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The map label for this gene is luxQ [H]

Identifier: 116621999

GI number: 116621999

Start: 3655752

End: 3657632

Strand: Direct

Name: luxQ [H]

Synonym: Acid_2884

Alternate gene names: 116621999

Gene position: 3655752-3657632 (Clockwise)

Preceding gene: 116621998

Following gene: 116622000

Centisome position: 36.68

GC content: 63.26

Gene sequence:

>1881_bases
GTGGTCGCGATCAGCCTTTTGCGGCGCGGGCGACTGCGTGCGGCCGGCCTGATCTACCTGTTAGGCATCTGGGTGATGTC
CACCGGTATTATCGTACTGAATCGCGGGATCCATAGCGTAGGACTGGTGTACTATGTCGCGTTGCCGGTGACGGGGGCTT
GGTTGTTCGGGTTCCAGGGCGCGCTGCGGATTGCCGCGGGGTGCGTCGGGAGTGCACTAGTGCTGGCACTCCTGGAAATG
GCGGGCTTGCCGCTGCCGACATATTTTCCGGAAAGGCCTTTCGGAATCTGGACGATGGTGGCGGCGGCCACGGTGATGAC
CACGGTACCGGTGGCGCGGGTGCTTCAGCTGCTGAAGCAGACGCTGACGATGCACCGGGCGGCGCAGAAGGCGCTCAGGG
AGTATCAGAGCCGGCTGGAGGAAGTGGTGCAGCGGCGGACGGCGGAACTGGTGGAGGCGCGAGACCAGGCACAGGCCGCC
AGCCGCGCGAAAAGCGTATTTCTGGCGAACATGAGCCACGAACTGCGCACACCGCTGAACGCGATTCTGGGATTCTCCAA
GCTGGTGCGAGGAGGGCCGGGACTTTCGGAGGTGCAGCGCAAGGATCTGGACATCATCAGCCGGAGCGGCGCGCACCTGC
TGGATATGATCGACGAAGTTCTGGACCGGGCCAAGATCGAAACCGGGGGAGTAACGACGAAGAAGACGGCGGTGGATCTT
CACCGGGTGGTGCACGAGGTGGTGGAACTGATGCGGCCGCGGGCACAGGCGAAGAACCTGGAGTTCGTGTTCGAGCACCC
GGAGACTTACCCATACTGCATACGCTCCGATGCGGGGAAACTGCGGCAGGTATTGTTGAACCTCACCGGCAACGCGATTA
AGTTCACGCAACGGGGCAGTGTCACTCTGCGGCTCTGGTTGGAACCTATGGCGGGCGACGCTCCCGGGAGTCAAATGCTT
TTAACCCTGGACGTGTCGGACACCGGGATTGGGATTGCGCCGGAAGACCAGGAACGGATCTTCGAACCGTTCGCCCAGGC
CGGCAATGGGGGCGCGGCGCGAGGTACAGGGCTGGGCTTGAGCATCAGCAGGGAGTTCGTGCGAGCGATGGGAGGAAGCC
TGGCGGTGCAAAGCATCCTGCGCGTGGGTTCGCGGTTCCACGTGGAACTGCCGGTGGAATGCGCCGCGGACGGGGTCAAA
GGAGAAGGCGAGGCGCGCGAAGAGGTGATCGGCCTGGAGGCAGGACAGCCTGAATATCGAACGCTATTGGTGGGTGACGA
GCAGGACAATATCGTGCTGCTGGAGCGGCTGCTGGAGGACGCGGGCTTCCGGGTGTGCGCAGCGGAGAGCGGCGCCGACG
GCATTGAGGTGTTTCAGATCTGGCATCCGCATTTGATCCTGGCTGACTTGCGTCTCTCCGGGATGAGCAGCGTGGAACTG
GCACGGTGCGTGCGGCAAATGGAGGGTGGGCAGGAGGTAAAGATCGTGGCGTTGACGGCCTCCCTATCCGAAGCGCAGCC
GGGGGTGGACGAGACTCTGCGCAATCCTTGCGAAAGCCGCGAGATCTTCGACTGCATCCAGCGGATGCTGGGAGTGCGGT
ACCGGTATGGTACGGCAGGCGCATCGCTTCGGGCTACCGAAGGTGAGGCGGGACTCAACCCGGCGGCGCTCTCGGCGATT
TCGCCGGGATTGCGGGATGAACTTGAAAATGCGCTGATCCTGCTGGATGTGAAGCGTGTGACGACGCTTGTACAGGAAGT
GGCGGAGCAGGCTCCGGCATTGGGCTCGGCGATGGCGGGACTGGCGGAGCGGCTGGCCTACACGTCTATCCTGCAGGCGA
TCGCGGTTCGGAAGTCGAGCGCTCTAGAGGGACAAGCGTGA

Upstream 100 bases:

>100_bases
ACTGTGCTGGTTTGTCCTCCAGGTCGCGGTTATCTTGCCCTTTTTTGCGTTCCGGAAGGCGGCATCGGCGGCTACGGCAG
TATTTGCGGGGATCGCGTGC

Downstream 100 bases:

>100_bases
GCGGGATCAGTACCATTCTGGTGGTGGACGACGACTCGGATTCGCTGCGGTTGTTGACCGATATTTTGACGGCGGAAGGA
TATCGGGTACGCCCCGCGGA

Product: integral membrane sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MVAISLLRRGRLRAAGLIYLLGIWVMSTGIIVLNRGIHSVGLVYYVALPVTGAWLFGFQGALRIAAGCVGSALVLALLEM
AGLPLPTYFPERPFGIWTMVAAATVMTTVPVARVLQLLKQTLTMHRAAQKALREYQSRLEEVVQRRTAELVEARDQAQAA
SRAKSVFLANMSHELRTPLNAILGFSKLVRGGPGLSEVQRKDLDIISRSGAHLLDMIDEVLDRAKIETGGVTTKKTAVDL
HRVVHEVVELMRPRAQAKNLEFVFEHPETYPYCIRSDAGKLRQVLLNLTGNAIKFTQRGSVTLRLWLEPMAGDAPGSQML
LTLDVSDTGIGIAPEDQERIFEPFAQAGNGGAARGTGLGLSISREFVRAMGGSLAVQSILRVGSRFHVELPVECAADGVK
GEGEAREEVIGLEAGQPEYRTLLVGDEQDNIVLLERLLEDAGFRVCAAESGADGIEVFQIWHPHLILADLRLSGMSSVEL
ARCVRQMEGGQEVKIVALTASLSEAQPGVDETLRNPCESREIFDCIQRMLGVRYRYGTAGASLRATEGEAGLNPAALSAI
SPGLRDELENALILLDVKRVTTLVQEVAEQAPALGSAMAGLAERLAYTSILQAIAVRKSSALEGQA

Sequences:

>Translated_626_residues
MVAISLLRRGRLRAAGLIYLLGIWVMSTGIIVLNRGIHSVGLVYYVALPVTGAWLFGFQGALRIAAGCVGSALVLALLEM
AGLPLPTYFPERPFGIWTMVAAATVMTTVPVARVLQLLKQTLTMHRAAQKALREYQSRLEEVVQRRTAELVEARDQAQAA
SRAKSVFLANMSHELRTPLNAILGFSKLVRGGPGLSEVQRKDLDIISRSGAHLLDMIDEVLDRAKIETGGVTTKKTAVDL
HRVVHEVVELMRPRAQAKNLEFVFEHPETYPYCIRSDAGKLRQVLLNLTGNAIKFTQRGSVTLRLWLEPMAGDAPGSQML
LTLDVSDTGIGIAPEDQERIFEPFAQAGNGGAARGTGLGLSISREFVRAMGGSLAVQSILRVGSRFHVELPVECAADGVK
GEGEAREEVIGLEAGQPEYRTLLVGDEQDNIVLLERLLEDAGFRVCAAESGADGIEVFQIWHPHLILADLRLSGMSSVEL
ARCVRQMEGGQEVKIVALTASLSEAQPGVDETLRNPCESREIFDCIQRMLGVRYRYGTAGASLRATEGEAGLNPAALSAI
SPGLRDELENALILLDVKRVTTLVQEVAEQAPALGSAMAGLAERLAYTSILQAIAVRKSSALEGQA
>Mature_626_residues
MVAISLLRRGRLRAAGLIYLLGIWVMSTGIIVLNRGIHSVGLVYYVALPVTGAWLFGFQGALRIAAGCVGSALVLALLEM
AGLPLPTYFPERPFGIWTMVAAATVMTTVPVARVLQLLKQTLTMHRAAQKALREYQSRLEEVVQRRTAELVEARDQAQAA
SRAKSVFLANMSHELRTPLNAILGFSKLVRGGPGLSEVQRKDLDIISRSGAHLLDMIDEVLDRAKIETGGVTTKKTAVDL
HRVVHEVVELMRPRAQAKNLEFVFEHPETYPYCIRSDAGKLRQVLLNLTGNAIKFTQRGSVTLRLWLEPMAGDAPGSQML
LTLDVSDTGIGIAPEDQERIFEPFAQAGNGGAARGTGLGLSISREFVRAMGGSLAVQSILRVGSRFHVELPVECAADGVK
GEGEAREEVIGLEAGQPEYRTLLVGDEQDNIVLLERLLEDAGFRVCAAESGADGIEVFQIWHPHLILADLRLSGMSSVEL
ARCVRQMEGGQEVKIVALTASLSEAQPGVDETLRNPCESREIFDCIQRMLGVRYRYGTAGASLRATEGEAGLNPAALSAI
SPGLRDELENALILLDVKRVTTLVQEVAEQAPALGSAMAGLAERLAYTSILQAIAVRKSSALEGQA

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=417, Percent_Identity=32.3741007194245, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI48994928, Length=382, Percent_Identity=31.9371727748691, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1789149, Length=273, Percent_Identity=36.6300366300366, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1788713, Length=363, Percent_Identity=32.2314049586777, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=34.1085271317829, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1786912, Length=281, Percent_Identity=27.7580071174377, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=29.4605809128631, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786600, Length=254, Percent_Identity=27.9527559055118, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=31.1688311688312, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=27.0742358078603, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790861, Length=214, Percent_Identity=28.5046728971963, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=235, Percent_Identity=26.3829787234043, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788279, Length=235, Percent_Identity=25.1063829787234, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=24.8908296943231, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790346, Length=228, Percent_Identity=25.8771929824561, Blast_Score=63, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=190, Percent_Identity=33.6842105263158, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67635; Mature: 67635

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAISLLRRGRLRAAGLIYLLGIWVMSTGIIVLNRGIHSVGLVYYVALPVTGAWLFGFQG
CHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ALRIAAGCVGSALVLALLEMAGLPLPTYFPERPFGIWTMVAAATVMTTVPVARVLQLLKQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TLTMHRAAQKALREYQSRLEEVVQRRTAELVEARDQAQAASRAKSVFLANMSHELRTPLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AILGFSKLVRGGPGLSEVQRKDLDIISRSGAHLLDMIDEVLDRAKIETGGVTTKKTAVDL
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
HRVVHEVVELMRPRAQAKNLEFVFEHPETYPYCIRSDAGKLRQVLLNLTGNAIKFTQRGS
HHHHHHHHHHHCCHHHHCCCEEEEECCCCCCEEECCCHHHHHHHHHHCCCCEEEEEECCC
VTLRLWLEPMAGDAPGSQMLLTLDVSDTGIGIAPEDQERIFEPFAQAGNGGAARGTGLGL
EEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCH
SISREFVRAMGGSLAVQSILRVGSRFHVELPVECAADGVKGEGEAREEVIGLEAGQPEYR
HHHHHHHHHHCCHHHHHHHHHCCCCEEEEECHHHCCCCCCCCCCHHHHHCCCCCCCCCCE
TLLVGDEQDNIVLLERLLEDAGFRVCAAESGADGIEVFQIWHPHLILADLRLSGMSSVEL
EEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCHHHHEECCCHHEEEHHHHCCCCHHHH
ARCVRQMEGGQEVKIVALTASLSEAQPGVDETLRNPCESREIFDCIQRMLGVRYRYGTAG
HHHHHHHCCCCEEEEEEEEEEHHHCCCCHHHHHCCCCCCHHHHHHHHHHHCCEEEECCCC
ASLRATEGEAGLNPAALSAISPGLRDELENALILLDVKRVTTLVQEVAEQAPALGSAMAG
CCEEECCCCCCCCHHHHHHCCCCHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHH
LAERLAYTSILQAIAVRKSSALEGQA
HHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVAISLLRRGRLRAAGLIYLLGIWVMSTGIIVLNRGIHSVGLVYYVALPVTGAWLFGFQG
CHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ALRIAAGCVGSALVLALLEMAGLPLPTYFPERPFGIWTMVAAATVMTTVPVARVLQLLKQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TLTMHRAAQKALREYQSRLEEVVQRRTAELVEARDQAQAASRAKSVFLANMSHELRTPLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AILGFSKLVRGGPGLSEVQRKDLDIISRSGAHLLDMIDEVLDRAKIETGGVTTKKTAVDL
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
HRVVHEVVELMRPRAQAKNLEFVFEHPETYPYCIRSDAGKLRQVLLNLTGNAIKFTQRGS
HHHHHHHHHHHCCHHHHCCCEEEEECCCCCCEEECCCHHHHHHHHHHCCCCEEEEEECCC
VTLRLWLEPMAGDAPGSQMLLTLDVSDTGIGIAPEDQERIFEPFAQAGNGGAARGTGLGL
EEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCH
SISREFVRAMGGSLAVQSILRVGSRFHVELPVECAADGVKGEGEAREEVIGLEAGQPEYR
HHHHHHHHHHCCHHHHHHHHHCCCCEEEEECHHHCCCCCCCCCCHHHHHCCCCCCCCCCE
TLLVGDEQDNIVLLERLLEDAGFRVCAAESGADGIEVFQIWHPHLILADLRLSGMSSVEL
EEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCHHHHEECCCHHEEEHHHHCCCCHHHH
ARCVRQMEGGQEVKIVALTASLSEAQPGVDETLRNPCESREIFDCIQRMLGVRYRYGTAG
HHHHHHHCCCCEEEEEEEEEEHHHCCCCHHHHHCCCCCCHHHHHHHHHHHCCEEEECCCC
ASLRATEGEAGLNPAALSAISPGLRDELENALILLDVKRVTTLVQEVAEQAPALGSAMAG
CCEEECCCCCCCCHHHHHHCCCCHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHH
LAERLAYTSILQAIAVRKSSALEGQA
HHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]