC
SDGFENFKYPLLG
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA