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The map label for this gene is exuT [H]

Identifier: 116624402

GI number: 116624402

Start: 6672298

End: 6673533

Strand: Reverse

Name: exuT [H]

Synonym: Acid_5324

Alternate gene names: 116624402

Gene position: 6673533-6672298 (Counterclockwise)

Preceding gene: 116624403

Following gene: 116624401

Centisome position: 66.97

GC content: 64.89

Gene sequence:

>1236_bases
ATGGAAACGGCCGCGCACCGCATGCGCTGGAGCATCGCGATCCTCGTAAGTGCCGCGATCGCGGTCAGCTACTTCGATCG
CCAGACCCTGCCCGTCGCGATCGCTGCCATCCAGCGCGACATCCCCGTTTCGAATACCCAGTTCTCCTACCTCCAGGGCG
CGTTCCTGCTGGCCTACGCGGGCATGTATGCGGGCGGCGGCAAACTGATCGACGTGCTGGGCACGCGCCGCGGCTTCTTG
TGGATCATGATCTGGTGGTCGCTGGCCTGCGCCAGTCATGGACTCGCGGCGAGCTTCGGCATGCTGGCCGCCAGCCGGTT
TCTGCTCGGGATGGGCGAAGGCGGCGGCTTCCCGGCGGCAACCAAAGCGGTGTCGGAATGGTTCCCCGCGCACGAGCGCT
CCACCGCCATGGGGATCATCAACGCAGGCTCCGCCGTGGGCGCCGTGATGGCGCCGCCGGGTATCGCGTTCGTGATCGCG
ACCTGGAACTGGCGCTGGGTCTTCCTGCTCTCGGGCGCCGTCGGCATGCTGTGGACGCTCTGGTGGTCGCGCACCTACTT
CGTGCCGCCGCGCGCCGCGCAGACGGAAGCGAGCTCAGACATCTCGTGGTCGCGCCTCTTCACCTACCGCCAGGTCTGGG
GCCTCGTGACCGCGAAGTTCCTGAGTGACGCCGCCTGGTATTTCTACATCTTCTGGCTGCCGAAATATCTCTACGATGTG
CGCGGCTTCGATACCAAACAAGTCGGCTACTTCGCCTGGATTCCCTACGCCGCGTCGGGAGTAGGCAGCCTCTGCGGCGG
CTGGTTTTCGAGCCACCTGCTGCGCTCCGGATGCTCGCTGGACCGGTCGCGTAAGATTGCGCTGGGCGCCAGCGCGGGCT
TGATGCCGCTGATCTTCTTCGTGACTCAGGCGCCGGTCCAGGTGGCGATCTTGCTGTTCTCGATCGCGTTCTTTGGACAG
CAGTCCTGGTCCACGCTGGTGATGATTCTGCCCGCCGACCTCTTCCCGCATGAAGTGGTGGGCTCGGTTGCGGGGCTGGT
GGGTTTCGGCGGCGCCATGGGCGGCTTCGTCTTCGGGCTCGTAGTTGGATACCTGTTGGATCACGGCTTCGGCTACGGCA
CGGTCTTTCCTATGGTGAGCACCATGCACGTGATCGCATTCGGCGTCATCCTGCTGACCGTGCGCAAGGTCGCGCCGCTG
GCGGCGTTCCGCGAGAAGATAGAAAAACGACCATGA

Upstream 100 bases:

>100_bases
CGCGCAGCAGCGCGTCGTCGGCGACGAGGAAGCGAACCGGTTGCTGCGCCGGCCCTATCGCGAGCCGTGGGTGCATCCCA
CGCCGGAATCGGTCTGAGGG

Downstream 100 bases:

>100_bases
AGATCACTGAGATTCGCACCCGCGTCGTCGAGTGGCGCGGCAAGACCGTGCCGCCGCAGCCGCACTTCTGCACCAACCCA
ATGGACATCCTCGACCTTCC

Product: major facilitator transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
METAAHRMRWSIAILVSAAIAVSYFDRQTLPVAIAAIQRDIPVSNTQFSYLQGAFLLAYAGMYAGGGKLIDVLGTRRGFL
WIMIWWSLACASHGLAASFGMLAASRFLLGMGEGGGFPAATKAVSEWFPAHERSTAMGIINAGSAVGAVMAPPGIAFVIA
TWNWRWVFLLSGAVGMLWTLWWSRTYFVPPRAAQTEASSDISWSRLFTYRQVWGLVTAKFLSDAAWYFYIFWLPKYLYDV
RGFDTKQVGYFAWIPYAASGVGSLCGGWFSSHLLRSGCSLDRSRKIALGASAGLMPLIFFVTQAPVQVAILLFSIAFFGQ
QSWSTLVMILPADLFPHEVVGSVAGLVGFGGAMGGFVFGLVVGYLLDHGFGYGTVFPMVSTMHVIAFGVILLTVRKVAPL
AAFREKIEKRP

Sequences:

>Translated_411_residues
METAAHRMRWSIAILVSAAIAVSYFDRQTLPVAIAAIQRDIPVSNTQFSYLQGAFLLAYAGMYAGGGKLIDVLGTRRGFL
WIMIWWSLACASHGLAASFGMLAASRFLLGMGEGGGFPAATKAVSEWFPAHERSTAMGIINAGSAVGAVMAPPGIAFVIA
TWNWRWVFLLSGAVGMLWTLWWSRTYFVPPRAAQTEASSDISWSRLFTYRQVWGLVTAKFLSDAAWYFYIFWLPKYLYDV
RGFDTKQVGYFAWIPYAASGVGSLCGGWFSSHLLRSGCSLDRSRKIALGASAGLMPLIFFVTQAPVQVAILLFSIAFFGQ
QSWSTLVMILPADLFPHEVVGSVAGLVGFGGAMGGFVFGLVVGYLLDHGFGYGTVFPMVSTMHVIAFGVILLTVRKVAPL
AAFREKIEKRP
>Mature_411_residues
METAAHRMRWSIAILVSAAIAVSYFDRQTLPVAIAAIQRDIPVSNTQFSYLQGAFLLAYAGMYAGGGKLIDVLGTRRGFL
WIMIWWSLACASHGLAASFGMLAASRFLLGMGEGGGFPAATKAVSEWFPAHERSTAMGIINAGSAVGAVMAPPGIAFVIA
TWNWRWVFLLSGAVGMLWTLWWSRTYFVPPRAAQTEASSDISWSRLFTYRQVWGLVTAKFLSDAAWYFYIFWLPKYLYDV
RGFDTKQVGYFAWIPYAASGVGSLCGGWFSSHLLRSGCSLDRSRKIALGASAGLMPLIFFVTQAPVQVAILLFSIAFFGQ
QSWSTLVMILPADLFPHEVVGSVAGLVGFGGAMGGFVFGLVVGYLLDHGFGYGTVFPMVSTMHVIAFGVILLTVRKVAPL
AAFREKIEKRP

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=387, Percent_Identity=22.7390180878553, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI6912666, Length=191, Percent_Identity=26.1780104712042, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI21322234, Length=404, Percent_Identity=23.5148514851485, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI9945322, Length=404, Percent_Identity=23.5148514851485, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI9966811, Length=356, Percent_Identity=24.1573033707865, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI2367193, Length=425, Percent_Identity=30.8235294117647, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI87082320, Length=422, Percent_Identity=27.4881516587678, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789515, Length=404, Percent_Identity=27.4752475247525, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789152, Length=441, Percent_Identity=25.3968253968254, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI2367379, Length=395, Percent_Identity=26.3291139240506, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87082071, Length=385, Percent_Identity=23.1168831168831, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI115533554, Length=236, Percent_Identity=25.8474576271186, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI115533556, Length=236, Percent_Identity=25.8474576271186, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17535049, Length=402, Percent_Identity=22.3880597014925, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560030, Length=282, Percent_Identity=22.3404255319149, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129235, Length=399, Percent_Identity=27.5689223057644, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24584153, Length=353, Percent_Identity=24.6458923512748, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI19920686, Length=406, Percent_Identity=24.1379310344828, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583789, Length=291, Percent_Identity=25.7731958762887, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24580790, Length=209, Percent_Identity=25.8373205741627, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24648416, Length=322, Percent_Identity=24.5341614906832, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356189, Length=322, Percent_Identity=24.5341614906832, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550460, Length=405, Percent_Identity=24.4444444444444, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639764, Length=325, Percent_Identity=21.8461538461538, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24653727, Length=368, Percent_Identity=24.1847826086957, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44797; Mature: 44797

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METAAHRMRWSIAILVSAAIAVSYFDRQTLPVAIAAIQRDIPVSNTQFSYLQGAFLLAYA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
GMYAGGGKLIDVLGTRRGFLWIMIWWSLACASHGLAASFGMLAASRFLLGMGEGGGFPAA
HHHCCCCHHEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCCCCCHH
TKAVSEWFPAHERSTAMGIINAGSAVGAVMAPPGIAFVIATWNWRWVFLLSGAVGMLWTL
HHHHHHHCCCCCCCCEEEEEECCCCCCCEECCCCEEEEEEECCEEEEEEHHHHHHHHHHH
WWSRTYFVPPRAAQTEASSDISWSRLFTYRQVWGLVTAKFLSDAAWYFYIFWLPKYLYDV
HHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGFDTKQVGYFAWIPYAASGVGSLCGGWFSSHLLRSGCSLDRSRKIALGASAGLMPLIFF
CCCCCCCCCEEEECCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHH
VTQAPVQVAILLFSIAFFGQQSWSTLVMILPADLFPHEVVGSVAGLVGFGGAMGGFVFGL
HHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHH
VVGYLLDHGFGYGTVFPMVSTMHVIAFGVILLTVRKVAPLAAFREKIEKRP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
METAAHRMRWSIAILVSAAIAVSYFDRQTLPVAIAAIQRDIPVSNTQFSYLQGAFLLAYA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
GMYAGGGKLIDVLGTRRGFLWIMIWWSLACASHGLAASFGMLAASRFLLGMGEGGGFPAA
HHHCCCCHHEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCCCCCHH
TKAVSEWFPAHERSTAMGIINAGSAVGAVMAPPGIAFVIATWNWRWVFLLSGAVGMLWTL
HHHHHHHCCCCCCCCEEEEEECCCCCCCEECCCCEEEEEEECCEEEEEEHHHHHHHHHHH
WWSRTYFVPPRAAQTEASSDISWSRLFTYRQVWGLVTAKFLSDAAWYFYIFWLPKYLYDV
HHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGFDTKQVGYFAWIPYAASGVGSLCGGWFSSHLLRSGCSLDRSRKIALGASAGLMPLIFF
CCCCCCCCCEEEECCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHH
VTQAPVQVAILLFSIAFFGQQSWSTLVMILPADLFPHEVVGSVAGLVGFGGAMGGFVFGL
HHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHH
VVGYLLDHGFGYGTVFPMVSTMHVIAFGVILLTVRKVAPLAAFREKIEKRP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]