Click here to switch to the map view.

The map label for this gene is obgE

Identifier: 116622266

GI number: 116622266

Start: 4003264

End: 4004277

Strand: Direct

Name: obgE

Synonym: Acid_3160

Alternate gene names: 116622266

Gene position: 4003264-4004277 (Clockwise)

Preceding gene: 116622265

Following gene: 116622271

Centisome position: 40.17

GC content: 65.78

Gene sequence:

>1014_bases
ATGTTTATAGATGAAGTCAGAATCCTCGTAAAAGCAGGCGACGGCGGCAATGGCTGTCTGGCCTTCCGTAGGGAGAAGTT
CGTCCCCCGCGGAGGTCCCAGCGGCGGCGATGGCGGCCGCGGCGGCGATGTCACGCTCGTGTGCAGCGAACACGCCAACA
CCCTGCTCCAGTTCCGGTTCAACCCCGAGCACAAGGCCGAGCGCGGCCGCCACGGCGAGGGTAGCCAGCGCACCGGCGCC
GAAGGGCGTTCCATCGACGTGGCCGTGCCCGTCGGCACCGTTGTCTACGACGAAGCCACCGGCGAGCGCCTTTACGATTT
CACGGTCCCCGGCGAACGCTTCGTTGTTGCTCGCGGCGGCAGGGGCGGCCGCGGCAACCAGCACTTCGCCACTCCCACCC
ATCAGGCCCCCACCGAACATGAACCCGGACGCCCTGGCGAAGAAAAGCGTCTCCGCCTCGAATTAAAGCTGCTCGCCGAC
GTCGGACTGGTCGGTTTCCCCAACGCCGGCAAGAGCACCCTCATCTCCCGCATCTCCGCGGCCAAGCCCAAGATCGCCGC
CTACCCGTTCACCACCCTGGAACCCAATCTCGGCGTGGTCCAGATGGAAGGCTTCCGGAGCTTCGTCGTCGCCGACATCC
CCGGCATCATCGAGGGCGCCCATGAAGGCCACGGTCTCGGCATCCAGTTCCTCCGCCACATCGAGCGGACCCGCCTCCTC
GCGCACCTGGTAGACGTCTCCGAAGAGAGCGGCCGCGACCCGGTTCAGGATTTCGAAATCATCATGCAGGAACTCGCCAG
ATTCAGCGACCAGCTGGTCGCCAAGCCCATGATCGTGGTCGCCACCAAGATGGACGTCGCCCAGGACCCCGCGCGCGTCG
AAGCTCTCCGCGACCTGGCGAAATCCCGCGACCTCCCCTTCTTCGAAATCTCCAGCGCAACCGGCCAGGGCATCGACGCC
CTGAAACACGCTATGGCGGATCGCGTCCTCGCCCCCGTCCCGGTCCCGGAATAA

Upstream 100 bases:

>100_bases
GCGGACGGATGGGCAAGTTCGTCAACATCAACGCCTCCGTTTAGTCGTACCGTCTTTCCTAAAAGGGCCGCCGGTTTGCA
GGCATTCCGGCGGCTTTCCT

Downstream 100 bases:

>100_bases
GGCCTCAGCGGATCAGCCGCAGCAATCCGTAACAGACCAGGCACATCCAGAAATCCACGGCCAGTCCCCAGTCGATCTGG
TAAATCTGGTGTTGCGCGCG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MFIDEVRILVKAGDGGNGCLAFRREKFVPRGGPSGGDGGRGGDVTLVCSEHANTLLQFRFNPEHKAERGRHGEGSQRTGA
EGRSIDVAVPVGTVVYDEATGERLYDFTVPGERFVVARGGRGGRGNQHFATPTHQAPTEHEPGRPGEEKRLRLELKLLAD
VGLVGFPNAGKSTLISRISAAKPKIAAYPFTTLEPNLGVVQMEGFRSFVVADIPGIIEGAHEGHGLGIQFLRHIERTRLL
AHLVDVSEESGRDPVQDFEIIMQELARFSDQLVAKPMIVVATKMDVAQDPARVEALRDLAKSRDLPFFEISSATGQGIDA
LKHAMADRVLAPVPVPE

Sequences:

>Translated_337_residues
MFIDEVRILVKAGDGGNGCLAFRREKFVPRGGPSGGDGGRGGDVTLVCSEHANTLLQFRFNPEHKAERGRHGEGSQRTGA
EGRSIDVAVPVGTVVYDEATGERLYDFTVPGERFVVARGGRGGRGNQHFATPTHQAPTEHEPGRPGEEKRLRLELKLLAD
VGLVGFPNAGKSTLISRISAAKPKIAAYPFTTLEPNLGVVQMEGFRSFVVADIPGIIEGAHEGHGLGIQFLRHIERTRLL
AHLVDVSEESGRDPVQDFEIIMQELARFSDQLVAKPMIVVATKMDVAQDPARVEALRDLAKSRDLPFFEISSATGQGIDA
LKHAMADRVLAPVPVPE
>Mature_337_residues
MFIDEVRILVKAGDGGNGCLAFRREKFVPRGGPSGGDGGRGGDVTLVCSEHANTLLQFRFNPEHKAERGRHGEGSQRTGA
EGRSIDVAVPVGTVVYDEATGERLYDFTVPGERFVVARGGRGGRGNQHFATPTHQAPTEHEPGRPGEEKRLRLELKLLAD
VGLVGFPNAGKSTLISRISAAKPKIAAYPFTTLEPNLGVVQMEGFRSFVVADIPGIIEGAHEGHGLGIQFLRHIERTRLL
AHLVDVSEESGRDPVQDFEIIMQELARFSDQLVAKPMIVVATKMDVAQDPARVEALRDLAKSRDLPFFEISSATGQGIDA
LKHAMADRVLAPVPVPE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=320, Percent_Identity=40.3125, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI111955139, Length=352, Percent_Identity=37.2159090909091, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI111955063, Length=185, Percent_Identity=40, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4758796, Length=118, Percent_Identity=38.9830508474576, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI58761500, Length=141, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI55953087, Length=179, Percent_Identity=30.1675977653631, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789574, Length=322, Percent_Identity=50.3105590062112, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI1787454, Length=129, Percent_Identity=37.984496124031, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790615, Length=173, Percent_Identity=29.4797687861272, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=323, Percent_Identity=39.938080495356, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17552324, Length=320, Percent_Identity=30.625, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17509631, Length=184, Percent_Identity=32.6086956521739, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=36.4406779661017, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=193, Percent_Identity=38.860103626943, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321649, Length=138, Percent_Identity=32.6086956521739, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319281, Length=108, Percent_Identity=38.8888888888889, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321612, Length=90, Percent_Identity=38.8888888888889, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI20129375, Length=330, Percent_Identity=38.7878787878788, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24585318, Length=293, Percent_Identity=38.2252559726962, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24640873, Length=134, Percent_Identity=36.5671641791045, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24640877, Length=134, Percent_Identity=36.5671641791045, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24640875, Length=134, Percent_Identity=36.5671641791045, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17981711, Length=118, Percent_Identity=36.4406779661017, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_SOLUE (Q022G3)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_824422.1
- ProteinModelPortal:   Q022G3
- SMR:   Q022G3
- STRING:   Q022G3
- GeneID:   4428999
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_3160
- NMPDR:   fig|234267.9.peg.2999
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- PhylomeDB:   Q022G3
- ProtClustDB:   PRK12299
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 36447; Mature: 36447

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIDEVRILVKAGDGGNGCLAFRREKFVPRGGPSGGDGGRGGDVTLVCSEHANTLLQFRF
CCCCEEEEEEEECCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEE
NPEHKAERGRHGEGSQRTGAEGRSIDVAVPVGTVVYDEATGERLYDFTVPGERFVVARGG
CCHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCEEEEEECCCCEEEEEECC
RGGRGNQHFATPTHQAPTEHEPGRPGEEKRLRLELKLLADVGLVGFPNAGKSTLISRISA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEEEHHCCCEECCCCCHHHHHHHHHH
AKPKIAAYPFTTLEPNLGVVQMEGFRSFVVADIPGIIEGAHEGHGLGIQFLRHIERTRLL
CCCCEEECCCCCCCCCCCEEEECCCCEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHH
AHLVDVSEESGRDPVQDFEIIMQELARFSDQLVAKPMIVVATKMDVAQDPARVEALRDLA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
KSRDLPFFEISSATGQGIDALKHAMADRVLAPVPVPE
HHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFIDEVRILVKAGDGGNGCLAFRREKFVPRGGPSGGDGGRGGDVTLVCSEHANTLLQFRF
CCCCEEEEEEEECCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEE
NPEHKAERGRHGEGSQRTGAEGRSIDVAVPVGTVVYDEATGERLYDFTVPGERFVVARGG
CCHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCEEEEEECCCCEEEEEECC
RGGRGNQHFATPTHQAPTEHEPGRPGEEKRLRLELKLLADVGLVGFPNAGKSTLISRISA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEEEHHCCCEECCCCCHHHHHHHHHH
AKPKIAAYPFTTLEPNLGVVQMEGFRSFVVADIPGIIEGAHEGHGLGIQFLRHIERTRLL
CCCCEEECCCCCCCCCCCEEEECCCCEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHH
AHLVDVSEESGRDPVQDFEIIMQELARFSDQLVAKPMIVVATKMDVAQDPARVEALRDLA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
KSRDLPFFEISSATGQGIDALKHAMADRVLAPVPVPE
HHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA