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The map label for this gene is qacE [H]

Identifier: 116689581

GI number: 116689581

Start: 1724635

End: 1724973

Strand: Direct

Name: qacE [H]

Synonym: Bcen2424_1559

Alternate gene names: 116689581

Gene position: 1724635-1724973 (Clockwise)

Preceding gene: 116689580

Following gene: 116689582

Centisome position: 49.5

GC content: 66.37

Gene sequence:

>339_bases
ATGCAATTGCCCGGTTACGCATGGCTCGCGATCGCGATCGTCGCGGAAGTGATCGGCACGTCCGCGCTGCGCGCGGCGGA
CGGCTTCACGCGCTTGTGGCCGTCGGTGCTCGTCGTCGCCGGTTACGGCGTCGCGTTCTACTGCCTGTCGCTCACGTTGC
GCACGATGCCCGTCGGCATCATCTATGCAGTCTGGTCGGGCGCCGGCATCGTGCTGATCACGCTCGTCGCGATGCTGCTC
TATCGCCAGGTGCCGGACGTGCCGGCGGTGATCGGCCTCGGGCTGATCATCGCGGGCGTCGTGGTGCTGAACCTGTTCTC
GAAGATGCAGGCGCACTGA

Upstream 100 bases:

>100_bases
CGGGTTGCCGCAGCGTGCGGACCACGAGTTCGTCGTCGAGGCGCTGTGTGCGGAGCTCGGCCACGACTACGCGGTACTGG
CCCTCGCAAGGAGCTGAGCG

Downstream 100 bases:

>100_bases
GCGTGCGACCGCCGTTTGCCGGATGACCTTCATGACCGATTCCCTTTCCGCCGCCGTTTCCGCCGAATCCGCCCAGCCCG
ACGTGCGCGCCTATGTCGCG

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MQLPGYAWLAIAIVAEVIGTSALRAADGFTRLWPSVLVVAGYGVAFYCLSLTLRTMPVGIIYAVWSGAGIVLITLVAMLL
YRQVPDVPAVIGLGLIIAGVVVLNLFSKMQAH

Sequences:

>Translated_112_residues
MQLPGYAWLAIAIVAEVIGTSALRAADGFTRLWPSVLVVAGYGVAFYCLSLTLRTMPVGIIYAVWSGAGIVLITLVAMLL
YRQVPDVPAVIGLGLIIAGVVVLNLFSKMQAH
>Mature_112_residues
MQLPGYAWLAIAIVAEVIGTSALRAADGFTRLWPSVLVVAGYGVAFYCLSLTLRTMPVGIIYAVWSGAGIVLITLVAMLL
YRQVPDVPAVIGLGLIIAGVVVLNLFSKMQAH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=107, Percent_Identity=49.5327102803738, Blast_Score=103, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11859; Mature: 11859

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLPGYAWLAIAIVAEVIGTSALRAADGFTRLWPSVLVVAGYGVAFYCLSLTLRTMPVGI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYAVWSGAGIVLITLVAMLLYRQVPDVPAVIGLGLIIAGVVVLNLFSKMQAH
HHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLPGYAWLAIAIVAEVIGTSALRAADGFTRLWPSVLVVAGYGVAFYCLSLTLRTMPVGI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYAVWSGAGIVLITLVAMLLYRQVPDVPAVIGLGLIIAGVVVLNLFSKMQAH
HHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]