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The map label for this gene is uvrD [H]

Identifier: 116689464

GI number: 116689464

Start: 1593654

End: 1596017

Strand: Direct

Name: uvrD [H]

Synonym: Bcen2424_1442

Alternate gene names: 116689464

Gene position: 1593654-1596017 (Clockwise)

Preceding gene: 116689461

Following gene: 116689465

Centisome position: 45.74

GC content: 67.22

Gene sequence:

>2364_bases
ATGCCCGATCTGCTCGCCAATCTGAACCCCGAACAACTCGCCGCCGTCACGTTGCCGAACGAACCGGCGCTGATCCTCGC
AGGGGCGGGCAGCGGCAAGACCCGCGTGCTGATCACGCGCATCGCGTGGCTGATCCAGCAGGGCTATGCATCGCCGCCCA
CCGTGCTCGCCGTCACCTTCACGAACAAGGCAGCGCGCGAGATGATGGCGCGCCTGTCGGCGATGATGCCGATCGACACG
CGCGGGATGTGGATCGGCACGTTCCACGGCCTGTGCAACCGGATGCTGCGCACGCACTGGCGCGACGCCGGCCTGCCGCA
GACCTTCCAGATCCTCGACACGGCCGACCAGCTGTCCGCGATCAAGCGGCTGATGAAGGCGGCGAACGTCGACGACGAAA
AGTACCCGCCGAAGAACGTCCAGTACTTCATCAACAACGCGAAGGAGCAGGGGCTGCGCCCGGACAAGGTCGACGCGACC
GACAACTTCAATCGCAAGTTCGTCGAGCTGTACCAGGCGTACGACCAGCAGTGCCAGCGCGAAGGCGTCGTCGATTTCCC
CGAGCTGCTGCTGCGCTGCTACGAACTGCTCGCGTACAACGCGCCGCTGCGCGCGCACTACCAGGCGCGCTTCCGGCACA
TCCTCGTCGACGAGTTCCAGGACACCAACAAGCTGCAGTACGCGTGGCTCAAGATGCTCGCGGGCGGCGAGAACGCGATC
TTCGCGGTCGGCGACGACGACCAGTCGATCTATGCGTTCCGCGGCGCGAACGTCGGCAACATGCGCGACTTCGAAGACGA
ATTCCGCGTGCGCAACCTGATCAAGCTCGAGCAGAACTACCGTTCGCACGGCAACATCCTCGACGCGGCGAACCAGCTGA
TCTCGAACAACGCGCACCGCCTCGGCAAGAACCTGCGTACCGATGCCGGCCACGGCGAGCCGGTGCGCGTGTACGAAGCC
AGCACCGATTCGCAGGAAGCCGGCTGGATCGTCGAGGAGATCCGTTCGCTGATCAATACCGGGATGGCGCGCAGCGAAGT
GGCCGTCCTGTACCGCAGCAACGCGCAATCGCGCTCGATCGAGCACACGCTGATGTCGTCGGGCATTCCATACCGCGTGT
ACGGCGGCCTGCGCTTTTTCGAGCGGCAGGAAGTGAAGCACGCGCTCGCGTACCTGCGCCTGATCGACAACCCGAACGAC
GACACGGCATTCGCGCGCGTCGTGAATTTCCCGACCCGCGGTATCGGCGCGCGCTCGGTCGAGCAACTGGCCGACGCTGC
GCGCTTGTACGGCTGCTCGATGGCCGCCGCGATTCCGTACGTGACCGGCAAGGCCGGCACGAGCCTCGGCGGGTTCGCGA
ACCTGATCGCGAAGATGCGTGCCGACACGCAGCACATGAACCTGCCCGACACCGTCGAGCACATCGTGCGCGCGAGCGGC
CTCGCCGATTTCTACCAGGGCGAGCGCGAAGGGCAGGATCGCCTCGAAAACCTGCAGGAACTCGTAAACGCGGCCACCGC
GTTCATCGCCGAGGAAGGCTACGGGCTCGACACGCCGGCCCGCTCGATCCCGCTGCGCGCGGGCGCGATCGCGGCGCCCG
AGCTCGGCACCGCAACCGACGATCCGGCGGTCGACGTGCTCGATCCGGCGTCGCCCGCCGACCCCGCACAGAACCCCGAC
ACGATGACGCCGCTCGCCGGCTTCCTGTCGCACGCGGCGCTGGAGGCCGGCGACAACCAGGCGCAGGCCGGTCAGGACGC
CGTGCAGCTGATGACCGTGCACGCGGCGAAAGGGCTCGAATTCTCGGCCGTGTTCATCACGGGGCTCGAGGAGGGGCTGT
TCCCGCACGAGAACAGCGTGCTCGAATCGGATGGCCTGGAGGAAGAGCGCCGGCTGATGTACGTCGCGATCACGCGCGCG
AAGGAGCGGCTCTACCTGTCGTTCGCGCAGAGCCGGATGCTGCACGGCCAGACCCGCTACAACGTGCGCTCGCGCTTCTT
CGACGAACTGCCGGAGCACGTGCTGAAGTGGCTCACGCCGAAGGTCGAGGCCGGGTCGCGCTGGGGCGGCCGTTCGGACA
ATGCCGGCTACGGGCGTGACTGGTTCGCGCGGCCGGGCGGCGGCAGCCGCGAGCAGATCGTCGATGCGGCCGTGTCCGCG
CCGCTGCCCGCGTTCGCGAACAAGCAGCGCGCGGCCGACACCGGCTTCCGGGTCGGCCAGCAGGTGTTCCACACCAAGTT
CGGCGAAGGCACGGTCACCGCGCTCGAAGGCAACGGCACCGACGCGAAGGCGCAGGTGAAGTTCAAGCGCCACGGCGAGA
AATGGCTCGCGCTCGCGGTCGCGAAACTGCAGGCGGTGGAATGA

Upstream 100 bases:

>100_bases
AACATGCAGGCAGCGTGCGACCGAACGGATCGGAAACGGCATCGCGCGGCCGACTTATAATGTCGGGTCCGCATTTTTCT
CGCCCGTTAGCCGCCGCTCC

Downstream 100 bases:

>100_bases
TGGACGTCGACCTCGCCGTGACGCCTGCCGCGCGCCCGCTCGGCATTCTGGCCGCGCTGCCCGAGGAGCTCGGCGACCTG
ATCGCCGCGATGCGCGCCGA

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 787; Mature: 786

Protein sequence:

>787_residues
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPPTVLAVTFTNKAAREMMARLSAMMPIDT
RGMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDAT
DNFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAI
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEA
STDSQEAGWIVEEIRSLINTGMARSEVAVLYRSNAQSRSIEHTLMSSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSVEQLADAARLYGCSMAAAIPYVTGKAGTSLGGFANLIAKMRADTQHMNLPDTVEHIVRASG
LADFYQGEREGQDRLENLQELVNAATAFIAEEGYGLDTPARSIPLRAGAIAAPELGTATDDPAVDVLDPASPADPAQNPD
TMTPLAGFLSHAALEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNVRSRFFDELPEHVLKWLTPKVEAGSRWGGRSDNAGYGRDWFARPGGGSREQIVDAAVSA
PLPAFANKQRAADTGFRVGQQVFHTKFGEGTVTALEGNGTDAKAQVKFKRHGEKWLALAVAKLQAVE

Sequences:

>Translated_787_residues
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPPTVLAVTFTNKAAREMMARLSAMMPIDT
RGMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDAT
DNFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAI
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEA
STDSQEAGWIVEEIRSLINTGMARSEVAVLYRSNAQSRSIEHTLMSSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSVEQLADAARLYGCSMAAAIPYVTGKAGTSLGGFANLIAKMRADTQHMNLPDTVEHIVRASG
LADFYQGEREGQDRLENLQELVNAATAFIAEEGYGLDTPARSIPLRAGAIAAPELGTATDDPAVDVLDPASPADPAQNPD
TMTPLAGFLSHAALEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNVRSRFFDELPEHVLKWLTPKVEAGSRWGGRSDNAGYGRDWFARPGGGSREQIVDAAVSA
PLPAFANKQRAADTGFRVGQQVFHTKFGEGTVTALEGNGTDAKAQVKFKRHGEKWLALAVAKLQAVE
>Mature_786_residues
PDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPPTVLAVTFTNKAAREMMARLSAMMPIDTR
GMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATD
NFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAIF
AVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEAS
TDSQEAGWIVEEIRSLINTGMARSEVAVLYRSNAQSRSIEHTLMSSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDD
TAFARVVNFPTRGIGARSVEQLADAARLYGCSMAAAIPYVTGKAGTSLGGFANLIAKMRADTQHMNLPDTVEHIVRASGL
ADFYQGEREGQDRLENLQELVNAATAFIAEEGYGLDTPARSIPLRAGAIAAPELGTATDDPAVDVLDPASPADPAQNPDT
MTPLAGFLSHAALEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAK
ERLYLSFAQSRMLHGQTRYNVRSRFFDELPEHVLKWLTPKVEAGSRWGGRSDNAGYGRDWFARPGGGSREQIVDAAVSAP
LPAFANKQRAADTGFRVGQQVFHTKFGEGTVTALEGNGTDAKAQVKFKRHGEKWLALAVAKLQAVE

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=792, Percent_Identity=44.4444444444444, Blast_Score=646, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=685, Percent_Identity=35.036496350365, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=27.9411764705882, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=761, Percent_Identity=27.5952693823916, Blast_Score=217, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6324477, Length=726, Percent_Identity=22.8650137741047, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 87004; Mature: 86873

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPPTVLAVTF
CCCCCCCCCHHHEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATDNFNRKFVELYQAYDQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAI
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHR
EEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LGKNLRTDAGHGEPVRVYEASTDSQEAGWIVEEIRSLINTGMARSEVAVLYRSNAQSRSI
HHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHEEEEEECCCCHHHH
EHTLMSSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSV
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLYGCSMAAAIPYVTGKAGTSLGGFANLIAKMRADTQHMNLPDTVEHIVRASG
HHHHHHHHHHCCHHHHHCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
LADFYQGEREGQDRLENLQELVNAATAFIAEEGYGLDTPARSIPLRAGAIAAPELGTATD
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DPAVDVLDPASPADPAQNPDTMTPLAGFLSHAALEAGDNQAQAGQDAVQLMTVHAAKGLE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCHHHHHHHHHHHHHCCCE
FSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEECHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NVRSRFFDELPEHVLKWLTPKVEAGSRWGGRSDNAGYGRDWFARPGGGSREQIVDAAVSA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
PLPAFANKQRAADTGFRVGQQVFHTKFGEGTVTALEGNGTDAKAQVKFKRHGEKWLALAV
CCCHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEHHHCCHHHHHHHH
AKLQAVE
HHHHHCC
>Mature Secondary Structure 
PDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPPTVLAVTF
CCCCCCCCHHHEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATDNFNRKFVELYQAYDQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAI
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHR
EEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LGKNLRTDAGHGEPVRVYEASTDSQEAGWIVEEIRSLINTGMARSEVAVLYRSNAQSRSI
HHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHEEEEEECCCCHHHH
EHTLMSSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSV
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLYGCSMAAAIPYVTGKAGTSLGGFANLIAKMRADTQHMNLPDTVEHIVRASG
HHHHHHHHHHCCHHHHHCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
LADFYQGEREGQDRLENLQELVNAATAFIAEEGYGLDTPARSIPLRAGAIAAPELGTATD
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DPAVDVLDPASPADPAQNPDTMTPLAGFLSHAALEAGDNQAQAGQDAVQLMTVHAAKGLE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCHHHHHHHHHHHHHCCCE
FSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEECHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NVRSRFFDELPEHVLKWLTPKVEAGSRWGGRSDNAGYGRDWFARPGGGSREQIVDAAVSA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
PLPAFANKQRAADTGFRVGQQVFHTKFGEGTVTALEGNGTDAKAQVKFKRHGEKWLALAV
CCCHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEHHHCCHHHHHHHH
AKLQAVE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]