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The map label for this gene is galE [C]

Identifier: 116622122

GI number: 116622122

Start: 3808572

End: 3809693

Strand: Direct

Name: galE [C]

Synonym: Acid_3010

Alternate gene names: 116622122

Gene position: 3808572-3809693 (Clockwise)

Preceding gene: 116622121

Following gene: 116622123

Centisome position: 38.22

GC content: 58.56

Gene sequence:

>1122_bases
ATGGGAAAGAAGCTGATACTAATCACCGGTGGTGCGGGGTTTATCGGCTCCCATGTAACTCGGGAGCTACTCGCGCACAA
TTATTCTGTCCGAATTCTGGACTGCTTGGCGCCCCAGGTCCACGGCGCAGGAGGGCGGAGGCCTGCGTATCTCGAGCCTG
AAGCCGAATTAATCACCGCGGACATACGAGACGCGGATGCCGTCGCCCAAGCGCTGAGGCACGTGGATGCTGTCATACAT
CTGGTTGCCTTGGTAGGCGTCGGACAAAGCATGTATCAGATGGTGGAATACACGAGCGTCAATAATCTGGGCACCGCGAT
TCTCCTGGAAGCGCTGAGCACCCACCCCGTGGAGAAGCTGATAGTCGCGTCCAGCATGAGTATTTATGGCGAGGGAGCAT
ATCAGGACCTGGACGGCAAGGGCTACGCCGCCACGGATCGGACACTTGAGCAACTCCGCCGAAAGGATTGGGAGATAAAG
GACCATCTCGGGCGGCCGCTGGTTCCGGTTCCAACACCCGAGAGCAAGACGCCTGCGTTGGCATCCACTTATGCACTTTC
GAAATTCGATCAGGAGCGGCTTTGCCTGATACTCGGACGGGCGTATAGTATCCCGAGCGTGGCGCTACGTTTCTTCAATA
CCTATGGGCCGAACCAGGCACTCTCCAACCCTTATACAGGAGTACTCAGCAATTTTGCGTCGCGCGTTCTCAACGGGAAT
GCACCTCTGATTTTTGAGGACGGACTGCAGAAGCGCGATTTCGTCAGCGTATTCGATGTGGCACGAGCATGCAGGCTCGC
ACTGGAAACGCCCGCCGCCGACGGAAAGGCGTTCAACATTTCGAGTGGCGTGCCGATGACGGTTAAGGAAGTGGCAGACC
GCACGGTGCGGGCGATCGGCGGGCGACGTATCGAACCGCAGATCACGGGCAATTATCGCGCGGGGGATATTCGCCATTGC
TTCGCCGATATCAGCCAGGCGAAGCGAGTGCTGGGCTGGCAACCAAAGGTCACGCTGGAGCAGGGGTTGGTGAACCTGGC
GGAATGGCTGGAGAGCCAGACTGCGGTGGATCGCGGTATGGAGGCACGGGCGGAACTGGCTGCCCGTGGGCTGATGGTAT
GA

Upstream 100 bases:

>100_bases
ATCTTTGACAACTTACGTTGGTTGAAGAAATGCAAACTGGAGCGACGTGACCCCAGGAGGTTTGGCGGCTACTTAGTAAA
TCCAACCGCAAGGATGTGGA

Downstream 100 bases:

>100_bases
AGCACCCATCCAAGAATGGGTCGTGCAAAACACGGAAGCCGCTGCTCGGGATCGTGGAATGGTTTCGCCCCGGAGAATAC
GAACGAGTGGAGGAGGTGCT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MGKKLILITGGAGFIGSHVTRELLAHNYSVRILDCLAPQVHGAGGRRPAYLEPEAELITADIRDADAVAQALRHVDAVIH
LVALVGVGQSMYQMVEYTSVNNLGTAILLEALSTHPVEKLIVASSMSIYGEGAYQDLDGKGYAATDRTLEQLRRKDWEIK
DHLGRPLVPVPTPESKTPALASTYALSKFDQERLCLILGRAYSIPSVALRFFNTYGPNQALSNPYTGVLSNFASRVLNGN
APLIFEDGLQKRDFVSVFDVARACRLALETPAADGKAFNISSGVPMTVKEVADRTVRAIGGRRIEPQITGNYRAGDIRHC
FADISQAKRVLGWQPKVTLEQGLVNLAEWLESQTAVDRGMEARAELAARGLMV

Sequences:

>Translated_373_residues
MGKKLILITGGAGFIGSHVTRELLAHNYSVRILDCLAPQVHGAGGRRPAYLEPEAELITADIRDADAVAQALRHVDAVIH
LVALVGVGQSMYQMVEYTSVNNLGTAILLEALSTHPVEKLIVASSMSIYGEGAYQDLDGKGYAATDRTLEQLRRKDWEIK
DHLGRPLVPVPTPESKTPALASTYALSKFDQERLCLILGRAYSIPSVALRFFNTYGPNQALSNPYTGVLSNFASRVLNGN
APLIFEDGLQKRDFVSVFDVARACRLALETPAADGKAFNISSGVPMTVKEVADRTVRAIGGRRIEPQITGNYRAGDIRHC
FADISQAKRVLGWQPKVTLEQGLVNLAEWLESQTAVDRGMEARAELAARGLMV
>Mature_372_residues
GKKLILITGGAGFIGSHVTRELLAHNYSVRILDCLAPQVHGAGGRRPAYLEPEAELITADIRDADAVAQALRHVDAVIHL
VALVGVGQSMYQMVEYTSVNNLGTAILLEALSTHPVEKLIVASSMSIYGEGAYQDLDGKGYAATDRTLEQLRRKDWEIKD
HLGRPLVPVPTPESKTPALASTYALSKFDQERLCLILGRAYSIPSVALRFFNTYGPNQALSNPYTGVLSNFASRVLNGNA
PLIFEDGLQKRDFVSVFDVARACRLALETPAADGKAFNISSGVPMTVKEVADRTVRAIGGRRIEPQITGNYRAGDIRHCF
ADISQAKRVLGWQPKVTLEQGLVNLAEWLESQTAVDRGMEARAELAARGLMV

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=370, Percent_Identity=28.6486486486486, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI56118217, Length=370, Percent_Identity=28.6486486486486, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI189083684, Length=370, Percent_Identity=28.6486486486486, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1786974, Length=373, Percent_Identity=27.8820375335121, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788353, Length=362, Percent_Identity=29.2817679558011, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71982035, Length=383, Percent_Identity=25.8485639686684, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71982038, Length=385, Percent_Identity=25.974025974026, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319493, Length=385, Percent_Identity=26.2337662337662, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19923002, Length=381, Percent_Identity=25.7217847769029, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 40553; Mature: 40422

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKLILITGGAGFIGSHVTRELLAHNYSVRILDCLAPQVHGAGGRRPAYLEPEAELITA
CCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEHHHHCHHHCCCCCCCCCCCCCCHHEEEE
DIRDADAVAQALRHVDAVIHLVALVGVGQSMYQMVEYTSVNNLGTAILLEALSTHPVEKL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHH
IVASSMSIYGEGAYQDLDGKGYAATDRTLEQLRRKDWEIKDHLGRPLVPVPTPESKTPAL
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCHH
ASTYALSKFDQERLCLILGRAYSIPSVALRFFNTYGPNQALSNPYTGVLSNFASRVLNGN
HHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCC
APLIFEDGLQKRDFVSVFDVARACRLALETPAADGKAFNISSGVPMTVKEVADRTVRAIG
CCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHC
GRRIEPQITGNYRAGDIRHCFADISQAKRVLGWQPKVTLEQGLVNLAEWLESQTAVDRGM
CCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCH
EARAELAARGLMV
HHHHHHHHCCCCC
>Mature Secondary Structure 
GKKLILITGGAGFIGSHVTRELLAHNYSVRILDCLAPQVHGAGGRRPAYLEPEAELITA
CCEEEEEECCCCHHHHHHHHHHHHCCCCEEEHHHHCHHHCCCCCCCCCCCCCCHHEEEE
DIRDADAVAQALRHVDAVIHLVALVGVGQSMYQMVEYTSVNNLGTAILLEALSTHPVEKL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHH
IVASSMSIYGEGAYQDLDGKGYAATDRTLEQLRRKDWEIKDHLGRPLVPVPTPESKTPAL
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCHH
ASTYALSKFDQERLCLILGRAYSIPSVALRFFNTYGPNQALSNPYTGVLSNFASRVLNGN
HHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCC
APLIFEDGLQKRDFVSVFDVARACRLALETPAADGKAFNISSGVPMTVKEVADRTVRAIG
CCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHC
GRRIEPQITGNYRAGDIRHCFADISQAKRVLGWQPKVTLEQGLVNLAEWLESQTAVDRGM
CCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCH
EARAELAARGLMV
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]