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The map label for this gene is lpxD [H]

Identifier: 116621963

GI number: 116621963

Start: 3608173

End: 3609201

Strand: Reverse

Name: lpxD [H]

Synonym: Acid_2848

Alternate gene names: 116621963

Gene position: 3609201-3608173 (Counterclockwise)

Preceding gene: 116621964

Following gene: 116621962

Centisome position: 36.22

GC content: 66.08

Gene sequence:

>1029_bases
ATGCGAGTTCGCGAATTGGCGGAATGGCTGGGAGCCACGTTTGAAGGCGATGGCGAGCGGGAGCTGACGGGCGTGGCGAC
GCTGGAATCGGCGGGCACGGAAGAGGTGGCGTTCGTAGGCAATCGCAAGGCGGCGGAGATGGCGGAAGCGTCAGCGGCGG
GCTGCCTGATTGTGCCGATGGAATGGCCCTCGCCCGCGTACCGAACGGTGATCCGGGCGGCAGAGCCAAGGACGGCGTTC
GCCCGCGCGATGAACCGATTTTATCCGACTGCGGAGTTGAAACCGGGCGTGCATCCGACGGCGGTGGTCGGAAAGGACGT
CGAGATGGCGGCGATGGTGTATGTGGGGCCGCACGCGACGGTGGGAGACGGGACGCGGATCGGAGTGGCCAGTTCGATCG
GGGCAGGCTGCATTGTGGGCAAGCGAGTCCAGATTGCGGAAGGGTGCGTGCTCCATCCCAATGTGACGGTGTACGACAAC
GTGGACATCGGGCGCGGCAGCGTGCTGCATTCGGGGTGCGTGATCGGTGCCGACGGGTTCGGGTACGTGATGGAGCACGG
GCGGTGGCACAAATTTCCCCAGGTGGGACGGGTGGAGATCGGGGACTTCGTGGAGATTGGGGCGAACTCGTGCGTGGACC
GCGCGGCGCTGGGCGTCACGTCGATCGGCGAAGGTACGAAGCTCGACAACATGGTGCACGTGGGGCACAACTGCCGGATC
GGGAAGCACGTGGTGGTGGCGGCGCAGACCGGATTTTCGGGCGGCGTGGTGGTGGAGGATTACGCGGTGATCGGCGGGCA
GGTGGGGATTGGCGACAAGGCGCGGATCGAGACGCGGGCGGTGCTGGGATCGGGCTGCGGGGTGCTGACGTCGAAGATCG
TGCGCAGTGGAGAGACGGTGTGGGGGACGCCGGCGCGGCCGTTGAAGCGTCATCTGGAAGAGCTGGCGAGTTTGGGGAGA
CTGCCCGAGCTGCGCAAGGAGATGAGCGATTTGAAGCGGCGGCTGGCAGAGTTGGAGAGGAAGGCCTGA

Upstream 100 bases:

>100_bases
TGTAGCGGCGCGTAAGCGGGCCAGTCCGGTGGCGGTGTGCAGGGCCACCACCGCGTCAGAACTACGGCCCGGATCCCGTC
CGGGGCGCTATGATCGTGGC

Downstream 100 bases:

>100_bases
ATGCTGGTGGTGGTGGGCGGTCACTCGAGAAACATCGGAAAGACGGGGCTCGCGGCGGGGCTGATCCGGCGGACGCGCGG
GATGAAGTGGACGGCGCTGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MRVRELAEWLGATFEGDGERELTGVATLESAGTEEVAFVGNRKAAEMAEASAAGCLIVPMEWPSPAYRTVIRAAEPRTAF
ARAMNRFYPTAELKPGVHPTAVVGKDVEMAAMVYVGPHATVGDGTRIGVASSIGAGCIVGKRVQIAEGCVLHPNVTVYDN
VDIGRGSVLHSGCVIGADGFGYVMEHGRWHKFPQVGRVEIGDFVEIGANSCVDRAALGVTSIGEGTKLDNMVHVGHNCRI
GKHVVVAAQTGFSGGVVVEDYAVIGGQVGIGDKARIETRAVLGSGCGVLTSKIVRSGETVWGTPARPLKRHLEELASLGR
LPELRKEMSDLKRRLAELERKA

Sequences:

>Translated_342_residues
MRVRELAEWLGATFEGDGERELTGVATLESAGTEEVAFVGNRKAAEMAEASAAGCLIVPMEWPSPAYRTVIRAAEPRTAF
ARAMNRFYPTAELKPGVHPTAVVGKDVEMAAMVYVGPHATVGDGTRIGVASSIGAGCIVGKRVQIAEGCVLHPNVTVYDN
VDIGRGSVLHSGCVIGADGFGYVMEHGRWHKFPQVGRVEIGDFVEIGANSCVDRAALGVTSIGEGTKLDNMVHVGHNCRI
GKHVVVAAQTGFSGGVVVEDYAVIGGQVGIGDKARIETRAVLGSGCGVLTSKIVRSGETVWGTPARPLKRHLEELASLGR
LPELRKEMSDLKRRLAELERKA
>Mature_342_residues
MRVRELAEWLGATFEGDGERELTGVATLESAGTEEVAFVGNRKAAEMAEASAAGCLIVPMEWPSPAYRTVIRAAEPRTAF
ARAMNRFYPTAELKPGVHPTAVVGKDVEMAAMVYVGPHATVGDGTRIGVASSIGAGCIVGKRVQIAEGCVLHPNVTVYDN
VDIGRGSVLHSGCVIGADGFGYVMEHGRWHKFPQVGRVEIGDFVEIGANSCVDRAALGVTSIGEGTKLDNMVHVGHNCRI
GKHVVVAAQTGFSGGVVVEDYAVIGGQVGIGDKARIETRAVLGSGCGVLTSKIVRSGETVWGTPARPLKRHLEELASLGR
LPELRKEMSDLKRRLAELERKA

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=341, Percent_Identity=34.0175953079179, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI1786378, Length=209, Percent_Identity=30.622009569378, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36236; Mature: 36236

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVRELAEWLGATFEGDGERELTGVATLESAGTEEVAFVGNRKAAEMAEASAAGCLIVPM
CCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHHHHCCCCEEEEEE
EWPSPAYRTVIRAAEPRTAFARAMNRFYPTAELKPGVHPTAVVGKDVEMAAMVYVGPHAT
CCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCHHEECCCCEEEEEEEECCCCC
VGDGTRIGVASSIGAGCIVGKRVQIAEGCVLHPNVTVYDNVDIGRGSVLHSGCVIGADGF
CCCCCEECCHHCCCCCEEECCEEECCCCEEECCCEEEEECCCCCCCCEEECCEEEECCCH
GYVMEHGRWHKFPQVGRVEIGDFVEIGANSCVDRAALGVTSIGEGTKLDNMVHVGHNCRI
HHHHHCCCCCCCCCCCCEECCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCC
GKHVVVAAQTGFSGGVVVEDYAVIGGQVGIGDKARIETRAVLGSGCGVLTSKIVRSGETV
CCEEEEEEECCCCCCEEEEEHEEECCEECCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCE
WGTPARPLKRHLEELASLGRLPELRKEMSDLKRRLAELERKA
ECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVRELAEWLGATFEGDGERELTGVATLESAGTEEVAFVGNRKAAEMAEASAAGCLIVPM
CCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHHHHCCCCEEEEEE
EWPSPAYRTVIRAAEPRTAFARAMNRFYPTAELKPGVHPTAVVGKDVEMAAMVYVGPHAT
CCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCHHEECCCCEEEEEEEECCCCC
VGDGTRIGVASSIGAGCIVGKRVQIAEGCVLHPNVTVYDNVDIGRGSVLHSGCVIGADGF
CCCCCEECCHHCCCCCEEECCEEECCCCEEECCCEEEEECCCCCCCCEEECCEEEECCCH
GYVMEHGRWHKFPQVGRVEIGDFVEIGANSCVDRAALGVTSIGEGTKLDNMVHVGHNCRI
HHHHHCCCCCCCCCCCCEECCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCC
GKHVVVAAQTGFSGGVVVEDYAVIGGQVGIGDKARIETRAVLGSGCGVLTSKIVRSGETV
CCEEEEEEECCCCCCEEEEEHEEECCEECCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCE
WGTPARPLKRHLEELASLGRLPELRKEMSDLKRRLAELERKA
ECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA