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The map label for this gene is merR [H]

Identifier: 117676254

GI number: 117676254

Start: 203557

End: 203949

Strand: Reverse

Name: merR [H]

Synonym: Shewana3_4315

Alternate gene names: 117676254

Gene position: 203949-203557 (Counterclockwise)

Preceding gene: 117676255

Following gene: 117676253

Centisome position: 73.12

GC content: 48.09

Gene sequence:

>393_bases
ATGAACATGACAAGAACTATCAGTAAAGTTGCCAAAGAACTGGCTATCAATATAGAAACCGTTCGCTTCTATGAGCGTCG
TGGATTAATAGAGCAACCGCCAAAACCCGAGTTGGGCTACCGCCATTATCCCGATGAAACGGTTAATCGCATCCGGTTCA
TTAAGCGGGCGCAAGAATTGGGGTTTACCCTGGAAGAGATCGCCAACCTGCTAAGCTTGAATGACCGCCCATGTGCTCAG
GTGCAGGAGCTGGCCGAGTATAAACTCAGCGCCGTCATGGAAAAAATTGCCGATCTGAAGCGGCTCGAAAGCGCACTCAA
GGCATTATTGACGCAATGTCAGAGTAATAACGATGACTCACATTGTCCCATTATCGACTCCCTGCAACCTTAA

Upstream 100 bases:

>100_bases
GGGAGTACATTGAAGAAGGACAGCAGCTCTCCAATAACGCTACCCATATATTGATGGAGAAAATGGCGGTTCTTATAGAT
ACCGTTCGGGTAAAAGAGAT

Downstream 100 bases:

>100_bases
TTAGTTTTACACGGGCATCACAAAAACGTTTGACTCCGTACATCGGTACGGAGATTACACTTGCTCCATACACTGAAATC
AGAGGAGTAAGTCGTGTCAC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MNMTRTISKVAKELAINIETVRFYERRGLIEQPPKPELGYRHYPDETVNRIRFIKRAQELGFTLEEIANLLSLNDRPCAQ
VQELAEYKLSAVMEKIADLKRLESALKALLTQCQSNNDDSHCPIIDSLQP

Sequences:

>Translated_130_residues
MNMTRTISKVAKELAINIETVRFYERRGLIEQPPKPELGYRHYPDETVNRIRFIKRAQELGFTLEEIANLLSLNDRPCAQ
VQELAEYKLSAVMEKIADLKRLESALKALLTQCQSNNDDSHCPIIDSLQP
>Mature_130_residues
MNMTRTISKVAKELAINIETVRFYERRGLIEQPPKPELGYRHYPDETVNRIRFIKRAQELGFTLEEIANLLSLNDRPCAQ
VQELAEYKLSAVMEKIADLKRLESALKALLTQCQSNNDDSHCPIIDSLQP

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=125, Percent_Identity=35.2, Blast_Score=76, Evalue=8e-16,
Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=30.46875, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14957; Mature: 14957

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMTRTISKVAKELAINIETVRFYERRGLIEQPPKPELGYRHYPDETVNRIRFIKRAQEL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GFTLEEIANLLSLNDRPCAQVQELAEYKLSAVMEKIADLKRLESALKALLTQCQSNNDDS
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HCPIIDSLQP
CCCCCCCCCC
>Mature Secondary Structure
MNMTRTISKVAKELAINIETVRFYERRGLIEQPPKPELGYRHYPDETVNRIRFIKRAQEL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GFTLEEIANLLSLNDRPCAQVQELAEYKLSAVMEKIADLKRLESALKALLTQCQSNNDDS
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HCPIIDSLQP
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6091128; 2551364 [H]