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The map label for this gene is atsA [H]

Identifier: 116621986

GI number: 116621986

Start: 3631671

End: 3633056

Strand: Reverse

Name: atsA [H]

Synonym: Acid_2871

Alternate gene names: 116621986

Gene position: 3633056-3631671 (Counterclockwise)

Preceding gene: 116621987

Following gene: 116621983

Centisome position: 36.46

GC content: 65.37

Gene sequence:

>1386_bases
ATGATTCTGGACCGCCGGAGCTTTATCAAATCCGCCGGCGCGGCAGCCATGGCGGCGGCGCTTCGCGGTCAGCAGCGCCA
ACCGAATATCGTGGTGATCCTGGCCGACGATCTCGGTTATGGCGACCTCGGCTGCTATGGCTCACCGATCGCCACTCCCA
ACATCGATCGCCTCGCCGAGGAAGGCGCGCGCTTCACCAGCTTCTATTCCGCGAGCCCGGTCTGCTCGCCCTCGCGCGCC
GCGCTGATGACCGGCCGCTATCCGACCCGCGTCGAAGTCCCGGTCGTACTTGGCCCCGGCGACGCAGGACTGCCGGATAG
TGAAATCACCATGGCGCAGGTCCTCAAATCCGCCGGGTATCGCACTTCCTGCATCGGTAAATGGCACATCGGCTCCACGC
CCGGCTACCTGCCCACCAATCGCGGTTTCGACGAATTCTTCGGCGTGCCTTATAGCGCCGACATCACGCCCTGCCCACTC
ATGCGCGGGAGTTCGGTGGTCGCGCCCGCGGTGGATTGCAGCACATTGACCTCGAGCTTCACGCAGGAAGCGCTGGATTT
CATGAGGCGCGCGCAGGACAATCCGTTCTTCCTGTACCTGGCGCATACCGCGCCGCACCTTCCGCTCGCCGCCTCACCGC
GCTTCGCCGGCCAGTCCGGTCTCGGCATGTACGCGGACGTAGTCCAGGAGCTCGATTGGAGCACCGGCCAGGTGATGGCC
GCTCTCAAGGCGACCGGACTCGACTCCAATACGCTCGTCATGTTCTCCAGCGACAACGGTCCGTGGTACCAGGGCAGCCA
GGGCAAGTTGCGCGGCCGTAAAGGCGAGACGTACGAAGGCGGTATGCGTGAGCCATTCCTTGCGCGCTACCCCGGCGTGA
TCCCTTCGGGCATCGGCTGCGCCGGGCTCGCCACCACAATGGATCTCCTGCCCACGCTGGCGCGCCTCGCGGGTGCGCAG
ACTCCTTCCAATCCGCTCGATGGCGTCGATATCTGGCCGGTCCTCACCGGCGAACGCGCGGAGGTCGATCGCGATGTGTT
TCTCTATTTCGACGCCGTGTACCTTCAGTGCGCGCGCCTCGGCCGATGGAAGCTTCACCTCTCGCGCTACAACACCAAAG
CATGGTCGCCGCTTCCGCCCGGGGGACGGGTAAATCTGCCGCTACCCCGTCCGGAACTGTACGACGTGGTCAGCGACCCG
CAGGAGAGCTACGATTGCGCCGCTTCGCATCCGGCAATCGTCGCCGACATCCGCGCGCGCGTCGAGCGCATGGTCCAGAC
ATTTCCGCCCGGCATCATCGACGCCTGGCAGTACACGCTTTCGCAGAAGGTAATCGATGCCCCGGTCGATGGGCTCCCGG
TCCCTGGCGGCGGCCAGGGCGGCTAG

Upstream 100 bases:

>100_bases
TCAATACGGGCGGCTCCAGTATTTTTACCGTGCGCACCGCCGCGCCGGTCTACCGTTCGTACCGCCTCGCCGATATGTAT
AGTCCCGTGAGAGGCACGCG

Downstream 100 bases:

>100_bases
CCAGTTCAGGAGATGATGCCCTTGCGCACGGCGTAGAGGATTAACTCGGGTACGCTATGAATGTCCAGCTTTTGCAGGAT
GTGGGCGCGATGCGTCTCGA

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MILDRRSFIKSAGAAAMAAALRGQQRQPNIVVILADDLGYGDLGCYGSPIATPNIDRLAEEGARFTSFYSASPVCSPSRA
ALMTGRYPTRVEVPVVLGPGDAGLPDSEITMAQVLKSAGYRTSCIGKWHIGSTPGYLPTNRGFDEFFGVPYSADITPCPL
MRGSSVVAPAVDCSTLTSSFTQEALDFMRRAQDNPFFLYLAHTAPHLPLAASPRFAGQSGLGMYADVVQELDWSTGQVMA
ALKATGLDSNTLVMFSSDNGPWYQGSQGKLRGRKGETYEGGMREPFLARYPGVIPSGIGCAGLATTMDLLPTLARLAGAQ
TPSNPLDGVDIWPVLTGERAEVDRDVFLYFDAVYLQCARLGRWKLHLSRYNTKAWSPLPPGGRVNLPLPRPELYDVVSDP
QESYDCAASHPAIVADIRARVERMVQTFPPGIIDAWQYTLSQKVIDAPVDGLPVPGGGQGG

Sequences:

>Translated_461_residues
MILDRRSFIKSAGAAAMAAALRGQQRQPNIVVILADDLGYGDLGCYGSPIATPNIDRLAEEGARFTSFYSASPVCSPSRA
ALMTGRYPTRVEVPVVLGPGDAGLPDSEITMAQVLKSAGYRTSCIGKWHIGSTPGYLPTNRGFDEFFGVPYSADITPCPL
MRGSSVVAPAVDCSTLTSSFTQEALDFMRRAQDNPFFLYLAHTAPHLPLAASPRFAGQSGLGMYADVVQELDWSTGQVMA
ALKATGLDSNTLVMFSSDNGPWYQGSQGKLRGRKGETYEGGMREPFLARYPGVIPSGIGCAGLATTMDLLPTLARLAGAQ
TPSNPLDGVDIWPVLTGERAEVDRDVFLYFDAVYLQCARLGRWKLHLSRYNTKAWSPLPPGGRVNLPLPRPELYDVVSDP
QESYDCAASHPAIVADIRARVERMVQTFPPGIIDAWQYTLSQKVIDAPVDGLPVPGGGQGG
>Mature_461_residues
MILDRRSFIKSAGAAAMAAALRGQQRQPNIVVILADDLGYGDLGCYGSPIATPNIDRLAEEGARFTSFYSASPVCSPSRA
ALMTGRYPTRVEVPVVLGPGDAGLPDSEITMAQVLKSAGYRTSCIGKWHIGSTPGYLPTNRGFDEFFGVPYSADITPCPL
MRGSSVVAPAVDCSTLTSSFTQEALDFMRRAQDNPFFLYLAHTAPHLPLAASPRFAGQSGLGMYADVVQELDWSTGQVMA
ALKATGLDSNTLVMFSSDNGPWYQGSQGKLRGRKGETYEGGMREPFLARYPGVIPSGIGCAGLATTMDLLPTLARLAGAQ
TPSNPLDGVDIWPVLTGERAEVDRDVFLYFDAVYLQCARLGRWKLHLSRYNTKAWSPLPPGGRVNLPLPRPELYDVVSDP
QESYDCAASHPAIVADIRARVERMVQTFPPGIIDAWQYTLSQKVIDAPVDGLPVPGGGQGG

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=423, Percent_Identity=41.6075650118203, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI146229329, Length=423, Percent_Identity=41.6075650118203, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI6005990, Length=423, Percent_Identity=41.6075650118203, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI146229324, Length=423, Percent_Identity=41.6075650118203, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI4503899, Length=397, Percent_Identity=40.8060453400504, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI45430057, Length=486, Percent_Identity=32.7160493827161, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI38569405, Length=465, Percent_Identity=31.3978494623656, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI109389362, Length=460, Percent_Identity=30.4347826086957, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI146229327, Length=353, Percent_Identity=37.3937677053824, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI59797060, Length=455, Percent_Identity=32.0879120879121, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI38569407, Length=343, Percent_Identity=35.5685131195335, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI53831991, Length=316, Percent_Identity=30.0632911392405, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI157266309, Length=140, Percent_Identity=47.1428571428571, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI71852586, Length=140, Percent_Identity=47.1428571428571, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI58743319, Length=140, Percent_Identity=47.8571428571429, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI71852584, Length=140, Percent_Identity=47.1428571428571, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI31742482, Length=168, Percent_Identity=43.452380952381, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1790233, Length=465, Percent_Identity=26.8817204301075, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87081924, Length=377, Percent_Identity=30.2387267904509, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1790112, Length=482, Percent_Identity=26.3485477178423, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI115533416, Length=445, Percent_Identity=28.314606741573, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI115533418, Length=437, Percent_Identity=28.1464530892449, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17559078, Length=245, Percent_Identity=38.3673469387755, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24666175, Length=378, Percent_Identity=33.3333333333333, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281366397, Length=516, Percent_Identity=30.0387596899225, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI281366395, Length=516, Percent_Identity=30.0387596899225, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24666163, Length=516, Percent_Identity=30.0387596899225, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24666109, Length=379, Percent_Identity=33.245382585752, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI281363223, Length=391, Percent_Identity=32.7365728900256, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 49501; Mature: 49501

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2 ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDRRSFIKSAGAAAMAAALRGQQRQPNIVVILADDLGYGDLGCYGSPIATPNIDRLAE
CCCCHHHHHHHCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHH
EGARFTSFYSASPVCSPSRAALMTGRYPTRVEVPVVLGPGDAGLPDSEITMAQVLKSAGY
CCCCEEEECCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCC
RTSCIGKWHIGSTPGYLPTNRGFDEFFGVPYSADITPCPLMRGSSVVAPAVDCSTLTSSF
CEEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
TQEALDFMRRAQDNPFFLYLAHTAPHLPLAASPRFAGQSGLGMYADVVQELDWSTGQVMA
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHH
ALKATGLDSNTLVMFSSDNGPWYQGSQGKLRGRKGETYEGGMREPFLARYPGVIPSGIGC
HHHHCCCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCH
AGLATTMDLLPTLARLAGAQTPSNPLDGVDIWPVLTGERAEVDRDVFLYFDAVYLQCARL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHCCCCEEEEEHHHHHHHHHHC
GRWKLHLSRYNTKAWSPLPPGGRVNLPLPRPELYDVVSDPQESYDCAASHPAIVADIRAR
CCEEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHCCCHHHCCCCCCCCHHHHHHHHH
VERMVQTFPPGIIDAWQYTLSQKVIDAPVDGLPVPGGGQGG
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MILDRRSFIKSAGAAAMAAALRGQQRQPNIVVILADDLGYGDLGCYGSPIATPNIDRLAE
CCCCHHHHHHHCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHH
EGARFTSFYSASPVCSPSRAALMTGRYPTRVEVPVVLGPGDAGLPDSEITMAQVLKSAGY
CCCCEEEECCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCC
RTSCIGKWHIGSTPGYLPTNRGFDEFFGVPYSADITPCPLMRGSSVVAPAVDCSTLTSSF
CEEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
TQEALDFMRRAQDNPFFLYLAHTAPHLPLAASPRFAGQSGLGMYADVVQELDWSTGQVMA
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHH
ALKATGLDSNTLVMFSSDNGPWYQGSQGKLRGRKGETYEGGMREPFLARYPGVIPSGIGC
HHHHCCCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCH
AGLATTMDLLPTLARLAGAQTPSNPLDGVDIWPVLTGERAEVDRDVFLYFDAVYLQCARL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHCCCCEEEEEHHHHHHHHHHC
GRWKLHLSRYNTKAWSPLPPGGRVNLPLPRPELYDVVSDPQESYDCAASHPAIVADIRAR
CCEEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHCCCHHHCCCCCCCCHHHHHHHHH
VERMVQTFPPGIIDAWQYTLSQKVIDAPVDGLPVPGGGQGG
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]