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The map label for this gene is uppS [H]

Identifier: 116622347

GI number: 116622347

Start: 4102624

End: 4103463

Strand: Reverse

Name: uppS [H]

Synonym: Acid_3241

Alternate gene names: 116622347

Gene position: 4103463-4102624 (Counterclockwise)

Preceding gene: 116622349

Following gene: 116622346

Centisome position: 41.18

GC content: 62.74

Gene sequence:

>840_bases
ATGAAGGCTTTACTGGAAGCGCTCCAGCCAGGGGAGATGGATTGGAATCTGGCCCGGGCCATCGACCCCGCCAGGCTGCC
CGCGCATATCGCCATAATCATGGACGGCAACGGCCGCTGGGCGGGACGCCGCCTGCTGCCGCGAGTGGCCGGACACAAGG
CCGGAATCGGTCCCGTCAGGTCCACGGTGGAGACTTGCGCGCGTTTGGGCGTGAAGGCGCTCACACTGTACGCGTTCTCC
GTGGAAAACTGGAAACGTCCGCGCGCCGAAGTCGAAACCCTGTGGCGGCTGCTGCGCTATTACTTAAAGCAAGAGCTTCC
CGACCTTCAGAAGAACGACATTCGCCTGCAAGCCATCGGACGCCTGGACGCGCTGCCCATGCAAGTGCGCCGCGAGCTCG
ACTCGGCGGTGGAATCGACCTCCGCCAATCGCGGACTCCTGGTCAATTTGGCGATCAATTATGGAGGCCGGGCCGAGATT
GTGGACGCGGTCAACTCGATTCTCGAAATGGCGCGCCTGGAAGGCAGTCTCGACACCCTCAAGATGGATGAGGACCTGAT
CGCGACCAGCCTTTACACCGCATCCTGTCCCGACCCCGATCTGCTGATTCGCACGTCCGGCGAAATGCGCATCAGCAACT
TTTTGTTGTGGCAGATCGCGTACGCGGAGCTCTACGTCACCGAGACGTTGTGGCCCGACTTCACGCGCACGGACCTGCTG
CGGGCGGTGCTGGAGTATCAAAAGCGTGACCGCCGCTACGGCGGCCTCAGCGGCGCCGACGGAACCGGGTCTGTCAAGAC
CGGCGACGAGACCCTCATCGAAGCGCTTCGCAGCTCATGA

Upstream 100 bases:

>100_bases
AATTCGGGACAGCCCGGACGCCGTCCCCTCGCGGGACGCGGTGTTCGATCACGGGACGGGACGCTTCGCGAGTCCGTGGT
GTACCATAAGGAATTACTGA

Downstream 100 bases:

>100_bases
AGCGGGTCCTCACCGCGCTGGCGTTGATCCCGATCGTCGGGTGGGTAGTCCTGGCGGCGAATCCTTCCATCTTCCTCGGC
GTGCTCGTGGTGGTGTCGTG

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MKALLEALQPGEMDWNLARAIDPARLPAHIAIIMDGNGRWAGRRLLPRVAGHKAGIGPVRSTVETCARLGVKALTLYAFS
VENWKRPRAEVETLWRLLRYYLKQELPDLQKNDIRLQAIGRLDALPMQVRRELDSAVESTSANRGLLVNLAINYGGRAEI
VDAVNSILEMARLEGSLDTLKMDEDLIATSLYTASCPDPDLLIRTSGEMRISNFLLWQIAYAELYVTETLWPDFTRTDLL
RAVLEYQKRDRRYGGLSGADGTGSVKTGDETLIEALRSS

Sequences:

>Translated_279_residues
MKALLEALQPGEMDWNLARAIDPARLPAHIAIIMDGNGRWAGRRLLPRVAGHKAGIGPVRSTVETCARLGVKALTLYAFS
VENWKRPRAEVETLWRLLRYYLKQELPDLQKNDIRLQAIGRLDALPMQVRRELDSAVESTSANRGLLVNLAINYGGRAEI
VDAVNSILEMARLEGSLDTLKMDEDLIATSLYTASCPDPDLLIRTSGEMRISNFLLWQIAYAELYVTETLWPDFTRTDLL
RAVLEYQKRDRRYGGLSGADGTGSVKTGDETLIEALRSS
>Mature_279_residues
MKALLEALQPGEMDWNLARAIDPARLPAHIAIIMDGNGRWAGRRLLPRVAGHKAGIGPVRSTVETCARLGVKALTLYAFS
VENWKRPRAEVETLWRLLRYYLKQELPDLQKNDIRLQAIGRLDALPMQVRRELDSAVESTSANRGLLVNLAINYGGRAEI
VDAVNSILEMARLEGSLDTLKMDEDLIATSLYTASCPDPDLLIRTSGEMRISNFLLWQIAYAELYVTETLWPDFTRTDLL
RAVLEYQKRDRRYGGLSGADGTGSVKTGDETLIEALRSS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=235, Percent_Identity=38.7234042553192, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI45580742, Length=235, Percent_Identity=38.7234042553192, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1786371, Length=240, Percent_Identity=44.1666666666667, Blast_Score=205, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71993029, Length=239, Percent_Identity=33.4728033472803, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=35.981308411215, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=240, Percent_Identity=30, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18857969, Length=231, Percent_Identity=38.961038961039, Blast_Score=161, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 31183; Mature: 31183

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALLEALQPGEMDWNLARAIDPARLPAHIAIIMDGNGRWAGRRLLPRVAGHKAGIGPVR
CHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHH
STVETCARLGVKALTLYAFSVENWKRPRAEVETLWRLLRYYLKQELPDLQKNDIRLQAIG
HHHHHHHHCCHHHHHHEEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
RLDALPMQVRRELDSAVESTSANRGLLVNLAINYGGRAEIVDAVNSILEMARLEGSLDTL
CCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHH
KMDEDLIATSLYTASCPDPDLLIRTSGEMRISNFLLWQIAYAELYVTETLWPDFTRTDLL
HCCHHHHHHHHEECCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RAVLEYQKRDRRYGGLSGADGTGSVKTGDETLIEALRSS
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKALLEALQPGEMDWNLARAIDPARLPAHIAIIMDGNGRWAGRRLLPRVAGHKAGIGPVR
CHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHH
STVETCARLGVKALTLYAFSVENWKRPRAEVETLWRLLRYYLKQELPDLQKNDIRLQAIG
HHHHHHHHCCHHHHHHEEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
RLDALPMQVRRELDSAVESTSANRGLLVNLAINYGGRAEIVDAVNSILEMARLEGSLDTL
CCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHH
KMDEDLIATSLYTASCPDPDLLIRTSGEMRISNFLLWQIAYAELYVTETLWPDFTRTDLL
HCCHHHHHHHHEECCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RAVLEYQKRDRRYGGLSGADGTGSVKTGDETLIEALRSS
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12446909 [H]