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The map label for this gene is bfmBAB [H]

Identifier: 116622051

GI number: 116622051

Start: 3719196

End: 3720389

Strand: Reverse

Name: bfmBAB [H]

Synonym: Acid_2937

Alternate gene names: 116622051

Gene position: 3720389-3719196 (Counterclockwise)

Preceding gene: 116622057

Following gene: 116622050

Centisome position: 37.33

GC content: 58.96

Gene sequence:

>1194_bases
ATGCATCCTTGCCGAAAGGACACCCTGATTCGCAACCGCGTTTTGACTCCAGATGAGGTGGAAGCATTTAGGGCCTCCAT
CAAAAGCGAGGTAGATCAGGCTGCCGCCGAAGCCGACAGCCATCCGCAGCCAGCCACTAGTAATCTCCTGGCACATATCT
ATTCCGAAAGGACAGCTCCCGCCATCGTGCGCCCCACGTATCTGGCGGAAAAGCCGGTGACGATGATCGATGCCATTAAT
CACGGGCTGCGCGAGGAAATGGAGCGCAATCCTAAGATTGTAATGTGGGGCGAAGACATCGCCGATCCAAAGGGTGGCGT
CTTCGGTGTTACCCGCGGCCTGTCCAGTGCCCTCCCTGGGCGTGTATTCAATGCGCCGTTGGCCGAGGCGAGCATCGCCG
GCGTCGCTGCTGGAATGGCGATCGCCGGCTACAAACCAATTATCGAAATCCAGTTCGCCGACTACACCTGGCCCGCGTTT
ATGCAACTTCGAAATGAAATCGCGACGGTAAGGTGGCGGAGTCAAGGTACTTGGAATTGCCCGGTAGTGGTCCGCATTGC
CGCCGGCGCTTATATCAAGGGCGGTCCCTGGCACTCGGCCTGCGTCGAAGGCGTTTTCGCTCACATCCCGGGGTGGCGCG
TGCTGTTTCCCAGTTGCGCTGAGGATGCCAAGGGCCTCATCAAGATGGCTGCGCGCTTGGAGGACCCGGTGATCTTCCTG
GAACATAAGGGACTCTACCGTAAGGTCCAGGCTCAGACCAACGAGCCGGACAGCGATTTCGTGATTCCGTTTGGCAAAGG
CCGCATTGCCCGCGCGGGTACGGACCTGACTATCGTCGCTTGGGGGTACACAGTCCATTTGGCGCAAGAAGCCGCGCGAC
AACTCGAGGCGCAGGGCAAGTCAGTAGAGGTCATCGACCTCCGATCGATTTCACCGTTGGATGAAGACCTGATCTCTCGG
AGCGTGCGAAAAACAAATCGCGTGATAGTGGCTCACGAAGACTCCCTCACGATGGGGTTCGGCGCCGAAGTCGCAGCGCG
AATCGCGGAGAATTGCTTTGAGTACCTGGACGCCCCGGTCCGGCGAATTGCAGCGGCGGATTCTTTCGTCCCCACTGCAC
CGAACCTCGAGGCGTTGACGCTTCCGTCGGTCGCTGATTTACGGGTGGCTGCCGAAGAGCTGTTGGGCTGGTAA

Upstream 100 bases:

>100_bases
CTTTGACGGAAGTACCAATGGTTCGCATGCATAATCATTCGTCAGCCTAAGCTGTTTACCTTAGACGAACAGACGGCGAA
ATGCCCAATAAATCCAAACT

Downstream 100 bases:

>100_bases
TGCTGTGGGCTATTTGCCCAGCCCGCGATCGGTGGCGCGAAATGCAAATCTGAAATGGCAAAGTACTGATACGCAAACCT
CTTGCGGATTGGGACCTCGG

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MHPCRKDTLIRNRVLTPDEVEAFRASIKSEVDQAAAEADSHPQPATSNLLAHIYSERTAPAIVRPTYLAEKPVTMIDAIN
HGLREEMERNPKIVMWGEDIADPKGGVFGVTRGLSSALPGRVFNAPLAEASIAGVAAGMAIAGYKPIIEIQFADYTWPAF
MQLRNEIATVRWRSQGTWNCPVVVRIAAGAYIKGGPWHSACVEGVFAHIPGWRVLFPSCAEDAKGLIKMAARLEDPVIFL
EHKGLYRKVQAQTNEPDSDFVIPFGKGRIARAGTDLTIVAWGYTVHLAQEAARQLEAQGKSVEVIDLRSISPLDEDLISR
SVRKTNRVIVAHEDSLTMGFGAEVAARIAENCFEYLDAPVRRIAAADSFVPTAPNLEALTLPSVADLRVAAEELLGW

Sequences:

>Translated_397_residues
MHPCRKDTLIRNRVLTPDEVEAFRASIKSEVDQAAAEADSHPQPATSNLLAHIYSERTAPAIVRPTYLAEKPVTMIDAIN
HGLREEMERNPKIVMWGEDIADPKGGVFGVTRGLSSALPGRVFNAPLAEASIAGVAAGMAIAGYKPIIEIQFADYTWPAF
MQLRNEIATVRWRSQGTWNCPVVVRIAAGAYIKGGPWHSACVEGVFAHIPGWRVLFPSCAEDAKGLIKMAARLEDPVIFL
EHKGLYRKVQAQTNEPDSDFVIPFGKGRIARAGTDLTIVAWGYTVHLAQEAARQLEAQGKSVEVIDLRSISPLDEDLISR
SVRKTNRVIVAHEDSLTMGFGAEVAARIAENCFEYLDAPVRRIAAADSFVPTAPNLEALTLPSVADLRVAAEELLGW
>Mature_397_residues
MHPCRKDTLIRNRVLTPDEVEAFRASIKSEVDQAAAEADSHPQPATSNLLAHIYSERTAPAIVRPTYLAEKPVTMIDAIN
HGLREEMERNPKIVMWGEDIADPKGGVFGVTRGLSSALPGRVFNAPLAEASIAGVAAGMAIAGYKPIIEIQFADYTWPAF
MQLRNEIATVRWRSQGTWNCPVVVRIAAGAYIKGGPWHSACVEGVFAHIPGWRVLFPSCAEDAKGLIKMAARLEDPVIFL
EHKGLYRKVQAQTNEPDSDFVIPFGKGRIARAGTDLTIVAWGYTVHLAQEAARQLEAQGKSVEVIDLRSISPLDEDLISR
SVRKTNRVIVAHEDSLTMGFGAEVAARIAENCFEYLDAPVRRIAAADSFVPTAPNLEALTLPSVADLRVAAEELLGW

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=308, Percent_Identity=39.6103896103896, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI34101272, Length=308, Percent_Identity=39.6103896103896, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI156564403, Length=341, Percent_Identity=37.8299120234604, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI291084858, Length=341, Percent_Identity=36.6568914956012, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1786622, Length=267, Percent_Identity=25.4681647940075, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17506935, Length=320, Percent_Identity=41.5625, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17538422, Length=318, Percent_Identity=38.0503144654088, Blast_Score=203, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319698, Length=357, Percent_Identity=35.5742296918768, Blast_Score=209, Evalue=8e-55,
Organism=Drosophila melanogaster, GI160714832, Length=304, Percent_Identity=41.7763157894737, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI160714828, Length=304, Percent_Identity=41.7763157894737, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21358145, Length=332, Percent_Identity=39.7590361445783, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24650940, Length=332, Percent_Identity=39.7590361445783, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 43352; Mature: 43352

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPCRKDTLIRNRVLTPDEVEAFRASIKSEVDQAAAEADSHPQPATSNLLAHIYSERTAP
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
AIVRPTYLAEKPVTMIDAINHGLREEMERNPKIVMWGEDIADPKGGVFGVTRGLSSALPG
CEECCCHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEHHHHHHHHHCCC
RVFNAPLAEASIAGVAAGMAIAGYKPIIEIQFADYTWPAFMQLRNEIATVRWRSQGTWNC
CHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHEEEECCCCCCCC
PVVVRIAAGAYIKGGPWHSACVEGVFAHIPGWRVLFPSCAEDAKGLIKMAARLEDPVIFL
CEEEEEECCCEECCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEE
EHKGLYRKVQAQTNEPDSDFVIPFGKGRIARAGTDLTIVAWGYTVHLAQEAARQLEAQGK
ECCCHHHHHHCCCCCCCCCEEEECCCCEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCC
SVEVIDLRSISPLDEDLISRSVRKTNRVIVAHEDSLTMGFGAEVAARIAENCFEYLDAPV
EEEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHH
RRIAAADSFVPTAPNLEALTLPSVADLRVAAEELLGW
HHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MHPCRKDTLIRNRVLTPDEVEAFRASIKSEVDQAAAEADSHPQPATSNLLAHIYSERTAP
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
AIVRPTYLAEKPVTMIDAINHGLREEMERNPKIVMWGEDIADPKGGVFGVTRGLSSALPG
CEECCCHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEHHHHHHHHHCCC
RVFNAPLAEASIAGVAAGMAIAGYKPIIEIQFADYTWPAFMQLRNEIATVRWRSQGTWNC
CHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHEEEECCCCCCCC
PVVVRIAAGAYIKGGPWHSACVEGVFAHIPGWRVLFPSCAEDAKGLIKMAARLEDPVIFL
CEEEEEECCCEECCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEE
EHKGLYRKVQAQTNEPDSDFVIPFGKGRIARAGTDLTIVAWGYTVHLAQEAARQLEAQGK
ECCCHHHHHHCCCCCCCCCEEEECCCCEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCC
SVEVIDLRSISPLDEDLISRSVRKTNRVIVAHEDSLTMGFGAEVAARIAENCFEYLDAPV
EEEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHH
RRIAAADSFVPTAPNLEALTLPSVADLRVAAEELLGW
HHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]