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The map label for this gene is hisS [H]

Identifier: 116689832

GI number: 116689832

Start: 2012291

End: 2013631

Strand: Reverse

Name: hisS [H]

Synonym: Bcen2424_1811

Alternate gene names: 116689832

Gene position: 2013631-2012291 (Counterclockwise)

Preceding gene: 116689833

Following gene: 116689831

Centisome position: 57.8

GC content: 64.5

Gene sequence:

>1341_bases
ATGACTGAACAGAAACGCAAGATCGAGAAGCTCACCGGCGTCAAAGGCATGAACGACATCCTTCCGCAGGATGCCGGCCT
GTGGGAATTCTTCGAAGCTACCGTGAAATCGCTGCTGCGCGCGTACGGCTACCAGAACATCCGCACGCCGATCGTCGAAC
ATACGCAGCTCTTCACGCGCGGCATCGGCGAGGTCACGGACATCGTCGAGAAGGAGATGTACAGCTTCACCGACGCGCTG
AACGGCGAGAACCTGACGATGCGCCCGGAAAACACCGCGGCCGTCGTGCGTGCGTCGATCGAGCACAACATGCTGTACGA
CGGCCCGAAGCGCCTGTGGTACATCGGCCCGATGTTCCGTCACGAGCGTCCGCAGCGCGGCCGCTATCGCCAGTTCCACC
AGGTCGGCGTCGAGGCGCTCGGCTTCGCGGGTCCCGATGCGGATGCCGAGATCATCATGATGTGCCAGCGCCTGTGGGAC
GACCTCGGCCTGACCGGCATCAAGCTCGAGATCAACTCGCTCGGCCTCGCCGAAGAGCGCGCCGCGCACCGCGTCGAACT
GATCAAGTACCTCGAGCAGTTTGCCGACGTGCTCGACGAGGACGCGAAGCGCCGCCTGTATACGAACCCGCTGCGCGTGC
TCGACACGAAGAACCCGGCGCTGCAGGACATCGCGCAGAACGCACCGAAGCTGATCGACTTCCTCGGCGACGAATCGCGC
GCGCATTTCGAAGGGCTGCAGCGCCTGCTGCTCGCGAACAACATTCCGTTCAAGATCAACCCGCGTCTCGTGCGTGGCCT
CGATTACTACAACCTGACCGTGTTCGAGTGGGTGACCGACAAGCTCGGCGCGCAGGGTACGGTCGCGGCCGGCGGTCGCT
ACGATCCGCTGATCGAGCAGCTCGGCGGCAAGCCGACCGCCGCGTGCGGCTGGGCGATGGGCATCGAGCGCATCCTCGAG
CTGCTGAAGGAAGAGGATCTCGCGCCCGAGCAGGAAGGCGTCGACGTGTACGTCGTGCACCAGGGCGACACCGCGCGCGA
ACAGGCGTTCATCGCGGCCGAGCGCCTGCGCGACACGGGCCTCGACGTGATCTTCCACTGCAGCGCCGACGGCGCGCCGG
CGAGCTTCAAGTCGCAGATGAAGCGGGCCGATGCAAGCGGCGCCGCGTTCGCGGTGATCTTCGGCGAAGAAGAGGTCGCG
AACGGCACGGTGGGCGTGAAAGCGTTGCGCGGCGCGGGTGCGGAAGGGGAAAAGAACGTTCAGCAGACCGTACCGGTCGA
AAGCTTGACCGAATTCCTAATCAATGCGATGGTTGCATCCGCCGAAGACGGCGACGACTGA

Upstream 100 bases:

>100_bases
AGCGGATCGCCGAGGAATTCCAGCAGATCGTCAGCGACTACGTCGCACGCAATTACGGCCGCACCGAGGCCCTGAACTAA
TTCGTCCACACACACGAACG

Downstream 100 bases:

>100_bases
TCGCGCTGGCATCCGCTCGACAAGAAAAGCCTGAACAGGAAGAAGGAATCGCTCGCCGATGAGTTATCACGACGAACAAG
AATCGATTGAAAGTCTCAAG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTEQKRKIEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFTDAL
NGENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWD
DLGLTGIKLEINSLGLAEERAAHRVELIKYLEQFADVLDEDAKRRLYTNPLRVLDTKNPALQDIAQNAPKLIDFLGDESR
AHFEGLQRLLLANNIPFKINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGIERILE
LLKEEDLAPEQEGVDVYVVHQGDTAREQAFIAAERLRDTGLDVIFHCSADGAPASFKSQMKRADASGAAFAVIFGEEEVA
NGTVGVKALRGAGAEGEKNVQQTVPVESLTEFLINAMVASAEDGDD

Sequences:

>Translated_446_residues
MTEQKRKIEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFTDAL
NGENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWD
DLGLTGIKLEINSLGLAEERAAHRVELIKYLEQFADVLDEDAKRRLYTNPLRVLDTKNPALQDIAQNAPKLIDFLGDESR
AHFEGLQRLLLANNIPFKINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGIERILE
LLKEEDLAPEQEGVDVYVVHQGDTAREQAFIAAERLRDTGLDVIFHCSADGAPASFKSQMKRADASGAAFAVIFGEEEVA
NGTVGVKALRGAGAEGEKNVQQTVPVESLTEFLINAMVASAEDGDD
>Mature_445_residues
TEQKRKIEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFTDALN
GENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDD
LGLTGIKLEINSLGLAEERAAHRVELIKYLEQFADVLDEDAKRRLYTNPLRVLDTKNPALQDIAQNAPKLIDFLGDESRA
HFEGLQRLLLANNIPFKINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGIERILEL
LKEEDLAPEQEGVDVYVVHQGDTAREQAFIAAERLRDTGLDVIFHCSADGAPASFKSQMKRADASGAAFAVIFGEEEVAN
GTVGVKALRGAGAEGEKNVQQTVPVESLTEFLINAMVASAEDGDD

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=470, Percent_Identity=23.1914893617021, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788861, Length=406, Percent_Identity=55.1724137931034, Blast_Score=444, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 49586; Mature: 49455

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQKRKIEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTR
CCCHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GIGEVTDIVEKEMYSFTDALNGENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFR
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCEECCCCCEEEECHHHH
HERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDDLGLTGIKLEINSLGLAEER
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
AAHRVELIKYLEQFADVLDEDAKRRLYTNPLRVLDTKNPALQDIAQNAPKLIDFLGDESR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHHHHCCHHHHHHHCCCCH
AHFEGLQRLLLANNIPFKINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQ
HHHHHHHHHHHHCCCCEEECHHHHHCCCCCCCHHHHHHHHHHCCCCEECCCCCCCHHHHH
LGGKPTAACGWAMGIERILELLKEEDLAPEQEGVDVYVVHQGDTAREQAFIAAERLRDTG
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCC
LDVIFHCSADGAPASFKSQMKRADASGAAFAVIFGEEEVANGTVGVKALRGAGAEGEKNV
CCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCHHHCCCCHHHHHHHCCCCCCCCCH
QQTVPVESLTEFLINAMVASAEDGDD
HHHCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TEQKRKIEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTR
CCHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GIGEVTDIVEKEMYSFTDALNGENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFR
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCEECCCCCEEEECHHHH
HERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDDLGLTGIKLEINSLGLAEER
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
AAHRVELIKYLEQFADVLDEDAKRRLYTNPLRVLDTKNPALQDIAQNAPKLIDFLGDESR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHHHHCCHHHHHHHCCCCH
AHFEGLQRLLLANNIPFKINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQ
HHHHHHHHHHHHCCCCEEECHHHHHCCCCCCCHHHHHHHHHHCCCCEECCCCCCCHHHHH
LGGKPTAACGWAMGIERILELLKEEDLAPEQEGVDVYVVHQGDTAREQAFIAAERLRDTG
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCC
LDVIFHCSADGAPASFKSQMKRADASGAAFAVIFGEEEVANGTVGVKALRGAGAEGEKNV
CCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCHHHCCCCHHHHHHHCCCCCCCCCH
QQTVPVESLTEFLINAMVASAEDGDD
HHHCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA