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The map label for this gene is pgcA [H]

Identifier: 116872278

GI number: 116872278

Start: 891488

End: 893161

Strand: Direct

Name: pgcA [H]

Synonym: lwe0858

Alternate gene names: 116872278

Gene position: 891488-893161 (Clockwise)

Preceding gene: 116872277

Following gene: 116872279

Centisome position: 31.68

GC content: 35.66

Gene sequence:

>1674_bases
ATGACTTGGCAAAACAATCTAAAAGCATGGCAAAATGCTGATCTACCCAAAAAGTGGCAAAACGAATTAAATCAAGTAGC
AAATGAAAGAGAGCGATTTGATGGTTATTTAACGTTTGGAACAGGCGGAATGCGTGGTAAAATGGGTATTGGTTCGAAAC
GCATCAATCGTTACACCATTAGAAGAGTAGCAAGAGGGCTAGGGGAATATGTTGTTGCAAACGGAGGCAAAGAACAGGGC
GTTGCAATTGCTTATGATTCTAGACATCAATCAAATGAGTTTGCCGCTGAAACAGCAAAAGTTTTGTCAGCATTAGGAAT
TAAGGTTTATTTATCTGATGCGATTCGTCCAACTCCTGCTTTATCTTTTTGTGTTCGAGAAAAAGCAGCTTTTGCGGGTG
TTGTAATTACGGCCAGCCATAATCCTTCTATTTATAATGGATTTAAAGTTTATGATAAAAATGGTTGCCAAATCACACTT
GGAGTAGCAGAGGAAATTGCTGGCTATTTAGCGGAAATAACGGATATTTTTAGTATACCAGTGTGTGAATTGCCAAATCT
CCATGTAACTTCCAGGAGTAAAGAAATGGACGATGCTTATTTAAATGCTTTGACTAAAGTAGTGTCTCGTCCAGATTTAC
TAGCTGATTACGGGAATGAACTGGGGATTTGCTATACACCTCTCCATGGCGCTGGAAAAGAGCTTGTTATGCGAGGTCTT
TTGAAAAATGGTTTTTCGAATATAACACTAATTTCAGAACAAAGTGAGCCAGATGGGGATTTTCCAACAGTGAGTTCACC
TAATCCGGAAGAAGAAAACAGTTTTTCGTTAGCTAAAAAACAAGCGGAAAAAGTACAAGCTGATATTATTTTAGCGACCG
ATCCAGATGCGGACAGACTCGGAGTAGCTGTTTTAAATGACCAAAACGAGTATCAAATTTTAACAGGAAATCAGCTTGGA
GCTTTACTTTTAGATTATATTTTAGCAGCAAAAGCGGATTTATCTAAAACAGATACGATGATTAATACGATTGTAACAGG
GGATTTAGGTGGTAAAATAGCGCAGCATTTTGGTATTAATCATATTCAAACTCTTACTGGATTCAAATTTATTGGTGAAA
AAATAGCCGAGATGGAAAATACAGAAGCTCATTTTATTTTTGGATATGAAGAAAGTTATGGGTATTTGATTGCACCTTTT
GTTCGTGATAAAGATGCAGTTCAAGCGGCATTATTAACAGCTGAAATGGCTTTGTTTTATAAAAAAGAAGGAATAACCCT
TTTAACAAAATTGAAAAAATTATATAAAGCATTTGGTTATCATAAAGAGCATCTCCACACAATAACACTTGAAGACAATA
ATGGTTTAGAAAAAATGAACCAAGTGTTAGATTCACTACGAAAAGAACCTGCTTTTTTAGCAGAAATAGTAGCTGTAGAA
GACTTTTTTACGAGCGTGCGAACGAATCTTTTAACAAATGAAACAGTAAGCATTGAATTACCTAGAGAAAATGTATTGAA
ATTTTACTTGGCGGATGGATCTTGGTTTGCAATACGACCGTCGGGAACTGAACCAAAGTGTAAAATATATTTCCAAACCG
TAGCTAAAACAGAAGAAAATGCAACAAAAGCAATGAATAATCTAAAAAAACAAGTATTAGTTAAATGGAAGTAA

Upstream 100 bases:

>100_bases
GGGACACGTTGCATATGTATTATGGCGTGGCAGATACTTCCATGGCGGGTTGTGATATGAAAATCAGCGAAATTTTACAT
CAGTTAGAAGTGGAAAATAA

Downstream 100 bases:

>100_bases
TAAATAGCTGGAAATCATTTTGAATGGTTTTCAGCTATTTTTAAAAAATTCTAACCATAAAATAGCTAGAGACCCTTGAT
AAGCGTACATTTAGAAGGAA

Product: phosphoglucomutase/phosphomannomutase family protein

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MTWQNNLKAWQNADLPKKWQNELNQVANERERFDGYLTFGTGGMRGKMGIGSKRINRYTIRRVARGLGEYVVANGGKEQG
VAIAYDSRHQSNEFAAETAKVLSALGIKVYLSDAIRPTPALSFCVREKAAFAGVVITASHNPSIYNGFKVYDKNGCQITL
GVAEEIAGYLAEITDIFSIPVCELPNLHVTSRSKEMDDAYLNALTKVVSRPDLLADYGNELGICYTPLHGAGKELVMRGL
LKNGFSNITLISEQSEPDGDFPTVSSPNPEEENSFSLAKKQAEKVQADIILATDPDADRLGVAVLNDQNEYQILTGNQLG
ALLLDYILAAKADLSKTDTMINTIVTGDLGGKIAQHFGINHIQTLTGFKFIGEKIAEMENTEAHFIFGYEESYGYLIAPF
VRDKDAVQAALLTAEMALFYKKEGITLLTKLKKLYKAFGYHKEHLHTITLEDNNGLEKMNQVLDSLRKEPAFLAEIVAVE
DFFTSVRTNLLTNETVSIELPRENVLKFYLADGSWFAIRPSGTEPKCKIYFQTVAKTEENATKAMNNLKKQVLVKWK

Sequences:

>Translated_557_residues
MTWQNNLKAWQNADLPKKWQNELNQVANERERFDGYLTFGTGGMRGKMGIGSKRINRYTIRRVARGLGEYVVANGGKEQG
VAIAYDSRHQSNEFAAETAKVLSALGIKVYLSDAIRPTPALSFCVREKAAFAGVVITASHNPSIYNGFKVYDKNGCQITL
GVAEEIAGYLAEITDIFSIPVCELPNLHVTSRSKEMDDAYLNALTKVVSRPDLLADYGNELGICYTPLHGAGKELVMRGL
LKNGFSNITLISEQSEPDGDFPTVSSPNPEEENSFSLAKKQAEKVQADIILATDPDADRLGVAVLNDQNEYQILTGNQLG
ALLLDYILAAKADLSKTDTMINTIVTGDLGGKIAQHFGINHIQTLTGFKFIGEKIAEMENTEAHFIFGYEESYGYLIAPF
VRDKDAVQAALLTAEMALFYKKEGITLLTKLKKLYKAFGYHKEHLHTITLEDNNGLEKMNQVLDSLRKEPAFLAEIVAVE
DFFTSVRTNLLTNETVSIELPRENVLKFYLADGSWFAIRPSGTEPKCKIYFQTVAKTEENATKAMNNLKKQVLVKWK
>Mature_556_residues
TWQNNLKAWQNADLPKKWQNELNQVANERERFDGYLTFGTGGMRGKMGIGSKRINRYTIRRVARGLGEYVVANGGKEQGV
AIAYDSRHQSNEFAAETAKVLSALGIKVYLSDAIRPTPALSFCVREKAAFAGVVITASHNPSIYNGFKVYDKNGCQITLG
VAEEIAGYLAEITDIFSIPVCELPNLHVTSRSKEMDDAYLNALTKVVSRPDLLADYGNELGICYTPLHGAGKELVMRGLL
KNGFSNITLISEQSEPDGDFPTVSSPNPEEENSFSLAKKQAEKVQADIILATDPDADRLGVAVLNDQNEYQILTGNQLGA
LLLDYILAAKADLSKTDTMINTIVTGDLGGKIAQHFGINHIQTLTGFKFIGEKIAEMENTEAHFIFGYEESYGYLIAPFV
RDKDAVQAALLTAEMALFYKKEGITLLTKLKKLYKAFGYHKEHLHTITLEDNNGLEKMNQVLDSLRKEPAFLAEIVAVED
FFTSVRTNLLTNETVSIELPRENVLKFYLADGSWFAIRPSGTEPKCKIYFQTVAKTEENATKAMNNLKKQVLVKWK

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=548, Percent_Identity=32.1167883211679, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI31377548, Length=550, Percent_Identity=32.5454545454545, Blast_Score=248, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71993870, Length=576, Percent_Identity=32.1180555555556, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71993878, Length=315, Percent_Identity=33.6507936507937, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323934, Length=554, Percent_Identity=29.9638989169675, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI20129809, Length=559, Percent_Identity=30.7692307692308, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24651977, Length=435, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24653722, Length=550, Percent_Identity=27.6363636363636, Blast_Score=216, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 61828; Mature: 61697

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWQNNLKAWQNADLPKKWQNELNQVANERERFDGYLTFGTGGMRGKMGIGSKRINRYTI
CCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHH
RRVARGLGEYVVANGGKEQGVAIAYDSRHQSNEFAAETAKVLSALGIKVYLSDAIRPTPA
HHHHHHCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCHH
LSFCVREKAAFAGVVITASHNPSIYNGFKVYDKNGCQITLGVAEEIAGYLAEITDIFSIP
HHHHHHHHHHHEEEEEEECCCCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHCCC
VCELPNLHVTSRSKEMDDAYLNALTKVVSRPDLLADYGNELGICYTPLHGAGKELVMRGL
CCCCCCCEECCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEECCCCCCCHHHHHHHH
LKNGFSNITLISEQSEPDGDFPTVSSPNPEEENSFSLAKKQAEKVQADIILATDPDADRL
HHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEEEECCCCCCC
GVAVLNDQNEYQILTGNQLGALLLDYILAAKADLSKTDTMINTIVTGDLGGKIAQHFGIN
EEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHEEECCCCHHHHHHHCCC
HIQTLTGFKFIGEKIAEMENTEAHFIFGYEESYGYLIAPFVRDKDAVQAALLTAEMALFY
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHH
KKEGITLLTKLKKLYKAFGYHKEHLHTITLEDNNGLEKMNQVLDSLRKEPAFLAEIVAVE
HCCCCHHHHHHHHHHHHHCCCCHHEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHH
DFFTSVRTNLLTNETVSIELPRENVLKFYLADGSWFAIRPSGTEPKCKIYFQTVAKTEEN
HHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCEEEEECCCCCCCEEEEEEEHHCCHHH
ATKAMNNLKKQVLVKWK
HHHHHHHHHHHEEEECC
>Mature Secondary Structure 
TWQNNLKAWQNADLPKKWQNELNQVANERERFDGYLTFGTGGMRGKMGIGSKRINRYTI
CCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHH
RRVARGLGEYVVANGGKEQGVAIAYDSRHQSNEFAAETAKVLSALGIKVYLSDAIRPTPA
HHHHHHCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCHH
LSFCVREKAAFAGVVITASHNPSIYNGFKVYDKNGCQITLGVAEEIAGYLAEITDIFSIP
HHHHHHHHHHHEEEEEEECCCCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHCCC
VCELPNLHVTSRSKEMDDAYLNALTKVVSRPDLLADYGNELGICYTPLHGAGKELVMRGL
CCCCCCCEECCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEECCCCCCCHHHHHHHH
LKNGFSNITLISEQSEPDGDFPTVSSPNPEEENSFSLAKKQAEKVQADIILATDPDADRL
HHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEEEECCCCCCC
GVAVLNDQNEYQILTGNQLGALLLDYILAAKADLSKTDTMINTIVTGDLGGKIAQHFGIN
EEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHEEECCCCHHHHHHHCCC
HIQTLTGFKFIGEKIAEMENTEAHFIFGYEESYGYLIAPFVRDKDAVQAALLTAEMALFY
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHH
KKEGITLLTKLKKLYKAFGYHKEHLHTITLEDNNGLEKMNQVLDSLRKEPAFLAEIVAVE
HCCCCHHHHHHHHHHHHHCCCCHHEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHH
DFFTSVRTNLLTNETVSIELPRENVLKFYLADGSWFAIRPSGTEPKCKIYFQTVAKTEEN
HHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCEEEEECCCCCCCEEEEEEEHHCCHHH
ATKAMNNLKKQVLVKWK
HHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]