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The map label for this gene is msrA [H]

Identifier: 116872316

GI number: 116872316

Start: 928036

End: 929607

Strand: Direct

Name: msrA [H]

Synonym: lwe0898

Alternate gene names: 116872316

Gene position: 928036-929607 (Clockwise)

Preceding gene: 116872315

Following gene: 116872317

Centisome position: 32.98

GC content: 36.83

Gene sequence:

>1572_bases
ATGTCTATAATCGAAATTAATCAATTAAAAATAGAAGTAGCAGACAGGATTTTAGTAGAAATCCCCCATTTACTAGTTAA
TAAAAAAGCAAGAATTGGCATCATCGGTCAAAATGGTCTAGGAAAAACAACGCTAATGGAAGTGATTGCTGGCGCCAAAG
AAGCCACATCTGGCACCGTAATTACACAAGGAAAACTCGCATACATCAAACAACTTTCCAATGATAAGAGCACCAAAAGC
GGTGGCGAAAAAACACGAAAAGCTATCCAGCAAGCGATGCGCCAAAATCCAAGTGTTCTCTTAGCAGACGAACCAACGAG
CAATCTGGATGTCGAAAGCGTAAAACATTTAGAACGCCAGTGGAGTGATTTTCACGGTGCACTTCTGATTATCTCGCATG
ACCGAGCCTTTCTAGATGCACTTTGCACAGAAATATGGGAAATCAAAAATCAAACTATTCATGTCTACAAAGGCAATTAT
CATGCCTATTTAGAGCAAAAACAACAACATGAAAACCAAGCGGAACTCGCTTACAAAGAATTTAAAAACAAAAAGAAACA
ACTACAGGCATCTCAAACGCATCACGAAATCGAAGCAGGACGAATTGTTAAACCAGGTAAACGCTTAAACAACAAGGAAG
CCAGTGCTTTTAAAGCAGGAAAAGGCACGCAACAAAAGAAACAGCATAGCACCATAAAAGCCTTAGAAAAACGAATTGAG
CGACTCGGTAATGTCGAAAAACCTCATACAACTAAACCAATCAAAATTATCACTCCAGATAATCGAATAATTAAAAAAGG
TAATACTATATTAAGTGTCAGAGAATCAACATACGAAATTACTGGACGAAAATTGTTTAAAACAGAGGCTTTCTCAATAA
AATCTGGTGACAAAGTAGCTCTTATTGGTGAAAACGCAAGTGGAAAAACCACATTTTTAAGAGAAATAATCCAAGGAAAT
CCAACTATCACATGTAATACTCAAGCAAAAGTGGCTTATTTTGATCAAGAATTAAAAGGACTAGATTTAGCGAAAACTCT
TTTAGAAAACATGACAAATATTAGCGTTCAAACCAAGCAAGTAAACAGAGAAGTCCTTGGTAGCATGCACTTTAAAGAAA
GCGATTTGTATAAAGAAGTGCGCATGCTCTCTGGCGGGGAACGGGTAAAATTACTTCTCAGCATGCTTCTTGTTAGCGAT
GCGAATTTTCTTATCCTAGATGAACCAACGAACTATTTGGACATTTACGCAATGGAAGCTTTGGAAGCATTAATCAAACA
ATTTACTGGAACGATCTTATTTGTTTCTCATGATAGAACCTTTGTAAATCAAGTAGCAGAAGAGGTAGTCGCAATTGAAA
ACAATCAAATGACTTTCCACCGAATGACTTTCTCAGAATATGAAGAAAGTAAAACCCCAAGTCGCTTTTCAGAAGAAGAT
AAATTGATTTTAGAGATGCGGATGTCAGAAATCGCCGCAAAACTAATGCAACCCAATTTAAAGCCAGCAGAAAAAGCAAT
GCTCGAACAAACTTATCAAGAAATTATCACAAAAAGACAGCAATTTACCTAA

Upstream 100 bases:

>100_bases
GGGATTCGTATGTTCATTTTGCATGATAACTCTAGCTATAGGCTTTTTTTGGCGTAGCTCCGCGGATTCCTCTCTGAAAA
TATTCAGGAGGTTATTTTTT

Downstream 100 bases:

>100_bases
ATTGTTGTCTTTTTCTGCAAGCAAAATAATAAATATTCTCATTTATCTTTTACTTGATTTCTTTAAAAGATAGGCTTAGA
ATCAAATAGTTATTAAAAAG

Product: ABC transporter ATP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSIIEINQLKIEVADRILVEIPHLLVNKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTVITQGKLAYIKQLSNDKSTKS
GGEKTRKAIQQAMRQNPSVLLADEPTSNLDVESVKHLERQWSDFHGALLIISHDRAFLDALCTEIWEIKNQTIHVYKGNY
HAYLEQKQQHENQAELAYKEFKNKKKQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIE
RLGNVEKPHTTKPIKIITPDNRIIKKGNTILSVRESTYEITGRKLFKTEAFSIKSGDKVALIGENASGKTTFLREIIQGN
PTITCNTQAKVAYFDQELKGLDLAKTLLENMTNISVQTKQVNREVLGSMHFKESDLYKEVRMLSGGERVKLLLSMLLVSD
ANFLILDEPTNYLDIYAMEALEALIKQFTGTILFVSHDRTFVNQVAEEVVAIENNQMTFHRMTFSEYEESKTPSRFSEED
KLILEMRMSEIAAKLMQPNLKPAEKAMLEQTYQEIITKRQQFT

Sequences:

>Translated_523_residues
MSIIEINQLKIEVADRILVEIPHLLVNKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTVITQGKLAYIKQLSNDKSTKS
GGEKTRKAIQQAMRQNPSVLLADEPTSNLDVESVKHLERQWSDFHGALLIISHDRAFLDALCTEIWEIKNQTIHVYKGNY
HAYLEQKQQHENQAELAYKEFKNKKKQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIE
RLGNVEKPHTTKPIKIITPDNRIIKKGNTILSVRESTYEITGRKLFKTEAFSIKSGDKVALIGENASGKTTFLREIIQGN
PTITCNTQAKVAYFDQELKGLDLAKTLLENMTNISVQTKQVNREVLGSMHFKESDLYKEVRMLSGGERVKLLLSMLLVSD
ANFLILDEPTNYLDIYAMEALEALIKQFTGTILFVSHDRTFVNQVAEEVVAIENNQMTFHRMTFSEYEESKTPSRFSEED
KLILEMRMSEIAAKLMQPNLKPAEKAMLEQTYQEIITKRQQFT
>Mature_522_residues
SIIEINQLKIEVADRILVEIPHLLVNKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTVITQGKLAYIKQLSNDKSTKSG
GEKTRKAIQQAMRQNPSVLLADEPTSNLDVESVKHLERQWSDFHGALLIISHDRAFLDALCTEIWEIKNQTIHVYKGNYH
AYLEQKQQHENQAELAYKEFKNKKKQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIER
LGNVEKPHTTKPIKIITPDNRIIKKGNTILSVRESTYEITGRKLFKTEAFSIKSGDKVALIGENASGKTTFLREIIQGNP
TITCNTQAKVAYFDQELKGLDLAKTLLENMTNISVQTKQVNREVLGSMHFKESDLYKEVRMLSGGERVKLLLSMLLVSDA
NFLILDEPTNYLDIYAMEALEALIKQFTGTILFVSHDRTFVNQVAEEVVAIENNQMTFHRMTFSEYEESKTPSRFSEEDK
LILEMRMSEIAAKLMQPNLKPAEKAMLEQTYQEIITKRQQFT

Specific function: Confers resistance to 14-membered ring macrolides (like erythromycin) and to B streptogramins, by acting as an ATP- dependent efflux pump [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI10947137, Length=411, Percent_Identity=27.4939172749392, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI27881506, Length=411, Percent_Identity=27.4939172749392, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI148612853, Length=433, Percent_Identity=26.5588914549654, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI10947135, Length=419, Percent_Identity=25.0596658711217, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI69354671, Length=419, Percent_Identity=25.0596658711217, Blast_Score=130, Evalue=4e-30,
Organism=Escherichia coli, GI2367384, Length=405, Percent_Identity=35.5555555555556, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1787182, Length=387, Percent_Identity=33.0749354005168, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1787041, Length=427, Percent_Identity=28.1030444964871, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1789751, Length=409, Percent_Identity=27.3838630806846, Blast_Score=155, Evalue=8e-39,
Organism=Escherichia coli, GI1786345, Length=219, Percent_Identity=24.2009132420091, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789891, Length=212, Percent_Identity=27.3584905660377, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559834, Length=413, Percent_Identity=27.1186440677966, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17553372, Length=396, Percent_Identity=28.7878787878788, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17555318, Length=383, Percent_Identity=27.9373368146214, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320874, Length=398, Percent_Identity=26.8844221105528, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6321121, Length=398, Percent_Identity=25.1256281407035, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324314, Length=186, Percent_Identity=28.494623655914, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325030, Length=212, Percent_Identity=31.1320754716981, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323278, Length=242, Percent_Identity=25.2066115702479, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24642252, Length=398, Percent_Identity=26.8844221105528, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI18859989, Length=398, Percent_Identity=26.8844221105528, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24666836, Length=410, Percent_Identity=29.0243902439024, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24641342, Length=412, Percent_Identity=27.4271844660194, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 59284; Mature: 59153

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIEINQLKIEVADRILVEIPHLLVNKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTV
CCEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEE
ITQGKLAYIKQLSNDKSTKSGGEKTRKAIQQAMRQNPSVLLADEPTSNLDVESVKHLERQ
EECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHH
WSDFHGALLIISHDRAFLDALCTEIWEIKNQTIHVYKGNYHAYLEQKQQHENQAELAYKE
HHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHH
FKNKKKQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIE
HHHHHHHHHHHHHHHHHCCCCEECCCHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHH
RLGNVEKPHTTKPIKIITPDNRIIKKGNTILSVRESTYEITGRKLFKTEAFSIKSGDKVA
HHCCCCCCCCCCCEEEECCCCCEEECCCEEEEEECCHHHHCCCEEEEEHEEEECCCCEEE
LIGENASGKTTFLREIIQGNPTITCNTQAKVAYFDQELKGLDLAKTLLENMTNISVQTKQ
EEECCCCCHHHHHHHHHCCCCCEEECCCCEEEEHHHHHCCHHHHHHHHHHHHCCEEEHHH
VNREVLGSMHFKESDLYKEVRMLSGGERVKLLLSMLLVSDANFLILDEPTNYLDIYAMEA
HHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
LEALIKQFTGTILFVSHDRTFVNQVAEEVVAIENNQMTFHRMTFSEYEESKTPSRFSEED
HHHHHHHHCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCCCCH
KLILEMRMSEIAAKLMQPNLKPAEKAMLEQTYQEIITKRQQFT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIIEINQLKIEVADRILVEIPHLLVNKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTV
CEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEE
ITQGKLAYIKQLSNDKSTKSGGEKTRKAIQQAMRQNPSVLLADEPTSNLDVESVKHLERQ
EECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHH
WSDFHGALLIISHDRAFLDALCTEIWEIKNQTIHVYKGNYHAYLEQKQQHENQAELAYKE
HHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHH
FKNKKKQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIE
HHHHHHHHHHHHHHHHHCCCCEECCCHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHH
RLGNVEKPHTTKPIKIITPDNRIIKKGNTILSVRESTYEITGRKLFKTEAFSIKSGDKVA
HHCCCCCCCCCCCEEEECCCCCEEECCCEEEEEECCHHHHCCCEEEEEHEEEECCCCEEE
LIGENASGKTTFLREIIQGNPTITCNTQAKVAYFDQELKGLDLAKTLLENMTNISVQTKQ
EEECCCCCHHHHHHHHHCCCCCEEECCCCEEEEHHHHHCCHHHHHHHHHHHHCCEEEHHH
VNREVLGSMHFKESDLYKEVRMLSGGERVKLLLSMLLVSDANFLILDEPTNYLDIYAMEA
HHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
LEALIKQFTGTILFVSHDRTFVNQVAEEVVAIENNQMTFHRMTFSEYEESKTPSRFSEED
HHHHHHHHCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCCCCH
KLILEMRMSEIAAKLMQPNLKPAEKAMLEQTYQEIITKRQQFT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2233255 [H]