Definition Listeria welshimeri serovar 6b str. SLCC5334, complete genome.
Accession NC_008555
Length 2,814,130

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The map label for this gene is mvaA [H]

Identifier: 116872239

GI number: 116872239

Start: 846440

End: 847717

Strand: Direct

Name: mvaA [H]

Synonym: lwe0819

Alternate gene names: 116872239

Gene position: 846440-847717 (Clockwise)

Preceding gene: 116872238

Following gene: 116872240

Centisome position: 30.08

GC content: 41.55

Gene sequence:

>1278_bases
ATGCAATCTTTTGATAAATTTTATAAAAAAACACTAGAAGAACGTCAAGTAATTTTGGCAGAATATGCTAATCTAAATGA
GGAGGAACAAGCCTTTTTAGCTTCTACGGGGGCACTTTCGTTTGATAAAGCAAACCATATGATTGAAAATACAGTCGGAA
TTTATTCGCTTCCTTTAGGCTTAGGGATGAATATGCTTTTAAATGATAAAAAATATATCGTACCAATGGCGATGGAAGAG
CCTTCTGTTGTTGCTGCTCAAAGTTCAGGCGCTAAACTAATCGCTCAAAATGGCGGAATTACAAGTACTGCAACTGACAG
AAAAATGATTGGACAAATCGAACTAATTACCGTGCCAGATGTGGAAGCTGCAGAAGAAAAAGTCATTGCTAATCGAGAGA
AACTTATTGCCATTGCCAATAATGCCCATCCATCTTTACTAAAACGAGGCGGGGGAGCTGTAGACTTACAAGTACGTACT
ACCAAAACCGCGAGTGGTGAAACTTTATTTATCATTCATTTACTTGTAGATACGCAAGAAGCAATGGGCGCCAACATGGT
AAACACAATGGTCGAAACATTAGCCCCGGAGCTAGAAATACTGACTGGCGGGGTAGCAAATATGCGAATATTATCCAATT
TGGTAGATGATGCGACTGCCACAGCCACCTGCCGCTTGTCCCCTGAAAGCTTATCGACAAAAACGCAAAGTGGCGAATGG
GTACGTGATCGAATTATTGCAGCTTATGAATTTGCAGATGCAGATATTTACCGTGCAGCAACTCATAACAAAGGAATTAT
GAATGGGATAGATGCCGTAATTATGGCTTTTGGAAATGATTGGCGTGCAGTGGAAGCAGCAAGCCATGCCTATACTGCCC
GGACAGGAAGCTATAAGCCCATGTCTAAATGGTCAAAAGATGCGGATGGGTACTTGATTGGGGAATTAACTTTACCGATG
CCAGTTGCCTTTGTTGGCGGTTCTATAGCGATTCATCCAATTGCCACTCTCTCAAAAAAAATCGCGCGAGTAGAATCAGC
GAAAGAACTGGCTATGTTGGTATGCGCAGTGGGCTTAACGCAAAATTTAGCCGCTTTAAAGGCGCTCGTTACGGAAGGCA
TCCAGCGTGGACATATGTCACTACAAGCAAAATCTCTCGCAATGACAGCGGGTGCAGAAGCAAATGAAATCGAACAAGTT
GCCCAATTTTTACAAGAAACGAAACAATTGAATGTGATGGCAGCTAAGAAATATATTGCTGAATTACGAACAAAATAA

Upstream 100 bases:

>100_bases
CAAATAGAACTACAAGGAGAATACTGGGATCGTTACATCCAGTTTCGGAATATGCTATAGTCAAGTATGCAGAGAAATTT
TAATTTGAGGTGATTATGCA

Downstream 100 bases:

>100_bases
AGCGAATATCAGGTGAGGAGCGGGATTTTATATATCGTTATTGTTTTGTTGGCCATACAAATAATATTGCAGGATTAGCA
CTTAGACTGAATGAATAGAA

Product: hydroxymethylglutaryl-coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MQSFDKFYKKTLEERQVILAEYANLNEEEQAFLASTGALSFDKANHMIENTVGIYSLPLGLGMNMLLNDKKYIVPMAMEE
PSVVAAQSSGAKLIAQNGGITSTATDRKMIGQIELITVPDVEAAEEKVIANREKLIAIANNAHPSLLKRGGGAVDLQVRT
TKTASGETLFIIHLLVDTQEAMGANMVNTMVETLAPELEILTGGVANMRILSNLVDDATATATCRLSPESLSTKTQSGEW
VRDRIIAAYEFADADIYRAATHNKGIMNGIDAVIMAFGNDWRAVEAASHAYTARTGSYKPMSKWSKDADGYLIGELTLPM
PVAFVGGSIAIHPIATLSKKIARVESAKELAMLVCAVGLTQNLAALKALVTEGIQRGHMSLQAKSLAMTAGAEANEIEQV
AQFLQETKQLNVMAAKKYIAELRTK

Sequences:

>Translated_425_residues
MQSFDKFYKKTLEERQVILAEYANLNEEEQAFLASTGALSFDKANHMIENTVGIYSLPLGLGMNMLLNDKKYIVPMAMEE
PSVVAAQSSGAKLIAQNGGITSTATDRKMIGQIELITVPDVEAAEEKVIANREKLIAIANNAHPSLLKRGGGAVDLQVRT
TKTASGETLFIIHLLVDTQEAMGANMVNTMVETLAPELEILTGGVANMRILSNLVDDATATATCRLSPESLSTKTQSGEW
VRDRIIAAYEFADADIYRAATHNKGIMNGIDAVIMAFGNDWRAVEAASHAYTARTGSYKPMSKWSKDADGYLIGELTLPM
PVAFVGGSIAIHPIATLSKKIARVESAKELAMLVCAVGLTQNLAALKALVTEGIQRGHMSLQAKSLAMTAGAEANEIEQV
AQFLQETKQLNVMAAKKYIAELRTK
>Mature_425_residues
MQSFDKFYKKTLEERQVILAEYANLNEEEQAFLASTGALSFDKANHMIENTVGIYSLPLGLGMNMLLNDKKYIVPMAMEE
PSVVAAQSSGAKLIAQNGGITSTATDRKMIGQIELITVPDVEAAEEKVIANREKLIAIANNAHPSLLKRGGGAVDLQVRT
TKTASGETLFIIHLLVDTQEAMGANMVNTMVETLAPELEILTGGVANMRILSNLVDDATATATCRLSPESLSTKTQSGEW
VRDRIIAAYEFADADIYRAATHNKGIMNGIDAVIMAFGNDWRAVEAASHAYTARTGSYKPMSKWSKDADGYLIGELTLPM
PVAFVGGSIAIHPIATLSKKIARVESAKELAMLVCAVGLTQNLAALKALVTEGIQRGHMSLQAKSLAMTAGAEANEIEQV
AQFLQETKQLNVMAAKKYIAELRTK

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 45838; Mature: 45838

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSFDKFYKKTLEERQVILAEYANLNEEEQAFLASTGALSFDKANHMIENTVGIYSLPLG
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEHHH
LGMNMLLNDKKYIVPMAMEEPSVVAAQSSGAKLIAQNGGITSTATDRKMIGQIELITVPD
CCCCEEECCCEEEEEEECCCCCEEEECCCCCEEEEECCCCCCCCCCHHHHCEEEEEECCC
VEAAEEKVIANREKLIAIANNAHPSLLKRGGGAVDLQVRTTKTASGETLFIIHLLVDTQE
CHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCEEEEEEEEECCCCCCEEEEEEEEECCHH
AMGANMVNTMVETLAPELEILTGGVANMRILSNLVDDATATATCRLSPESLSTKTQSGEW
HHCHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCHH
VRDRIIAAYEFADADIYRAATHNKGIMNGIDAVIMAFGNDWRAVEAASHAYTARTGSYKP
HHHHHHHHEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCC
MSKWSKDADGYLIGELTLPMPVAFVGGSIAIHPIATLSKKIARVESAKELAMLVCAVGLT
HHHCCCCCCCEEEEEEECCCCEEHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNLAALKALVTEGIQRGHMSLQAKSLAMTAGAEANEIEQVAQFLQETKQLNVMAAKKYIA
HHHHHHHHHHHHHHHHCCHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRTK
HHCCC
>Mature Secondary Structure
MQSFDKFYKKTLEERQVILAEYANLNEEEQAFLASTGALSFDKANHMIENTVGIYSLPLG
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEHHH
LGMNMLLNDKKYIVPMAMEEPSVVAAQSSGAKLIAQNGGITSTATDRKMIGQIELITVPD
CCCCEEECCCEEEEEEECCCCCEEEECCCCCEEEEECCCCCCCCCCHHHHCEEEEEECCC
VEAAEEKVIANREKLIAIANNAHPSLLKRGGGAVDLQVRTTKTASGETLFIIHLLVDTQE
CHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCEEEEEEEEECCCCCCEEEEEEEEECCHH
AMGANMVNTMVETLAPELEILTGGVANMRILSNLVDDATATATCRLSPESLSTKTQSGEW
HHCHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCHH
VRDRIIAAYEFADADIYRAATHNKGIMNGIDAVIMAFGNDWRAVEAASHAYTARTGSYKP
HHHHHHHHEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCC
MSKWSKDADGYLIGELTLPMPVAFVGGSIAIHPIATLSKKIARVESAKELAMLVCAVGLT
HHHCCCCCCCEEEEEEECCCCEEHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNLAALKALVTEGIQRGHMSLQAKSLAMTAGAEANEIEQVAQFLQETKQLNVMAAKKYIA
HHHHHHHHHHHHHHHHCCHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRTK
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]