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The map label for this gene is bioI [H]

Identifier: 116621895

GI number: 116621895

Start: 3523398

End: 3524789

Strand: Reverse

Name: bioI [H]

Synonym: Acid_2780

Alternate gene names: 116621895

Gene position: 3524789-3523398 (Counterclockwise)

Preceding gene: 116621898

Following gene: 116621891

Centisome position: 35.37

GC content: 58.62

Gene sequence:

>1392_bases
ATGGCACGCTCATCCGGAGTCGAAGGATCGGTAAACGCAGGACCACTCGCGGTTAACCTGGCGTCTTCCAAATGCTCGTC
TTGGCGGGTAACGAGAACCTCCGCGGCCCGTGGGGTTCCTGATAAAATCCATGGCCATGCGGTTTCCAATCTCTCTGTCG
AAGGAACAGCGCTCGTGATCGACCTTTTCTCACCGGAAGTCCGGCGGAATCCCTGGCCTGTCTACGATCAGCTCCGCACG
GAGTCGCCGGTTCTGCATGTCCCGCCGCCATTCAACGGGTGGATGGTTTTCGATTACGAAACCGTGAAATGGATCATGAC
GGATCACGCGTCATTCAGTTCGCGGATTCCCGCGCCCAATTTCTCATTCATCTTCACCGACCCGCCCGACCATACCAGGT
TGCGGAACCTCATCTCGCGCGCATTCACGCCACGCGCAATTGCCGATCTGGAACCGGCTATCAATGATATCTCAAACGAA
TTATTTGACAGCGCTATGGCCGCCGGAAAGATGGAGTTCTCCGCGGAGTTCTCTGCCCCGCTTGCGATGAGAGTCATCGC
CAGTGTAGTGGGCATCGCGCCCGAGGACTGGCCGCGTTACAAGGGATGGAACGACAAACTCCTTGGTCTCACATTCAGCC
GAAGTGGAGGCGACCGGGCGCAAGAGGCGTTGCGTGATTTCAACAGCGTCACAGAAGAAATGAGCGTCTATCTGGCGGAA
AAGGTCGAGGAGCGGCGAAGCTCGCCGCGAAACGATTTGCTGACGCGCCTCCTCGAAGCGGAAGTGGACGGCGATCGTCT
GACGCACGAAGAGATACTCGCTTTTTTCCGGCTGCTGATGTTCGCCGGCCAGGAAACAACGATGAATCTGCTGAACAACG
CCGTCGTATGCTTTCTCGATCACCCGGACCAGCTATCGAAGCTGCGCAATGCGCCGCAACTTCTCCCGTCAGCGATTGAA
GAAGTGCTGCGCTACCGCTCGCCATTCCAATGGGCCATGCGTACACCGCTCCGCGATGTGGAGGTGCACGGCACCTTAAT
TCCGAAAGGCGCTTTTTTGCTTCCGGTGGCGGGTGCCGCAAATCGGGACCCGAAGTATTTTCCGCATCCCGACCGGTTCG
ATATCGCCCGCGACCCCAACCCTCATCTCGCATTCGGCCATGGCATCCATTTCTGCCTCGGCGCGGCCCTCGCACGTCTG
GAAGCGAGAATCGCATTGTCCGATCTGCTCTCGCGATTTGAGAGCTTTACATATGCAGGCGATGAGCCCTGGCAGCCGCG
CGAAGGCCTCATCGCGCACGGTCCCGCCAGCCTGCCGATCCGGTTCGAGGTGAAGCGAACGGACCCGGCCCACGTTCCAC
TTTCGCAAGTTGACCCGATCGCCTCCAGCTAA

Upstream 100 bases:

>100_bases
TACTCTCGTGAAGTCATCATCGCAACTGAAACGGGACGGAGCTGGCCGGCACTCCCGCGGTTTCGCCGTTTCCCGCCAAG
TTGACGCGGAACAGCTTTAC

Downstream 100 bases:

>100_bases
CGGCGCAGCGTTTACGAATCCTAGCGTATCGGCGTAACGCGGAGCGCGGCGCCGGAGAATTCCCCCGAGCGCACGGTGAC
GGGGACGGCTTGATTAACCG

Product: cytochrome P450

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MARSSGVEGSVNAGPLAVNLASSKCSSWRVTRTSAARGVPDKIHGHAVSNLSVEGTALVIDLFSPEVRRNPWPVYDQLRT
ESPVLHVPPPFNGWMVFDYETVKWIMTDHASFSSRIPAPNFSFIFTDPPDHTRLRNLISRAFTPRAIADLEPAINDISNE
LFDSAMAAGKMEFSAEFSAPLAMRVIASVVGIAPEDWPRYKGWNDKLLGLTFSRSGGDRAQEALRDFNSVTEEMSVYLAE
KVEERRSSPRNDLLTRLLEAEVDGDRLTHEEILAFFRLLMFAGQETTMNLLNNAVVCFLDHPDQLSKLRNAPQLLPSAIE
EVLRYRSPFQWAMRTPLRDVEVHGTLIPKGAFLLPVAGAANRDPKYFPHPDRFDIARDPNPHLAFGHGIHFCLGAALARL
EARIALSDLLSRFESFTYAGDEPWQPREGLIAHGPASLPIRFEVKRTDPAHVPLSQVDPIASS

Sequences:

>Translated_463_residues
MARSSGVEGSVNAGPLAVNLASSKCSSWRVTRTSAARGVPDKIHGHAVSNLSVEGTALVIDLFSPEVRRNPWPVYDQLRT
ESPVLHVPPPFNGWMVFDYETVKWIMTDHASFSSRIPAPNFSFIFTDPPDHTRLRNLISRAFTPRAIADLEPAINDISNE
LFDSAMAAGKMEFSAEFSAPLAMRVIASVVGIAPEDWPRYKGWNDKLLGLTFSRSGGDRAQEALRDFNSVTEEMSVYLAE
KVEERRSSPRNDLLTRLLEAEVDGDRLTHEEILAFFRLLMFAGQETTMNLLNNAVVCFLDHPDQLSKLRNAPQLLPSAIE
EVLRYRSPFQWAMRTPLRDVEVHGTLIPKGAFLLPVAGAANRDPKYFPHPDRFDIARDPNPHLAFGHGIHFCLGAALARL
EARIALSDLLSRFESFTYAGDEPWQPREGLIAHGPASLPIRFEVKRTDPAHVPLSQVDPIASS
>Mature_462_residues
ARSSGVEGSVNAGPLAVNLASSKCSSWRVTRTSAARGVPDKIHGHAVSNLSVEGTALVIDLFSPEVRRNPWPVYDQLRTE
SPVLHVPPPFNGWMVFDYETVKWIMTDHASFSSRIPAPNFSFIFTDPPDHTRLRNLISRAFTPRAIADLEPAINDISNEL
FDSAMAAGKMEFSAEFSAPLAMRVIASVVGIAPEDWPRYKGWNDKLLGLTFSRSGGDRAQEALRDFNSVTEEMSVYLAEK
VEERRSSPRNDLLTRLLEAEVDGDRLTHEEILAFFRLLMFAGQETTMNLLNNAVVCFLDHPDQLSKLRNAPQLLPSAIEE
VLRYRSPFQWAMRTPLRDVEVHGTLIPKGAFLLPVAGAANRDPKYFPHPDRFDIARDPNPHLAFGHGIHFCLGAALARLE
ARIALSDLLSRFESFTYAGDEPWQPREGLIAHGPASLPIRFEVKRTDPAHVPLSQVDPIASS

Specific function: Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid [H]

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI4503213, Length=191, Percent_Identity=29.8429319371728, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI13435386, Length=211, Percent_Identity=27.9620853080569, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI262290932, Length=196, Percent_Identity=27.0408163265306, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4503231, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45552577, Length=231, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24943083, Length=231, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17933518, Length=235, Percent_Identity=27.2340425531915, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: NA

Molecular weight: Translated: 51510; Mature: 51379

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSSGVEGSVNAGPLAVNLASSKCSSWRVTRTSAARGVPDKIHGHAVSNLSVEGTALVI
CCCCCCCCCCCCCCCEEEEECCCCCCCCEEEHHHHCCCCCHHHCCCEECCCEECCEEEEE
DLFSPEVRRNPWPVYDQLRTESPVLHVPPPFNGWMVFDYETVKWIMTDHASFSSRIPAPN
ECCCCHHCCCCCCHHHHHCCCCCEEECCCCCCCEEEEEHHHEEEEEECCCCHHCCCCCCC
FSFIFTDPPDHTRLRNLISRAFTPRAIADLEPAINDISNELFDSAMAAGKMEFSAEFSAP
CEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCH
LAMRVIASVVGIAPEDWPRYKGWNDKLLGLTFSRSGGDRAQEALRDFNSVTEEMSVYLAE
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KVEERRSSPRNDLLTRLLEAEVDGDRLTHEEILAFFRLLMFAGQETTMNLLNNAVVCFLD
HHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCEEEEEEC
HPDQLSKLRNAPQLLPSAIEEVLRYRSPFQWAMRTPLRDVEVHGTLIPKGAFLLPVAGAA
CCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEECCEECCCCCEEEEECCCC
NRDPKYFPHPDRFDIARDPNPHLAFGHGIHFCLGAALARLEARIALSDLLSRFESFTYAG
CCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DEPWQPREGLIAHGPASLPIRFEVKRTDPAHVPLSQVDPIASS
CCCCCCCCCEEECCCCCCCEEEEEECCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
ARSSGVEGSVNAGPLAVNLASSKCSSWRVTRTSAARGVPDKIHGHAVSNLSVEGTALVI
CCCCCCCCCCCCCCEEEEECCCCCCCCEEEHHHHCCCCCHHHCCCEECCCEECCEEEEE
DLFSPEVRRNPWPVYDQLRTESPVLHVPPPFNGWMVFDYETVKWIMTDHASFSSRIPAPN
ECCCCHHCCCCCCHHHHHCCCCCEEECCCCCCCEEEEEHHHEEEEEECCCCHHCCCCCCC
FSFIFTDPPDHTRLRNLISRAFTPRAIADLEPAINDISNELFDSAMAAGKMEFSAEFSAP
CEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCH
LAMRVIASVVGIAPEDWPRYKGWNDKLLGLTFSRSGGDRAQEALRDFNSVTEEMSVYLAE
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KVEERRSSPRNDLLTRLLEAEVDGDRLTHEEILAFFRLLMFAGQETTMNLLNNAVVCFLD
HHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCEEEEEEC
HPDQLSKLRNAPQLLPSAIEEVLRYRSPFQWAMRTPLRDVEVHGTLIPKGAFLLPVAGAA
CCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEECCEECCCCCEEEEECCCC
NRDPKYFPHPDRFDIARDPNPHLAFGHGIHFCLGAALARLEARIALSDLLSRFESFTYAG
CCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DEPWQPREGLIAHGPASLPIRFEVKRTDPAHVPLSQVDPIASS
CCCCCCCCCEEECCCCCCCEEEEEECCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]