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The map label for this gene is pcoA [H]

Identifier: 117676226

GI number: 117676226

Start: 170147

End: 172075

Strand: Direct

Name: pcoA [H]

Synonym: Shewana3_4287

Alternate gene names: 117676226

Gene position: 170147-172075 (Clockwise)

Preceding gene: 117676225

Following gene: 117676227

Centisome position: 61.0

GC content: 45.26

Gene sequence:

>1929_bases
ATGAAATCGCAATACATGATAAAACCCATGATTCAAATGACAAACAGTGAACTCAACAACAGCCGACGCCGGTTTGTGTT
TGGTGCATCCGCCATGTTGGCATTGATGTCGATCCCTTTCCCTAAAAATGCCGTTGCCAATGCGTTAAGCCAATCGTTGA
GCCAGCTCTCTGGCAAAGTGTTTGACTTAACAATTGACTATAAAATGGTTAATTTTACCGGGAAATCTGCTCGAGCTACT
GTGGTAAACCAATTACTGCCCGCGCCGTTATTACGTTGGAAAGAAGGTGAAACAGTCACCTTAAGAGTAAAAAATAATCT
CGACCATGATAGCTCTATTCACTGGCACGGTATTATTTTACCCACCGAAATGGACGGTGTGCCTGGCTTTAGCTTTGATG
GCATTAAACCCGGTGAAACATTTGAGTATCAATTTACCGTCCAGCAAAGTGGCACATATTGGTATCACAGTCATTCAGGC
TATCAAGAACAAACCGGTTTATTCGGCGCTATTGTGATTGATCCAGCGACCCCCGATCCGGTTATATATGACCGTGACTA
TGTGATCATGCTGTCAGATTGGTCTGACGAAGCCCCTGAAAACATTTATGCCAAATTAAAGAAACAAGCCGATTACTATA
ATTACCGTGAGCGTACGGTAATGGATTTTTTCTCTGACGTGAATAAAAATGGCTTAGCCAATACGTGGAACGCTCGTTCG
ATGTGGAATAACGCGCGCATGAGTGACAGAGACATATCTGATGTTACGGGTTCAACTTACACCTATTTAATGAATGGCAA
TCCTCCGCAACAGGGCTGGCAAGGGTTGTTTGAACAAGGTGAGAAGGTGCGCTTACGCTTTATAAATAGTTCTGCTATGA
CCATATTTGATGTACGTATACCGGGTCTCAAAATGAGTGTTGTCGCCAGTGATGGTCAGAACATTCAACCGGTATCTGTG
GATGAATTTCGAATCGGTGTTGCTGAAACCTATGATGTGGTTATTGAGCCAGAGGTTGATAATGCCTATTGTATTTTCGC
TCAAAGTATTGACCGCACCGGCTTTACGGTAGGTAACCTTACCTCAGATGCCAGTTTACATGCTCCTATTCCCCCAATGG
ATCCAAGGCCAGTCCTTGGCCACAGTGATATGGGCATGGATATGAGTGATATGGATATGAGCGGTATGGATCATAGCAAA
ATGGACATGGGCGCTGGTGATATGTCAGGCATGGATCACAGCAAGATGGCTATGGGTGGCGGTGATATGTCAGGCATGGA
TCACAGCAAGATGGCTATGGGTGGCGGTGATATGTCAGGCATGGATCACAGCAAAATGGCCATGGACGCTGCGAAAGCGA
CAGTCTCAGGACTAGGGCTTGCAGGCTTTGGCAGTAACAATGAAATTAAACACATTGACACCGAGTTCGGCCCACAAGTG
GATATGCGTGCAGATGCGCCAAAAAGTGGTTTACACGATCCCGGGATTGGATTGCGTGACCATCAACAACAATTTAATCG
CAAAGTATTAACTTATGGCGATATTAAAGGCTTACATCCTACCTACGACACGCGCCAACCTAGCCGCGAAATTCAACTGC
ATTTAACCGGCAATATGAACCGATATATGTGGTCTGTGAATGGGGTGAAATTTATGGACGCCGCGCCATTAGAGTTTGAA
TACGGAGAAAGACTGCGGATCACCTTAGTGAACGACACGATGATGACTCACCCTATGCATTTGCATGGTATGTGGAGTGA
GTTAGAGACAGGCGACCCTGATTTTATTCCCCGTAAGCACACGGTATTAGTTCAGCCGGGTTCTAAGATCAGTTACTTAG
TCACCGCCGATGCAAAAGGGCAATGGGCATATCATTGCCACTTGTTATTCCACATGCCAGGCATGTTCAGAAAAGTCGTG
GTGAAATAA

Upstream 100 bases:

>100_bases
AGTACCAAGATAAATTTATGCCATATCAAGTCTTACTGTTGAAAAAAGATGGCAGTAGTGAAGTTTACGCCCAAGTGAAC
TCGCTTGAGGAGTCTGTACA

Downstream 100 bases:

>100_bases
GGGGTATACAAAGGGGTATACAGATGAATAAAACGAATTTAGTGGCATTGGGACTGTTGAGTCTGAGCGCCTCATTGGCT
AGCTCAGCTGTGTTTGCCGG

Product: CopA family copper resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MKSQYMIKPMIQMTNSELNNSRRRFVFGASAMLALMSIPFPKNAVANALSQSLSQLSGKVFDLTIDYKMVNFTGKSARAT
VVNQLLPAPLLRWKEGETVTLRVKNNLDHDSSIHWHGIILPTEMDGVPGFSFDGIKPGETFEYQFTVQQSGTYWYHSHSG
YQEQTGLFGAIVIDPATPDPVIYDRDYVIMLSDWSDEAPENIYAKLKKQADYYNYRERTVMDFFSDVNKNGLANTWNARS
MWNNARMSDRDISDVTGSTYTYLMNGNPPQQGWQGLFEQGEKVRLRFINSSAMTIFDVRIPGLKMSVVASDGQNIQPVSV
DEFRIGVAETYDVVIEPEVDNAYCIFAQSIDRTGFTVGNLTSDASLHAPIPPMDPRPVLGHSDMGMDMSDMDMSGMDHSK
MDMGAGDMSGMDHSKMAMGGGDMSGMDHSKMAMGGGDMSGMDHSKMAMDAAKATVSGLGLAGFGSNNEIKHIDTEFGPQV
DMRADAPKSGLHDPGIGLRDHQQQFNRKVLTYGDIKGLHPTYDTRQPSREIQLHLTGNMNRYMWSVNGVKFMDAAPLEFE
YGERLRITLVNDTMMTHPMHLHGMWSELETGDPDFIPRKHTVLVQPGSKISYLVTADAKGQWAYHCHLLFHMPGMFRKVV
VK

Sequences:

>Translated_642_residues
MKSQYMIKPMIQMTNSELNNSRRRFVFGASAMLALMSIPFPKNAVANALSQSLSQLSGKVFDLTIDYKMVNFTGKSARAT
VVNQLLPAPLLRWKEGETVTLRVKNNLDHDSSIHWHGIILPTEMDGVPGFSFDGIKPGETFEYQFTVQQSGTYWYHSHSG
YQEQTGLFGAIVIDPATPDPVIYDRDYVIMLSDWSDEAPENIYAKLKKQADYYNYRERTVMDFFSDVNKNGLANTWNARS
MWNNARMSDRDISDVTGSTYTYLMNGNPPQQGWQGLFEQGEKVRLRFINSSAMTIFDVRIPGLKMSVVASDGQNIQPVSV
DEFRIGVAETYDVVIEPEVDNAYCIFAQSIDRTGFTVGNLTSDASLHAPIPPMDPRPVLGHSDMGMDMSDMDMSGMDHSK
MDMGAGDMSGMDHSKMAMGGGDMSGMDHSKMAMGGGDMSGMDHSKMAMDAAKATVSGLGLAGFGSNNEIKHIDTEFGPQV
DMRADAPKSGLHDPGIGLRDHQQQFNRKVLTYGDIKGLHPTYDTRQPSREIQLHLTGNMNRYMWSVNGVKFMDAAPLEFE
YGERLRITLVNDTMMTHPMHLHGMWSELETGDPDFIPRKHTVLVQPGSKISYLVTADAKGQWAYHCHLLFHMPGMFRKVV
VK
>Mature_642_residues
MKSQYMIKPMIQMTNSELNNSRRRFVFGASAMLALMSIPFPKNAVANALSQSLSQLSGKVFDLTIDYKMVNFTGKSARAT
VVNQLLPAPLLRWKEGETVTLRVKNNLDHDSSIHWHGIILPTEMDGVPGFSFDGIKPGETFEYQFTVQQSGTYWYHSHSG
YQEQTGLFGAIVIDPATPDPVIYDRDYVIMLSDWSDEAPENIYAKLKKQADYYNYRERTVMDFFSDVNKNGLANTWNARS
MWNNARMSDRDISDVTGSTYTYLMNGNPPQQGWQGLFEQGEKVRLRFINSSAMTIFDVRIPGLKMSVVASDGQNIQPVSV
DEFRIGVAETYDVVIEPEVDNAYCIFAQSIDRTGFTVGNLTSDASLHAPIPPMDPRPVLGHSDMGMDMSDMDMSGMDHSK
MDMGAGDMSGMDHSKMAMGGGDMSGMDHSKMAMGGGDMSGMDHSKMAMDAAKATVSGLGLAGFGSNNEIKHIDTEFGPQV
DMRADAPKSGLHDPGIGLRDHQQQFNRKVLTYGDIKGLHPTYDTRQPSREIQLHLTGNMNRYMWSVNGVKFMDAAPLEFE
YGERLRITLVNDTMMTHPMHLHGMWSELETGDPDFIPRKHTVLVQPGSKISYLVTADAKGQWAYHCHLLFHMPGMFRKVV
VK

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=449, Percent_Identity=25.1670378619154, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539950, Length=279, Percent_Identity=24.3727598566308, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320714, Length=280, Percent_Identity=25, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6321067, Length=279, Percent_Identity=26.8817204301075, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323703, Length=148, Percent_Identity=33.1081081081081, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28574104, Length=633, Percent_Identity=23.8546603475513, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24650186, Length=261, Percent_Identity=26.8199233716475, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI18859919, Length=279, Percent_Identity=27.9569892473118, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI281360167, Length=268, Percent_Identity=28.3582089552239, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585842, Length=266, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221330000, Length=266, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221329998, Length=266, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 71736; Mature: 71736

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00079 MULTICOPPER_OXIDASE1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
7.2 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
7.2 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSQYMIKPMIQMTNSELNNSRRRFVFGASAMLALMSIPFPKNAVANALSQSLSQLSGKV
CCCCCEEHHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEE
FDLTIDYKMVNFTGKSARATVVNQLLPAPLLRWKEGETVTLRVKNNLDHDSSIHWHGIIL
EEEEEEEEEEEECCCCHHHHHHHHHCCCHHHEECCCCEEEEEEECCCCCCCCEEEEEEEE
PTEMDGVPGFSFDGIKPGETFEYQFTVQQSGTYWYHSHSGYQEQTGLFGAIVIDPATPDP
ECCCCCCCCCCCCCCCCCCEEEEEEEEEECCEEEEECCCCCCHHCCEEEEEEECCCCCCC
VIYDRDYVIMLSDWSDEAPENIYAKLKKQADYYNYRERTVMDFFSDVNKNGLANTWNARS
EEECCCEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
MWNNARMSDRDISDVTGSTYTYLMNGNPPQQGWQGLFEQGEKVRLRFINSSAMTIFDVRI
HHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEC
PGLKMSVVASDGQNIQPVSVDEFRIGVAETYDVVIEPEVDNAYCIFAQSIDRTGFTVGNL
CCEEEEEEECCCCCCCCCCHHHEEECEEEEEEEEEEECCCCEEEEEEECCCCCCCEECCC
TSDASLHAPIPPMDPRPVLGHSDMGMDMSDMDMSGMDHSKMDMGAGDMSGMDHSKMAMGG
CCCCEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECC
GDMSGMDHSKMAMGGGDMSGMDHSKMAMDAAKATVSGLGLAGFGSNNEIKHIDTEFGPQV
CCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEEECCCCCCCC
DMRADAPKSGLHDPGIGLRDHQQQFNRKVLTYGDIKGLHPTYDTRQPSREIQLHLTGNMN
CCCCCCCCCCCCCCCCCCCHHHHHHCCEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCC
RYMWSVNGVKFMDAAPLEFEYGERLRITLVNDTMMTHPMHLHGMWSELETGDPDFIPRKH
EEEEEECCEEEECCCCCEECCCCEEEEEEECCCCCCCCEEEEECHHHCCCCCCCCCCCCE
TVLVQPGSKISYLVTADAKGQWAYHCHLLFHMPGMFRKVVVK
EEEECCCCCEEEEEEECCCCCEEEEEEEEECCCCHHHHHHCC
>Mature Secondary Structure
MKSQYMIKPMIQMTNSELNNSRRRFVFGASAMLALMSIPFPKNAVANALSQSLSQLSGKV
CCCCCEEHHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEE
FDLTIDYKMVNFTGKSARATVVNQLLPAPLLRWKEGETVTLRVKNNLDHDSSIHWHGIIL
EEEEEEEEEEEECCCCHHHHHHHHHCCCHHHEECCCCEEEEEEECCCCCCCCEEEEEEEE
PTEMDGVPGFSFDGIKPGETFEYQFTVQQSGTYWYHSHSGYQEQTGLFGAIVIDPATPDP
ECCCCCCCCCCCCCCCCCCEEEEEEEEEECCEEEEECCCCCCHHCCEEEEEEECCCCCCC
VIYDRDYVIMLSDWSDEAPENIYAKLKKQADYYNYRERTVMDFFSDVNKNGLANTWNARS
EEECCCEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
MWNNARMSDRDISDVTGSTYTYLMNGNPPQQGWQGLFEQGEKVRLRFINSSAMTIFDVRI
HHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEC
PGLKMSVVASDGQNIQPVSVDEFRIGVAETYDVVIEPEVDNAYCIFAQSIDRTGFTVGNL
CCEEEEEEECCCCCCCCCCHHHEEECEEEEEEEEEEECCCCEEEEEEECCCCCCCEECCC
TSDASLHAPIPPMDPRPVLGHSDMGMDMSDMDMSGMDHSKMDMGAGDMSGMDHSKMAMGG
CCCCEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECC
GDMSGMDHSKMAMGGGDMSGMDHSKMAMDAAKATVSGLGLAGFGSNNEIKHIDTEFGPQV
CCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEEECCCCCCCC
DMRADAPKSGLHDPGIGLRDHQQQFNRKVLTYGDIKGLHPTYDTRQPSREIQLHLTGNMN
CCCCCCCCCCCCCCCCCCCHHHHHHCCEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCC
RYMWSVNGVKFMDAAPLEFEYGERLRITLVNDTMMTHPMHLHGMWSELETGDPDFIPRKH
EEEEEECCEEEECCCCCEECCCCEEEEEEECCCCCCCCEEEEECHHHCCCCCCCCCCCCE
TVLVQPGSKISYLVTADAKGQWAYHCHLLFHMPGMFRKVVVK
EEEECCCCCEEEEEEECCCCCEEEEEEEEECCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]