Click here to switch to the map view.

The map label for this gene is relA [H]

Identifier: 116689495

GI number: 116689495

Start: 1626121

End: 1628358

Strand: Direct

Name: relA [H]

Synonym: Bcen2424_1473

Alternate gene names: 116689495

Gene position: 1626121-1628358 (Clockwise)

Preceding gene: 116689494

Following gene: 116689496

Centisome position: 46.68

GC content: 68.05

Gene sequence:

>2238_bases
ATGACCGAATCCGTTTCCGCCTCTCCCGTCGCGGCGCCGTCGTTCGACGACGTGCTCGCGTTCGTGCGCGAGCGGGCCGG
CGACGCGCGCCTGTCGTCCGGCGAGCTGCTCGCCGATCACTCGGCGGGCACGGCGGCGATCATGCGCACGCTGAACGTCG
ATCCGCACGCGATGCAGGCCGCCGCGCTGTTCGTGCTGACGCCGCACCTGAGCGACCCCGAGCGCGAGCTGACCGAGCGT
TTCGGCGACGAAGTCGCGCGGCTCGTGTCCGACGTGCGCAAGCTGTTGCGGCTCGGCACCGTCAGCCTGCGCGCCGCGCA
GAATGCCGCGAAGCCCGACTCCGGGCGCGACGCGGCGGAAGAGCGGCGCACGCAAATCGAGGCGCTGCGCAAGATGCTGC
TCGCCTTCGCGCAGGACATCCGCGTGGTGCTGATCCGGCTCGCGTCGCGGTTGCAGTCGCTGCGCTACTACGCGGCCGCG
AAGCTCGATCCGCCGCCCGACGTCGCGCGCGAGACGCTGGAGATCTATGCGCCGCTCGCGAACCGTCTCGGCATCTGGCA
ACTGAAGTGGGAGCTCGAGGATCTCGCGTTCCGCTTCGAGGATCCCGTCACCTACAAGCGGATCGCGAAGCTGCTCGACG
AGAAGCGCATCGAGCGCGAGGCGTACGTCACGCAGGCGATCGCGCGGCTGCAGCACGAGCTCGCGCAAGCGCACATCCAG
GCCGACGTGAGCGGCCGGCCGAAGCATATCTACAGCATCTGGCGCAAGATGCGCGGCAAGGAGCTCGACTTCTCCGAGCT
GTACGACGTGCGCGCGTTTCGCGTGATCGTGCCCGACATCAAGGATTGCTACGCGGTGCTGGGCATCGTGCATCACCTGT
GGCAGCCGGTGCCGAAGGAATTCGACGACTACATCTCGCGGCCGAAGCCGAACGGCTACAAGTCGCTGCATACGGTCGTG
ATCGGCGACGACGGCCGTGCGTTCGAAGTGCAGATCCGCACGCAGGAGATGCATCGTTTCGCCGAGTACGGCGTCGCCGC
GCACTGGCGCTACAAGGAGGCCGGCGCGCGCGGCTACGGCGGCCAGTTCTCCGCGAGCGACAAGTACGACGAGAAGATCG
CGTGGCTGCGCCAGTTGCTCGCGTGGAAGGACGACGTCGAGGACGGCACCGAAGTGTCGGGCGACCAGGCGTGGGCGCAA
TTGCGCGAGACGTCGCTCGACGACGACCACATCTATGTACTGACGCCGCAGGCGCGCGTGATCGCGTTGCCGCAGGGCGC
GACGCCGGTCGATTTCGCGTATCACCTGCATAGCGAGCTCGGCCATCGCTGCCGTGGCGCGCGCGTCGACGGCGTGATGG
TGCCGCTGAACACGTCGCTGGCGAACGGCCAGACGGTCGAGATCGTCGCGGTGAAGGAAGGCGGGCCGTCGCGCGACTGG
CTGAACCTGCAGCTCGGTTACCTGAAGAGCTCGCGCGCGCGGCAGAAGGTGCGTGCGTGGTTCAACTCGATCGAGCAGGA
AGAAAACGTCGCGCACGGGCGCGCGCTCGTCGAAAAGACGCTGCAGCGCGAGGGCAAGACGTCGGTCAACCTGGACAACC
TCGCCGCGAAGCTCGGCTTCAAGTCGCCCGAGGAGTTGTTCTCGGTCGTCGGCAAGGAAGAATTCAGCCTGCGCAACGTC
GAGCACGCGCTGTCCGATGCGCCGCCGCCGGAACCGGCGCCCGAGGCGCCGGCCGATTTCGAGAAGCGCAGCAGCGGCGC
GAGCGTCGCGCACGGCGCGTCGACCGGCGTGCTGGTGGTGGGCGTCGACGCGCTGCTGACGCAGTTGGCGCGCTGCTGCC
GTCCGGCGCCGCCCGATCCGATCAGCGGTTTCGTCACGCGCGGCAAGGGAATGTCGATTCATCGCAGCGACTGCCCGACG
TTTCGCCGGATGGTCGAGCGCGCGCCGGAGCGCGTGCTGCAGACGACCTGGTCGGCCGACGTGCTGGGCGGGCGCGGCGC
GTCCGTGTATCCGGTCGACCTGATGATCGAGGCGAGCGACCGGCAAGGGTTGCTGCGCGATATCTCCGAAGTGTTCGCAC
GCGAAAAGATCAATGTCGTGGGCGTGAAGACGCAGAGTCGCCGCAATGCGGCATTCATGCAGTTCACGGTCGAGGTATCG
AATTCGGCGCAGGTGCAGCGCGCGTGCACGCTGCTCGGCGAGGTGCAGGGCGTCGTGCGGGCAGGGCGGAAATCGTGA

Upstream 100 bases:

>100_bases
GAAGCTCGCCGATCCGGCGCTGCTCGTCGAGATCGTGGTCGTCGCCGCGCAGCGGAGCTGAGCGTTATCCGACGATGACC
GTATTCCGGCAGGCCGTGCA

Downstream 100 bases:

>100_bases
TAGGGTTGGAACGACATTGTTTTGCTGCGACCGCATAAAACACTTGCCAAGTCGGTAGCCGCTCCATATAATCTTAGCTT
CTCTAGGCTCGTAGCTCAGT

Product: (p)ppGpp synthetase I, SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MTESVSASPVAAPSFDDVLAFVRERAGDARLSSGELLADHSAGTAAIMRTLNVDPHAMQAAALFVLTPHLSDPERELTER
FGDEVARLVSDVRKLLRLGTVSLRAAQNAAKPDSGRDAAEERRTQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAA
KLDPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVTQAIARLQHELAQAHIQ
ADVSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVV
IGDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQFSASDKYDEKIAWLRQLLAWKDDVEDGTEVSGDQAWAQ
LRETSLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGVMVPLNTSLANGQTVEIVAVKEGGPSRDW
LNLQLGYLKSSRARQKVRAWFNSIEQEENVAHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPEELFSVVGKEEFSLRNV
EHALSDAPPPEPAPEAPADFEKRSSGASVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCPT
FRRMVERAPERVLQTTWSADVLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKINVVGVKTQSRRNAAFMQFTVEVS
NSAQVQRACTLLGEVQGVVRAGRKS

Sequences:

>Translated_745_residues
MTESVSASPVAAPSFDDVLAFVRERAGDARLSSGELLADHSAGTAAIMRTLNVDPHAMQAAALFVLTPHLSDPERELTER
FGDEVARLVSDVRKLLRLGTVSLRAAQNAAKPDSGRDAAEERRTQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAA
KLDPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVTQAIARLQHELAQAHIQ
ADVSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVV
IGDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQFSASDKYDEKIAWLRQLLAWKDDVEDGTEVSGDQAWAQ
LRETSLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGVMVPLNTSLANGQTVEIVAVKEGGPSRDW
LNLQLGYLKSSRARQKVRAWFNSIEQEENVAHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPEELFSVVGKEEFSLRNV
EHALSDAPPPEPAPEAPADFEKRSSGASVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCPT
FRRMVERAPERVLQTTWSADVLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKINVVGVKTQSRRNAAFMQFTVEVS
NSAQVQRACTLLGEVQGVVRAGRKS
>Mature_744_residues
TESVSASPVAAPSFDDVLAFVRERAGDARLSSGELLADHSAGTAAIMRTLNVDPHAMQAAALFVLTPHLSDPERELTERF
GDEVARLVSDVRKLLRLGTVSLRAAQNAAKPDSGRDAAEERRTQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAK
LDPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVTQAIARLQHELAQAHIQA
DVSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVI
GDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQFSASDKYDEKIAWLRQLLAWKDDVEDGTEVSGDQAWAQL
RETSLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGVMVPLNTSLANGQTVEIVAVKEGGPSRDWL
NLQLGYLKSSRARQKVRAWFNSIEQEENVAHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPEELFSVVGKEEFSLRNVE
HALSDAPPPEPAPEAPADFEKRSSGASVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCPTF
RRMVERAPERVLQTTWSADVLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKINVVGVKTQSRRNAAFMQFTVEVSN
SAQVQRACTLLGEVQGVVRAGRKS

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=704, Percent_Identity=40.625, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI1790082, Length=729, Percent_Identity=34.2935528120713, Blast_Score=389, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82883; Mature: 82752

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESVSASPVAAPSFDDVLAFVRERAGDARLSSGELLADHSAGTAAIMRTLNVDPHAMQA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHCCCCHHHHHH
AALFVLTPHLSDPERELTERFGDEVARLVSDVRKLLRLGTVSLRAAQNAAKPDSGRDAAE
HEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHH
ERRTQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKLDPPPDVARETLEIYAPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
NRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVTQAIARLQHELAQAHIQ
HCCCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADVSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKE
HCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCHH
FDDYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYG
HHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHCCCCEEEEEHHCCCCCCC
GQFSASDKYDEKIAWLRQLLAWKDDVEDGTEVSGDQAWAQLRETSLDDDHIYVLTPQARV
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEE
IALPQGATPVDFAYHLHSELGHRCRGARVDGVMVPLNTSLANGQTVEIVAVKEGGPSRDW
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCE
LNLQLGYLKSSRARQKVRAWFNSIEQEENVAHGRALVEKTLQREGKTSVNLDNLAAKLGF
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
KSPEELFSVVGKEEFSLRNVEHALSDAPPPEPAPEAPADFEKRSSGASVAHGASTGVLVV
CCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCEECCCCCCEEEE
GVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCPTFRRMVERAPERVLQTTWSAD
EHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCC
VLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKINVVGVKTQSRRNAAFMQFTVEVS
CCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEEC
NSAQVQRACTLLGEVQGVVRAGRKS
CCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TESVSASPVAAPSFDDVLAFVRERAGDARLSSGELLADHSAGTAAIMRTLNVDPHAMQA
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHCCCCHHHHHH
AALFVLTPHLSDPERELTERFGDEVARLVSDVRKLLRLGTVSLRAAQNAAKPDSGRDAAE
HEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHH
ERRTQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKLDPPPDVARETLEIYAPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
NRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVTQAIARLQHELAQAHIQ
HCCCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADVSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKE
HCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCHH
FDDYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYG
HHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHCCCCEEEEEHHCCCCCCC
GQFSASDKYDEKIAWLRQLLAWKDDVEDGTEVSGDQAWAQLRETSLDDDHIYVLTPQARV
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEE
IALPQGATPVDFAYHLHSELGHRCRGARVDGVMVPLNTSLANGQTVEIVAVKEGGPSRDW
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCE
LNLQLGYLKSSRARQKVRAWFNSIEQEENVAHGRALVEKTLQREGKTSVNLDNLAAKLGF
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
KSPEELFSVVGKEEFSLRNVEHALSDAPPPEPAPEAPADFEKRSSGASVAHGASTGVLVV
CCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCEECCCCCCEEEE
GVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCPTFRRMVERAPERVLQTTWSAD
EHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCC
VLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKINVVGVKTQSRRNAAFMQFTVEVS
CCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEEC
NSAQVQRACTLLGEVQGVVRAGRKS
CCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]