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The map label for this gene is yngG [H]

Identifier: 116689714

GI number: 116689714

Start: 1880585

End: 1881547

Strand: Direct

Name: yngG [H]

Synonym: Bcen2424_1692

Alternate gene names: 116689714

Gene position: 1880585-1881547 (Clockwise)

Preceding gene: 116689713

Following gene: 116689715

Centisome position: 53.98

GC content: 69.16

Gene sequence:

>963_bases
ATGAACCGGCATCCGCAACGACTCCATATCCACGAAGTCGCGACTCGCGACGGTTTCCAGAACGAGGCCGCGTTCGTCGA
CACCGACGACAAGATCGCGCTCGTCGACGCGCTGAGCGCCTGCGGCTACGCGAAGATCGAGGTCACGTCGTTCACGTCGC
CGAAGGCGATTCCCGCGCTGCGCGACGCGGAAGCCGTGATGCACGGCATCGTGCGCGCGCCGGGCGTCGTCTATACGGTG
CTCGTGCCGAACGTGCGCGGCGCCGAGCGCGCGCTGTCATGCGGCGTCGACGAGGTGAACCTCGTGATGTCGATGAGCGA
GAGCCACAACCGCGCGAACCTGCGGATGACGCGCGAGCAGTCGTTCGCGCAGTTGCGCGACGTGATCGACACGGTGCGCG
GCACGGGTGTCGCGATCAACGTGTCGCTGTCGACCGCGATGGGCTGCCCGATGGAAGGCGACGTGCCGGCCGAAACGGTG
CTCGCGTGGATGCAGCGCTTCGCGGATCTCGGTGTGCACGGCTTCACGCTGTGCGACACGACCGGCATGGCGTTTCCGTC
GCAGGTGCGCGATTTGTCGCGCCGCGCACGCGAGCGCTTCGGCGCGTTGCAACTCACGCTGCACTTCCACAACACGCGCG
GGATGGCGCTTGCCAACACGCTCGCGGCGCTCGACGCCGGCATCGACCGCTTCGACGCGTCGCTCGGCGGGCTCGGCGGC
TGCCCGTACGCGCCGGGCGCGACCGGCAACGCGTGCACCGAGGAACTGGTGCACATGCTCGAGCTCGACGGCTACGATAC
GGGCATCGATCTTGCGGCCGTGCTCGCCGCATCGGCGCGGCTGCCTGCGCTGATCGGGCACGACGTGCCGAGCCAGATCC
TGAAGGCCGGGCGCCGGTCGGACCTTCATTCGCCGCCGCGCGCCGACGCCGGCGACATGCCCGCGCAACGCGCTTTCTCG
TGA

Upstream 100 bases:

>100_bases
GGATACCGACGCGGTCCTCGAATCGCTCGGCATCGATGCGGCGACGCGCGACGACTGGCGCACGCGCGGCGTGATCTGAC
ACAACCATCGGGACGAACCC

Downstream 100 bases:

>100_bases
ATCGTGAACCCCAACAGGAACAGGAGGGAATCCCATGGCGCTGATCGACCATCTCGATCATCTCGTGCTGACCTGCGTCG
ATCCGGAACGGACGAAGCAT

Product: pyruvate carboxyltransferase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MNRHPQRLHIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIVRAPGVVYTV
LVPNVRGAERALSCGVDEVNLVMSMSESHNRANLRMTREQSFAQLRDVIDTVRGTGVAINVSLSTAMGCPMEGDVPAETV
LAWMQRFADLGVHGFTLCDTTGMAFPSQVRDLSRRARERFGALQLTLHFHNTRGMALANTLAALDAGIDRFDASLGGLGG
CPYAPGATGNACTEELVHMLELDGYDTGIDLAAVLAASARLPALIGHDVPSQILKAGRRSDLHSPPRADAGDMPAQRAFS

Sequences:

>Translated_320_residues
MNRHPQRLHIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIVRAPGVVYTV
LVPNVRGAERALSCGVDEVNLVMSMSESHNRANLRMTREQSFAQLRDVIDTVRGTGVAINVSLSTAMGCPMEGDVPAETV
LAWMQRFADLGVHGFTLCDTTGMAFPSQVRDLSRRARERFGALQLTLHFHNTRGMALANTLAALDAGIDRFDASLGGLGG
CPYAPGATGNACTEELVHMLELDGYDTGIDLAAVLAASARLPALIGHDVPSQILKAGRRSDLHSPPRADAGDMPAQRAFS
>Mature_320_residues
MNRHPQRLHIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIVRAPGVVYTV
LVPNVRGAERALSCGVDEVNLVMSMSESHNRANLRMTREQSFAQLRDVIDTVRGTGVAINVSLSTAMGCPMEGDVPAETV
LAWMQRFADLGVHGFTLCDTTGMAFPSQVRDLSRRARERFGALQLTLHFHNTRGMALANTLAALDAGIDRFDASLGGLGG
CPYAPGATGNACTEELVHMLELDGYDTGIDLAAVLAASARLPALIGHDVPSQILKAGRRSDLHSPPRADAGDMPAQRAFS

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=296, Percent_Identity=37.8378378378378, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI109150422, Length=292, Percent_Identity=36.3013698630137, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI109150427, Length=292, Percent_Identity=36.3013698630137, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI260654708, Length=135, Percent_Identity=38.5185185185185, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17510563, Length=289, Percent_Identity=35.9861591695502, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320019, Length=224, Percent_Identity=27.6785714285714, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320071, Length=224, Percent_Identity=27.6785714285714, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582381, Length=293, Percent_Identity=35.1535836177474, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 34188; Mature: 34188

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRHPQRLHIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPAL
CCCCCCEEHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCH
RDAEAVMHGIVRAPGVVYTVLVPNVRGAERALSCGVDEVNLVMSMSESHNRANLRMTREQ
HHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCEEEHHHH
SFAQLRDVIDTVRGTGVAINVSLSTAMGCPMEGDVPAETVLAWMQRFADLGVHGFTLCDT
HHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECC
TGMAFPSQVRDLSRRARERFGALQLTLHFHNTRGMALANTLAALDAGIDRFDASLGGLGG
CCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
CPYAPGATGNACTEELVHMLELDGYDTGIDLAAVLAASARLPALIGHDVPSQILKAGRRS
CCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHCCCCC
DLHSPPRADAGDMPAQRAFS
CCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MNRHPQRLHIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPAL
CCCCCCEEHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCH
RDAEAVMHGIVRAPGVVYTVLVPNVRGAERALSCGVDEVNLVMSMSESHNRANLRMTREQ
HHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCEEEHHHH
SFAQLRDVIDTVRGTGVAINVSLSTAMGCPMEGDVPAETVLAWMQRFADLGVHGFTLCDT
HHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECC
TGMAFPSQVRDLSRRARERFGALQLTLHFHNTRGMALANTLAALDAGIDRFDASLGGLGG
CCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
CPYAPGATGNACTEELVHMLELDGYDTGIDLAAVLAASARLPALIGHDVPSQILKAGRRS
CCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHCCCCC
DLHSPPRADAGDMPAQRAFS
CCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]