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The map label for this gene is rnr [H]

Identifier: 116624324

GI number: 116624324

Start: 6575998

End: 6578286

Strand: Reverse

Name: rnr [H]

Synonym: Acid_5242

Alternate gene names: 116624324

Gene position: 6578286-6575998 (Counterclockwise)

Preceding gene: 116624330

Following gene: 116624323

Centisome position: 66.01

GC content: 62.43

Gene sequence:

>2289_bases
ATGACCGATGCGTCCATCGTCGCCCACATTTCCCGGCTGCCCCACGCCAGGGCAAACTTCAAGCAGTTGGTCCGCGAAAT
GGGGTTAAAAGGTGCGAAACGCGACGAGCTGGATACCGCGCTCGATCGCCTCGTTGCGCGCGGCGAGCTGATTGAACTGC
GCAGTGGCGAGTATACGGTCACCTCCCTGAGCCGCGAATTTGTGGTGGGCCGGCTCAACCTGCATCGCGACGGCTACGGC
TTTCTGATTGCCGACAGGCAGATTCCACGCGTCGTCGGCGACATCTTCATCCCGCCCGACTCCGCTTCCCAGGCGATGCA
CGGCGACCGCGTGCTCGTCCGCATCGCGCGTATCGAGCCCGATGGCCGCGCCGACGGCAATATCGTAAAGGTGCTGAAAC
GCGCCCATGCCACCGTGGTCGGCGAATTCAAAATCGGGCGCCGCGGATGTTACGTCGTGCCGCATGATGAGCGCCTGCAG
CAGTGGGTGGACATCCCCGAAGGCATGGAGTTCCCTCCAGCCGGAGCCTCCGTGGACCGCATCGGCGTCACCGCTCCCAA
GGTCGCCACCGTCGAACAGCTCGACGGCATGATCGTCAATGTGGAGATTATGGAATATGCCGGGCGCGGCGAATCACCGG
TCGGACGGGTCGTCGAAATCCTCGGACACCCCGATGATTTCGGGGTCGATGTCGAGATCGTCATCCGCAAGCACCACCTG
CCGCACCAGTTTCCGCCCGAAGTCATTGAGCAGGCCCAGGCCATCCCCGGCGTGATCCCGCCCGCCGAATTCGAAGGCCG
CCGCGACTTCCGCGGCATGGATATCGTCACCATCGATGGCGAAACCGCGCGCGATTTCGACGACGCCGTCTGGGTGGACA
AACTCCCCAGCGGCAACTACGTCCTGCATGTTCACATCGCCGATGTCAGCCATTACGTGCGTCCCGGTACTCCCATCGAC
CGGGAGGCCCTGCTCCGCGGCACCAGCGTCTATTTTCCCGACCGCGCCGTTCCGATGCTGCCCTTCGAGCTTTCCACCAA
CCTCTGCTCGCTCGTGCCGCTTGAGGACCGCCTAGTTCTCTCGGCGTTGATGGAGATCGATCACCGCGGTGAAGTCGTCC
GCCAGGAGTTCACCGAGGGCGTGATCCGCAGCGTTGCCCGCATGACTTACACCAACGTGCACAAACTGCTCGAAGGCGAC
CAGGTTCTGCGCGAGCGCTACAAGCCCCTGGTGCCGCGTTTCGAGCTGATGCAGGAACTCGCCCTGGTGCTCAATCGTAA
GCGTGTGCGCCGCGGTTCGATTGACTTCGATCTTCCGGAGCCGCTGATCGAGTTCGACGACCTCGGCGCCATGATCGGCG
TCACGCGCGCCCCGCGCAATATCGCCAACCGCCTTATCGAAGAATTCATGCTGGCCGCGAATGAAAGCGTGGCGGGCCAC
CTGGAGAATGCCGGCATCGCTTCCATTTATCGAATTCACGAGAAGCCCGACCCCAAACGTGTCATGGAATTCGAGGAAGT
TGCCGCCCACTTCGGCGTGTCGCTCGGCGTCGGCGCCATCGAGGTCAAGCGCTTCAAGGTTACAGACAAGCGCCGCGACG
GCACCAAGAAACAGCAGGCCATCGTGCTCGCTGACAATACCAACATCAACTCGCGCCACTACCAGAAGCTCGTCGCCAAA
ATCGAAGGCAAGCCCGAGGAGCGCATACTCAGCTTCCTCATGTTGCGCTCCCTGCGCCAGGCGCGCTACAGCACCGAGAA
CACCGGCCACTTTGCTCTCGCCGCCGACACCTACACGCATTTCACATCGCCCATCCGGCGCTATCCCGACCTCATCGTGC
ATCGTCTGCTGCGCGCCGTGCTGCTCGGCAAGCCGACCCCCGACGAGAGTGAGCTCGGCCCAATCGCCGACGATTGCTCC
CAATCCGAACGTCGCGCCGCCGACGCGGAGCGCGAACTGGTGGAGTGGAAGAAAGTGAAGTTCATGGCCGACCGCGTCGG
CGAAGATTTCGACGCGCTGGTCATCTCCACCACCAAGTACGGCCTCTTCGTGGAACTCACCAACCTGTTCATCGAGGGCC
TTGTCCCCATCGATACGCTGCCCGACGATCAGTACACCTACCAGGAGAACGTCCGCAAGGTGGTCGGCAAGCGGACCCGC
CGCCAATTTTCGATCGGCGACAAACTACGCGTGGTCCTCGACCGCATCGACGCCAACGATCGCAAACTCCAGTTCTCGAT
CTTCGAAGTCGTCCCGCAGCGCACGAAACAGAAGCGCCGCCCACGGTAA

Upstream 100 bases:

>100_bases
TTCTCATTTCGTATCGTCCGGAGGGCAGCAACGGGAGGGCCAGTGTGACGCGATGACCCATCGTCGTGCGCGCTATGCGG
CGACCCCTTAGAATCGGGAT

Downstream 100 bases:

>100_bases
AGTAGCGATCATCGATTTCCGCGCCGTCTTGTATTACACTGCTCTTGTTTGCTCGGAGGCCGCAAACATTTCTCACGAGC
CGCGACCGTGAGGGAGCGCA

Product: RNAse R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 762; Mature: 761

Protein sequence:

>762_residues
MTDASIVAHISRLPHARANFKQLVREMGLKGAKRDELDTALDRLVARGELIELRSGEYTVTSLSREFVVGRLNLHRDGYG
FLIADRQIPRVVGDIFIPPDSASQAMHGDRVLVRIARIEPDGRADGNIVKVLKRAHATVVGEFKIGRRGCYVVPHDERLQ
QWVDIPEGMEFPPAGASVDRIGVTAPKVATVEQLDGMIVNVEIMEYAGRGESPVGRVVEILGHPDDFGVDVEIVIRKHHL
PHQFPPEVIEQAQAIPGVIPPAEFEGRRDFRGMDIVTIDGETARDFDDAVWVDKLPSGNYVLHVHIADVSHYVRPGTPID
REALLRGTSVYFPDRAVPMLPFELSTNLCSLVPLEDRLVLSALMEIDHRGEVVRQEFTEGVIRSVARMTYTNVHKLLEGD
QVLRERYKPLVPRFELMQELALVLNRKRVRRGSIDFDLPEPLIEFDDLGAMIGVTRAPRNIANRLIEEFMLAANESVAGH
LENAGIASIYRIHEKPDPKRVMEFEEVAAHFGVSLGVGAIEVKRFKVTDKRRDGTKKQQAIVLADNTNINSRHYQKLVAK
IEGKPEERILSFLMLRSLRQARYSTENTGHFALAADTYTHFTSPIRRYPDLIVHRLLRAVLLGKPTPDESELGPIADDCS
QSERRAADAERELVEWKKVKFMADRVGEDFDALVISTTKYGLFVELTNLFIEGLVPIDTLPDDQYTYQENVRKVVGKRTR
RQFSIGDKLRVVLDRIDANDRKLQFSIFEVVPQRTKQKRRPR

Sequences:

>Translated_762_residues
MTDASIVAHISRLPHARANFKQLVREMGLKGAKRDELDTALDRLVARGELIELRSGEYTVTSLSREFVVGRLNLHRDGYG
FLIADRQIPRVVGDIFIPPDSASQAMHGDRVLVRIARIEPDGRADGNIVKVLKRAHATVVGEFKIGRRGCYVVPHDERLQ
QWVDIPEGMEFPPAGASVDRIGVTAPKVATVEQLDGMIVNVEIMEYAGRGESPVGRVVEILGHPDDFGVDVEIVIRKHHL
PHQFPPEVIEQAQAIPGVIPPAEFEGRRDFRGMDIVTIDGETARDFDDAVWVDKLPSGNYVLHVHIADVSHYVRPGTPID
REALLRGTSVYFPDRAVPMLPFELSTNLCSLVPLEDRLVLSALMEIDHRGEVVRQEFTEGVIRSVARMTYTNVHKLLEGD
QVLRERYKPLVPRFELMQELALVLNRKRVRRGSIDFDLPEPLIEFDDLGAMIGVTRAPRNIANRLIEEFMLAANESVAGH
LENAGIASIYRIHEKPDPKRVMEFEEVAAHFGVSLGVGAIEVKRFKVTDKRRDGTKKQQAIVLADNTNINSRHYQKLVAK
IEGKPEERILSFLMLRSLRQARYSTENTGHFALAADTYTHFTSPIRRYPDLIVHRLLRAVLLGKPTPDESELGPIADDCS
QSERRAADAERELVEWKKVKFMADRVGEDFDALVISTTKYGLFVELTNLFIEGLVPIDTLPDDQYTYQENVRKVVGKRTR
RQFSIGDKLRVVLDRIDANDRKLQFSIFEVVPQRTKQKRRPR
>Mature_761_residues
TDASIVAHISRLPHARANFKQLVREMGLKGAKRDELDTALDRLVARGELIELRSGEYTVTSLSREFVVGRLNLHRDGYGF
LIADRQIPRVVGDIFIPPDSASQAMHGDRVLVRIARIEPDGRADGNIVKVLKRAHATVVGEFKIGRRGCYVVPHDERLQQ
WVDIPEGMEFPPAGASVDRIGVTAPKVATVEQLDGMIVNVEIMEYAGRGESPVGRVVEILGHPDDFGVDVEIVIRKHHLP
HQFPPEVIEQAQAIPGVIPPAEFEGRRDFRGMDIVTIDGETARDFDDAVWVDKLPSGNYVLHVHIADVSHYVRPGTPIDR
EALLRGTSVYFPDRAVPMLPFELSTNLCSLVPLEDRLVLSALMEIDHRGEVVRQEFTEGVIRSVARMTYTNVHKLLEGDQ
VLRERYKPLVPRFELMQELALVLNRKRVRRGSIDFDLPEPLIEFDDLGAMIGVTRAPRNIANRLIEEFMLAANESVAGHL
ENAGIASIYRIHEKPDPKRVMEFEEVAAHFGVSLGVGAIEVKRFKVTDKRRDGTKKQQAIVLADNTNINSRHYQKLVAKI
EGKPEERILSFLMLRSLRQARYSTENTGHFALAADTYTHFTSPIRRYPDLIVHRLLRAVLLGKPTPDESELGPIADDCSQ
SERRAADAERELVEWKKVKFMADRVGEDFDALVISTTKYGLFVELTNLFIEGLVPIDTLPDDQYTYQENVRKVVGKRTRR
QFSIGDKLRVVLDRIDANDRKLQFSIFEVVPQRTKQKRRPR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=596, Percent_Identity=28.5234899328859, Blast_Score=206, Evalue=9e-53,
Organism=Homo sapiens, GI190014623, Length=596, Percent_Identity=28.5234899328859, Blast_Score=206, Evalue=9e-53,
Organism=Homo sapiens, GI134288890, Length=474, Percent_Identity=29.535864978903, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI19115966, Length=502, Percent_Identity=27.6892430278884, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI219521928, Length=502, Percent_Identity=27.6892430278884, Blast_Score=146, Evalue=7e-35,
Organism=Escherichia coli, GI87082383, Length=697, Percent_Identity=36.0114777618364, Blast_Score=423, Evalue=1e-119,
Organism=Escherichia coli, GI1787542, Length=645, Percent_Identity=27.1317829457364, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17553506, Length=516, Percent_Identity=29.6511627906977, Blast_Score=185, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI212645896, Length=558, Percent_Identity=28.494623655914, Blast_Score=180, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324552, Length=538, Percent_Identity=28.4386617100372, Blast_Score=181, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6320499, Length=562, Percent_Identity=22.2419928825623, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24649634, Length=466, Percent_Identity=30.68669527897, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19922976, Length=497, Percent_Identity=27.9678068410463, Blast_Score=155, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24654597, Length=497, Percent_Identity=27.9678068410463, Blast_Score=155, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24654592, Length=568, Percent_Identity=26.7605633802817, Blast_Score=155, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 86180; Mature: 86049

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDASIVAHISRLPHARANFKQLVREMGLKGAKRDELDTALDRLVARGELIELRSGEYTV
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCCCEEE
TSLSREFVVGRLNLHRDGYGFLIADRQIPRVVGDIFIPPDSASQAMHGDRVLVRIARIEP
EHHHHHHEEEEEEECCCCCEEEEECCHHHHHHHCEECCCCCCCHHHCCCEEEEEEEEECC
DGRADGNIVKVLKRAHATVVGEFKIGRRGCYVVPHDERLQQWVDIPEGMEFPPAGASVDR
CCCCCCHHHHHHHHHHHHEEEEEEECCCCCEECCCHHHHHHHHCCCCCCCCCCCCCCCCC
IGVTAPKVATVEQLDGMIVNVEIMEYAGRGESPVGRVVEILGHPDDFGVDVEIVIRKHHL
CCCCCCCHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEEEEECCC
PHQFPPEVIEQAQAIPGVIPPAEFEGRRDFRGMDIVTIDGETARDFDDAVWVDKLPSGNY
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCCE
VLHVHIADVSHYVRPGTPIDREALLRGTSVYFPDRAVPMLPFELSTNLCSLVPLEDRLVL
EEEEEEECCHHHCCCCCCCCHHHHHCCCEEECCCCCCCCCCHHHCCCCEEECCCHHHHHH
SALMEIDHRGEVVRQEFTEGVIRSVARMTYTNVHKLLEGDQVLRERYKPLVPRFELMQEL
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ALVLNRKRVRRGSIDFDLPEPLIEFDDLGAMIGVTRAPRNIANRLIEEFMLAANESVAGH
HHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHH
LENAGIASIYRIHEKPDPKRVMEFEEVAAHFGVSLGVGAIEVKRFKVTDKRRDGTKKQQA
CCCCCHHHHHEECCCCCHHHHHHHHHHHHHHCHHCCCCEEEEEEEEECCCCCCCCCHHCE
IVLADNTNINSRHYQKLVAKIEGKPEERILSFLMLRSLRQARYSTENTGHFALAADTYTH
EEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHH
FTSPIRRYPDLIVHRLLRAVLLGKPTPDESELGPIADDCSQSERRAADAERELVEWKKVK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FMADRVGEDFDALVISTTKYGLFVELTNLFIEGLVPIDTLPDDQYTYQENVRKVVGKRTR
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RQFSIGDKLRVVLDRIDANDRKLQFSIFEVVPQRTKQKRRPR
HHCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDASIVAHISRLPHARANFKQLVREMGLKGAKRDELDTALDRLVARGELIELRSGEYTV
CCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCCCEEE
TSLSREFVVGRLNLHRDGYGFLIADRQIPRVVGDIFIPPDSASQAMHGDRVLVRIARIEP
EHHHHHHEEEEEEECCCCCEEEEECCHHHHHHHCEECCCCCCCHHHCCCEEEEEEEEECC
DGRADGNIVKVLKRAHATVVGEFKIGRRGCYVVPHDERLQQWVDIPEGMEFPPAGASVDR
CCCCCCHHHHHHHHHHHHEEEEEEECCCCCEECCCHHHHHHHHCCCCCCCCCCCCCCCCC
IGVTAPKVATVEQLDGMIVNVEIMEYAGRGESPVGRVVEILGHPDDFGVDVEIVIRKHHL
CCCCCCCHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEEEEECCC
PHQFPPEVIEQAQAIPGVIPPAEFEGRRDFRGMDIVTIDGETARDFDDAVWVDKLPSGNY
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCCE
VLHVHIADVSHYVRPGTPIDREALLRGTSVYFPDRAVPMLPFELSTNLCSLVPLEDRLVL
EEEEEEECCHHHCCCCCCCCHHHHHCCCEEECCCCCCCCCCHHHCCCCEEECCCHHHHHH
SALMEIDHRGEVVRQEFTEGVIRSVARMTYTNVHKLLEGDQVLRERYKPLVPRFELMQEL
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ALVLNRKRVRRGSIDFDLPEPLIEFDDLGAMIGVTRAPRNIANRLIEEFMLAANESVAGH
HHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHH
LENAGIASIYRIHEKPDPKRVMEFEEVAAHFGVSLGVGAIEVKRFKVTDKRRDGTKKQQA
CCCCCHHHHHEECCCCCHHHHHHHHHHHHHHCHHCCCCEEEEEEEEECCCCCCCCCHHCE
IVLADNTNINSRHYQKLVAKIEGKPEERILSFLMLRSLRQARYSTENTGHFALAADTYTH
EEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHH
FTSPIRRYPDLIVHRLLRAVLLGKPTPDESELGPIADDCSQSERRAADAERELVEWKKVK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FMADRVGEDFDALVISTTKYGLFVELTNLFIEGLVPIDTLPDDQYTYQENVRKVVGKRTR
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RQFSIGDKLRVVLDRIDANDRKLQFSIFEVVPQRTKQKRRPR
HHCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]