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The map label for this gene is dgoD1 [H]

Identifier: 116622097

GI number: 116622097

Start: 3770639

End: 3771970

Strand: Reverse

Name: dgoD1 [H]

Synonym: Acid_2984

Alternate gene names: 116622097

Gene position: 3771970-3770639 (Counterclockwise)

Preceding gene: 116622098

Following gene: 116622094

Centisome position: 37.85

GC content: 60.81

Gene sequence:

>1332_bases
ATGAAGCGGCGGCAATTTCTGGCCGGGGTCGGGACAATGGCCGGCGGCAAATTGATGGGATCGCCGGAAGGCCGACCGTC
GCTATCGTTCTGCGACTGCGCTATGCAGCCCCAGTTCGCGATGCCGCCCGGAGCGAGCACCCTTGCTGCCGTCGGCTCCA
AAGTGAGAATCACGAACCTCAAGACATTCGGCGTGACCATTCCGGGAGCTCCGGCCGACCGGCCGTACGTGTTCGTGAAG
TTGGAAACGAACGCTGGCCTGGTCGGATGGGGCGAGGGGACCTTGGAAGGCAAGGCCGGCTCCGTAATGGCCTGCATTAA
CGATTTCCATGACTTCCTGATCGGCGCCGATCCGATGCCGGTGGAACACCACTGGCAGTCGATGTATGTCCACAGCTTCT
ATCGCGCAGGACCGGTGATTGGCTCGGCCATCTCGGCCATCGACCAAGCGTTGTGGGACCTCCGCGGCAAGATCCTCGGC
GTGCCCGTCTACAAGCTGCTTGGCGGGCCCAACGATCCGGAGGGCGTGCGCGGCTATTATGTCGCCAACGCCCGATCGCT
TGATGATTTGAAGCGGCTGCGCGAGACCGCCCAATCGCAAGGAATCACCGCGTTCAAAGGCGGCTTGCCGGATTACTACG
AATGGATCGAAACCAGCGCCAAAATCACCGAGGCCATTCGCCACGTGGAGATGTTGCGCGAGGGATTAGGCCCCGACATC
GATATCGCAGTGGACTTTCACGCCAAGACCAGCCCCACCGTAGCGTCAGTAATCATCAAGGAACTAGACCCGCTGGAGTT
GCTCTGGGTGGAAGAGCCGTGCCCGCCTGAAAACGCCTGGGCGATGGGGCGCATTGCCAAGCGCGTGCGAACTCCGATCG
CAACGGGCGAGCGCCTGGTCGCAGCTCACGGAGTGCGCGAAATCGTGGAGCAGGCAGTAGTCGACATCATCCAGACCGAC
GCCAACCACGTGGGTGGCATCACCGCATTGTGGAAGGTAGCCGCGATGGCCGATCTTTCCTCGATTTCCATGGCGCCTCA
CGCCTGTGAAGGACCCATTGGCATGCTGGCCTCGCTCCATGTGGACGCATCGATCCCCAATTTCCTGATCCAGGAATGCT
GCGGACAGGCAGTGCCGCAAACCCGCGATAAGGTGTGGGAAGAATGGTTCGGGTTTCCGGCGATGCGCATGGTCAATGGG
AAGTATCCTCTACCCGACAAACCCGGACTCGGTTTCGAACTCACCGAGGATGCGCTCAAGAAATATCCCTTCGCTGGAAC
CCGCCCGATGACTCGCGTTTTTCACAAGGATGGCTCCGTGGCCGAGTGGTAG

Upstream 100 bases:

>100_bases
TCGAAGCTGTCAAGGACGGATTTCTTGAACTGCCGCGGGGTCCGGGATTGGGAGTCCGGGTGAACGAGGCGGCGCTGAAT
GAGTATCGGGAGGTCGAAGG

Downstream 100 bases:

>100_bases
AGGCCGGTTTCAATTCCGATCGCCGTCAATTGGCGTAAACCGCACTTCGTCCTCGGCCAGGTATTCGCCCTCTCTCGAAC
CCGAGAACTGGATGTAGGCG

Product: galactonate dehydratase

Products: NA

Alternate protein names: GalD 1 [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKRRQFLAGVGTMAGGKLMGSPEGRPSLSFCDCAMQPQFAMPPGASTLAAVGSKVRITNLKTFGVTIPGAPADRPYVFVK
LETNAGLVGWGEGTLEGKAGSVMACINDFHDFLIGADPMPVEHHWQSMYVHSFYRAGPVIGSAISAIDQALWDLRGKILG
VPVYKLLGGPNDPEGVRGYYVANARSLDDLKRLRETAQSQGITAFKGGLPDYYEWIETSAKITEAIRHVEMLREGLGPDI
DIAVDFHAKTSPTVASVIIKELDPLELLWVEEPCPPENAWAMGRIAKRVRTPIATGERLVAAHGVREIVEQAVVDIIQTD
ANHVGGITALWKVAAMADLSSISMAPHACEGPIGMLASLHVDASIPNFLIQECCGQAVPQTRDKVWEEWFGFPAMRMVNG
KYPLPDKPGLGFELTEDALKKYPFAGTRPMTRVFHKDGSVAEW

Sequences:

>Translated_443_residues
MKRRQFLAGVGTMAGGKLMGSPEGRPSLSFCDCAMQPQFAMPPGASTLAAVGSKVRITNLKTFGVTIPGAPADRPYVFVK
LETNAGLVGWGEGTLEGKAGSVMACINDFHDFLIGADPMPVEHHWQSMYVHSFYRAGPVIGSAISAIDQALWDLRGKILG
VPVYKLLGGPNDPEGVRGYYVANARSLDDLKRLRETAQSQGITAFKGGLPDYYEWIETSAKITEAIRHVEMLREGLGPDI
DIAVDFHAKTSPTVASVIIKELDPLELLWVEEPCPPENAWAMGRIAKRVRTPIATGERLVAAHGVREIVEQAVVDIIQTD
ANHVGGITALWKVAAMADLSSISMAPHACEGPIGMLASLHVDASIPNFLIQECCGQAVPQTRDKVWEEWFGFPAMRMVNG
KYPLPDKPGLGFELTEDALKKYPFAGTRPMTRVFHKDGSVAEW
>Mature_443_residues
MKRRQFLAGVGTMAGGKLMGSPEGRPSLSFCDCAMQPQFAMPPGASTLAAVGSKVRITNLKTFGVTIPGAPADRPYVFVK
LETNAGLVGWGEGTLEGKAGSVMACINDFHDFLIGADPMPVEHHWQSMYVHSFYRAGPVIGSAISAIDQALWDLRGKILG
VPVYKLLGGPNDPEGVRGYYVANARSLDDLKRLRETAQSQGITAFKGGLPDYYEWIETSAKITEAIRHVEMLREGLGPDI
DIAVDFHAKTSPTVASVIIKELDPLELLWVEEPCPPENAWAMGRIAKRVRTPIATGERLVAAHGVREIVEQAVVDIIQTD
ANHVGGITALWKVAAMADLSSISMAPHACEGPIGMLASLHVDASIPNFLIQECCGQAVPQTRDKVWEEWFGFPAMRMVNG
KYPLPDKPGLGFELTEDALKKYPFAGTRPMTRVFHKDGSVAEW

Specific function: Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=438, Percent_Identity=23.0593607305936, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI186972148, Length=348, Percent_Identity=22.7011494252874, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI48994953, Length=375, Percent_Identity=36.5333333333333, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1787864, Length=421, Percent_Identity=31.1163895486936, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI226510960, Length=374, Percent_Identity=26.2032085561497, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.6 [H]

Molecular weight: Translated: 48093; Mature: 48093

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00908 MR_MLE_1 ; PS00909 MR_MLE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRQFLAGVGTMAGGKLMGSPEGRPSLSFCDCAMQPQFAMPPGASTLAAVGSKVRITNL
CCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHCCCEEEEEEE
KTFGVTIPGAPADRPYVFVKLETNAGLVGWGEGTLEGKAGSVMACINDFHDFLIGADPMP
EEEEEECCCCCCCCCEEEEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
VEHHWQSMYVHSFYRAGPVIGSAISAIDQALWDLRGKILGVPVYKLLGGPNDPEGVRGYY
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCEECCCHHHHCCCCCCCCCCCEEE
VANARSLDDLKRLRETAQSQGITAFKGGLPDYYEWIETSAKITEAIRHVEMLREGLGPDI
EECCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
DIAVDFHAKTSPTVASVIIKELDPLELLWVEEPCPPENAWAMGRIAKRVRTPIATGERLV
EEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHH
AAHGVREIVEQAVVDIIQTDANHVGGITALWKVAAMADLSSISMAPHACEGPIGMLASLH
HHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHE
VDASIPNFLIQECCGQAVPQTRDKVWEEWFGFPAMRMVNGKYPLPDKPGLGFELTEDALK
ECCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEHCCCCCCCCCCCCCCCEECHHHHH
KYPFAGTRPMTRVFHKDGSVAEW
HCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKRRQFLAGVGTMAGGKLMGSPEGRPSLSFCDCAMQPQFAMPPGASTLAAVGSKVRITNL
CCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHCCCEEEEEEE
KTFGVTIPGAPADRPYVFVKLETNAGLVGWGEGTLEGKAGSVMACINDFHDFLIGADPMP
EEEEEECCCCCCCCCEEEEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
VEHHWQSMYVHSFYRAGPVIGSAISAIDQALWDLRGKILGVPVYKLLGGPNDPEGVRGYY
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCEECCCHHHHCCCCCCCCCCCEEE
VANARSLDDLKRLRETAQSQGITAFKGGLPDYYEWIETSAKITEAIRHVEMLREGLGPDI
EECCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
DIAVDFHAKTSPTVASVIIKELDPLELLWVEEPCPPENAWAMGRIAKRVRTPIATGERLV
EEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHH
AAHGVREIVEQAVVDIIQTDANHVGGITALWKVAAMADLSSISMAPHACEGPIGMLASLH
HHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHE
VDASIPNFLIQECCGQAVPQTRDKVWEEWFGFPAMRMVNGKYPLPDKPGLGFELTEDALK
ECCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEHCCCCCCCCCCCCCCCEECHHHHH
KYPFAGTRPMTRVFHKDGSVAEW
HCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA