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The map label for this gene is dnaX [H]

Identifier: 116622271

GI number: 116622271

Start: 4008884

End: 4010590

Strand: Direct

Name: dnaX [H]

Synonym: Acid_3165

Alternate gene names: 116622271

Gene position: 4008884-4010590 (Clockwise)

Preceding gene: 116622266

Following gene: 116622272

Centisome position: 40.23

GC content: 64.67

Gene sequence:

>1707_bases
ATGTATCAGGTAATCGCGCGTAAATACCGGCCGCAATCCTTTGCCGACGTGATTTGTCAGGAACACGTTAAGACCACGCT
GGAGAACGCGATCGCGCAGCACCGCATCGCCCACGGCTACATCTTCTCGGGCCAGCGCGGCACCGGTAAAACCACCATCG
CCCGCATCCTGGCGCGCTGCCTAAATTGCGTACAGGGTCCCACCGCGACGCCCTGCGGCGTGTGCGCCAGCTGCAAGGAG
ATCTCCGAAGGCGGCACCGTGGACGTCATCGAAATCGATGCTGCCAGCAATCGCGGCATCAACGAAATGCGCGAGTTGCG
CGAAAACGTGCGCTACCAGCCGGCGCGCGACCGCTATAAGATCTTCATCATCGACGAAGCCCACCAGATCACCAACGAAG
CGTTCAACGCGCTCCTGAAGACGATCGAGGAGCCGCCCGAGTGGGCCGTCTTCGTCCTCTGCACCACCGAATCGCACAAG
ATCCCGGCCACCATCGCCTCCCGCTGCCAGCACTTCAGTTTCCGCAGCGTGGATTTCCAGGAGCTGGTGGACCGCATGTC
GTGGATCTGCGGCCAGGAAGGCATCGAGGCCGATGCCGAAGCGCTGGCAGTGCTCGCCGCTGCCGGCGAAGGCTCGGTTC
GCGATTCGCTCTCCGCGCTCGACCAGGCCATCGCCTGCTGCGGCGCCAAAATCACGGCCCCCGAAGTCCGCGCGCTGCTC
GGCGCCTTCTCGCTCGAATCGCTCGAAAAGGTCACCGAGGCGCTGGCCGCCGGGGAATCGCGCATGATGCTCGAAGTGGT
GGATGAGTTGGAACGCAACGGCCAGAACCTGCAACATTTCAGCCGCGAACTTTCGCGCTACTTCCGCAATCTGCTGGTCA
CCCGGATCGCCGGCGCCGATACCCGCCTGGTGGCGGCCAGCGCGGCCCAGCGCGAAAAATTGGGTCACATCGCCGGACAA
TTCTCCGAAGAAGACCTCTCGCGCTACCTTCAACTCTCTCTCGATATCTTCCGCGACCTCCAATTCTCGCTGCAGCCCCG
TTTCCACCTGGAGATTGGCCTGGTGCGCCTGGTCCAGGCCGGACGCCTGCTGCCGATCGAAGAGGCGCTGGCCGGACTGA
CCGCAGCGCCTCCAGCCCCGCGCGCCGCCCAAATTCCCCAAGCTCCGCCGCCGCGCGCCGCCGCGCCTCCACAGCGTCCA
CCGGCGCCCCTGCCGCGCGTCGGACCGTCGCCCTTCGAACTCGATCGCATCAAAAAGGGAATCGGCCCTTCCGAGCCGCA
GTCGTCGGGAGCCAACGCGCTCGCACCCGAACCCGCGGCGCCCGCGATGTCGGCCGGCGATCCGCGCCAGAAGTTGCATG
CCTGGTTCCACGAGAAAGGCAACGCGCACCTGGCCGACGCGGTCGAGAATGCCGCGTTCACCGTCACCGGCGGAGACCTC
AACATCGTGGCGCCGAAATCCTACGGCCTGTACTTCCGCGACAAAGCCTTCGAGGAAGCTGTCCGCGAAGTTTTCGGCCG
TCCGCTACGCTTGAAAATCACCACCGGCGACGCATCGGCCGCCGGACCGGCACCGGTCAGCCTCTCGGCGCCGAAATCCG
ATGCCGAGGATGAAGTCACCGGCCGCGCGTTGGCCAACCCGGAAGTTCAGCGTTTCCGCGAAATCTTCGGCGGCGAAGTG
CGCAAAGTTCGCAATCTCAAAGATTAG

Upstream 100 bases:

>100_bases
CAACGCTCCGGCTGCAAACCCCGCCAGGTCCGGAAGGAAGCAACGGTAGTGGTTTGGACGTGTGCCGCGGATTACCCGGG
GCCTGGCATAAGCCCACCCC

Downstream 100 bases:

>100_bases
GAGTAGATCATGAAACTACCCGGCAACATGCAGAACATGATGCGCCAGGCGCAGCAGATGCAGGAGAAGATGCAGCAGGA
GATCGCGCTCATCCGCGTCG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MYQVIARKYRPQSFADVICQEHVKTTLENAIAQHRIAHGYIFSGQRGTGKTTIARILARCLNCVQGPTATPCGVCASCKE
ISEGGTVDVIEIDAASNRGINEMRELRENVRYQPARDRYKIFIIDEAHQITNEAFNALLKTIEEPPEWAVFVLCTTESHK
IPATIASRCQHFSFRSVDFQELVDRMSWICGQEGIEADAEALAVLAAAGEGSVRDSLSALDQAIACCGAKITAPEVRALL
GAFSLESLEKVTEALAAGESRMMLEVVDELERNGQNLQHFSRELSRYFRNLLVTRIAGADTRLVAASAAQREKLGHIAGQ
FSEEDLSRYLQLSLDIFRDLQFSLQPRFHLEIGLVRLVQAGRLLPIEEALAGLTAAPPAPRAAQIPQAPPPRAAAPPQRP
PAPLPRVGPSPFELDRIKKGIGPSEPQSSGANALAPEPAAPAMSAGDPRQKLHAWFHEKGNAHLADAVENAAFTVTGGDL
NIVAPKSYGLYFRDKAFEEAVREVFGRPLRLKITTGDASAAGPAPVSLSAPKSDAEDEVTGRALANPEVQRFREIFGGEV
RKVRNLKD

Sequences:

>Translated_568_residues
MYQVIARKYRPQSFADVICQEHVKTTLENAIAQHRIAHGYIFSGQRGTGKTTIARILARCLNCVQGPTATPCGVCASCKE
ISEGGTVDVIEIDAASNRGINEMRELRENVRYQPARDRYKIFIIDEAHQITNEAFNALLKTIEEPPEWAVFVLCTTESHK
IPATIASRCQHFSFRSVDFQELVDRMSWICGQEGIEADAEALAVLAAAGEGSVRDSLSALDQAIACCGAKITAPEVRALL
GAFSLESLEKVTEALAAGESRMMLEVVDELERNGQNLQHFSRELSRYFRNLLVTRIAGADTRLVAASAAQREKLGHIAGQ
FSEEDLSRYLQLSLDIFRDLQFSLQPRFHLEIGLVRLVQAGRLLPIEEALAGLTAAPPAPRAAQIPQAPPPRAAAPPQRP
PAPLPRVGPSPFELDRIKKGIGPSEPQSSGANALAPEPAAPAMSAGDPRQKLHAWFHEKGNAHLADAVENAAFTVTGGDL
NIVAPKSYGLYFRDKAFEEAVREVFGRPLRLKITTGDASAAGPAPVSLSAPKSDAEDEVTGRALANPEVQRFREIFGGEV
RKVRNLKD
>Mature_568_residues
MYQVIARKYRPQSFADVICQEHVKTTLENAIAQHRIAHGYIFSGQRGTGKTTIARILARCLNCVQGPTATPCGVCASCKE
ISEGGTVDVIEIDAASNRGINEMRELRENVRYQPARDRYKIFIIDEAHQITNEAFNALLKTIEEPPEWAVFVLCTTESHK
IPATIASRCQHFSFRSVDFQELVDRMSWICGQEGIEADAEALAVLAAAGEGSVRDSLSALDQAIACCGAKITAPEVRALL
GAFSLESLEKVTEALAAGESRMMLEVVDELERNGQNLQHFSRELSRYFRNLLVTRIAGADTRLVAASAAQREKLGHIAGQ
FSEEDLSRYLQLSLDIFRDLQFSLQPRFHLEIGLVRLVQAGRLLPIEEALAGLTAAPPAPRAAQIPQAPPPRAAAPPQRP
PAPLPRVGPSPFELDRIKKGIGPSEPQSSGANALAPEPAAPAMSAGDPRQKLHAWFHEKGNAHLADAVENAAFTVTGGDL
NIVAPKSYGLYFRDKAFEEAVREVFGRPLRLKITTGDASAAGPAPVSLSAPKSDAEDEVTGRALANPEVQRFREIFGGEV
RKVRNLKD

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI194306571, Length=241, Percent_Identity=29.045643153527, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI194306567, Length=241, Percent_Identity=29.045643153527, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI4506491, Length=296, Percent_Identity=26.6891891891892, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI31881687, Length=296, Percent_Identity=26.6891891891892, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI6677723, Length=238, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI31563534, Length=224, Percent_Identity=26.3392857142857, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786676, Length=388, Percent_Identity=39.1752577319588, Blast_Score=283, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71986063, Length=297, Percent_Identity=24.9158249158249, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554730, Length=228, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17541988, Length=220, Percent_Identity=26.3636363636364, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322528, Length=323, Percent_Identity=25.3869969040248, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324039, Length=230, Percent_Identity=26.5217391304348, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=225, Percent_Identity=25.3333333333333, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19921076, Length=339, Percent_Identity=25.6637168141593, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI18859927, Length=288, Percent_Identity=25, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17647857, Length=270, Percent_Identity=27.037037037037, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 61817; Mature: 61817

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQVIARKYRPQSFADVICQEHVKTTLENAIAQHRIAHGYIFSGQRGTGKTTIARILARC
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHH
LNCVQGPTATPCGVCASCKEISEGGTVDVIEIDAASNRGINEMRELRENVRYQPARDRYK
HHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEE
IFIIDEAHQITNEAFNALLKTIEEPPEWAVFVLCTTESHKIPATIASRCQHFSFRSVDFQ
EEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCHH
ELVDRMSWICGQEGIEADAEALAVLAAAGEGSVRDSLSALDQAIACCGAKITAPEVRALL
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GAFSLESLEKVTEALAAGESRMMLEVVDELERNGQNLQHFSRELSRYFRNLLVTRIAGAD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TRLVAASAAQREKLGHIAGQFSEEDLSRYLQLSLDIFRDLQFSLQPRFHLEIGLVRLVQA
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHC
GRLLPIEEALAGLTAAPPAPRAAQIPQAPPPRAAAPPQRPPAPLPRVGPSPFELDRIKKG
CCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHC
IGPSEPQSSGANALAPEPAAPAMSAGDPRQKLHAWFHEKGNAHLADAVENAAFTVTGGDL
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCEEEEECCCE
NIVAPKSYGLYFRDKAFEEAVREVFGRPLRLKITTGDASAAGPAPVSLSAPKSDAEDEVT
EEECCCCCCCEEHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHC
GRALANPEVQRFREIFGGEVRKVRNLKD
CCCCCCHHHHHHHHHHCHHHHHHCCCCC
>Mature Secondary Structure
MYQVIARKYRPQSFADVICQEHVKTTLENAIAQHRIAHGYIFSGQRGTGKTTIARILARC
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHH
LNCVQGPTATPCGVCASCKEISEGGTVDVIEIDAASNRGINEMRELRENVRYQPARDRYK
HHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEE
IFIIDEAHQITNEAFNALLKTIEEPPEWAVFVLCTTESHKIPATIASRCQHFSFRSVDFQ
EEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCHH
ELVDRMSWICGQEGIEADAEALAVLAAAGEGSVRDSLSALDQAIACCGAKITAPEVRALL
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GAFSLESLEKVTEALAAGESRMMLEVVDELERNGQNLQHFSRELSRYFRNLLVTRIAGAD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TRLVAASAAQREKLGHIAGQFSEEDLSRYLQLSLDIFRDLQFSLQPRFHLEIGLVRLVQA
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHC
GRLLPIEEALAGLTAAPPAPRAAQIPQAPPPRAAAPPQRPPAPLPRVGPSPFELDRIKKG
CCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHC
IGPSEPQSSGANALAPEPAAPAMSAGDPRQKLHAWFHEKGNAHLADAVENAAFTVTGGDL
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCEEEEECCCE
NIVAPKSYGLYFRDKAFEEAVREVFGRPLRLKITTGDASAAGPAPVSLSAPKSDAEDEVT
EEECCCCCCCEEHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHC
GRALANPEVQRFREIFGGEVRKVRNLKD
CCCCCCHHHHHHHHHHCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]