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The map label for this gene is kynU [H]

Identifier: 116621990

GI number: 116621990

Start: 3638170

End: 3639336

Strand: Reverse

Name: kynU [H]

Synonym: Acid_2875

Alternate gene names: 116621990

Gene position: 3639336-3638170 (Counterclockwise)

Preceding gene: 116621993

Following gene: 116621989

Centisome position: 36.52

GC content: 63.32

Gene sequence:

>1167_bases
ATGTTAACCATGGATTCGCTGCTTGCCTGGCGCAAGGAATTTCCCATCCTTGCCCACACCACCTACATGATCAGCCACTC
CCTCGGCGCCATGCCCGACCGCACCCGGGCGCGCATGCAGGAGTACGCCGAGACCTGGGCTACCCGCGGCATCCGCGCCT
GGGAAGAGGGCTGGTGGATGATGCCGGTCACCGTCGGCGACAAGGTCGGCCGCATCATAGGCGCGGGCGAGGGCGAAGTG
GTCATGCAGTTGAACGTTTCTACCTGCCAGTCGATCGTCACTTCGTGCTTCGATTGGGGAGCACGCCGCAACAAGCTGGT
CACCGACGGGCTCAACTTTCCTTCGAACAACTATGTCTACCATTCGCTCGAGCGCGCCGGCGCACGCGTCACCACGGTCC
CTTCCCCCGATGGCTTCACGCTGCCTGTGGAAGACATCCTGGCCGCGATCGATGAAGAGACCGCGCTGGTCTCGGTGTCG
CATGTCGCCTTCCGCAGTTCCTACGTGCAGGACCTTGCCGCCATCACCGAGCGCGCCCATGCGGTCGGTGCCATGATCGT
CGCCGATCTCTATCAGTCGGCCGGCACCGTGCCCGTCGATGTTCGCGCGCTCGGAGTCGATTTCGCCACCGGCGGCTCCG
TCAAATGGCTCTGCGGCGGTCCTGGCGCCGGGTATTTGTACGTGCGCCGCGATCTCTGGGAGCAGCTCGCCCCCGCCGCC
ACCGGCTGGATGGCGCATGAAGAACCCTTCGCCTTTGCCTCCGGTCCCATCCGCTACACCAATGGCATCTATCGCTTCCT
CAATGGCACGCCGAATGTCCCTGCGATGTATTCGGCGCAATCCGGCTATGAGATCGTGAATGAAATCGGCGTCCCCGCAA
TCCGTGAGAAGTCCCTGCGCCAGACCTCGCTGCTGATCGCTCTCGCCGATGAAGCCGGCATCAAGATCAATACCTGCCGC
AACCCGGCGCAGCGCGGGGGCACCGTGGTGCTTGATGTCCCCGACGGCTATCAGGTCACGCAGGAACTCGCCCGCCGCCA
GATCCTGGTGGATTACCGGCCGCAGGCCGGCATCCGTGTAGCCCCGCACTTCTATACAACCGACGACGAGATCCGCCACA
CTGTAAGTGAAATCCGCTCCATCGTGAGCACCGGAGTAACTGCATGA

Upstream 100 bases:

>100_bases
TCAGCTTTCCATCCACCACAATCGGTCCCGCCGCGCGGTAGCACGTGTAGCGGGCAGGCTCCAAATTCAACGGCGCAAGA
GGATCGTACATGACGCTACC

Downstream 100 bases:

>100_bases
AGAAGGTTGTACTCGCCCTGTCGGTAATCCTGCCCCTCGCCGCGCAGGTCAAGATCACGCCCCAGGGCAAAGAAAAGATC
TCCATCGAAATCGATGGCAA

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MLTMDSLLAWRKEFPILAHTTYMISHSLGAMPDRTRARMQEYAETWATRGIRAWEEGWWMMPVTVGDKVGRIIGAGEGEV
VMQLNVSTCQSIVTSCFDWGARRNKLVTDGLNFPSNNYVYHSLERAGARVTTVPSPDGFTLPVEDILAAIDEETALVSVS
HVAFRSSYVQDLAAITERAHAVGAMIVADLYQSAGTVPVDVRALGVDFATGGSVKWLCGGPGAGYLYVRRDLWEQLAPAA
TGWMAHEEPFAFASGPIRYTNGIYRFLNGTPNVPAMYSAQSGYEIVNEIGVPAIREKSLRQTSLLIALADEAGIKINTCR
NPAQRGGTVVLDVPDGYQVTQELARRQILVDYRPQAGIRVAPHFYTTDDEIRHTVSEIRSIVSTGVTA

Sequences:

>Translated_388_residues
MLTMDSLLAWRKEFPILAHTTYMISHSLGAMPDRTRARMQEYAETWATRGIRAWEEGWWMMPVTVGDKVGRIIGAGEGEV
VMQLNVSTCQSIVTSCFDWGARRNKLVTDGLNFPSNNYVYHSLERAGARVTTVPSPDGFTLPVEDILAAIDEETALVSVS
HVAFRSSYVQDLAAITERAHAVGAMIVADLYQSAGTVPVDVRALGVDFATGGSVKWLCGGPGAGYLYVRRDLWEQLAPAA
TGWMAHEEPFAFASGPIRYTNGIYRFLNGTPNVPAMYSAQSGYEIVNEIGVPAIREKSLRQTSLLIALADEAGIKINTCR
NPAQRGGTVVLDVPDGYQVTQELARRQILVDYRPQAGIRVAPHFYTTDDEIRHTVSEIRSIVSTGVTA
>Mature_388_residues
MLTMDSLLAWRKEFPILAHTTYMISHSLGAMPDRTRARMQEYAETWATRGIRAWEEGWWMMPVTVGDKVGRIIGAGEGEV
VMQLNVSTCQSIVTSCFDWGARRNKLVTDGLNFPSNNYVYHSLERAGARVTTVPSPDGFTLPVEDILAAIDEETALVSVS
HVAFRSSYVQDLAAITERAHAVGAMIVADLYQSAGTVPVDVRALGVDFATGGSVKWLCGGPGAGYLYVRRDLWEQLAPAA
TGWMAHEEPFAFASGPIRYTNGIYRFLNGTPNVPAMYSAQSGYEIVNEIGVPAIREKSLRQTSLLIALADEAGIKINTCR
NPAQRGGTVVLDVPDGYQVTQELARRQILVDYRPQAGIRVAPHFYTTDDEIRHTVSEIRSIVSTGVTA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=397, Percent_Identity=27.2040302267003, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI74101437, Length=211, Percent_Identity=27.9620853080569, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787970, Length=272, Percent_Identity=27.2058823529412, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI48994898, Length=346, Percent_Identity=23.4104046242775, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17550466, Length=397, Percent_Identity=26.1964735516373, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323261, Length=323, Percent_Identity=25.3869969040248, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 42532; Mature: 42532

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTMDSLLAWRKEFPILAHTTYMISHSLGAMPDRTRARMQEYAETWATRGIRAWEEGWWM
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCEE
MPVTVGDKVGRIIGAGEGEVVMQLNVSTCQSIVTSCFDWGARRNKLVTDGLNFPSNNYVY
EEEECCCHHHHEEECCCCCEEEEECHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEE
HSLERAGARVTTVPSPDGFTLPVEDILAAIDEETALVSVSHVAFRSSYVQDLAAITERAH
EEHHHCCCEEEECCCCCCCEECHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHH
AVGAMIVADLYQSAGTVPVDVRALGVDFATGGSVKWLCGGPGAGYLYVRRDLWEQLAPAA
HHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCEEEEECCCCCCEEEEHHHHHHHHCCHH
TGWMAHEEPFAFASGPIRYTNGIYRFLNGTPNVPAMYSAQSGYEIVNEIGVPAIREKSLR
HCCCCCCCCCCCCCCCEEHHCCHHHHHCCCCCCCEEEECCCCHHHHHHCCCCHHHHHHHH
QTSLLIALADEAGIKINTCRNPAQRGGTVVLDVPDGYQVTQELARRQILVDYRPQAGIRV
HHEEEEEEECCCCEEEECCCCHHHCCCEEEEECCCCHHHHHHHHHHCEEEEECCCCCCEE
APHFYTTDDEIRHTVSEIRSIVSTGVTA
CCCEECCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTMDSLLAWRKEFPILAHTTYMISHSLGAMPDRTRARMQEYAETWATRGIRAWEEGWWM
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCEE
MPVTVGDKVGRIIGAGEGEVVMQLNVSTCQSIVTSCFDWGARRNKLVTDGLNFPSNNYVY
EEEECCCHHHHEEECCCCCEEEEECHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEE
HSLERAGARVTTVPSPDGFTLPVEDILAAIDEETALVSVSHVAFRSSYVQDLAAITERAH
EEHHHCCCEEEECCCCCCCEECHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHH
AVGAMIVADLYQSAGTVPVDVRALGVDFATGGSVKWLCGGPGAGYLYVRRDLWEQLAPAA
HHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCEEEEECCCCCCEEEEHHHHHHHHCCHH
TGWMAHEEPFAFASGPIRYTNGIYRFLNGTPNVPAMYSAQSGYEIVNEIGVPAIREKSLR
HCCCCCCCCCCCCCCCEEHHCCHHHHHCCCCCCCEEEECCCCHHHHHHCCCCHHHHHHHH
QTSLLIALADEAGIKINTCRNPAQRGGTVVLDVPDGYQVTQELARRQILVDYRPQAGIRV
HHEEEEEEECCCCEEEECCCCHHHCCCEEEEECCCCHHHHHHHHHHCEEEEECCCCCCEE
APHFYTTDDEIRHTVSEIRSIVSTGVTA
CCCEECCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA