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The map label for this gene is zraR [H]

Identifier: 116689765

GI number: 116689765

Start: 1939135

End: 1940517

Strand: Reverse

Name: zraR [H]

Synonym: Bcen2424_1744

Alternate gene names: 116689765

Gene position: 1940517-1939135 (Counterclockwise)

Preceding gene: 116689769

Following gene: 116689764

Centisome position: 55.7

GC content: 69.7

Gene sequence:

>1383_bases
ATGAATCCGCACGACACCATTCCGATCGTCCCTGTTCCGCGCCGCGACGCGATGCCCGACGTGCGCGCGCTCGTCGCGTA
TCTCGAGCAGGACCCGCAGCCGATGATCGTGGTCGACCCCGACTACCGCATCCTCGCGGCGAACGATGCGTACCGGCGTC
AGTTCGGCGTGGCCGGCGTCGAGCACGTGGGCCGGCACTGTTTCCAGGTGTCGCATCACTACGACGTGCCGTGCGACCAG
GCCGGCGAGCATTGCCCGATGAAGCAGGCGCTCGAGTCGCGCGGGCTGAACCGCGTGCTGCACATCCATCACACGCCGCG
CGGCCCCGAGCATGTCGACGTTGAGCTGCGGCCGATCTTCGATGCACACGGCAACGTGATCGCGTACGTCGAGCGGCTGA
CGACCGTGCGCAGCGCGTCCGCGCAGCCGAGCGCGGAAGGGCTCGTCGGCGGCTCCGATGCGTTCAACGCGGCGCTCGGC
GCGTTGCAGCGCGTGGCGCCGTCGACACTGCCGGTGTTGCTGCTCGGCGAATCGGGCACCGGCAAGGAGCTGTTTGCCCG
CGCGCTGCACGAGGCGAGCGACCGCGCGATGGGGCCGTTCGTCGTCGTCGATTGCTCGGGGATCGCCGAGACGCTGTTCG
AGAGCGAACTGTTCGGCTACGAGAAGGGCGCGTTCACCGGCGCGAACCAGCGCAAGCCGGGCCTCGTCGAAACCGCGCAG
GGCGGCACGCTGTTTCTCGACGAGATCGGCGACGTGCCGCTGCCGATGCAGGTGAAGCTGCTGCGGCTGATCGAATCGGG
CACGTTCCGGCGCGTGGGCGGCGTCGAGGCGCTGCGTGCGGATTTCCGGCTGGTCGCGGCCACGCACAAGCCGCTGCGCG
AGATGATCGACGACGGTCGGTTCCGGCAGGATCTTTACTACCGGATCAACGCGTTTCCGATCCCGCTGCCGGCGCTGCGC
GAACGGCAGGGCGACGTCGCGCTGCTGGCTGAATCGATCCTGCGGCGGATCGCAAACGCGCGCGGCAAGGCGGGCGACGC
GAGTGCGCGGCCGTTCATGCTGACCGAGCGCGCAAGAGCGTGCCTCGACGCGTATGCATGGCCCGGCAACATCCGCGAGC
TGCGCAACGTGCTCGAACGCGCGTGCCTGTTCGCCGACGACGGGACGATCCGCGTCGAGCATCTGCCGGCCGAACTCGTC
GCGGCAGCGGCGGCGCCCCACGCGCAAGCGGCGGACGTGCGCGGCGTGTCGGATGCCGAGCTGGTTCGTATCGCGCGCAC
GTTCGACGGCACGCGCAAGGCGCTGGCCGAGCAACTCGGATTGAGCGAGCGGACACTGTACCGGCGGATGAAGGCGCTAG
GCCTCGGCTCGCGCGAGCGCTGA

Upstream 100 bases:

>100_bases
CGGCGGCAGACGGGGACTGCCACAACTGGCAGTGTCGTGGCAGAATTGGCAGCCAGCCTGGCAGTCCGTCCGGGCGCCCC
TTCGCCGAGCGAGCCGCCGC

Downstream 100 bases:

>100_bases
ACGGGCGGGTCGCGCGCGGCTGGCGGCGGCACGCGGCTTTGCCGATAATGGCGCGTTCGATTTCAGCGCTTTCGCCCCCG
CCGATGAAAAGACATGCCCT

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNPHDTIPIVPVPRRDAMPDVRALVAYLEQDPQPMIVVDPDYRILAANDAYRRQFGVAGVEHVGRHCFQVSHHYDVPCDQ
AGEHCPMKQALESRGLNRVLHIHHTPRGPEHVDVELRPIFDAHGNVIAYVERLTTVRSASAQPSAEGLVGGSDAFNAALG
ALQRVAPSTLPVLLLGESGTGKELFARALHEASDRAMGPFVVVDCSGIAETLFESELFGYEKGAFTGANQRKPGLVETAQ
GGTLFLDEIGDVPLPMQVKLLRLIESGTFRRVGGVEALRADFRLVAATHKPLREMIDDGRFRQDLYYRINAFPIPLPALR
ERQGDVALLAESILRRIANARGKAGDASARPFMLTERARACLDAYAWPGNIRELRNVLERACLFADDGTIRVEHLPAELV
AAAAAPHAQAADVRGVSDAELVRIARTFDGTRKALAEQLGLSERTLYRRMKALGLGSRER

Sequences:

>Translated_460_residues
MNPHDTIPIVPVPRRDAMPDVRALVAYLEQDPQPMIVVDPDYRILAANDAYRRQFGVAGVEHVGRHCFQVSHHYDVPCDQ
AGEHCPMKQALESRGLNRVLHIHHTPRGPEHVDVELRPIFDAHGNVIAYVERLTTVRSASAQPSAEGLVGGSDAFNAALG
ALQRVAPSTLPVLLLGESGTGKELFARALHEASDRAMGPFVVVDCSGIAETLFESELFGYEKGAFTGANQRKPGLVETAQ
GGTLFLDEIGDVPLPMQVKLLRLIESGTFRRVGGVEALRADFRLVAATHKPLREMIDDGRFRQDLYYRINAFPIPLPALR
ERQGDVALLAESILRRIANARGKAGDASARPFMLTERARACLDAYAWPGNIRELRNVLERACLFADDGTIRVEHLPAELV
AAAAAPHAQAADVRGVSDAELVRIARTFDGTRKALAEQLGLSERTLYRRMKALGLGSRER
>Mature_460_residues
MNPHDTIPIVPVPRRDAMPDVRALVAYLEQDPQPMIVVDPDYRILAANDAYRRQFGVAGVEHVGRHCFQVSHHYDVPCDQ
AGEHCPMKQALESRGLNRVLHIHHTPRGPEHVDVELRPIFDAHGNVIAYVERLTTVRSASAQPSAEGLVGGSDAFNAALG
ALQRVAPSTLPVLLLGESGTGKELFARALHEASDRAMGPFVVVDCSGIAETLFESELFGYEKGAFTGANQRKPGLVETAQ
GGTLFLDEIGDVPLPMQVKLLRLIESGTFRRVGGVEALRADFRLVAATHKPLREMIDDGRFRQDLYYRINAFPIPLPALR
ERQGDVALLAESILRRIANARGKAGDASARPFMLTERARACLDAYAWPGNIRELRNVLERACLFADDGTIRVEHLPAELV
AAAAAPHAQAADVRGVSDAELVRIARTFDGTRKALAEQLGLSERTLYRRMKALGLGSRER

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=307, Percent_Identity=43.6482084690554, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1788550, Length=302, Percent_Identity=40.3973509933775, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1789087, Length=333, Percent_Identity=39.9399399399399, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI1789233, Length=345, Percent_Identity=38.8405797101449, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1790299, Length=363, Percent_Identity=37.1900826446281, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI87082117, Length=328, Percent_Identity=39.3292682926829, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI87081872, Length=239, Percent_Identity=46.0251046025105, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1786524, Length=301, Percent_Identity=41.8604651162791, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI87082152, Length=238, Percent_Identity=44.9579831932773, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1788905, Length=228, Percent_Identity=43.859649122807, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1787583, Length=451, Percent_Identity=31.7073170731707, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1789828, Length=307, Percent_Identity=36.4820846905537, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081858, Length=299, Percent_Identity=32.7759197324415, Blast_Score=148, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50422; Mature: 50422

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPHDTIPIVPVPRRDAMPDVRALVAYLEQDPQPMIVVDPDYRILAANDAYRRQFGVAGV
CCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEEECCHHHHHHHCCCCH
EHVGRHCFQVSHHYDVPCDQAGEHCPMKQALESRGLNRVLHIHHTPRGPEHVDVELRPIF
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEEEE
DAHGNVIAYVERLTTVRSASAQPSAEGLVGGSDAFNAALGALQRVAPSTLPVLLLGESGT
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCC
GKELFARALHEASDRAMGPFVVVDCSGIAETLFESELFGYEKGAFTGANQRKPGLVETAQ
CHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECC
GGTLFLDEIGDVPLPMQVKLLRLIESGTFRRVGGVEALRADFRLVAATHKPLREMIDDGR
CCEEEECCCCCCCCCHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
FRQDLYYRINAFPIPLPALRERQGDVALLAESILRRIANARGKAGDASARPFMLTERARA
HHHHHHEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHH
CLDAYAWPGNIRELRNVLERACLFADDGTIRVEHLPAELVAAAAAPHAQAADVRGVSDAE
HHHHHCCCCCHHHHHHHHHHHHEECCCCEEEEEECCHHHHHHHCCCCCCHHCCCCCCHHH
LVRIARTFDGTRKALAEQLGLSERTLYRRMKALGLGSRER
HHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNPHDTIPIVPVPRRDAMPDVRALVAYLEQDPQPMIVVDPDYRILAANDAYRRQFGVAGV
CCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEEECCHHHHHHHCCCCH
EHVGRHCFQVSHHYDVPCDQAGEHCPMKQALESRGLNRVLHIHHTPRGPEHVDVELRPIF
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEEEE
DAHGNVIAYVERLTTVRSASAQPSAEGLVGGSDAFNAALGALQRVAPSTLPVLLLGESGT
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCC
GKELFARALHEASDRAMGPFVVVDCSGIAETLFESELFGYEKGAFTGANQRKPGLVETAQ
CHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECC
GGTLFLDEIGDVPLPMQVKLLRLIESGTFRRVGGVEALRADFRLVAATHKPLREMIDDGR
CCEEEECCCCCCCCCHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
FRQDLYYRINAFPIPLPALRERQGDVALLAESILRRIANARGKAGDASARPFMLTERARA
HHHHHHEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHH
CLDAYAWPGNIRELRNVLERACLFADDGTIRVEHLPAELVAAAAAPHAQAADVRGVSDAE
HHHHHCCCCCHHHHHHHHHHHHEECCCCEEEEEECCHHHHHHHCCCCCCHHCCCCCCHHH
LVRIARTFDGTRKALAEQLGLSERTLYRRMKALGLGSRER
HHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]