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The map label for this gene is glxR [H]

Identifier: 116690000

GI number: 116690000

Start: 2197119

End: 2198003

Strand: Direct

Name: glxR [H]

Synonym: Bcen2424_1979

Alternate gene names: 116690000

Gene position: 2197119-2198003 (Clockwise)

Preceding gene: 116689999

Following gene: 116690001

Centisome position: 63.06

GC content: 67.91

Gene sequence:

>885_bases
ATGCAAACCGCAGTCGGATTCATCGGCCTTGGCGTGATGGGCACGCCGATGGCGCTCAATCTCGCGCGGGCCGGCACGCC
GCTCGTCGCGTGGAGCCGTTCGCACGGCAGCGACGATGCGCTGCGCGACGCCGGCGCACGCGTGGCCGAAAACGTCGACG
ACGTCTTCGCGTCCTGCCGCACCGTGATCCTGATGCTCGCGAACGACGCGGCAATCGACGCCGCCCTTGCGCGCGGCTCA
CCCGGTTTTGCCGCCCGGGTCGGCGGACACACGATCGTCAACATGGGCACGAATGCGCCCGAATACTCTCGCGCACTCGC
CGACGAAATCGCCGCCGCATCGGGCCGCTACGTCGAGGCGCCCGTGTCGGGCTCGCGCAAGCCGGCCGAAGCCGGTCAAC
TCGTCGTGATGCTGGCCGGCGCGCCGGAGGACGTCGACGCCGTACGCGCGCTGGTGAAGCCGCTGTGCCGCGACAGCTTC
GTATGCGGCGACGTGCCGTCGGCGCTGACGATGAAGCTCGCCGTCAACCTGTTCCTGATCACGATGGTCACCGGTCTCAC
CGAAGCCACGCACTTCGCGCAACGCCACGGTATCGACCTTGCACGCTTCGCCGACGTGCTGAATGCCGGCCCGATGGCCA
GCGACGTGTCGCGCGTGAAGCTCGGCAAGCTCGTCGCGGAAGATTTCTCGGTGCAGGCCGCGATCACCGACGTGCTGAAG
AATGCGCGCCTCGTCGCCGAATCGGCACGCAGCATCGGCATCGCGTCGCCGCTGCTCGACATCTGCCATGCACTGTACGG
TGAAACCGAGCGAGCCGGACATGGGGCGGCCGACATGGTCGCCGTGATTCGTGCGATCGAACAGCGTACCGGAGACGCGC
GATGA

Upstream 100 bases:

>100_bases
TGGCGCGGCTTCCGCGCTCGCGCGGGTCACATGGCAGAGGCGCGTAAACGCTGCGATACTGACGCCCACGATCGTCGCCA
CCTACCGTGGGAGCCGCACC

Downstream 100 bases:

>100_bases
GCCGCGTGCACGTAGTACCCGCGTTCGTTCGAACCGACAGGTAGGCGCGACCATGTCCGCAACCGGCACGTCCGCAACCG
GCATGTCCGCAACCGGCAAC

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MQTAVGFIGLGVMGTPMALNLARAGTPLVAWSRSHGSDDALRDAGARVAENVDDVFASCRTVILMLANDAAIDAALARGS
PGFAARVGGHTIVNMGTNAPEYSRALADEIAAASGRYVEAPVSGSRKPAEAGQLVVMLAGAPEDVDAVRALVKPLCRDSF
VCGDVPSALTMKLAVNLFLITMVTGLTEATHFAQRHGIDLARFADVLNAGPMASDVSRVKLGKLVAEDFSVQAAITDVLK
NARLVAESARSIGIASPLLDICHALYGETERAGHGAADMVAVIRAIEQRTGDAR

Sequences:

>Translated_294_residues
MQTAVGFIGLGVMGTPMALNLARAGTPLVAWSRSHGSDDALRDAGARVAENVDDVFASCRTVILMLANDAAIDAALARGS
PGFAARVGGHTIVNMGTNAPEYSRALADEIAAASGRYVEAPVSGSRKPAEAGQLVVMLAGAPEDVDAVRALVKPLCRDSF
VCGDVPSALTMKLAVNLFLITMVTGLTEATHFAQRHGIDLARFADVLNAGPMASDVSRVKLGKLVAEDFSVQAAITDVLK
NARLVAESARSIGIASPLLDICHALYGETERAGHGAADMVAVIRAIEQRTGDAR
>Mature_294_residues
MQTAVGFIGLGVMGTPMALNLARAGTPLVAWSRSHGSDDALRDAGARVAENVDDVFASCRTVILMLANDAAIDAALARGS
PGFAARVGGHTIVNMGTNAPEYSRALADEIAAASGRYVEAPVSGSRKPAEAGQLVVMLAGAPEDVDAVRALVKPLCRDSF
VCGDVPSALTMKLAVNLFLITMVTGLTEATHFAQRHGIDLARFADVLNAGPMASDVSRVKLGKLVAEDFSVQAAITDVLK
NARLVAESARSIGIASPLLDICHALYGETERAGHGAADMVAVIRAIEQRTGDAR

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=299, Percent_Identity=29.0969899665552, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI40556376, Length=286, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1786719, Length=283, Percent_Identity=27.9151943462898, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI145693186, Length=196, Percent_Identity=30.1020408163265, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574115, Length=284, Percent_Identity=26.4084507042254, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24655230, Length=297, Percent_Identity=29.2929292929293, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI19922568, Length=297, Percent_Identity=29.2929292929293, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30488; Mature: 30488

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTAVGFIGLGVMGTPMALNLARAGTPLVAWSRSHGSDDALRDAGARVAENVDDVFASCR
CCCCHHHHHHCCCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TVILMLANDAAIDAALARGSPGFAARVGGHTIVNMGTNAPEYSRALADEIAAASGRYVEA
HHHHHHCCCHHHHHHHHCCCCCCEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEC
PVSGSRKPAEAGQLVVMLAGAPEDVDAVRALVKPLCRDSFVCGDVPSALTMKLAVNLFLI
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
TMVTGLTEATHFAQRHGIDLARFADVLNAGPMASDVSRVKLGKLVAEDFSVQAAITDVLK
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NARLVAESARSIGIASPLLDICHALYGETERAGHGAADMVAVIRAIEQRTGDAR
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQTAVGFIGLGVMGTPMALNLARAGTPLVAWSRSHGSDDALRDAGARVAENVDDVFASCR
CCCCHHHHHHCCCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TVILMLANDAAIDAALARGSPGFAARVGGHTIVNMGTNAPEYSRALADEIAAASGRYVEA
HHHHHHCCCHHHHHHHHCCCCCCEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEC
PVSGSRKPAEAGQLVVMLAGAPEDVDAVRALVKPLCRDSFVCGDVPSALTMKLAVNLFLI
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
TMVTGLTEATHFAQRHGIDLARFADVLNAGPMASDVSRVKLGKLVAEDFSVQAAITDVLK
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NARLVAESARSIGIASPLLDICHALYGETERAGHGAADMVAVIRAIEQRTGDAR
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]