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The map label for this gene is pgl [H]

Identifier: 116624358

GI number: 116624358

Start: 6616156

End: 6616881

Strand: Reverse

Name: pgl [H]

Synonym: Acid_5279

Alternate gene names: 116624358

Gene position: 6616881-6616156 (Counterclockwise)

Preceding gene: 116624359

Following gene: 116624355

Centisome position: 66.4

GC content: 62.95

Gene sequence:

>726_bases
ATGAGCGCTCACTGGCAGAAACTTCCGGACGCGCAGGCAGCCGCCGAGGCGTGCGCACATCACATTATCGGCCGGCTCGA
CGAAGCCATCTCGGGGCAGGAGTTCGCCTCTTTCGCGATCTCCGGAGGGTCCAGCCCCAAACCGATGTTCCATATTCTGG
CTGCGACGAATTTCCCTTGGGACAGGGTGCACATCTTCTGGGTGGACGAGCGCTGCGTGCCGCCCACGGACGATGCCAGC
AATTACAAGATGGCGATGGAATATCTGATTAAGCCGGCGCACATTCCGCAGCGCAACGTGCATCGCGTGTTCGGAGAGTT
GGCACCGCCGGCGGCGGCCAAGCGCTACGTCGAGGAGATCCGGGAGTTCTTTGGGCTGGCGGAAGGGGAACTGCCGCGCT
TCGACCTTGTTCATCGCGGGATGGGACCCGACGCGCACACCGCCAGCCTCTTTCCGGGCGAGCCGCTGATTGACGACCGC
GAGGGAATCGCGGCGCCGGTATATGTCGAGAAGTTCCATCAATGGCGCGTGACGCTGCTGCCCGGCGTCCTGCTGGCGGC
GAAGCACACGGTCTTCCTGGCGGTGGGCGAGGATAAGACCGACGCTGTGCGCGCGGTGTTCAAGGAAGAATACGATCCCA
AGAAATATCCCGCTCAGATCGCCTCGCACCACGGCCGCGGCGTGATGTGGTTTATGGATGAGCCGGCGGCACGGTTGCTG
GATTGA

Upstream 100 bases:

>100_bases
AGGAGCTGGGCATCGTAAGCCGCGACGTGGTGTTCGAGCGGACGCTGGCGTCGGCGGCACGTCTTGCGGTACCGTCAGCG
GAGCATCCACCGGAAAAACC

Downstream 100 bases:

>100_bases
AGCAACGAGCCGCGACGGTGAGGGAGCGTTACGGCAGCGCTCCCTCTCACCTCACGGTCGCGGCTTCCATGAGAAGGCCC
CCCTCTGTCAAGAAAATAAT

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSAHWQKLPDAQAAAEACAHHIIGRLDEAISGQEFASFAISGGSSPKPMFHILAATNFPWDRVHIFWVDERCVPPTDDAS
NYKMAMEYLIKPAHIPQRNVHRVFGELAPPAAAKRYVEEIREFFGLAEGELPRFDLVHRGMGPDAHTASLFPGEPLIDDR
EGIAAPVYVEKFHQWRVTLLPGVLLAAKHTVFLAVGEDKTDAVRAVFKEEYDPKKYPAQIASHHGRGVMWFMDEPAARLL
D

Sequences:

>Translated_241_residues
MSAHWQKLPDAQAAAEACAHHIIGRLDEAISGQEFASFAISGGSSPKPMFHILAATNFPWDRVHIFWVDERCVPPTDDAS
NYKMAMEYLIKPAHIPQRNVHRVFGELAPPAAAKRYVEEIREFFGLAEGELPRFDLVHRGMGPDAHTASLFPGEPLIDDR
EGIAAPVYVEKFHQWRVTLLPGVLLAAKHTVFLAVGEDKTDAVRAVFKEEYDPKKYPAQIASHHGRGVMWFMDEPAARLL
D
>Mature_240_residues
SAHWQKLPDAQAAAEACAHHIIGRLDEAISGQEFASFAISGGSSPKPMFHILAATNFPWDRVHIFWVDERCVPPTDDASN
YKMAMEYLIKPAHIPQRNVHRVFGELAPPAAAKRYVEEIREFFGLAEGELPRFDLVHRGMGPDAHTASLFPGEPLIDDRE
GIAAPVYVEKFHQWRVTLLPGVLLAAKHTVFLAVGEDKTDAVRAVFKEEYDPKKYPAQIASHHGRGVMWFMDEPAARLLD

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=176, Percent_Identity=38.0681818181818, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI52145310, Length=206, Percent_Identity=33.495145631068, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI115533058, Length=219, Percent_Identity=30.1369863013699, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115533060, Length=219, Percent_Identity=30.1369863013699, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321957, Length=227, Percent_Identity=29.9559471365639, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324362, Length=214, Percent_Identity=29.4392523364486, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319918, Length=211, Percent_Identity=30.8056872037915, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641119, Length=194, Percent_Identity=28.3505154639175, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26959; Mature: 26828

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHWQKLPDAQAAAEACAHHIIGRLDEAISGQEFASFAISGGSSPKPMFHILAATNFPW
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHEECCCCCCCCEEEEEEECCCCC
DRVHIFWVDERCVPPTDDASNYKMAMEYLIKPAHIPQRNVHRVFGELAPPAAAKRYVEEI
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
REFFGLAEGELPRFDLVHRGMGPDAHTASLFPGEPLIDDREGIAAPVYVEKFHQWRVTLL
HHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
PGVLLAAKHTVFLAVGEDKTDAVRAVFKEEYDPKKYPAQIASHHGRGVMWFMDEPAARLL
HHHHHHHCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCHHHHC
D
C
>Mature Secondary Structure 
SAHWQKLPDAQAAAEACAHHIIGRLDEAISGQEFASFAISGGSSPKPMFHILAATNFPW
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHEECCCCCCCCEEEEEEECCCCC
DRVHIFWVDERCVPPTDDASNYKMAMEYLIKPAHIPQRNVHRVFGELAPPAAAKRYVEEI
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
REFFGLAEGELPRFDLVHRGMGPDAHTASLFPGEPLIDDREGIAAPVYVEKFHQWRVTLL
HHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
PGVLLAAKHTVFLAVGEDKTDAVRAVFKEEYDPKKYPAQIASHHGRGVMWFMDEPAARLL
HHHHHHHCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCHHHHC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]