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The map label for this gene is norM [H]

Identifier: 116689856

GI number: 116689856

Start: 2038603

End: 2039955

Strand: Direct

Name: norM [H]

Synonym: Bcen2424_1835

Alternate gene names: 116689856

Gene position: 2038603-2039955 (Clockwise)

Preceding gene: 116689855

Following gene: 116689863

Centisome position: 58.51

GC content: 69.99

Gene sequence:

>1353_bases
ATGTTCGGCGACATCCGCCGGATCGTCGGTCTCGCGTGGCCGGTGCTGGTCGGCCAGCTCGCGATCATCGCGTTCGGCGT
GATCGACACCGCGATGGTCGGCCGCTACTCGGCCGTCGATCTCGCCGCGCTCGGGCTCGGCTCGTCGATCTACGTATCGA
TCTACATCGGCCTGACGGGTATCCTGTCCGCGCTGCAGCCGATCACCGGGCAACTGTACGGCGCGCGGCGCTATGCCGAG
ATCGGCGAGGAAGTGCGCCAGGCGCTGTGGCTCGCGCTGCTGCTCTCGATTCCGGGCTTCCTGCTGCTGCATTTTCCCGA
GCCGCTGCTGCGCGTCGCGCACGCGCCCGCCGCGCTGCACGATCGCACCGTCGACTACCTGCGCGTCCTGTCGTACGGGC
TGCCCGCCAGCCTCGTATTCCGCATCTATAACGCGCTGACCAACGCGGCCGGCAAGCCGCGGCTCGCGATGATCCTCCAG
ATCGGCGCGCTGCTGCTCAAGTTTCCGCTGAACGTGTGGTTCATCTTCGGCGGCTTCGGCGTACCGGCGCTCGGCGGCCC
CGGCTGCGGGCTGGCCAGCACGCTGATCAACTGGGCGCTCGCGCTGATCGGCTACACGCTGCTCGCGAAGCTCGACGTGT
TCGCGCCGCTCGCGATCTTCTCGCGCTTCTGCTGGCCCGTCTGGGCGCGCCAGAAGGCGATCCTGAAGCTCGGCGTGCCG
ATGGGCCTGTCGTACCTGATCGAGGTCACGTCGTACACGTGCATGGCGCTGTTCATCGCGCAGTTCGGCACGACGACGCT
CGCCGGCCACCAGATCGCCGGCAACATCGGCGCGGTGCTGTACATGACGCCGCTGTCGATCGGCGTGGCGGCGTCGACGC
TGGTCGCGCGCGCGCTCGGCGCGGGACGCGCCGAGGAAGCCCGGCTGCTCGGCCGGCACAGCGTGTTCTTCGCGTGCGGC
GTGGCGGCCGCCTACGGCGTGCTCGTGTTCGCGCTGCGCCCGCTGATCATCGGCGGCTATACGCCGAACCCGGCCGTCGC
CGCGGCCGCGATGCCGCTCGTCGCGATCGTCGCGTGCTACCACATGTTCGATGCGCTGCAGGTCACGTCCGCGTTCGTGC
TGCGCGCGTACAAGGTGGCGGTCGTGCCGACCGTGATCTATGCGGTCGCGCTGTGGGGTGTCGGACTCAGCGGCGGCTAC
GTGCTCGGCTTCGACGTGGGCGGGATCGCGCCCGCGTGGCTGACCGGCGCGCGCGGCTTCTGGTTCGCGAACACGGTCAG
CCTGATGCTCGCGGGCGCGGGGCTCGTGCTGTACCTGCGCCGCATCAGTCGCGCGCACGCCGCCTTGGCCTGA

Upstream 100 bases:

>100_bases
TCGCCGACCGCGACGAGCGCTTCCGCCTGTACGAGCGCATCGAACGGCCGAAGACGCCCGTCAAACGGCGTCCGCCGCGC
CGCCAGGCGGCCGATTGACG

Downstream 100 bases:

>100_bases
CGCGCGGCGCGCTACGCGCTCTCCAGCACGTCGGCCGCGTGATACGACGACCGCACGAGCGGGCCGGCGACGACTTCCCT
GAAACCGAGCGCGAGCGCCT

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFGDIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYVSIYIGLTGILSALQPITGQLYGARRYAE
IGEEVRQALWLALLLSIPGFLLLHFPEPLLRVAHAPAALHDRTVDYLRVLSYGLPASLVFRIYNALTNAAGKPRLAMILQ
IGALLLKFPLNVWFIFGGFGVPALGGPGCGLASTLINWALALIGYTLLAKLDVFAPLAIFSRFCWPVWARQKAILKLGVP
MGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVAASTLVARALGAGRAEEARLLGRHSVFFACG
VAAAYGVLVFALRPLIIGGYTPNPAVAAAAMPLVAIVACYHMFDALQVTSAFVLRAYKVAVVPTVIYAVALWGVGLSGGY
VLGFDVGGIAPAWLTGARGFWFANTVSLMLAGAGLVLYLRRISRAHAALA

Sequences:

>Translated_450_residues
MFGDIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYVSIYIGLTGILSALQPITGQLYGARRYAE
IGEEVRQALWLALLLSIPGFLLLHFPEPLLRVAHAPAALHDRTVDYLRVLSYGLPASLVFRIYNALTNAAGKPRLAMILQ
IGALLLKFPLNVWFIFGGFGVPALGGPGCGLASTLINWALALIGYTLLAKLDVFAPLAIFSRFCWPVWARQKAILKLGVP
MGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVAASTLVARALGAGRAEEARLLGRHSVFFACG
VAAAYGVLVFALRPLIIGGYTPNPAVAAAAMPLVAIVACYHMFDALQVTSAFVLRAYKVAVVPTVIYAVALWGVGLSGGY
VLGFDVGGIAPAWLTGARGFWFANTVSLMLAGAGLVLYLRRISRAHAALA
>Mature_450_residues
MFGDIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYVSIYIGLTGILSALQPITGQLYGARRYAE
IGEEVRQALWLALLLSIPGFLLLHFPEPLLRVAHAPAALHDRTVDYLRVLSYGLPASLVFRIYNALTNAAGKPRLAMILQ
IGALLLKFPLNVWFIFGGFGVPALGGPGCGLASTLINWALALIGYTLLAKLDVFAPLAIFSRFCWPVWARQKAILKLGVP
MGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVAASTLVARALGAGRAEEARLLGRHSVFFACG
VAAAYGVLVFALRPLIIGGYTPNPAVAAAAMPLVAIVACYHMFDALQVTSAFVLRAYKVAVVPTVIYAVALWGVGLSGGY
VLGFDVGGIAPAWLTGARGFWFANTVSLMLAGAGLVLYLRRISRAHAALA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=423, Percent_Identity=24.3498817966903, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI48994890, Length=447, Percent_Identity=31.7673378076063, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI226510954, Length=427, Percent_Identity=24.3559718969555, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320545, Length=411, Percent_Identity=26.7639902676399, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321821, Length=334, Percent_Identity=22.1556886227545, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47565; Mature: 47565

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGDIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYVSIYIGLTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEHHHHHHH
ILSALQPITGQLYGARRYAEIGEEVRQALWLALLLSIPGFLLLHFPEPLLRVAHAPAALH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHCCHHHHHHHCCCHHHH
DRTVDYLRVLSYGLPASLVFRIYNALTNAAGKPRLAMILQIGALLLKFPLNVWFIFGGFG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
VPALGGPGCGLASTLINWALALIGYTLLAKLDVFAPLAIFSRFCWPVWARQKAILKLGVP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVAASTLVARALG
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCEEEEECHHHHHHHHHHHHHHHHC
AGRAEEARLLGRHSVFFACGVAAAYGVLVFALRPLIIGGYTPNPAVAAAAMPLVAIVACY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
HMFDALQVTSAFVLRAYKVAVVPTVIYAVALWGVGLSGGYVLGFDVGGIAPAWLTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHCCCCH
WFANTVSLMLAGAGLVLYLRRISRAHAALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFGDIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYVSIYIGLTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEHHHHHHH
ILSALQPITGQLYGARRYAEIGEEVRQALWLALLLSIPGFLLLHFPEPLLRVAHAPAALH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHCCHHHHHHHCCCHHHH
DRTVDYLRVLSYGLPASLVFRIYNALTNAAGKPRLAMILQIGALLLKFPLNVWFIFGGFG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
VPALGGPGCGLASTLINWALALIGYTLLAKLDVFAPLAIFSRFCWPVWARQKAILKLGVP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVAASTLVARALG
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCEEEEECHHHHHHHHHHHHHHHHC
AGRAEEARLLGRHSVFFACGVAAAYGVLVFALRPLIIGGYTPNPAVAAAAMPLVAIVACY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
HMFDALQVTSAFVLRAYKVAVVPTVIYAVALWGVGLSGGYVLGFDVGGIAPAWLTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHCCCCH
WFANTVSLMLAGAGLVLYLRRISRAHAALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA