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The map label for this gene is malL [H]

Identifier: 116872275

GI number: 116872275

Start: 887954

End: 889486

Strand: Direct

Name: malL [H]

Synonym: lwe0855

Alternate gene names: 116872275

Gene position: 887954-889486 (Clockwise)

Preceding gene: 116872274

Following gene: 116872276

Centisome position: 31.55

GC content: 37.25

Gene sequence:

>1533_bases
TTGGAGTTTTGGCGTGGTAGTGTTTTTTATGAAATTTATATGAAATCATTTCAAGATAGTAATGGTGATGGTTTGGGTGA
CTTTGTAGGACTCACTAGTAGACTAGATTATCTGGCGGATTTAGGCGTGGATGGTATTTGGCTTACCCCATTTTATCCAT
CACCACAAGTGGATAATGGTTATGATGTGTCGGATTACTGCGAAATAAACCCGGATTACGGCAATATGACTGATTTCCGC
GAGTTTATGAAAGCAGCAGATGAGCGAGGTATCAAAGTTATTATTGATCTCGTGTTGAATCATTCTTCTACGGAGCATGT
TTGGTTTAAGGAATCACGTAAGAATAAAACCAATTCTAAACGAGATTATTATATTTGGCGCGAAAAACCAAATAATTGGG
AGTCGTTTTTCGGTGGTTCAGCATGGGAATTAGACGATCTTACTGGTGAATATTATTATCATAGCTTTGCAAAAGAACAA
GCAGATTTAAACTGGTCCAATCAAGCTGTTCGAGCAGAAATTGAGCAGATTTTAGCATTTTGGTTGAATGAAGGAGTGGC
GGGATTCCGATTAGACGTCATCAATAATTTAACACTTGTACTCGAGTTTCCAGATAATCCTGTAGTAGACGGGGAGATGG
AGCATGTTTATGACCGGAATCAGCAAGGGTTAGAACAGGCATTAGAAGATATTGCCTCGTTTTGTCGTAAAGAGCGAGAA
GTATTTTTAGTAGGTGAAATTAGTTCTGACAAACTACCGGAAATTGCGAAATATAGTTCAGAGAAAATGCTGGATGTTAC
GTTTAATTTTAATTTTGGAAGTGTGGAACAAATTGACGCAAAATCCGTATTTACTTCATTGAATGAGATGGAAACAGCGC
TAAATGAAGGACAATGGCCAACGTTGTTCTTTGGAAGTCATGATATGAGCAGATTTTTAACGCGACTTGCGGATGGAAAT
TTGTCGAAAACAAAGCTTTTAGCATTTTTAATGTTAACTGCTAAAGGAGTGCCATTTATTTATTACGGGGAAGAAGTAGG
GCTGCCAGATTTGCCTTTTTCTTCAGTGAAAGAGATGCGCGACATTCAAGGAACAAACGCTTATTATCAAGCATTAAAAA
CAGGTTCAAATGAAGAAGATGCACTTAAAATTGCGATAGGAAAAACAAGAGATAAAGCACGCGGACCAATGGTTTTTCCA
GATAAACGACCATTCACTTTAGATGAACCATGGATTAAAATGGCTAGTTTAAAAGAAGAGGAAGCACTTTCCATGTGGCA
GTTTTATAAAACATTACTTGCTTTTCGAAAAGCACATGATTTTAAAGAAAAAGAATATGCTTTTTTAAGATTGGATGGTG
AAATATTAAGTTATCAGCGTGGTGAATTCTTATTTTTACTTCATTTTGGAGAAGATAAGGTATTATATCCGCTTTCAGGT
CAAAAGCAACTTGTTTTTGGGGAGGCTGATATGTTAGAAACTGGTATTAGATTGGGTGCTTACACAGGGATTGCGCTCAG
AGTGGAGGATTAA

Upstream 100 bases:

>100_bases
TGTATTATTAACGCTTCCGCTTATTATTTTATTCTTATTCTTCTCAAAGAAATTCCAAGAAGGAATGCAATTTACTTTGA
AATAAAAGGAGCGACTGAAC

Downstream 100 bases:

>100_bases
AATGAAATCAATAGAAACTTTATTGCAAACATTTCGCGAACATACGATAGCGAACGGGACACGTATTCAGTTAAATGGTG
CTGGGGAAAAAGATGTATAT

Product: O-glycosyl hydrolase

Products: NA

Alternate protein names: Dextrin 6-alpha-D-glucanohydrolase; Oligosaccharide alpha-1,6-glucosidase; Sucrase-isomaltase; Isomaltase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MEFWRGSVFYEIYMKSFQDSNGDGLGDFVGLTSRLDYLADLGVDGIWLTPFYPSPQVDNGYDVSDYCEINPDYGNMTDFR
EFMKAADERGIKVIIDLVLNHSSTEHVWFKESRKNKTNSKRDYYIWREKPNNWESFFGGSAWELDDLTGEYYYHSFAKEQ
ADLNWSNQAVRAEIEQILAFWLNEGVAGFRLDVINNLTLVLEFPDNPVVDGEMEHVYDRNQQGLEQALEDIASFCRKERE
VFLVGEISSDKLPEIAKYSSEKMLDVTFNFNFGSVEQIDAKSVFTSLNEMETALNEGQWPTLFFGSHDMSRFLTRLADGN
LSKTKLLAFLMLTAKGVPFIYYGEEVGLPDLPFSSVKEMRDIQGTNAYYQALKTGSNEEDALKIAIGKTRDKARGPMVFP
DKRPFTLDEPWIKMASLKEEEALSMWQFYKTLLAFRKAHDFKEKEYAFLRLDGEILSYQRGEFLFLLHFGEDKVLYPLSG
QKQLVFGEADMLETGIRLGAYTGIALRVED

Sequences:

>Translated_510_residues
MEFWRGSVFYEIYMKSFQDSNGDGLGDFVGLTSRLDYLADLGVDGIWLTPFYPSPQVDNGYDVSDYCEINPDYGNMTDFR
EFMKAADERGIKVIIDLVLNHSSTEHVWFKESRKNKTNSKRDYYIWREKPNNWESFFGGSAWELDDLTGEYYYHSFAKEQ
ADLNWSNQAVRAEIEQILAFWLNEGVAGFRLDVINNLTLVLEFPDNPVVDGEMEHVYDRNQQGLEQALEDIASFCRKERE
VFLVGEISSDKLPEIAKYSSEKMLDVTFNFNFGSVEQIDAKSVFTSLNEMETALNEGQWPTLFFGSHDMSRFLTRLADGN
LSKTKLLAFLMLTAKGVPFIYYGEEVGLPDLPFSSVKEMRDIQGTNAYYQALKTGSNEEDALKIAIGKTRDKARGPMVFP
DKRPFTLDEPWIKMASLKEEEALSMWQFYKTLLAFRKAHDFKEKEYAFLRLDGEILSYQRGEFLFLLHFGEDKVLYPLSG
QKQLVFGEADMLETGIRLGAYTGIALRVED
>Mature_510_residues
MEFWRGSVFYEIYMKSFQDSNGDGLGDFVGLTSRLDYLADLGVDGIWLTPFYPSPQVDNGYDVSDYCEINPDYGNMTDFR
EFMKAADERGIKVIIDLVLNHSSTEHVWFKESRKNKTNSKRDYYIWREKPNNWESFFGGSAWELDDLTGEYYYHSFAKEQ
ADLNWSNQAVRAEIEQILAFWLNEGVAGFRLDVINNLTLVLEFPDNPVVDGEMEHVYDRNQQGLEQALEDIASFCRKERE
VFLVGEISSDKLPEIAKYSSEKMLDVTFNFNFGSVEQIDAKSVFTSLNEMETALNEGQWPTLFFGSHDMSRFLTRLADGN
LSKTKLLAFLMLTAKGVPFIYYGEEVGLPDLPFSSVKEMRDIQGTNAYYQALKTGSNEEDALKIAIGKTRDKARGPMVFP
DKRPFTLDEPWIKMASLKEEEALSMWQFYKTLLAFRKAHDFKEKEYAFLRLDGEILSYQRGEFLFLLHFGEDKVLYPLSG
QKQLVFGEADMLETGIRLGAYTGIALRVED

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=394, Percent_Identity=32.48730964467, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1790687, Length=466, Percent_Identity=38.6266094420601, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI1786604, Length=348, Percent_Identity=27.5862068965517, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25147709, Length=372, Percent_Identity=29.8387096774194, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI32565753, Length=369, Percent_Identity=24.390243902439, Blast_Score=106, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322245, Length=500, Percent_Identity=34.4, Blast_Score=279, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6321726, Length=494, Percent_Identity=35.4251012145749, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321731, Length=532, Percent_Identity=33.8345864661654, Blast_Score=267, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6319776, Length=532, Percent_Identity=33.8345864661654, Blast_Score=266, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6322241, Length=553, Percent_Identity=32.5497287522604, Blast_Score=260, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6322021, Length=553, Percent_Identity=32.5497287522604, Blast_Score=260, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6324416, Length=553, Percent_Identity=32.5497287522604, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI45549022, Length=528, Percent_Identity=32.0075757575758, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24583747, Length=503, Percent_Identity=32.20675944334, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24583749, Length=503, Percent_Identity=32.20675944334, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI221330053, Length=519, Percent_Identity=31.2138728323699, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24583745, Length=500, Percent_Identity=31.8, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24586599, Length=525, Percent_Identity=32.7619047619048, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24586597, Length=483, Percent_Identity=31.6770186335404, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24586591, Length=516, Percent_Identity=30.2325581395349, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI24586589, Length=519, Percent_Identity=29.8651252408478, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24586593, Length=504, Percent_Identity=28.968253968254, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586587, Length=384, Percent_Identity=32.2916666666667, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI281360393, Length=448, Percent_Identity=26.7857142857143, Blast_Score=145, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 58713; Mature: 58713

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFWRGSVFYEIYMKSFQDSNGDGLGDFVGLTSRLDYLADLGVDGIWLTPFYPSPQVDNG
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
YDVSDYCEINPDYGNMTDFREFMKAADERGIKVIIDLVLNHSSTEHVWFKESRKNKTNSK
CCCCCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEHHCCCCCCEEEEEHHCCCCCCCC
RDYYIWREKPNNWESFFGGSAWELDDLTGEYYYHSFAKEQADLNWSNQAVRAEIEQILAF
CCEEEEECCCCCHHHHCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
WLNEGVAGFRLDVINNLTLVLEFPDNPVVDGEMEHVYDRNQQGLEQALEDIASFCRKERE
HHHCCCCEEEEEEECCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
VFLVGEISSDKLPEIAKYSSEKMLDVTFNFNFGSVEQIDAKSVFTSLNEMETALNEGQWP
EEEEEECCCCCCCHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
TLFFGSHDMSRFLTRLADGNLSKTKLLAFLMLTAKGVPFIYYGEEVGLPDLPFSSVKEMR
EEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHH
DIQGTNAYYQALKTGSNEEDALKIAIGKTRDKARGPMVFPDKRPFTLDEPWIKMASLKEE
HCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHH
EALSMWQFYKTLLAFRKAHDFKEKEYAFLRLDGEILSYQRGEFLFLLHFGEDKVLYPLSG
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHCCCCCCCEEEEEEECCCCEEEECCC
QKQLVFGEADMLETGIRLGAYTGIALRVED
CCEEEECCHHHHHHCCCEEEEEEEEEEECC
>Mature Secondary Structure
MEFWRGSVFYEIYMKSFQDSNGDGLGDFVGLTSRLDYLADLGVDGIWLTPFYPSPQVDNG
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
YDVSDYCEINPDYGNMTDFREFMKAADERGIKVIIDLVLNHSSTEHVWFKESRKNKTNSK
CCCCCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEHHCCCCCCEEEEEHHCCCCCCCC
RDYYIWREKPNNWESFFGGSAWELDDLTGEYYYHSFAKEQADLNWSNQAVRAEIEQILAF
CCEEEEECCCCCHHHHCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
WLNEGVAGFRLDVINNLTLVLEFPDNPVVDGEMEHVYDRNQQGLEQALEDIASFCRKERE
HHHCCCCEEEEEEECCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
VFLVGEISSDKLPEIAKYSSEKMLDVTFNFNFGSVEQIDAKSVFTSLNEMETALNEGQWP
EEEEEECCCCCCCHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
TLFFGSHDMSRFLTRLADGNLSKTKLLAFLMLTAKGVPFIYYGEEVGLPDLPFSSVKEMR
EEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHH
DIQGTNAYYQALKTGSNEEDALKIAIGKTRDKARGPMVFPDKRPFTLDEPWIKMASLKEE
HCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHH
EALSMWQFYKTLLAFRKAHDFKEKEYAFLRLDGEILSYQRGEFLFLLHFGEDKVLYPLSG
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHCCCCCCCEEEEEEECCCCEEEECCC
QKQLVFGEADMLETGIRLGAYTGIALRVED
CCEEEECCHHHHHHCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1761534 [H]